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Protein

Nucleoredoxin-like protein 1

Gene

NXNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoredoxin-like protein 1
Alternative name(s):
Thioredoxin-like protein 6
Gene namesi
Name:NXNL1
Synonyms:TXNL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171773.2
HGNCiHGNC:25179 NXNL1
MIMi608791 gene
neXtProtiNX_Q96CM4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi115861
OpenTargetsiENSG00000171773
PharmGKBiPA162398383

Polymorphism and mutation databases

BioMutaiNXNL1
DMDMi74731355

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195431 – 212Nucleoredoxin-like protein 1Add BLAST212

Proteomic databases

PaxDbiQ96CM4
PeptideAtlasiQ96CM4
PRIDEiQ96CM4
ProteomicsDBi76193

PTM databases

iPTMnetiQ96CM4
PhosphoSitePlusiQ96CM4

Expressioni

Gene expression databases

BgeeiENSG00000171773
CleanExiHS_NXNL1
GenevisibleiQ96CM4 HS

Organism-specific databases

HPAiHPA042010

Interactioni

Protein-protein interaction databases

BioGridi125460, 4 interactors
IntActiQ96CM4, 4 interactors
STRINGi9606.ENSP00000305631

Structurei

3D structure databases

ProteinModelPortaliQ96CM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 164ThioredoxinPROSITE-ProRule annotationAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi199 – 203Poly-Gly5

Sequence similaritiesi

Belongs to the nucleoredoxin family.Curated

Phylogenomic databases

eggNOGiKOG2501 Eukaryota
ENOG410ZIWC LUCA
GeneTreeiENSGT00530000063279
HOGENOMiHOG000259431
HOVERGENiHBG056831
InParanoidiQ96CM4
OMAiGPACFAN
OrthoDBiEOG091G079A
PhylomeDBiQ96CM4
TreeFamiTF331873

Family and domain databases

InterProiView protein in InterPro
IPR029520 RdCVF
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PANTHERiPTHR13871:SF25 PTHR13871:SF25, 1 hit
PfamiView protein in Pfam
PF13905 Thioredoxin_8, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96CM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLFSGRIL IRNNSDQDEL DTEAEVSRRL ENRLVLLFFG AGACPQCQAF
60 70 80 90 100
VPILKDFFVR LTDEFYVLRA AQLALVYVSQ DSTEEQQDLF LKDMPKKWLF
110 120 130 140 150
LPFEDDLRRD LGRQFSVERL PAVVVLKPDG DVLTRDGADE IQRLGTACFA
160 170 180 190 200
NWQEAAEVLD RNFQLPEDLE DQEPRSLTEC LRRHKYRVEK AARGGRDPGG
210
GGGEEGGAGG LF
Length:212
Mass (Da):23,943
Last modified:December 1, 2001 - v1
Checksum:iD252BFEFAE90E44C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471106 Genomic DNA Translation: EAW84608.1
BC014127 mRNA Translation: AAH14127.1
DQ426894 mRNA Translation: ABD90545.1
CCDSiCCDS12360.1
RefSeqiNP_612463.1, NM_138454.1
UniGeneiHs.661836

Genome annotation databases

EnsembliENST00000301944; ENSP00000305631; ENSG00000171773
GeneIDi115861
KEGGihsa:115861
UCSCiuc002ngs.4 human

Similar proteinsi

Entry informationi

Entry nameiNXNL1_HUMAN
AccessioniPrimary (citable) accession number: Q96CM4
Secondary accession number(s): Q0QD37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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