UniProtKB - Q96CH1 (GP146_HUMAN)
Protein
Probable G-protein coupled receptor 146
Gene
GPR146
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q96CH1 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 146Alternative name(s): G-protein coupled receptor PGR8 |
Gene namesi | Name:GPR146 Synonyms:PGR8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164849.8 |
HGNCi | HGNC:21718, GPR146 |
neXtProti | NX_Q96CH1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 52 – 65 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 66 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 102 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 103 – 123 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 146 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 147 – 167 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 189 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 190 – 210 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 233 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 234 – 254 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 279 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 280 – 300 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 301 – 333 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 115330 |
OpenTargetsi | ENSG00000164849 |
PharmGKBi | PA134958088 |
Miscellaneous databases
Pharosi | Q96CH1, Tdark |
Polymorphism and mutation databases
BioMutai | GPR146 |
DMDMi | 67461068 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069622 | 1 – 333 | Probable G-protein coupled receptor 146Add BLAST | 333 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q96CH1 |
PeptideAtlasi | Q96CH1 |
PRIDEi | Q96CH1 |
ProteomicsDBi | 76188 |
PTM databases
GlyGeni | Q96CH1, 1 site |
iPTMneti | Q96CH1 |
PhosphoSitePlusi | Q96CH1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164849, Expressed in subcutaneous adipose tissue and 177 other tissues |
ExpressionAtlasi | Q96CH1, baseline and differential |
Genevisiblei | Q96CH1, HS |
Organism-specific databases
HPAi | ENSG00000164849, Low tissue specificity |
Interactioni
Protein-protein interaction databases
IntActi | Q96CH1, 2 interactors |
MINTi | Q96CH1 |
STRINGi | 9606.ENSP00000380283 |
Miscellaneous databases
RNActi | Q96CH1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QPPG, Eukaryota |
GeneTreei | ENSGT01010000222293 |
InParanoidi | Q96CH1 |
OMAi | LFYVCNH |
OrthoDBi | 662615at2759 |
PhylomeDBi | Q96CH1 |
TreeFami | TF333506 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR037487, GPR146 |
PANTHERi | PTHR24226:SF3, PTHR24226:SF3, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96CH1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL
60 70 80 90 100
ANLHSKASMT MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE
110 120 130 140 150
VHVALQIPFN VSSLVAMYST ALLSLDHYIE RALPRTYMAS VYNTRHVCGF
160 170 180 190 200
VWGGALLTSF SSLLFYICSH VSTRALECAK MQNAEAADAT LVFIGYVVPA
210 220 230 240 250
LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC TQFGLWTPHY
260 270 280 290 300
LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN
310 320 330
QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J5X5 | C9J5X5_HUMAN | Probable G-protein-coupled receptor... | GPR146 | 38 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014241 mRNA Translation: AAH14241.1 AY255535 mRNA Translation: AAO85047.1 |
CCDSi | CCDS5321.1 |
RefSeqi | NP_001290402.1, NM_001303473.1 NP_001290403.1, NM_001303474.1 NP_612454.1, NM_138445.3 XP_005249670.1, XM_005249613.2 XP_006715706.1, XM_006715643.2 |
Genome annotation databases
Ensembli | ENST00000397095; ENSP00000380283; ENSG00000164849 ENST00000444847; ENSP00000410743; ENSG00000164849 |
GeneIDi | 115330 |
KEGGi | hsa:115330 |
UCSCi | uc003sjx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014241 mRNA Translation: AAH14241.1 AY255535 mRNA Translation: AAO85047.1 |
CCDSi | CCDS5321.1 |
RefSeqi | NP_001290402.1, NM_001303473.1 NP_001290403.1, NM_001303474.1 NP_612454.1, NM_138445.3 XP_005249670.1, XM_005249613.2 XP_006715706.1, XM_006715643.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q96CH1, 2 interactors |
MINTi | Q96CH1 |
STRINGi | 9606.ENSP00000380283 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q96CH1, 1 site |
iPTMneti | Q96CH1 |
PhosphoSitePlusi | Q96CH1 |
Polymorphism and mutation databases
BioMutai | GPR146 |
DMDMi | 67461068 |
Proteomic databases
PaxDbi | Q96CH1 |
PeptideAtlasi | Q96CH1 |
PRIDEi | Q96CH1 |
ProteomicsDBi | 76188 |
Protocols and materials databases
Antibodypediai | 10880, 282 antibodies |
DNASUi | 115330 |
Genome annotation databases
Ensembli | ENST00000397095; ENSP00000380283; ENSG00000164849 ENST00000444847; ENSP00000410743; ENSG00000164849 |
GeneIDi | 115330 |
KEGGi | hsa:115330 |
UCSCi | uc003sjx.5, human |
Organism-specific databases
CTDi | 115330 |
DisGeNETi | 115330 |
EuPathDBi | HostDB:ENSG00000164849.8 |
GeneCardsi | GPR146 |
HGNCi | HGNC:21718, GPR146 |
HPAi | ENSG00000164849, Low tissue specificity |
neXtProti | NX_Q96CH1 |
OpenTargetsi | ENSG00000164849 |
PharmGKBi | PA134958088 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPPG, Eukaryota |
GeneTreei | ENSGT01010000222293 |
InParanoidi | Q96CH1 |
OMAi | LFYVCNH |
OrthoDBi | 662615at2759 |
PhylomeDBi | Q96CH1 |
TreeFami | TF333506 |
Enzyme and pathway databases
PathwayCommonsi | Q96CH1 |
Miscellaneous databases
BioGRID-ORCSi | 115330, 4 hits in 840 CRISPR screens |
ChiTaRSi | GPR146, human |
GeneWikii | GPR146 |
GenomeRNAii | 115330 |
Pharosi | Q96CH1, Tdark |
PROi | PR:Q96CH1 |
RNActi | Q96CH1, protein |
Gene expression databases
Bgeei | ENSG00000164849, Expressed in subcutaneous adipose tissue and 177 other tissues |
ExpressionAtlasi | Q96CH1, baseline and differential |
Genevisiblei | Q96CH1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR037487, GPR146 |
PANTHERi | PTHR24226:SF3, PTHR24226:SF3, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP146_HUMAN | |
Accessioni | Q96CH1Primary (citable) accession number: Q96CH1 Secondary accession number(s): Q86SP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries