UniProtKB - Q96CN9 (GCC1_HUMAN)
Protein
GRIP and coiled-coil domain-containing protein 1
Gene
GCC1
Organism
Homo sapiens (Human)
Status
Functioni
Probably involved in maintaining Golgi structure.
GO - Molecular functioni
- ADP-ribosylation factor binding Source: FlyBase
- Rab GTPase binding Source: FlyBase
Enzyme and pathway databases
PathwayCommonsi | Q96CN9 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SIGNORi | Q96CN9 |
Names & Taxonomyi
Protein namesi | Recommended name: GRIP and coiled-coil domain-containing protein 1Alternative name(s): Golgi coiled-coil protein 1 |
Gene namesi | Name:GCC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19095, GCC1 |
MIMi | 607418, gene |
neXtProti | NX_Q96CN9 |
VEuPathDBi | HostDB:ENSG00000179562.2 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB-SubCell
- Golgi trans cisterna Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79571 |
OpenTargetsi | ENSG00000179562 |
PharmGKBi | PA38796 |
Miscellaneous databases
Pharosi | Q96CN9, Tbio |
Genetic variation databases
BioMutai | GCC1 |
DMDMi | 32699595 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190072 | 1 – 775 | GRIP and coiled-coil domain-containing protein 1Add BLAST | 775 |
Proteomic databases
EPDi | Q96CN9 |
jPOSTi | Q96CN9 |
MassIVEi | Q96CN9 |
MaxQBi | Q96CN9 |
PaxDbi | Q96CN9 |
PeptideAtlasi | Q96CN9 |
PRIDEi | Q96CN9 |
ProteomicsDBi | 76200 |
PTM databases
iPTMneti | Q96CN9 |
MetOSitei | Q96CN9 |
PhosphoSitePlusi | Q96CN9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179562, Expressed in testis and 223 other tissues |
ExpressionAtlasi | Q96CN9, baseline and differential |
Genevisiblei | Q96CN9, HS |
Organism-specific databases
HPAi | ENSG00000179562, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96CN9
GO - Molecular functioni
- ADP-ribosylation factor binding Source: FlyBase
- Rab GTPase binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 122718, 94 interactors |
IntActi | Q96CN9, 89 interactors |
MINTi | Q96CN9 |
STRINGi | 9606.ENSP00000318821 |
Miscellaneous databases
RNActi | Q96CN9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 713 – 763 | GRIPPROSITE-ProRule annotationAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 61 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 153 – 763 | Sequence analysisAdd BLAST | 611 |
Domaini
Extended rod-like protein with coiled-coil domains.
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ2S, Eukaryota |
GeneTreei | ENSGT00940000153772 |
HOGENOMi | CLU_020679_0_0_1 |
InParanoidi | Q96CN9 |
OMAi | FQADKKQ |
OrthoDBi | 979102at2759 |
PhylomeDBi | Q96CN9 |
TreeFami | TF324186 |
Family and domain databases
InterProi | View protein in InterPro IPR000237, GRIP_dom |
Pfami | View protein in Pfam PF01465, GRIP, 1 hit |
SMARTi | View protein in SMART SM00755, Grip, 1 hit |
PROSITEi | View protein in PROSITE PS50913, GRIP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96CN9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTST KGEFGVEDDR PARGPPPPKS EEASWSESGV SSSSGDGPFA
160 170 180 190 200
GGEVDKRLHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
310 320 330 340 350
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ
410 420 430 440 450
LDLENKTLAL AASSRSPLDS HGEESSLDVN VLKDKMEKLK RLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DLEIMPSSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE LEHQHQQEAD
560 570 580 590 600
DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
610 620 630 640 650
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE
660 670 680 690 700
PTFFLYAEQL ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA
710 720 730 740 750
ALQSHIEKNI RDQSREGANL EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL
760 770
HFSPEEKQVI MRLPTSASWW PSGKR
Sequence cautioni
