UniProtKB - Q96CN4 (EVI5L_HUMAN)
Protein
EVI5-like protein
Gene
EVI5L
Organism
Homo sapiens (Human)
Status
Functioni
Functions as a GTPase-activating protein (GAP) with a broad specificity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 156 | Arginine fingerBy similarity | 1 | |
Sitei | 197 | Glutamine fingerBy similarity | 1 |
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB
- Rab GTPase binding Source: UniProtKB
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
- negative regulation of cilium assembly Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q96CN4 |
Names & Taxonomyi
Protein namesi | Recommended name: EVI5-like proteinAlternative name(s): Ecotropic viral integration site 5-like protein |
Gene namesi | Name:EVI5L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000142459.8 |
HGNCi | HGNC:30464, EVI5L |
neXtProti | NX_Q96CN4 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 115704 |
OpenTargetsi | ENSG00000142459 |
PharmGKBi | PA134905968 |
Miscellaneous databases
Pharosi | Q96CN4, Tbio |
Polymorphism and mutation databases
BioMutai | EVI5L |
DMDMi | 74731362 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263097 | 1 – 794 | EVI5-like proteinAdd BLAST | 794 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 685 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96CN4 |
jPOSTi | Q96CN4 |
MassIVEi | Q96CN4 |
MaxQBi | Q96CN4 |
PaxDbi | Q96CN4 |
PeptideAtlasi | Q96CN4 |
PRIDEi | Q96CN4 |
ProteomicsDBi | 76196 [Q96CN4-1] 76197 [Q96CN4-2] |
PTM databases
iPTMneti | Q96CN4 |
PhosphoSitePlusi | Q96CN4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142459, Expressed in cerebellum and 207 other tissues |
ExpressionAtlasi | Q96CN4, baseline and differential |
Genevisiblei | Q96CN4, HS |
Organism-specific databases
HPAi | ENSG00000142459, Low tissue specificity |
Interactioni
Subunit structurei
May interact with RAB10.
Binary interactionsi
Hide detailsQ96CN4
GO - Molecular functioni
- Rab GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125449, 42 interactors |
IntActi | Q96CN4, 35 interactors |
STRINGi | 9606.ENSP00000445905 |
Miscellaneous databases
RNActi | Q96CN4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 300 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 186 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 358 – 449 | Sequence analysisAdd BLAST | 92 | |
Coiled coili | 569 – 709 | Sequence analysisAdd BLAST | 141 |
Domaini
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4436, Eukaryota |
GeneTreei | ENSGT00940000153846 |
HOGENOMi | CLU_005350_6_0_1 |
InParanoidi | Q96CN4 |
OMAi | DSMAVMA |
OrthoDBi | 191811at2759 |
PhylomeDBi | Q96CN4 |
TreeFami | TF317184 |
Family and domain databases
InterProi | View protein in InterPro IPR031214, Evi5 IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
PANTHERi | PTHR22957:SF254, PTHR22957:SF254, 1 hit |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96CN4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPTLSPDS SSQEALSAPT CSPTSDSENL SPDELELLAK LEEQNRLLEA
60 70 80 90 100
DSKSMRSMNG SRRNSGSSLV SSSSASSNLS HLEEDTWILW GRIANEWEEW
110 120 130 140 150
RRRKEKLLKE LIRKGIPHHF RAIVWQLLCS ATDMPVKNQY SELLKMSSPC
160 170 180 190 200
EKLIRRDIAR TYPEHEFFKG QDSLGQEVLF NVMKAYSLVD REVGYCQGSA
210 220 230 240 250
FIVGLLLMQM PEEEAFCVFV RLMQEYRLRE LFKPSMAELG LCIYQFEYML
260 270 280 290 300
QEQLPDLNTH FRSQSFHTSM YASSWFLTLF LTTFPLPVAT RVFDIFMYEG
310 320 330 340 350
LEIVFRVGLA LLQVNQAELM QLDMEGMSQY FQRVIPHQFD SCPDKLVLKA
360 370 380 390 400
YQVKYNPKKM KRLEKEYAAM KSKEMEEQIE IKRLRTENRL LKQRIETLEK
410 420 430 440 450
GQVTRAQEAE ENYVIKRELA VVRQQCSSAA EDLQKAQSTI RQLQEQQENP
460 470 480 490 500
RLTEDFVSHL ETELEQSRLR ETETLGALRE MQDKVLDMEK RNSSLPDENN
510 520 530 540 550
VAQLQEELKA LKVREGQAVA STRELKLQLQ ELSDTWQAHL ARGGRWKESP
560 570 580 590 600
RKLVVGELQD ELMSVRLREA QALAEGRELR QRVVELETQD HIHRNLLNRV
610 620 630 640 650
EAERAALQEK LQYLAAQNKG LQTQLSESRR KQAEAECKSK EEVMAVRLRE
660 670 680 690 700
ADSMAAVAEM RQRIAELEIQ REEGRIQGQL NHSDSSQYIR ELKDQIEELK
710 720 730 740 750
AEVRLLKGPP PFEDPLAFDG LSLARHLDED SLPSSDEELL GVGVGAALQD
760 770 780 790
ALYPLSPRDA RFFRRLERPA KDSEGSSDSD ADELAAPYSQ GLDN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R1Y1 | M0R1Y1_HUMAN | EVI5-like protein | EVI5L | 177 | Annotation score: | ||
M0QYX4 | M0QYX4_HUMAN | EVI5-like protein | EVI5L | 139 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043456 | 400 | K → KESAALADRLIQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB449874 mRNA Translation: BAH16617.1 AC008812 Genomic DNA No translation available. AC010336 Genomic DNA No translation available. BC014111 mRNA Translation: AAH14111.1 |
CCDSi | CCDS12188.1 [Q96CN4-1] CCDS54209.1 [Q96CN4-2] |
RefSeqi | NP_001153416.1, NM_001159944.2 [Q96CN4-2] NP_660288.1, NM_145245.4 [Q96CN4-1] XP_005272515.1, XM_005272458.4 XP_016881728.1, XM_017026239.1 [Q96CN4-2] |
Genome annotation databases
Ensembli | ENST00000270530; ENSP00000270530; ENSG00000142459 [Q96CN4-1] ENST00000538904; ENSP00000445905; ENSG00000142459 [Q96CN4-2] |
GeneIDi | 115704 |
KEGGi | hsa:115704 |
UCSCi | uc002min.4, human [Q96CN4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB449874 mRNA Translation: BAH16617.1 AC008812 Genomic DNA No translation available. AC010336 Genomic DNA No translation available. BC014111 mRNA Translation: AAH14111.1 |
CCDSi | CCDS12188.1 [Q96CN4-1] CCDS54209.1 [Q96CN4-2] |
RefSeqi | NP_001153416.1, NM_001159944.2 [Q96CN4-2] NP_660288.1, NM_145245.4 [Q96CN4-1] XP_005272515.1, XM_005272458.4 XP_016881728.1, XM_017026239.1 [Q96CN4-2] |
3D structure databases
SMRi | Q96CN4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125449, 42 interactors |
IntActi | Q96CN4, 35 interactors |
STRINGi | 9606.ENSP00000445905 |
PTM databases
iPTMneti | Q96CN4 |
PhosphoSitePlusi | Q96CN4 |
Polymorphism and mutation databases
BioMutai | EVI5L |
DMDMi | 74731362 |
Proteomic databases
EPDi | Q96CN4 |
jPOSTi | Q96CN4 |
MassIVEi | Q96CN4 |
MaxQBi | Q96CN4 |
PaxDbi | Q96CN4 |
PeptideAtlasi | Q96CN4 |
PRIDEi | Q96CN4 |
ProteomicsDBi | 76196 [Q96CN4-1] 76197 [Q96CN4-2] |
Protocols and materials databases
Antibodypediai | 24676, 83 antibodies |
Genome annotation databases
Ensembli | ENST00000270530; ENSP00000270530; ENSG00000142459 [Q96CN4-1] ENST00000538904; ENSP00000445905; ENSG00000142459 [Q96CN4-2] |
GeneIDi | 115704 |
KEGGi | hsa:115704 |
UCSCi | uc002min.4, human [Q96CN4-1] |
Organism-specific databases
CTDi | 115704 |
DisGeNETi | 115704 |
EuPathDBi | HostDB:ENSG00000142459.8 |
GeneCardsi | EVI5L |
HGNCi | HGNC:30464, EVI5L |
HPAi | ENSG00000142459, Low tissue specificity |
neXtProti | NX_Q96CN4 |
OpenTargetsi | ENSG00000142459 |
PharmGKBi | PA134905968 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4436, Eukaryota |
GeneTreei | ENSGT00940000153846 |
HOGENOMi | CLU_005350_6_0_1 |
InParanoidi | Q96CN4 |
OMAi | DSMAVMA |
OrthoDBi | 191811at2759 |
PhylomeDBi | Q96CN4 |
TreeFami | TF317184 |
Enzyme and pathway databases
PathwayCommonsi | Q96CN4 |
Miscellaneous databases
BioGRID-ORCSi | 115704, 3 hits in 843 CRISPR screens |
ChiTaRSi | EVI5L, human |
GenomeRNAii | 115704 |
Pharosi | Q96CN4, Tbio |
PROi | PR:Q96CN4 |
RNActi | Q96CN4, protein |
Gene expression databases
Bgeei | ENSG00000142459, Expressed in cerebellum and 207 other tissues |
ExpressionAtlasi | Q96CN4, baseline and differential |
Genevisiblei | Q96CN4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031214, Evi5 IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
PANTHERi | PTHR22957:SF254, PTHR22957:SF254, 1 hit |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EVI5L_HUMAN | |
Accessioni | Q96CN4Primary (citable) accession number: Q96CN4 Secondary accession number(s): B9A6I9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM