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Protein

GRIP and coiled-coil domain-containing protein 1

Gene

GCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 1
Alternative name(s):
Golgi coiled-coil protein 1
Gene namesi
Name:GCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000179562.2
HGNCiHGNC:19095 GCC1
MIMi607418 gene
neXtProtiNX_Q96CN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79571
OpenTargetsiENSG00000179562
PharmGKBiPA38796

Polymorphism and mutation databases

BioMutaiGCC1
DMDMi32699595

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900721 – 775GRIP and coiled-coil domain-containing protein 1Add BLAST775

Proteomic databases

EPDiQ96CN9
MaxQBiQ96CN9
PaxDbiQ96CN9
PeptideAtlasiQ96CN9
PRIDEiQ96CN9
ProteomicsDBi76200

PTM databases

iPTMnetiQ96CN9
PhosphoSitePlusiQ96CN9

Expressioni

Gene expression databases

BgeeiENSG00000179562 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExiHS_GCC1
ExpressionAtlasiQ96CN9 baseline and differential
GenevisibleiQ96CN9 HS

Organism-specific databases

HPAiHPA019369
HPA021323

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122718, 58 interactors
IntActiQ96CN9, 89 interactors
MINTiQ96CN9
STRINGi9606.ENSP00000318821

Structurei

3D structure databases

ProteinModelPortaliQ96CN9
SMRiQ96CN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 763GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 61Sequence analysisAdd BLAST49
Coiled coili153 – 763Sequence analysisAdd BLAST611

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEHR Eukaryota
ENOG410Y6HA LUCA
GeneTreeiENSGT00440000039893
HOGENOMiHOG000252925
HOVERGENiHBG039459
InParanoidiQ96CN9
KOiK20281
OMAiAEDWKQE
OrthoDBiEOG091G0R8Q
PhylomeDBiQ96CN9
TreeFamiTF324186

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q96CN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTST KGEFGVEDDR PARGPPPPKS EEASWSESGV SSSSGDGPFA
160 170 180 190 200
GGEVDKRLHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
310 320 330 340 350
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ
410 420 430 440 450
LDLENKTLAL AASSRSPLDS HGEESSLDVN VLKDKMEKLK RLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DLEIMPSSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE LEHQHQQEAD
560 570 580 590 600
DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
610 620 630 640 650
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE
660 670 680 690 700
PTFFLYAEQL ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA
710 720 730 740 750
ALQSHIEKNI RDQSREGANL EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL
760 770
HFSPEEKQVI MRLPTSASWW PSGKR
Length:775
Mass (Da):87,811
Last modified:December 1, 2001 - v1
Checksum:iED72FF26BDF8DAD6
GO

Sequence cautioni

The sequence AAH08902 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB15218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02190286R → W. Corresponds to variant dbSNP:rs17151044Ensembl.1
Natural variantiVAR_02015787C → W. Corresponds to variant dbSNP:rs2285348Ensembl.1
Natural variantiVAR_049259122A → V. Corresponds to variant dbSNP:rs35322201Ensembl.1
Natural variantiVAR_049260262Q → R. Corresponds to variant dbSNP:rs35390108Ensembl.1
Natural variantiVAR_049261274A → T. Corresponds to variant dbSNP:rs34887879Ensembl.1
Natural variantiVAR_049262618R → C. Corresponds to variant dbSNP:rs34883586Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525417 mRNA Translation: AAM91948.1
BC008902 mRNA Translation: AAH08902.2 Sequence problems.
BC014100 mRNA Translation: AAH14100.1
BC078665 mRNA Translation: AAH78665.1
AK025688 mRNA Translation: BAB15218.1 Different initiation.
CCDSiCCDS5796.1
RefSeqiNP_078799.2, NM_024523.5
UniGeneiHs.521168

Genome annotation databases

EnsembliENST00000321407; ENSP00000318821; ENSG00000179562
GeneIDi79571
KEGGihsa:79571
UCSCiuc003vma.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525417 mRNA Translation: AAM91948.1
BC008902 mRNA Translation: AAH08902.2 Sequence problems.
BC014100 mRNA Translation: AAH14100.1
BC078665 mRNA Translation: AAH78665.1
AK025688 mRNA Translation: BAB15218.1 Different initiation.
CCDSiCCDS5796.1
RefSeqiNP_078799.2, NM_024523.5
UniGeneiHs.521168

3D structure databases

ProteinModelPortaliQ96CN9
SMRiQ96CN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122718, 58 interactors
IntActiQ96CN9, 89 interactors
MINTiQ96CN9
STRINGi9606.ENSP00000318821

PTM databases

iPTMnetiQ96CN9
PhosphoSitePlusiQ96CN9

Polymorphism and mutation databases

BioMutaiGCC1
DMDMi32699595

Proteomic databases

EPDiQ96CN9
MaxQBiQ96CN9
PaxDbiQ96CN9
PeptideAtlasiQ96CN9
PRIDEiQ96CN9
ProteomicsDBi76200

Protocols and materials databases

DNASUi79571
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321407; ENSP00000318821; ENSG00000179562
GeneIDi79571
KEGGihsa:79571
UCSCiuc003vma.4 human

Organism-specific databases

CTDi79571
DisGeNETi79571
EuPathDBiHostDB:ENSG00000179562.2
GeneCardsiGCC1
H-InvDBiHIX0007045
HIX0167842
HGNCiHGNC:19095 GCC1
HPAiHPA019369
HPA021323
MIMi607418 gene
neXtProtiNX_Q96CN9
OpenTargetsiENSG00000179562
PharmGKBiPA38796
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHR Eukaryota
ENOG410Y6HA LUCA
GeneTreeiENSGT00440000039893
HOGENOMiHOG000252925
HOVERGENiHBG039459
InParanoidiQ96CN9
KOiK20281
OMAiAEDWKQE
OrthoDBiEOG091G0R8Q
PhylomeDBiQ96CN9
TreeFamiTF324186

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiGCC1 human
GeneWikiiGCC1
GenomeRNAii79571
PROiPR:Q96CN9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179562 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExiHS_GCC1
ExpressionAtlasiQ96CN9 baseline and differential
GenevisibleiQ96CN9 HS

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCC1_HUMAN
AccessioniPrimary (citable) accession number: Q96CN9
Secondary accession number(s): Q9H6N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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