The sequence AAH08902 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAB15218 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021902 | 86 | R → W. Corresponds to variant dbSNP:rs17151044Ensembl. | 1 | |
Natural variantiVAR_020157 | 87 | C → W. Corresponds to variant dbSNP:rs2285348Ensembl. | 1 | |
Natural variantiVAR_049259 | 122 | A → V. Corresponds to variant dbSNP:rs35322201Ensembl. | 1 | |
Natural variantiVAR_049260 | 262 | Q → R. Corresponds to variant dbSNP:rs35390108Ensembl. | 1 | |
Natural variantiVAR_049261 | 274 | A → T. Corresponds to variant dbSNP:rs34887879Ensembl. | 1 | |
Natural variantiVAR_049262 | 618 | R → C. Corresponds to variant dbSNP:rs34883586Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF525417 mRNA Translation: AAM91948.1 BC008902 mRNA Translation: AAH08902.2 Sequence problems. BC014100 mRNA Translation: AAH14100.1 BC078665 mRNA Translation: AAH78665.1 AK025688 mRNA Translation: BAB15218.1 Different initiation. |
CCDSi | CCDS5796.1 |
RefSeqi | NP_078799.2, NM_024523.5 |
Genome annotation databases
Ensembli | ENST00000321407; ENSP00000318821; ENSG00000179562 |
GeneIDi | 79571 |
KEGGi | hsa:79571 |
UCSCi | uc003vma.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF525417 mRNA Translation: AAM91948.1 BC008902 mRNA Translation: AAH08902.2 Sequence problems. BC014100 mRNA Translation: AAH14100.1 BC078665 mRNA Translation: AAH78665.1 AK025688 mRNA Translation: BAB15218.1 Different initiation. |
CCDSi | CCDS5796.1 |
RefSeqi | NP_078799.2, NM_024523.5 |
3D structure databases
SMRi | Q96CN9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122718, 94 interactors |
IntActi | Q96CN9, 89 interactors |
MINTi | Q96CN9 |
STRINGi | 9606.ENSP00000318821 |
PTM databases
iPTMneti | Q96CN9 |
MetOSitei | Q96CN9 |
PhosphoSitePlusi | Q96CN9 |
Genetic variation databases
BioMutai | GCC1 |
DMDMi | 32699595 |
Proteomic databases
EPDi | Q96CN9 |
jPOSTi | Q96CN9 |
MassIVEi | Q96CN9 |
MaxQBi | Q96CN9 |
PaxDbi | Q96CN9 |
PeptideAtlasi | Q96CN9 |
PRIDEi | Q96CN9 |
ProteomicsDBi | 76200 |
Protocols and materials databases
Antibodypediai | 17726, 152 antibodies |
DNASUi | 79571 |
Genome annotation databases
Ensembli | ENST00000321407; ENSP00000318821; ENSG00000179562 |
GeneIDi | 79571 |
KEGGi | hsa:79571 |
UCSCi | uc003vma.4, human |
Organism-specific databases
CTDi | 79571 |
DisGeNETi | 79571 |
GeneCardsi | GCC1 |
HGNCi | HGNC:19095, GCC1 |
HPAi | ENSG00000179562, Low tissue specificity |
MIMi | 607418, gene |
neXtProti | NX_Q96CN9 |
OpenTargetsi | ENSG00000179562 |
PharmGKBi | PA38796 |
VEuPathDBi | HostDB:ENSG00000179562.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ2S, Eukaryota |
GeneTreei | ENSGT00940000153772 |
HOGENOMi | CLU_020679_0_0_1 |
InParanoidi | Q96CN9 |
OMAi | FQADKKQ |
OrthoDBi | 979102at2759 |
PhylomeDBi | Q96CN9 |
TreeFami | TF324186 |
Enzyme and pathway databases
PathwayCommonsi | Q96CN9 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SIGNORi | Q96CN9 |
Miscellaneous databases
BioGRID-ORCSi | 79571, 5 hits in 873 CRISPR screens |
ChiTaRSi | GCC1, human |
GeneWikii | GCC1 |
GenomeRNAii | 79571 |
Pharosi | Q96CN9, Tbio |
PROi | PR:Q96CN9 |
RNActi | Q96CN9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179562, Expressed in testis and 223 other tissues |
ExpressionAtlasi | Q96CN9, baseline and differential |
Genevisiblei | Q96CN9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000237, GRIP_dom |
Pfami | View protein in Pfam PF01465, GRIP, 1 hit |
SMARTi | View protein in SMART SM00755, Grip, 1 hit |
PROSITEi | View protein in PROSITE PS50913, GRIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GCC1_HUMAN | |
Accessioni | Q96CN9Primary (citable) accession number: Q96CN9 Secondary accession number(s): Q9H6N7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM