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Entry version 139 (22 Apr 2020)
Sequence version 3 (12 Dec 2006)
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Protein

Isochorismatase domain-containing protein 1

Gene

ISOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Isochorismatase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ISOC1
ORF Names:CGI-111
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24254 ISOC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000066583

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973470

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96CN7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ISOC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119371160

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002686641 – 298Isochorismatase domain-containing protein 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphotyrosineBy similarity1
Modified residuei279N6-succinyllysineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-84
CPTAC-85

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96CN7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96CN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96CN7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CN7

PeptideAtlas

More...
PeptideAtlasi
Q96CN7

PRoteomics IDEntifications database

More...
PRIDEi
Q96CN7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066583 Expressed in myometrium and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96CN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000066583 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119222, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q96CN7, 15 interactors

Molecular INTeraction database

More...
MINTi
Q96CN7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000173527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96CN7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96CN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4044 Eukaryota
ENOG4111I3F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047255_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CN7

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSEEWGQ

Database of Orthologous Groups

More...
OrthoDBi
1100720at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CN7

TreeFam database of animal gene trees

More...
TreeFami
TF313459

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.850, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000868 Isochorismatase-like
IPR036380 Isochorismatase-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00857 Isochorismatase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52499 SSF52499, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96CN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL
60 70 80 90 100
IQKFLSLYGD QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL
110 120 130 140 150
QIQLTTLGNL TPSSTVFFCC DMQERFRPAI KYFGDIISVG QRLLQGARIL
160 170 180 190 200
GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL PKTKFSMVLP EVEAALAEIP
210 220 230 240 250
GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR SMMDRMFALE
260 270 280 290
RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV
Length:298
Mass (Da):32,237
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9843DA1A40E1BDA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGE2D6RGE2_HUMAN
Isochorismatase domain-containing p...
ISOC1
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08367 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH14105 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC008367 mRNA Translation: AAH08367.1 Different initiation.
BC014105 mRNA Translation: AAH14105.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43357.1

NCBI Reference Sequences

More...
RefSeqi
NP_057132.2, NM_016048.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000173527; ENSP00000173527; ENSG00000066583

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51015

UCSC genome browser

More...
UCSCi
uc003kva.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008367 mRNA Translation: AAH08367.1 Different initiation.
BC014105 mRNA Translation: AAH14105.2 Different initiation.
CCDSiCCDS43357.1
RefSeqiNP_057132.2, NM_016048.2

3D structure databases

SMRiQ96CN7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119222, 50 interactors
IntActiQ96CN7, 15 interactors
MINTiQ96CN7
STRINGi9606.ENSP00000173527

PTM databases

iPTMnetiQ96CN7
PhosphoSitePlusiQ96CN7

Polymorphism and mutation databases

BioMutaiISOC1
DMDMi119371160

Proteomic databases

CPTACiCPTAC-84
CPTAC-85
EPDiQ96CN7
jPOSTiQ96CN7
MassIVEiQ96CN7
MaxQBiQ96CN7
PaxDbiQ96CN7
PeptideAtlasiQ96CN7
PRIDEiQ96CN7
ProteomicsDBi76199

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q96CN7

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63783 49 antibodies

The DNASU plasmid repository

More...
DNASUi
51015

Genome annotation databases

EnsembliENST00000173527; ENSP00000173527; ENSG00000066583
GeneIDi51015
KEGGihsa:51015
UCSCiuc003kva.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51015

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ISOC1
HGNCiHGNC:24254 ISOC1
HPAiENSG00000066583 Low tissue specificity
neXtProtiNX_Q96CN7
OpenTargetsiENSG00000066583
PharmGKBiPA134973470

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4044 Eukaryota
ENOG4111I3F LUCA
GeneTreeiENSGT00390000006753
HOGENOMiCLU_047255_0_0_1
InParanoidiQ96CN7
OMAiFSEEWGQ
OrthoDBi1100720at2759
PhylomeDBiQ96CN7
TreeFamiTF313459

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ISOC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51015
PharosiQ96CN7 Tdark

Protein Ontology

More...
PROi
PR:Q96CN7
RNActiQ96CN7 protein

Gene expression databases

BgeeiENSG00000066583 Expressed in myometrium and 218 other tissues
ExpressionAtlasiQ96CN7 baseline and differential
GenevisibleiQ96CN7 HS

Family and domain databases

Gene3Di3.40.50.850, 1 hit
InterProiView protein in InterPro
IPR000868 Isochorismatase-like
IPR036380 Isochorismatase-like_sf
PfamiView protein in Pfam
PF00857 Isochorismatase, 1 hit
SUPFAMiSSF52499 SSF52499, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiISOC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CN7
Secondary accession number(s): Q7Z770
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 22, 2020
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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