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Protein

F-box/LRR-repeat protein 8

Gene

FBXL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Caution

While the gene symbol and protein names are indicative of the presence of LRR repeats, such repeats are not present in this protein.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 8
Alternative name(s):
F-box and leucine-rich repeat protein 8
F-box protein FBL8
Gene namesi
Name:FBXL8
Synonyms:FBL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000135722.8
HGNCiHGNC:17875 FBXL8
MIMi609077 gene
neXtProtiNX_Q96CD0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135722
PharmGKBiPA28028

Polymorphism and mutation databases

BioMutaiFBXL8
DMDMi38257737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198501 – 374F-box/LRR-repeat protein 8Add BLAST374

Proteomic databases

EPDiQ96CD0
MaxQBiQ96CD0
PaxDbiQ96CD0
PeptideAtlasiQ96CD0
PRIDEiQ96CD0
ProteomicsDBi76179

Expressioni

Gene expression databases

BgeeiENSG00000135722 Expressed in 87 organ(s), highest expression level in body of pancreas
CleanExiHS_FBXL8
ExpressionAtlasiQ96CD0 baseline and differential
GenevisibleiQ96CD0 HS

Organism-specific databases

HPAiHPA035587
HPA035588

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P6320812EBI-2321097,EBI-307486

Protein-protein interaction databases

BioGridi120617, 6 interactors
IntActiQ96CD0, 6 interactors
STRINGi9606.ENSP00000258200

Structurei

3D structure databases

ProteinModelPortaliQ96CD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 48F-boxPROSITE-ProRule annotationAdd BLAST47

Phylogenomic databases

eggNOGiENOG410IKPE Eukaryota
ENOG4111K6I LUCA
GeneTreeiENSGT00420000029943
HOGENOMiHOG000112553
HOVERGENiHBG051592
InParanoidiQ96CD0
KOiK10274
OMAiNHALVNS
OrthoDBiEOG091G07PY
PhylomeDBiQ96CD0
TreeFamiTF321665

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

Q96CD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPGEGLPE EVLALIFRHL SLRDRAAAAR VCRAWAAAAT CSAVWHDTKI
60 70 80 90 100
SCECELEGML PPYLSACLDH IHNLRLEFEP SRKPSRRAAI ELLMVLAGRA
110 120 130 140 150
PGLRGLRLEC RGEKPLFDAG RDVLEAVHAV CGAASQLRHL DLRRLSFTLD
160 170 180 190 200
DALVLQAARS CPELHSLFLD NSTLVGSVGP GSVLELLEAC PRLRALGLHL
210 220 230 240 250
ASLSHAILEA LAAPDRAPFA LLALRCACPE DARASPLPNE AWVALRRRHP
260 270 280 290 300
GLAVELELEP ALPAESVTRV LQPAVPVAAL RLNLSGDTVG PVRFAAHHYA
310 320 330 340 350
ATLCALEVRA AASAELNAAL EELAARCAAL REVHCFCVVS HSVLDAFRAH
360 370
CPRLRTYTLK LTREPHPWRP TLVA
Length:374
Mass (Da):40,516
Last modified:December 1, 2001 - v1
Checksum:i7B91444E31E95931
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIS0E5RIS0_HUMAN
F-box/LRR-repeat protein 8
FBXL8
128Annotation score:
E5RIE9E5RIE9_HUMAN
F-box/LRR-repeat protein 8
FBXL8
136Annotation score:
J3QRE3J3QRE3_HUMAN
F-box/LRR-repeat protein 8
FBXL8
51Annotation score:
E5RH15E5RH15_HUMAN
F-box/LRR-repeat protein 8
FBXL8
163Annotation score:
E5RFX2E5RFX2_HUMAN
F-box/LRR-repeat protein 8
FBXL8
62Annotation score:
E5RHS9E5RHS9_HUMAN
F-box/LRR-repeat protein 8
FBXL8
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135S → N in BAA92103 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002140 mRNA Translation: BAA92103.1
BC014414 mRNA Translation: AAH14414.1
CCDSiCCDS10831.1
RefSeqiNP_060848.2, NM_018378.2
UniGeneiHs.710714

Genome annotation databases

EnsembliENST00000258200; ENSP00000258200; ENSG00000135722
ENST00000519917; ENSP00000430490; ENSG00000135722
GeneIDi55336
KEGGihsa:55336
UCSCiuc002erk.2 human

Similar proteinsi

Entry informationi

Entry nameiFBXL8_HUMAN
AccessioniPrimary (citable) accession number: Q96CD0
Secondary accession number(s): Q9NUM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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