ACSF2

Functionⁱ

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044).

Has some preference toward medium-chain substrates (PubMed:17762044).

Plays a role in adipocyte differentiation (PubMed:16380219).

2 Publications

Catalytic activityⁱ

a medium chain fatty acid
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See the description of this molecule in ChEBI.
+
ATP
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+
CoA
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=
a medium-chain fatty acyl-CoA
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See the description of this molecule in ChEBI.
+
AMP
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diphosphate
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1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
  Watkins P.A., Maiguel D., Jia Z., Pevsner J.
  J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
EC:
6.2.1.2
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
  Watkins P.A., Maiguel D., Jia Z., Pevsner J.
  J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
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a medium chain fatty acid
zoom
+
ATP
+
CoA
=
a medium-chain fatty acyl-CoA
zoom
+
AMP
+
diphosphate
zoom
ATP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
CoA
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See the description of this molecule in ChEBI.
+
octanoate
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See the description of this molecule in ChEBI.
=
AMP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
diphosphate
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
octanoyl-CoA
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
  Watkins P.A., Maiguel D., Jia Z., Pevsner J.
  J. Lipid Res. 48:2736-2750(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
CoA
+
octanoate
zoom
=
AMP
+
diphosphate
zoom
+
octanoyl-CoA
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	493	ATPBy similarity	1
Binding siteⁱ	508	ATPBy similarity	1
Binding siteⁱ	599	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	263 – 271	ATPBy similarity		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q96CM8
Reactomeⁱ	R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation
SignaLinkⁱ	Q96CM8

Chemistry databases

SwissLipidsⁱ	SLP:000001145

SwissLipidsⁱ

SLP:000001145

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Medium-chain acyl-CoA ligase ACSF2, mitochondrialCurated (EC:6.2.1.21 Publication)
Gene namesⁱ	Name:ACSF2Imported ORF Names:UNQ493/PRO1009
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26101, ACSF2
MIMⁱ	610465, gene
neXtProtⁱ	NX_Q96CM8
VEuPathDBⁱ	HostDB:ENSG00000167107

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80221
Open Targets More...OpenTargetsⁱ	ENSG00000167107
PharmGKBⁱ	PA162375338

Miscellaneous databases

Pharosⁱ	Q96CM8, Tbio

Pharosⁱ

Q96CM8, Tbio

Genetic variation databases

BioMutaⁱ	ACSF2
DMDMⁱ	166198367

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 41	MitochondrionSequence analysisAdd BLAST		41
ChainⁱPRO_0000315793	42 – 615	Medium-chain acyl-CoA ligase ACSF2, mitochondrialAdd BLAST		574

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	179	N6-acetyllysineBy similarity	1
Modified residueⁱ	182	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	182	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	340	N6-acetyllysineBy similarity	1
Modified residueⁱ	398	N6-acetyllysineBy similarity	1
Modified residueⁱ	478	N6-succinyllysineBy similarity	1
Modified residueⁱ	510	N6-acetyllysineBy similarity	1
Modified residueⁱ	544	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	544	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	570	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	570	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	599	N6-succinyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-5 CPTAC-6
EPDⁱ	Q96CM8
jPOSTⁱ	Q96CM8
MassIVEⁱ	Q96CM8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96CM8
PaxDbⁱ	Q96CM8
PeptideAtlas More...PeptideAtlasⁱ	Q96CM8
PRIDEⁱ	Q96CM8
ProteomicsDBⁱ	4067 4247 5184 76194 [Q96CM8-1]
TopDownProteomicsⁱ	Q96CM8-1 [Q96CM8-1]

PTM databases

GlyGenⁱ	Q96CM8, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q96CM8
PhosphoSitePlusⁱ	Q96CM8

Expressionⁱ

Inductionⁱ

By PPARG.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167107, Expressed in right adrenal gland and 201 other tissues
ExpressionAtlasⁱ	Q96CM8, baseline and differential
Genevisibleⁱ	Q96CM8, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000167107, Tissue enhanced (kidney)

HPAⁱ

ENSG00000167107, Tissue enhanced (kidney)

Interactionⁱ

Binary interactionsⁱ

Hide details

Q96CM8

With	#Exp.	IntAct
AGTRAP [Q6RW13]	4	EBI-2876502,EBI-741181
APOA5 [Q6Q788]	3	EBI-2876502,EBI-3936819
APOC1 [P02654]	3	EBI-2876502,EBI-1220105
ARL13B [Q3SXY8]	3	EBI-2876502,EBI-11343438
ARL6IP1 [Q15041]	8	EBI-2876502,EBI-714543
C10orf67 - isoform 2 [Q8IYJ2-2]	3	EBI-2876502,EBI-13381098
CLEC10A [Q8IUN9]	3	EBI-2876502,EBI-2873246
CMTM5 [Q96DZ9]	5	EBI-2876502,EBI-2548702
CMTM5 - isoform 2 [Q96DZ9-2]	3	EBI-2876502,EBI-11522780
COQ9 [O75208]	4	EBI-2876502,EBI-724524
DGAT2L6 [Q6ZPD8]	3	EBI-2876502,EBI-12831978
GPR152 [Q8TDT2]	3	EBI-2876502,EBI-13345167
MICOS13 [Q5XKP0]	3	EBI-2876502,EBI-1053887
RDH10 [Q8IZV5]	3	EBI-2876502,EBI-11913715
RHBDD2 - isoform 3 [Q6NTF9-3]	3	EBI-2876502,EBI-17589229
SENP2 [Q9HC62]	3	EBI-2876502,EBI-714881
SH3GLB1 [Q9Y371]	3	EBI-2876502,EBI-2623095
SIGLEC12 [Q96PQ1]	3	EBI-2876502,EBI-17640454
SYNGR3 [O43761]	3	EBI-2876502,EBI-11321949

Protein-protein interaction databases

BioGRIDⁱ	123187, 130 interactors
IntActⁱ	Q96CM8, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q96CM8
STRINGⁱ	9606.ENSP00000401831

Miscellaneous databases

RNActⁱ	Q96CM8, protein

RNActⁱ

Q96CM8, protein

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	Q96CM8
SMRⁱ	Q96CM8
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1177, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156830
HOGENOMⁱ	CLU_000022_59_7_1
InParanoidⁱ	Q96CM8
OMAⁱ	KQSDMKA
Database of Orthologous Groups More...OrthoDBⁱ	386992at2759
PhylomeDBⁱ	Q96CM8
TreeFamⁱ	TF313466

Family and domain databases

Gene3Dⁱ	3.30.300.30, 1 hit
InterProⁱ	View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455, AMP_BINDING, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96CM8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM 
        60         70         80         90        100
VSTPIGGLSY VQGCTKKHLN SKTVGQCLET TAQRVPEREA LVVLHEDVRL 
       110        120        130        140        150
TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAGII 
       160        170        180        190        200
LVSVNPAYQA MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA 
       210        220        230        240        250
QPGALKSQRL PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ 
       260        270        280        290        300
FLSCHDPINI QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ 
       310        320        330        340        350
LRMILPNPLY HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG 
       360        370        380        390        400
TFLYGTPTMF VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN 
       410        420        430        440        450
MKDLVVAYGT TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG 
       460        470        480        490        500
TLAKLNTPGE LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ 
       510        520        530        540        550
GFCKIVGRSK DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE 
       560        570        580        590        600
EICACIRLKD GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI 
       610 
QKFKLREQME RHLNL

Length:615

Mass (Da):68,125

Last modified:January 15, 2008 - v2

Checksum:ⁱA3356EEA7C14730B

GO

Isoform 2 (identifier: Q96CM8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
43-43: S → SARGGMEAGRQRISVPSSFTASAAAH

« Hide

        10         20         30         40         50
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSARGGMEA 
        60         70         80         90        100
GRQRISVPSS FTASAAAHSR EVDRMVSTPI GGLSYVQGCT KKHLNSKTVG 
       110        120        130        140        150
QCLETTAQRV PEREALVVLH EDVRLTFAQL KEEVDKAASG LLSIGLCKGD 
       160        170        180        190        200
RLGMWGPNSY AWVLMQLATA QAGIILVSVN PAYQAMELEY VLKKVGCKAL 
       210        220        230        240        250
VFPKQFKTQQ YYNVLKQICP EVENAQPGAL KSQRLPDLTT VISVDAPLPG 
       260        270        280        290        300
TLLLDEVVAA GSTRQHLDQL QYNQQFLSCH DPINIQFTSG TTGSPKGATL 
       310        320        330        340        350
SHYNIVNNSN ILGERLKLHE KTPEQLRMIL PNPLYHCLGS VAGTMMCLMY 
       360        370        380        390        400
GATLILASPI FNGKKALEAI SRERGTFLYG TPTMFVDILN QPDFSSYDIS 
       410        420        430        440        450
TMCGGVIAGS PAPPELIRAI INKINMKDLV VAYGTTENSP VTFAHFPEDT 
       460        470        480        490        500
VEQKAESVGR IMPHTEARIM NMEAGTLAKL NTPGELCIRG YCVMLGYWGE 
       510        520        530        540        550
PQKTEEAVDQ DKWYWTGDVA TMNEQGFCKI VGRSKDMIIR GGENIYPAEL 
       560        570        580        590        600
EDFFHTHPKV QEVQVVGVKD DRMGEEICAC IRLKDGEETT VEEIKAFCKG 
       610        620        630        640
KISHFKIPKY IVFVTNYPLT ISGKIQKFKL REQMERHLNL

Show »

Length:640

Mass (Da):70,623

Checksum:ⁱDD1F4E5DEBDE9CE0

GO

Isoform 3 (identifier: Q96CM8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
146-158: Missing.

« Hide

        10         20         30         40         50
MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM 
        60         70         80         90        100
VSTPIGGLSY VQGCTKKHLN SKTVGQCLET TAQRVPEREA LVVLHEDVRL 
       110        120        130        140        150
TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAMEL 
       160        170        180        190        200
EYVLKKVGCK ALVFPKQFKT QQYYNVLKQI CPEVENAQPG ALKSQRLPDL 
       210        220        230        240        250
TTVISVDAPL PGTLLLDEVV AAGSTRQHLD QLQYNQQFLS CHDPINIQFT 
       260        270        280        290        300
SGTTGSPKGA TLSHYNIVNN SNILGERLKL HEKTPEQLRM ILPNPLYHCL 
       310        320        330        340        350
GSVAGTMMCL MYGATLILAS PIFNGKKALE AISRERGTFL YGTPTMFVDI 
       360        370        380        390        400
LNQPDFSSYD ISTMCGGVIA GSPAPPELIR AIINKINMKD LVVAYGTTEN 
       410        420        430        440        450
SPVTFAHFPE DTVEQKAESV GRIMPHTEAR IMNMEAGTLA KLNTPGELCI 
       460        470        480        490        500
RGYCVMLGYW GEPQKTEEAV DQDKWYWTGD VATMNEQGFC KIVGRSKDMI 
       510        520        530        540        550
IRGGENIYPA ELEDFFHTHP KVQEVQVVGV KDDRMGEEIC ACIRLKDGEE 
       560        570        580        590        600
TTVEEIKAFC KGKISHFKIP KYIVFVTNYP LTISGKIQKF KLREQMERHL 

NL

Show »

Length:602

Mass (Da):66,798

Checksum:ⁱCF7D0940C1611AC2

GO

Isoform 4 (identifier: Q96CM8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-160: Missing.

« Hide

        10         20         30         40         50
MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA QPGALKSQRL 
        60         70         80         90        100
PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ FLSCHDPINI 
       110        120        130        140        150
QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ LRMILPNPLY 
       160        170        180        190        200
HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG TFLYGTPTMF 
       210        220        230        240        250
VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN MKDLVVAYGT 
       260        270        280        290        300
TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG TLAKLNTPGE 
       310        320        330        340        350
LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ GFCKIVGRSK 
       360        370        380        390        400
DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE EICACIRLKD 
       410        420        430        440        450
GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI QKFKLREQME 

RHLNL

Show »

Length:455

Mass (Da):50,880

Checksum:ⁱ61FC83503081C5C9

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PF16	E9PF16_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	572	Annotation score:
D6RF87	D6RF87_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	183	Annotation score:
H0Y8N1	H0Y8N1_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	104	Annotation score:
H0Y8Y5	H0Y8Y5_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	85	Annotation score:
D6RF15	D6RF15_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	54	Annotation score:
E7EN53	E7EN53_HUMAN	Medium-chain acyl-CoA ligase ACSF2,... Medium-chain acyl-CoA ligase ACSF2, mitochondrial	ACSF2	45	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038304	75	G → V1 PublicationCorresponds to variant dbSNP:rs17856448Ensembl.		1
Natural variantⁱVAR_038305	316	V → M. Corresponds to variant dbSNP:rs3744523Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055803	1 – 160	Missing in isoform 4. 1 PublicationAdd BLAST	160
Alternative sequenceⁱVSP_055804	43	S → SARGGMEAGRQRISVPSSFT ASAAAH in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_055805	146 – 158	Missing in isoform 3. 1 PublicationAdd BLAST	13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358660 mRNA Translation: AAQ89023.1 AK024573 mRNA Translation: BAB14930.1 AK294205 mRNA Translation: BAG57517.1 AK295258 mRNA Translation: BAG58247.1 AK300625 mRNA Translation: BAG62317.1 AC004707 Genomic DNA No translation available. AC021491 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94612.1 BC012053 mRNA Translation: AAH12053.1 BC014123 mRNA Translation: AAH14123.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11567.1 [Q96CM8-1] CCDS74103.1 [Q96CM8-2] CCDS74104.1 [Q96CM8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001275897.1, NM_001288968.1 [Q96CM8-2] NP_001275898.1, NM_001288969.1 [Q96CM8-3] NP_001275899.1, NM_001288970.1 NP_001275900.1, NM_001288971.1 [Q96CM8-4] NP_001275901.1, NM_001288972.1 [Q96CM8-4] NP_079425.3, NM_025149.5 [Q96CM8-1]

Genome annotation databases

Ensemblⁱ	ENST00000300441.9; ENSP00000300441.4; ENSG00000167107.13 ENST00000427954.6; ENSP00000401831.2; ENSG00000167107.13 [Q96CM8-2] ENST00000502667.5; ENSP00000421884.1; ENSG00000167107.13 [Q96CM8-3]
GeneIDⁱ	80221
KEGGⁱ	hsa:80221
MANE-Selectⁱ	ENST00000300441.9; ENSP00000300441.4; NM_025149.6; NP_079425.3
UCSC genome browser More...UCSCⁱ	uc002iqu.4, human [Q96CM8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96CM8	ACSF2 isoform 2		PANTR		640	UniRef90_Q96CM8
Acyl-CoA synthetase family member 2		PANPA		615
Acyl-CoA synthetase family member 2		GORGO		608
Acyl-CoA synthetase family member 2		PANTR		640
Acyl-CoA synthetase family member 2		PANTR		615
+7
Q96CM8-2	Medium-chain acyl-CoA ligase ACSF2, mitochondrial		MACFA		618	UniRef90_Q96CM8-2
Isoform 4 of Medium-chain acyl-CoA ligase ACSF2, mitochondrial		HUMAN		455
Acyl-CoA synthetase family member 2		MACMU		657
Uncharacterized protein		RHIRO		657
Acyl-CoA synthetase family member 2		PANPA		640
+48

Protein	Similar proteins		Species	Score	Length	Source
Q96CM8	Medium-chain acyl-CoA ligase ACSF2, mitochondrial		BOVIN		615	UniRef50_Q96CM8
Medium-chain acyl-CoA ligase ACSF2, mitochondrial		PONAB		615
Medium-chain acyl-CoA ligase ACSF2, mitochondrial		MACFA		618
ACSF2 isoform 2		PANTR		640
Acyl-CoA synthetase family member 2		PANPA		615
+371

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358660 mRNA Translation: AAQ89023.1 AK024573 mRNA Translation: BAB14930.1 AK294205 mRNA Translation: BAG57517.1 AK295258 mRNA Translation: BAG58247.1 AK300625 mRNA Translation: BAG62317.1 AC004707 Genomic DNA No translation available. AC021491 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94612.1 BC012053 mRNA Translation: AAH12053.1 BC014123 mRNA Translation: AAH14123.1
CCDSⁱ	CCDS11567.1 [Q96CM8-1] CCDS74103.1 [Q96CM8-2] CCDS74104.1 [Q96CM8-3]
RefSeqⁱ	NP_001275897.1, NM_001288968.1 [Q96CM8-2] NP_001275898.1, NM_001288969.1 [Q96CM8-3] NP_001275899.1, NM_001288970.1 NP_001275900.1, NM_001288971.1 [Q96CM8-4] NP_001275901.1, NM_001288972.1 [Q96CM8-4] NP_079425.3, NM_025149.5 [Q96CM8-1]

