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Entry version 128 (13 Feb 2019)
Sequence version 2 (15 Jan 2008)
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Protein

Acyl-CoA synthetase family member 2, mitochondrial

Gene

ACSF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei493ATPBy similarity1
Binding sitei508ATPBy similarity1
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi263 – 271ATPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001145

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-CoA synthetase family member 2, mitochondrial (EC:6.2.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACSF2
ORF Names:UNQ493/PRO1009
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000167107.12

Human Gene Nomenclature Database

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HGNCi
HGNC:26101 ACSF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610465 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CM8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80221

Open Targets

More...
OpenTargetsi
ENSG00000167107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162375338

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACSF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166198367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031579342 – 615Acyl-CoA synthetase family member 2, mitochondrialAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei179N6-acetyllysineBy similarity1
Modified residuei182N6-acetyllysine; alternateBy similarity1
Modified residuei182N6-succinyllysine; alternateBy similarity1
Modified residuei340N6-acetyllysineBy similarity1
Modified residuei398N6-acetyllysineBy similarity1
Modified residuei478N6-succinyllysineBy similarity1
Modified residuei510N6-acetyllysineBy similarity1
Modified residuei544N6-acetyllysine; alternateBy similarity1
Modified residuei544N6-succinyllysine; alternateBy similarity1
Modified residuei570N6-acetyllysine; alternateBy similarity1
Modified residuei570N6-succinyllysine; alternateBy similarity1
Modified residuei599N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96CM8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96CM8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CM8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96CM8

PeptideAtlas

More...
PeptideAtlasi
Q96CM8

PRoteomics IDEntifications database

More...
PRIDEi
Q96CM8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76194

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96CM8-1 [Q96CM8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CM8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CM8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By PPARG.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167107 Expressed in 186 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96CM8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96CM8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024693

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123187, 15 interactors

Protein interaction database and analysis system

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IntActi
Q96CM8, 22 interactors

Molecular INTeraction database

More...
MINTi
Q96CM8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300441

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96CM8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96CM8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1177 Eukaryota
COG0318 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156830

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000229999

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103408

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CM8

KEGG Orthology (KO)

More...
KOi
K00666

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQGQIAH

Database of Orthologous Groups

More...
OrthoDBi
386992at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CM8

TreeFam database of animal gene trees

More...
TreeFami
TF313466

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96CM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM
60 70 80 90 100
VSTPIGGLSY VQGCTKKHLN SKTVGQCLET TAQRVPEREA LVVLHEDVRL
110 120 130 140 150
TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAGII
160 170 180 190 200
LVSVNPAYQA MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA
210 220 230 240 250
QPGALKSQRL PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ
260 270 280 290 300
FLSCHDPINI QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ
310 320 330 340 350
LRMILPNPLY HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG
360 370 380 390 400
TFLYGTPTMF VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN
410 420 430 440 450
MKDLVVAYGT TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG
460 470 480 490 500
TLAKLNTPGE LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ
510 520 530 540 550
GFCKIVGRSK DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE
560 570 580 590 600
EICACIRLKD GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI
610
QKFKLREQME RHLNL
Length:615
Mass (Da):68,125
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3356EEA7C14730B
GO
Isoform 2 (identifier: Q96CM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: S → SARGGMEAGRQRISVPSSFTASAAAH

Note: No experimental confirmation available.
Show »
Length:640
Mass (Da):70,623
Checksum:iDD1F4E5DEBDE9CE0
GO
Isoform 3 (identifier: Q96CM8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-158: Missing.

Note: No experimental confirmation available.
Show »
Length:602
Mass (Da):66,798
Checksum:iCF7D0940C1611AC2
GO
Isoform 4 (identifier: Q96CM8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-160: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):50,880
Checksum:i61FC83503081C5C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PF16E9PF16_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
572Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF87D6RF87_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8N1H0Y8N1_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8Y5H0Y8Y5_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF15D6RF15_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EN53E7EN53_HUMAN
Acyl-CoA synthetase family member 2...
ACSF2
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03830475G → V1 PublicationCorresponds to variant dbSNP:rs17856448Ensembl.1
Natural variantiVAR_038305316V → M. Corresponds to variant dbSNP:rs3744523Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558031 – 160Missing in isoform 4. 1 PublicationAdd BLAST160
Alternative sequenceiVSP_05580443S → SARGGMEAGRQRISVPSSFT ASAAAH in isoform 2. 1 Publication1
Alternative sequenceiVSP_055805146 – 158Missing in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358660 mRNA Translation: AAQ89023.1
AK024573 mRNA Translation: BAB14930.1
AK294205 mRNA Translation: BAG57517.1
AK295258 mRNA Translation: BAG58247.1
AK300625 mRNA Translation: BAG62317.1
AC004707 Genomic DNA No translation available.
AC021491 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94612.1
BC012053 mRNA Translation: AAH12053.1
BC014123 mRNA Translation: AAH14123.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11567.1 [Q96CM8-1]
CCDS74103.1 [Q96CM8-2]
CCDS74104.1 [Q96CM8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001275897.1, NM_001288968.1 [Q96CM8-2]
NP_001275898.1, NM_001288969.1 [Q96CM8-3]
NP_001275899.1, NM_001288970.1
NP_001275900.1, NM_001288971.1 [Q96CM8-4]
NP_001275901.1, NM_001288972.1 [Q96CM8-4]
NP_079425.3, NM_025149.5 [Q96CM8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.288959

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300441; ENSP00000300441; ENSG00000167107 [Q96CM8-1]
ENST00000427954; ENSP00000401831; ENSG00000167107 [Q96CM8-2]
ENST00000502667; ENSP00000421884; ENSG00000167107 [Q96CM8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80221

UCSC genome browser

More...
UCSCi
uc002iqu.4 human [Q96CM8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358660 mRNA Translation: AAQ89023.1
AK024573 mRNA Translation: BAB14930.1
AK294205 mRNA Translation: BAG57517.1
AK295258 mRNA Translation: BAG58247.1
AK300625 mRNA Translation: BAG62317.1
AC004707 Genomic DNA No translation available.
AC021491 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94612.1
BC012053 mRNA Translation: AAH12053.1
BC014123 mRNA Translation: AAH14123.1
CCDSiCCDS11567.1 [Q96CM8-1]
CCDS74103.1 [Q96CM8-2]
CCDS74104.1 [Q96CM8-3]
RefSeqiNP_001275897.1, NM_001288968.1 [Q96CM8-2]
NP_001275898.1, NM_001288969.1 [Q96CM8-3]
NP_001275899.1, NM_001288970.1
NP_001275900.1, NM_001288971.1 [Q96CM8-4]
NP_001275901.1, NM_001288972.1 [Q96CM8-4]
NP_079425.3, NM_025149.5 [Q96CM8-1]
UniGeneiHs.288959

3D structure databases

ProteinModelPortaliQ96CM8
SMRiQ96CM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123187, 15 interactors
IntActiQ96CM8, 22 interactors
MINTiQ96CM8
STRINGi9606.ENSP00000300441

Chemistry databases

SwissLipidsiSLP:000001145

PTM databases

iPTMnetiQ96CM8
PhosphoSitePlusiQ96CM8

Polymorphism and mutation databases

BioMutaiACSF2
DMDMi166198367

Proteomic databases

EPDiQ96CM8
jPOSTiQ96CM8
MaxQBiQ96CM8
PaxDbiQ96CM8
PeptideAtlasiQ96CM8
PRIDEiQ96CM8
ProteomicsDBi76194
TopDownProteomicsiQ96CM8-1 [Q96CM8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300441; ENSP00000300441; ENSG00000167107 [Q96CM8-1]
ENST00000427954; ENSP00000401831; ENSG00000167107 [Q96CM8-2]
ENST00000502667; ENSP00000421884; ENSG00000167107 [Q96CM8-3]
GeneIDi80221
KEGGihsa:80221
UCSCiuc002iqu.4 human [Q96CM8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80221
DisGeNETi80221
EuPathDBiHostDB:ENSG00000167107.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACSF2
HGNCiHGNC:26101 ACSF2
HPAiHPA024693
MIMi610465 gene
neXtProtiNX_Q96CM8
OpenTargetsiENSG00000167107
PharmGKBiPA162375338

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1177 Eukaryota
COG0318 LUCA
GeneTreeiENSGT00940000156830
HOGENOMiHOG000229999
HOVERGENiHBG103408
InParanoidiQ96CM8
KOiK00666
OMAiCQGQIAH
OrthoDBi386992at2759
PhylomeDBiQ96CM8
TreeFamiTF313466

Enzyme and pathway databases

ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACSF2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80221

Protein Ontology

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PROi
PR:Q96CM8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167107 Expressed in 186 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ96CM8 baseline and differential
GenevisibleiQ96CM8 HS

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CM8
Secondary accession number(s): B4DFQ6
, B4DHT5, B4DUF5, Q9H7G2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 13, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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