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Protein

Zinc finger protein 653

Gene

ZNF653

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri467 – 492C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri498 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • AF-2 domain binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW
  • receptor antagonist activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 653
Alternative name(s):
67 kDa zinc finger protein
Zinc finger protein Zip67
Gene namesi
Name:ZNF653
Synonyms:ZIP67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161914.9
HGNCiHGNC:25196 ZNF653
MIMi611371 gene
neXtProtiNX_Q96CK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161914
PharmGKBiPA134989597

Polymorphism and mutation databases

BioMutaiZNF653
DMDMi74760763

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002533441 – 615Zinc finger protein 653Add BLAST615

Proteomic databases

EPDiQ96CK0
MaxQBiQ96CK0
PaxDbiQ96CK0
PeptideAtlasiQ96CK0
PRIDEiQ96CK0
ProteomicsDBi76191

PTM databases

iPTMnetiQ96CK0
PhosphoSitePlusiQ96CK0

Expressioni

Tissue specificityi

Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.

Gene expression databases

BgeeiENSG00000161914 Expressed in 97 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ZNF653
ExpressionAtlasiQ96CK0 baseline and differential
GenevisibleiQ96CK0 HS

Organism-specific databases

HPAiHPA023631
HPA023635

Interactioni

Subunit structurei

Interacts with NR5A1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125464, 1 interactor
IntActiQ96CK0, 4 interactors
STRINGi9606.ENSP00000293771

Structurei

3D structure databases

ProteinModelPortaliQ96CK0
SMRiQ96CK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 118Nuclear localization signalSequence analysisAdd BLAST12
Motifi445 – 451Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 118Poly-Arg4
Compositional biasi195 – 207Poly-SerAdd BLAST13
Compositional biasi218 – 225Poly-Ala8

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri467 – 492C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri498 – 522C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri528 – 550C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 609C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155806
HOVERGENiHBG082431
InParanoidiQ96CK0
OMAiHLNMAAG
OrthoDBiEOG091G04KR
PhylomeDBiQ96CK0
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96CK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERALEPEA EAEAEAGAGG EAAAEEGAAG RKARGRPRLT ESDRARRRLE
60 70 80 90 100
SRKKYDVRRV YLGEAHGPWV DLRRRSGWSD AKLAAYLISL ERGQRSGRHG
110 120 130 140 150
KPWEQVPKKP KRKKRRRRNV NCLKNVVIWY EDHKHRCPYE PHLAELDPTF
160 170 180 190 200
GLYTTAVWQC EAGHRYFQDL HSPLKPLSDS DPDSDKVGNG LVAGSSDSSS
210 220 230 240 250
SGSASDSEES PEGQPVKAAA AAAAATPTSP VGSSGLITQE GVHIPFDVHH
260 270 280 290 300
VESLAEQGTP LCSNPAGNGP EALETVVCVP VPVQVGAGPS ALFENVPQEA
310 320 330 340 350
LGEVVASCPM PGMVPGSQVI IIAGPGYDAL TAEGIHLNMA AGSGVPGSGL
360 370 380 390 400
GEEVPCAMME GVAAYTQTEP EGSQPSTMDA TAVAGIETKK EKEDLCLLKK
410 420 430 440 450
EEKEEPVAPE LATTVPESAE PEAEADGEEL DGSDMSAIIY EIPKEPEKRR
460 470 480 490 500
RSKRSRVMDA DGLLEMFHCP YEGCSQVYVA LSSFQNHVNL VHRKGKTKVC
510 520 530 540 550
PHPGCGKKFY LSNHLRRHMI IHSGVREFTC ETCGKSFKRK NHLEVHRRTH
560 570 580 590 600
TGETPLQCEI CGYQCRQRAS LNWHMKKHTA EVQYNFTCDR CGKRFEKLDS
610
VKFHTLKSHP DHKPT
Length:615
Mass (Da):67,235
Last modified:December 1, 2001 - v1
Checksum:i7208224CD9CDA311
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJG9K7EJG9_HUMAN
Zinc finger protein 653
ZNF653
217Annotation score:
K7ENS4K7ENS4_HUMAN
Zinc finger protein 653
ZNF653
169Annotation score:
K7EKL4K7EKL4_HUMAN
Zinc finger protein 653
ZNF653
34Annotation score:
K7EL79K7EL79_HUMAN
Zinc finger protein 653
ZNF653
72Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02807654K → R1 PublicationCorresponds to variant dbSNP:rs17851437Ensembl.1
Natural variantiVAR_057438329A → T. Corresponds to variant dbSNP:rs35556595Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072704 mRNA Translation: AAL66763.1
BC014187 mRNA Translation: AAH14187.1
BC016816 mRNA Translation: AAH16816.1
CCDSiCCDS12261.1
RefSeqiNP_620138.2, NM_138783.3
UniGeneiHs.465928

Genome annotation databases

EnsembliENST00000293771; ENSP00000293771; ENSG00000161914
GeneIDi115950
KEGGihsa:115950
UCSCiuc002mrz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072704 mRNA Translation: AAL66763.1
BC014187 mRNA Translation: AAH14187.1
BC016816 mRNA Translation: AAH16816.1
CCDSiCCDS12261.1
RefSeqiNP_620138.2, NM_138783.3
UniGeneiHs.465928

3D structure databases

ProteinModelPortaliQ96CK0
SMRiQ96CK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125464, 1 interactor
IntActiQ96CK0, 4 interactors
STRINGi9606.ENSP00000293771

PTM databases

iPTMnetiQ96CK0
PhosphoSitePlusiQ96CK0

Polymorphism and mutation databases

BioMutaiZNF653
DMDMi74760763

Proteomic databases

EPDiQ96CK0
MaxQBiQ96CK0
PaxDbiQ96CK0
PeptideAtlasiQ96CK0
PRIDEiQ96CK0
ProteomicsDBi76191

Protocols and materials databases

DNASUi115950
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293771; ENSP00000293771; ENSG00000161914
GeneIDi115950
KEGGihsa:115950
UCSCiuc002mrz.2 human

Organism-specific databases

CTDi115950
EuPathDBiHostDB:ENSG00000161914.9
GeneCardsiZNF653
HGNCiHGNC:25196 ZNF653
HPAiHPA023631
HPA023635
MIMi611371 gene
neXtProtiNX_Q96CK0
OpenTargetsiENSG00000161914
PharmGKBiPA134989597
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155806
HOVERGENiHBG082431
InParanoidiQ96CK0
OMAiHLNMAAG
OrthoDBiEOG091G04KR
PhylomeDBiQ96CK0
TreeFamiTF332664

Miscellaneous databases

GenomeRNAii115950
PROiPR:Q96CK0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161914 Expressed in 97 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ZNF653
ExpressionAtlasiQ96CK0 baseline and differential
GenevisibleiQ96CK0 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN653_HUMAN
AccessioniPrimary (citable) accession number: Q96CK0
Secondary accession number(s): Q96AS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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