3D structure databases

AlphaFoldDBⁱ	Q96CM8
SMRⁱ	Q96CM8
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	123187, 130 interactors
IntActⁱ	Q96CM8, 34 interactors
MINTⁱ	Q96CM8
STRINGⁱ	9606.ENSP00000401831

Chemistry databases

SwissLipidsⁱ	SLP:000001145

SwissLipidsⁱ

SLP:000001145

PTM databases

GlyGenⁱ	Q96CM8, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q96CM8
PhosphoSitePlusⁱ	Q96CM8

Genetic variation databases

BioMutaⁱ	ACSF2
DMDMⁱ	166198367

Proteomic databases

CPTACⁱ	CPTAC-5 CPTAC-6
EPDⁱ	Q96CM8
jPOSTⁱ	Q96CM8
MassIVEⁱ	Q96CM8
MaxQBⁱ	Q96CM8
PaxDbⁱ	Q96CM8
PeptideAtlasⁱ	Q96CM8
PRIDEⁱ	Q96CM8
ProteomicsDBⁱ	4067 4247 5184 76194 [Q96CM8-1]
TopDownProteomicsⁱ	Q96CM8-1 [Q96CM8-1]

Protocols and materials databases

Antibodypediaⁱ	30532, 137 antibodies from 24 providers
The DNASU plasmid repository More...DNASUⁱ	80221

Genome annotation databases

Ensemblⁱ	ENST00000300441.9; ENSP00000300441.4; ENSG00000167107.13 ENST00000427954.6; ENSP00000401831.2; ENSG00000167107.13 [Q96CM8-2] ENST00000502667.5; ENSP00000421884.1; ENSG00000167107.13 [Q96CM8-3]
GeneIDⁱ	80221
KEGGⁱ	hsa:80221
MANE-Selectⁱ	ENST00000300441.9; ENSP00000300441.4; NM_025149.6; NP_079425.3
UCSCⁱ	uc002iqu.4, human [Q96CM8-1]

Organism-specific databases

CTDⁱ	80221
DisGeNETⁱ	80221
GeneCardsⁱ	ACSF2
HGNCⁱ	HGNC:26101, ACSF2
HPAⁱ	ENSG00000167107, Tissue enhanced (kidney)
MIMⁱ	610465, gene
neXtProtⁱ	NX_Q96CM8
OpenTargetsⁱ	ENSG00000167107
PharmGKBⁱ	PA162375338
VEuPathDBⁱ	HostDB:ENSG00000167107
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1177, Eukaryota
GeneTreeⁱ	ENSGT00940000156830
HOGENOMⁱ	CLU_000022_59_7_1
InParanoidⁱ	Q96CM8
OMAⁱ	KQSDMKA
OrthoDBⁱ	386992at2759
PhylomeDBⁱ	Q96CM8
TreeFamⁱ	TF313466

Enzyme and pathway databases

PathwayCommonsⁱ	Q96CM8
Reactomeⁱ	R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation
SignaLinkⁱ	Q96CM8

Miscellaneous databases

BioGRID-ORCSⁱ	80221, 18 hits in 1079 CRISPR screens
ChiTaRSⁱ	ACSF2, human
GenomeRNAiⁱ	80221
Pharosⁱ	Q96CM8, Tbio
Protein Ontology More...PROⁱ	PR:Q96CM8
RNActⁱ	Q96CM8, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167107, Expressed in right adrenal gland and 201 other tissues
ExpressionAtlasⁱ	Q96CM8, baseline and differential
Genevisibleⁱ	Q96CM8, HS

Family and domain databases

Gene3Dⁱ	3.30.300.30, 1 hit
InterProⁱ	View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig
Pfamⁱ	View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455, AMP_BINDING, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACSF2_HUMAN
Accessionⁱ	Q96CM8Primary (citable) accession number: Q96CM8 Secondary accession number(s): B4DFQ6 , B4DHT5, B4DUF5, Q9H7G2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	May 25, 2022
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q96CM8 (ACSF2_HUMAN)

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Medium-chain acyl-CoA ligase ACSF2, mitochondrial

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q96CM8

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Chemistry databases

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Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Enzyme and pathway databases

Miscellaneous databases

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