UniProtKB - Q96CD2 (COAC_HUMAN)
Protein
Phosphopantothenoylcysteine decarboxylase
Gene
PPCDC
Organism
Homo sapiens (Human)
Status
Functioni
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.2 Publications
Catalytic activityi
- EC:4.1.1.36
Cofactori
FMNNote: Binds 1 FMN per subunit.
: coenzyme A biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CoA from (R)-pantothenate.Proteins known to be involved in the 5 steps of the subpathway in this organism are:
- Pantothenate kinase 1 (PANK1), Pantothenate kinase 3 (PANK3), Pantothenate kinase 2, mitochondrial (PANK2)
- Phosphopantothenate--cysteine ligase (PPCS)
- Phosphopantothenoylcysteine decarboxylase (PPCDC)
- Bifunctional coenzyme A synthase (COASY)
- Bifunctional coenzyme A synthase (COASY)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 59 | FMN1 Publication | 1 | |
Binding sitei | 140 | SubstrateBy similarity | 1 | |
Active sitei | 173 | Proton donor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 104 – 107 | FMN1 Publication | 4 |
GO - Molecular functioni
- FMN binding Source: GO_Central
- identical protein binding Source: IntAct
- phosphopantothenoylcysteine decarboxylase activity Source: UniProtKB
GO - Biological processi
- coenzyme A biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Coenzyme A biosynthesis |
Ligand | Flavoprotein, FMN |
Enzyme and pathway databases
BioCyci | MetaCyc:HS13735-MONOMER |
PathwayCommonsi | Q96CD2 |
Reactomei | R-HSA-196783, Coenzyme A biosynthesis |
SABIO-RKi | Q96CD2 |
UniPathwayi | UPA00241;UER00354 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)Short name: PPC-DC Alternative name(s): CoaC |
Gene namesi | Name:PPCDC Synonyms:COAC ORF Names:MDS018, UNQ9365/PRO34154 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138621.11 |
HGNCi | HGNC:28107, PPCDC |
MIMi | 609854, gene |
neXtProti | NX_Q96CD2 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- phosphopantothenoylcysteine decarboxylase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 60490 |
OpenTargetsi | ENSG00000138621 |
PharmGKBi | PA142671157 |
Miscellaneous databases
Pharosi | Q96CD2, Tbio |
Chemistry databases
DrugBanki | DB03247, Flavin mononucleotide DB03738, Pantothenoylaminoethenethiol |
Polymorphism and mutation databases
BioMutai | PPCDC |
DMDMi | 296434457 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182030 | 1 – 204 | Phosphopantothenoylcysteine decarboxylaseAdd BLAST | 204 |
Proteomic databases
EPDi | Q96CD2 |
jPOSTi | Q96CD2 |
MassIVEi | Q96CD2 |
MaxQBi | Q96CD2 |
PaxDbi | Q96CD2 |
PeptideAtlasi | Q96CD2 |
PRIDEi | Q96CD2 |
ProteomicsDBi | 76180 [Q96CD2-1] 76181 [Q96CD2-2] |
PTM databases
iPTMneti | Q96CD2 |
PhosphoSitePlusi | Q96CD2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138621, Expressed in blood and 188 other tissues |
ExpressionAtlasi | Q96CD2, baseline and differential |
Genevisiblei | Q96CD2, HS |
Organism-specific databases
HPAi | ENSG00000138621, Low tissue specificity |
Interactioni
Subunit structurei
Homotrimer.
CuratedBinary interactionsi
Hide detailsQ96CD2
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121921, 16 interactors |
IntActi | Q96CD2, 16 interactors |
MINTi | Q96CD2 |
STRINGi | 9606.ENSP00000343190 |
Miscellaneous databases
RNActi | Q96CD2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96CD2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96CD2 |
Family & Domainsi
Sequence similaritiesi
Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.Curated
Phylogenomic databases
eggNOGi | KOG0672, Eukaryota |
GeneTreei | ENSGT00440000038107 |
HOGENOMi | CLU_033319_3_2_1 |
InParanoidi | Q96CD2 |
OMAi | MCVVRAW |
OrthoDBi | 1225808at2759 |
PhylomeDBi | Q96CD2 |
TreeFami | TF315740 |
Family and domain databases
Gene3Di | 3.40.50.1950, 1 hit |
InterProi | View protein in InterPro IPR036551, Flavin_trans-like IPR003382, Flavoprotein |
Pfami | View protein in Pfam PF02441, Flavoprotein, 1 hit |
SUPFAMi | SSF52507, SSF52507, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96CD2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPKASCPAA APLMERKFHV LVGVTGSVAA LKLPLLVSKL LDIPGLEVAV
60 70 80 90 100
VTTERAKHFY SPQDIPVTLY SDADEWEIWK SRSDPVLHID LRRWADLLLV
110 120 130 140 150
APLDANTLGK VASGICDNLL TCVMRAWDRS KPLLFCPAMN TAMWEHPITA
160 170 180 190 200
QQVDQLKAFG YVEIPCVAKK LVCGDEGLGA MAEVGTIVDK VKEVLFQHSG
FQQS
Isoform 2 (identifier: Q96CD2-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-78: MEPKASCPAA...LYSDADEWEI → M
Note: The Met-1 codon is associated with a polymorphism (dbSNP:rs2304899) that replaces the initiation ATG codon by an ATA codon.Curated
