GCC1

Functionⁱ

Probably involved in maintaining Golgi structure.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Reactomeⁱ

R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GRIP and coiled-coil domain-containing protein 1 Alternative name(s): Golgi coiled-coil protein 1
Gene namesⁱ	Name:GCC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179562.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19095 GCC1
MIMⁱ	607418 gene
neXtProtⁱ	NX_Q96CN9

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79571
Open Targets More...OpenTargetsⁱ	ENSG00000179562
PharmGKBⁱ	PA38796

Polymorphism and mutation databases

BioMutaⁱ	GCC1
DMDMⁱ	32699595

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000190072	1 – 775	GRIP and coiled-coil domain-containing protein 1Add BLAST		775

Proteomic databases

EPDⁱ	Q96CN9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96CN9
PaxDbⁱ	Q96CN9
PeptideAtlas More...PeptideAtlasⁱ	Q96CN9
PRIDEⁱ	Q96CN9
ProteomicsDBⁱ	76200

PTM databases

iPTMnetⁱ	Q96CN9
PhosphoSitePlusⁱ	Q96CN9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179562 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_GCC1
ExpressionAtlasⁱ	Q96CN9 baseline and differential
Genevisibleⁱ	Q96CN9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019369 HPA021323

HPAⁱ

HPA019369
HPA021323

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ABI2	Q9NYB9	3	EBI-746252,EBI-743598
ATF4	P18848	5	EBI-746252,EBI-492498
BIRC2	Q13490	5	EBI-746252,EBI-514538
C1orf94	Q6P1W5	3	EBI-746252,EBI-946029
CEP57	Q86XR8	4	EBI-746252,EBI-308614
CEP70	Q8NHQ1	5	EBI-746252,EBI-739624
DNAJA3	Q96EY1-2	3	EBI-746252,EBI-3952284
GLI1	P08151	3	EBI-746252,EBI-308084
GOLGA2	Q08379	5	EBI-746252,EBI-618309
KIAA0753	Q2KHM9	3	EBI-746252,EBI-2805604
LZTS2	Q9BRK4	3	EBI-746252,EBI-741037
NAB2	Q15742	3	EBI-746252,EBI-8641936
NAV1	Q8NEY1-4	3	EBI-746252,EBI-10270828
NECAB2	Q7Z6G3-2	3	EBI-746252,EBI-10172876
OIP5	O43482	3	EBI-746252,EBI-536879
PAK5	Q9P286	3	EBI-746252,EBI-741896
TFIP11	Q9UBB9	3	EBI-746252,EBI-1105213
TRIM29	Q14134	2	EBI-746252,EBI-702370
ZNF276	Q8N554-2	3	EBI-746252,EBI-10265849

Protein-protein interaction databases

BioGridⁱ	122718, 58 interactors
IntActⁱ	Q96CN9, 89 interactors
Molecular INTeraction database More...MINTⁱ	Q96CN9
STRINGⁱ	9606.ENSP00000318821

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96CN9
SMRⁱ	Q96CN9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	713 – 763	GRIPPROSITE-ProRule annotationAdd BLAST		51

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	13 – 61	Sequence analysisAdd BLAST		49
Coiled coilⁱ	153 – 763	Sequence analysisAdd BLAST		611

Domainⁱ

Extended rod-like protein with coiled-coil domains.

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEHR Eukaryota ENOG410Y6HA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039893
HOGENOMⁱ	HOG000252925
HOVERGENⁱ	HBG039459
InParanoidⁱ	Q96CN9
KEGG Orthology (KO) More...KOⁱ	K20281
OMAⁱ	AEDWKQE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R8Q
PhylomeDBⁱ	Q96CN9
TreeFamⁱ	TF324186

Family and domain databases

InterProⁱ	View protein in InterPro IPR000237 GRIP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01465 GRIP, 1 hit
SMARTⁱ	View protein in SMART SM00755 Grip, 1 hit
PROSITEⁱ	View protein in PROSITE PS50913 GRIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96CN9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE 
        60         70         80         90        100
ALEASIKVLS VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS 
       110        120        130        140        150
LDTAASLTST KGEFGVEDDR PARGPPPPKS EEASWSESGV SSSSGDGPFA 
       160        170        180        190        200
GGEVDKRLHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA 
       210        220        230        240        250
SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL 
       260        270        280        290        300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE 
       310        320        330        340        350
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED 
       360        370        380        390        400
QLRQQSQVEE QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ 
       410        420        430        440        450
LDLENKTLAL AASSRSPLDS HGEESSLDVN VLKDKMEKLK RLLQVAARKS 
       460        470        480        490        500
QVTLDVEKLC DLEIMPSSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ 
       510        520        530        540        550
VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE LEHQHQQEAD 
       560        570        580        590        600
DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD 
       610        620        630        640        650
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE 
       660        670        680        690        700
PTFFLYAEQL ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA 
       710        720        730        740        750
ALQSHIEKNI RDQSREGANL EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL 
       760        770 
HFSPEEKQVI MRLPTSASWW PSGKR

Length:775

Mass (Da):87,811

Last modified:December 1, 2001 - v1

Checksum:ⁱED72FF26BDF8DAD6

GO

Sequence cautionⁱ

The sequence AAH08902 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

The sequence BAB15218 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021902	86	R → W. Corresponds to variant dbSNP:rs17151044Ensembl.	1
Natural variantⁱVAR_020157	87	C → W. Corresponds to variant dbSNP:rs2285348Ensembl.	1
Natural variantⁱVAR_049259	122	A → V. Corresponds to variant dbSNP:rs35322201Ensembl.	1
Natural variantⁱVAR_049260	262	Q → R. Corresponds to variant dbSNP:rs35390108Ensembl.	1
Natural variantⁱVAR_049261	274	A → T. Corresponds to variant dbSNP:rs34887879Ensembl.	1
Natural variantⁱVAR_049262	618	R → C. Corresponds to variant dbSNP:rs34883586Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525417 mRNA Translation: AAM91948.1 BC008902 mRNA Translation: AAH08902.2 Sequence problems. BC014100 mRNA Translation: AAH14100.1 BC078665 mRNA Translation: AAH78665.1 AK025688 mRNA Translation: BAB15218.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5796.1
NCBI Reference Sequences More...RefSeqⁱ	NP_078799.2, NM_024523.5
UniGeneⁱ	Hs.521168

Genome annotation databases

Ensemblⁱ	ENST00000321407; ENSP00000318821; ENSG00000179562
GeneIDⁱ	79571
KEGGⁱ	hsa:79571
UCSC genome browser More...UCSCⁱ	uc003vma.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96CN9	GRIP and coiled-coil domain containing 1		HUMAN		775	UniRef100_Q96CN9

Protein	Similar proteins		Species	Score	Length	Source
Q96CN9	GRIP and coiled-coil domain-containing protein 1		MOUSE		778	UniRef90_Q96CN9
GRIP and coiled-coil domain containing 1		HUMAN		775
Uncharacterized protein		NEOLE		781
GRIP and coiled-coil domain-containing 1		RAT		778
GRIP and coiled-coil domain-containing protein 1		MESAU		778
+140

Protein	Similar proteins		Species	Score	Length	Source
Q96CN9	GRIP and coiled-coil domain-containing protein 1		MOUSE		778	UniRef50_Q96CN9
GRIP and coiled-coil domain containing 1		HUMAN		775
Uncharacterized protein		NEOLE		781
GRIP and coiled-coil domain-containing 1		RAT		778
GRIP and coiled-coil domain-containing protein 1		CRIGR		778
+254

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525417 mRNA Translation: AAM91948.1 BC008902 mRNA Translation: AAH08902.2 Sequence problems. BC014100 mRNA Translation: AAH14100.1 BC078665 mRNA Translation: AAH78665.1 AK025688 mRNA Translation: BAB15218.1 Different initiation.
CCDSⁱ	CCDS5796.1
RefSeqⁱ	NP_078799.2, NM_024523.5
UniGeneⁱ	Hs.521168

3D structure databases

ProteinModelPortalⁱ	Q96CN9
SMRⁱ	Q96CN9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122718, 58 interactors
IntActⁱ	Q96CN9, 89 interactors
MINTⁱ	Q96CN9
STRINGⁱ	9606.ENSP00000318821

PTM databases

iPTMnetⁱ	Q96CN9
PhosphoSitePlusⁱ	Q96CN9

Polymorphism and mutation databases

BioMutaⁱ	GCC1
DMDMⁱ	32699595

Proteomic databases

EPDⁱ	Q96CN9
MaxQBⁱ	Q96CN9
PaxDbⁱ	Q96CN9
PeptideAtlasⁱ	Q96CN9
PRIDEⁱ	Q96CN9
ProteomicsDBⁱ	76200

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79571
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000321407; ENSP00000318821; ENSG00000179562
GeneIDⁱ	79571
KEGGⁱ	hsa:79571
UCSCⁱ	uc003vma.4 human

Organism-specific databases

CTDⁱ	79571
DisGeNETⁱ	79571
EuPathDBⁱ	HostDB:ENSG00000179562.2
GeneCardsⁱ	GCC1
H-InvDBⁱ	HIX0007045 HIX0167842
HGNCⁱ	HGNC:19095 GCC1
HPAⁱ	HPA019369 HPA021323
MIMⁱ	607418 gene
neXtProtⁱ	NX_Q96CN9
OpenTargetsⁱ	ENSG00000179562
PharmGKBⁱ	PA38796
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEHR Eukaryota ENOG410Y6HA LUCA
GeneTreeⁱ	ENSGT00440000039893
HOGENOMⁱ	HOG000252925
HOVERGENⁱ	HBG039459
InParanoidⁱ	Q96CN9
KOⁱ	K20281
OMAⁱ	AEDWKQE
OrthoDBⁱ	EOG091G0R8Q
PhylomeDBⁱ	Q96CN9
TreeFamⁱ	TF324186

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Reactomeⁱ

R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSⁱ	GCC1 human
GeneWikiⁱ	GCC1
GenomeRNAiⁱ	79571
Protein Ontology More...PROⁱ	PR:Q96CN9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179562 Expressed in 209 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_GCC1
ExpressionAtlasⁱ	Q96CN9 baseline and differential
Genevisibleⁱ	Q96CN9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000237 GRIP_dom
Pfamⁱ	View protein in Pfam PF01465 GRIP, 1 hit
SMARTⁱ	View protein in SMART SM00755 Grip, 1 hit
PROSITEⁱ	View protein in PROSITE PS50913 GRIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GCC1_HUMAN
Accessionⁱ	Q96CN9Primary (citable) accession number: Q96CN9 Secondary accession number(s): Q9H6N7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q96CN9 (GCC1_HUMAN)

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GRIP and coiled-coil domain-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Cytosol

Golgi apparatus

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