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Entry version 125 (07 Apr 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane 4 L6 family member 18

Gene

TM4SF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96CE8

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.75.1.2, the transmembrane 4 superfamily 4 (tm4sf4) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 4 L6 family member 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TM4SF18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25181, TM4SF18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CE8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000163762.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 49ExtracellularSequence analysisAdd BLAST19
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 93CytoplasmicSequence analysisAdd BLAST23
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 157ExtracellularSequence analysisAdd BLAST43
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 201CytoplasmicSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116441

Open Targets

More...
OpenTargetsi
ENSG00000163762

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670801

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96CE8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TM4SF18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68053312

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193041 – 201Transmembrane 4 L6 family member 18Add BLAST201

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96CE8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96CE8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CE8

PeptideAtlas

More...
PeptideAtlasi
Q96CE8

PRoteomics IDEntifications database

More...
PRIDEi
Q96CE8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76182

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163762, Expressed in visceral pleura and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96CE8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CE8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163762, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125506, 42 interactors

Protein interaction database and analysis system

More...
IntActi
Q96CE8, 41 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96CE8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QS18, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222416

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CE8

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRCCQSE

Database of Orthologous Groups

More...
OrthoDBi
922490at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CE8

TreeFam database of animal gene trees

More...
TreeFami
TF331371

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008661, L6_membrane

The PANTHER Classification System

More...
PANTHERi
PTHR14198, PTHR14198, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05805, L6_membrane, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96CE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRKCGGCL SCLLIPLALW SIIVNILLYF PNGQTSYASS NKLTNYVWYF
60 70 80 90 100
EGICFSGIMM LIVTTVLLVL ENNNNYKCCQ SENCSKKYVT LLSIIFSSLG
110 120 130 140 150
IAFSGYCLVI SALGLVQGPY CRTLDGWEYA FEGTAGRFLT DSSIWIQCLE
160 170 180 190 200
PAHVVEWNII LFSILITLSG LQVIICLIRV VMQLSKILCG SYSVIFQPGI

I
Length:201
Mass (Da):22,277
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA49E70402164D336
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6Q4C9J6Q4_HUMAN
Transmembrane 4 L6 family member 18
TM4SF18
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK313400 mRNA Translation: BAG36197.1
CH471052 Genomic DNA Translation: EAW78877.1
CH471052 Genomic DNA Translation: EAW78878.1
CH471052 Genomic DNA Translation: EAW78879.1
BC014339 mRNA Translation: AAH14339.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3142.1

NCBI Reference Sequences

More...
RefSeqi
NP_001171652.1, NM_001184723.1
NP_620141.1, NM_138786.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296059; ENSP00000296059; ENSG00000163762
ENST00000470080; ENSP00000419278; ENSG00000163762

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116441

UCSC genome browser

More...
UCSCi
uc003exa.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313400 mRNA Translation: BAG36197.1
CH471052 Genomic DNA Translation: EAW78877.1
CH471052 Genomic DNA Translation: EAW78878.1
CH471052 Genomic DNA Translation: EAW78879.1
BC014339 mRNA Translation: AAH14339.1
CCDSiCCDS3142.1
RefSeqiNP_001171652.1, NM_001184723.1
NP_620141.1, NM_138786.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125506, 42 interactors
IntActiQ96CE8, 41 interactors
STRINGi9606.ENSP00000296059

Protein family/group databases

TCDBi8.A.75.1.2, the transmembrane 4 superfamily 4 (tm4sf4) family

PTM databases

iPTMnetiQ96CE8
PhosphoSitePlusiQ96CE8

Genetic variation databases

BioMutaiTM4SF18
DMDMi68053312

Proteomic databases

jPOSTiQ96CE8
MassIVEiQ96CE8
PaxDbiQ96CE8
PeptideAtlasiQ96CE8
PRIDEiQ96CE8
ProteomicsDBi76182

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
67990, 94 antibodies

The DNASU plasmid repository

More...
DNASUi
116441

Genome annotation databases

EnsembliENST00000296059; ENSP00000296059; ENSG00000163762
ENST00000470080; ENSP00000419278; ENSG00000163762
GeneIDi116441
KEGGihsa:116441
UCSCiuc003exa.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116441
DisGeNETi116441

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TM4SF18
HGNCiHGNC:25181, TM4SF18
HPAiENSG00000163762, Low tissue specificity
neXtProtiNX_Q96CE8
OpenTargetsiENSG00000163762
PharmGKBiPA142670801
VEuPathDBiHostDB:ENSG00000163762.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QS18, Eukaryota
GeneTreeiENSGT01010000222416
InParanoidiQ96CE8
OMAiYRCCQSE
OrthoDBi922490at2759
PhylomeDBiQ96CE8
TreeFamiTF331371

Enzyme and pathway databases

PathwayCommonsiQ96CE8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116441, 3 hits in 978 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TM4SF18, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116441
PharosiQ96CE8, Tdark

Protein Ontology

More...
PROi
PR:Q96CE8
RNActiQ96CE8, protein

Gene expression databases

BgeeiENSG00000163762, Expressed in visceral pleura and 189 other tissues
ExpressionAtlasiQ96CE8, baseline and differential
GenevisibleiQ96CE8, HS

Family and domain databases

InterProiView protein in InterPro
IPR008661, L6_membrane
PANTHERiPTHR14198, PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805, L6_membrane, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT4S18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CE8
Secondary accession number(s): B2R8K0, D3DNH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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