Show »Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRQ0 | H3BRQ0_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC | 172 | Annotation score: | ||
H3BQB0 | H3BQB0_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC | 161 | Annotation score: | ||
H3BSE3 | H3BSE3_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC | 129 | Annotation score: | ||
H3BU63 | H3BU63_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC hCG_21917 | 81 | Annotation score: | ||
H3BPW5 | H3BPW5_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC | 64 | Annotation score: | ||
H3BU34 | H3BU34_HUMAN | Phosphopantothenoylcysteine decarbo... | PPCDC | 62 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | A → S in BAB55151 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068974 | 78 | I → M. Corresponds to variant dbSNP:rs2304899Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044802 | 1 – 78 | MEPKA…DEWEI → M in isoform 2. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182419 mRNA Translation: AAG14955.1 AY358848 mRNA Translation: AAQ89207.1 AK027491 mRNA Translation: BAB55151.1 AC015720 Genomic DNA No translation available. BC014409 mRNA Translation: AAH14409.1 |
CCDSi | CCDS10275.1 [Q96CD2-1] |
RefSeqi | NP_001288030.1, NM_001301101.1 NP_001288031.1, NM_001301102.1 NP_001288032.1, NM_001301103.1 NP_001288033.1, NM_001301104.1 NP_001288034.1, NM_001301105.1 NP_068595.3, NM_021823.4 [Q96CD2-1] |
Genome annotation databases
Ensembli | ENST00000342932; ENSP00000343190; ENSG00000138621 [Q96CD2-1] |
GeneIDi | 60490 |
KEGGi | hsa:60490 |
UCSCi | uc002azo.4, human [Q96CD2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182419 mRNA Translation: AAG14955.1 AY358848 mRNA Translation: AAQ89207.1 AK027491 mRNA Translation: BAB55151.1 AC015720 Genomic DNA No translation available. BC014409 mRNA Translation: AAH14409.1 |
CCDSi | CCDS10275.1 [Q96CD2-1] |
RefSeqi | NP_001288030.1, NM_001301101.1 NP_001288031.1, NM_001301102.1 NP_001288032.1, NM_001301103.1 NP_001288033.1, NM_001301104.1 NP_001288034.1, NM_001301105.1 NP_068595.3, NM_021823.4 [Q96CD2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QZU | X-ray | 2.91 | A/B/C/D | 1-204 | [»] | |
SMRi | Q96CD2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121921, 16 interactors |
IntActi | Q96CD2, 16 interactors |
MINTi | Q96CD2 |
STRINGi | 9606.ENSP00000343190 |
Chemistry databases
DrugBanki | DB03247, Flavin mononucleotide DB03738, Pantothenoylaminoethenethiol |
PTM databases
iPTMneti | Q96CD2 |
PhosphoSitePlusi | Q96CD2 |
Polymorphism and mutation databases
BioMutai | PPCDC |
DMDMi | 296434457 |
Proteomic databases
EPDi | Q96CD2 |
jPOSTi | Q96CD2 |
MassIVEi | Q96CD2 |
MaxQBi | Q96CD2 |
PaxDbi | Q96CD2 |
PeptideAtlasi | Q96CD2 |
PRIDEi | Q96CD2 |
ProteomicsDBi | 76180 [Q96CD2-1] 76181 [Q96CD2-2] |
Protocols and materials databases
Antibodypediai | 14730, 89 antibodies |
DNASUi | 60490 |
Genome annotation databases
Ensembli | ENST00000342932; ENSP00000343190; ENSG00000138621 [Q96CD2-1] |
GeneIDi | 60490 |
KEGGi | hsa:60490 |
UCSCi | uc002azo.4, human [Q96CD2-1] |
Organism-specific databases
CTDi | 60490 |
DisGeNETi | 60490 |
EuPathDBi | HostDB:ENSG00000138621.11 |
GeneCardsi | PPCDC |
HGNCi | HGNC:28107, PPCDC |
HPAi | ENSG00000138621, Low tissue specificity |
MIMi | 609854, gene |
neXtProti | NX_Q96CD2 |
OpenTargetsi | ENSG00000138621 |
PharmGKBi | PA142671157 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0672, Eukaryota |
GeneTreei | ENSGT00440000038107 |
HOGENOMi | CLU_033319_3_2_1 |
InParanoidi | Q96CD2 |
OMAi | MCVVRAW |
OrthoDBi | 1225808at2759 |
PhylomeDBi | Q96CD2 |
TreeFami | TF315740 |
Enzyme and pathway databases
UniPathwayi | UPA00241;UER00354 |
BioCyci | MetaCyc:HS13735-MONOMER |
PathwayCommonsi | Q96CD2 |
Reactomei | R-HSA-196783, Coenzyme A biosynthesis |
SABIO-RKi | Q96CD2 |
Miscellaneous databases
BioGRID-ORCSi | 60490, 87 hits in 843 CRISPR screens |
ChiTaRSi | PPCDC, human |
EvolutionaryTracei | Q96CD2 |
GenomeRNAii | 60490 |
Pharosi | Q96CD2, Tbio |
PROi | PR:Q96CD2 |
RNActi | Q96CD2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138621, Expressed in blood and 188 other tissues |
ExpressionAtlasi | Q96CD2, baseline and differential |
Genevisiblei | Q96CD2, HS |
Family and domain databases
Gene3Di | 3.40.50.1950, 1 hit |
InterProi | View protein in InterPro IPR036551, Flavin_trans-like IPR003382, Flavoprotein |
Pfami | View protein in Pfam PF02441, Flavoprotein, 1 hit |
SUPFAMi | SSF52507, SSF52507, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COAC_HUMAN | |
Accessioni | Q96CD2Primary (citable) accession number: Q96CD2 Secondary accession number(s): Q96SX0, Q9HC17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations