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Protein

Integrator complex subunit 12

Gene

INTS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription by RNA polymerase II Source: Reactome

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
Gene namesi
Name:INTS12
Synonyms:PHF22
ORF Names:SBBI22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138785.14
HGNCiHGNC:25067 INTS12
MIMi611355 gene
neXtProtiNX_Q96CB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57117
OpenTargetsiENSG00000138785
PharmGKBiPA142671177

Polymorphism and mutation databases

BioMutaiINTS12
DMDMi73621394

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593121 – 462Integrator complex subunit 12Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei128PhosphoserineCombined sources1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96CB8
MaxQBiQ96CB8
PaxDbiQ96CB8
PeptideAtlasiQ96CB8
PRIDEiQ96CB8
ProteomicsDBi76174

PTM databases

iPTMnetiQ96CB8
PhosphoSitePlusiQ96CB8

Expressioni

Gene expression databases

BgeeiENSG00000138785 Expressed in 222 organ(s), highest expression level in myocardium
CleanExiHS_INTS12
ExpressionAtlasiQ96CB8 baseline and differential
GenevisibleiQ96CB8 HS

Organism-specific databases

HPAiHPA035772
HPA041814

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2IRD1Q9UHL93EBI-1049156,EBI-372530

Protein-protein interaction databases

BioGridi121381, 44 interactors
CORUMiQ96CB8
DIPiDIP-48479N
IntActiQ96CB8, 16 interactors
MINTiQ96CB8
STRINGi9606.ENSP00000340737

Structurei

3D structure databases

ProteinModelPortaliQ96CB8
SMRiQ96CB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 440Ser-richAdd BLAST171

Sequence similaritiesi

Belongs to the Integrator subunit 12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000005218
HOGENOMiHOG000059634
HOVERGENiHBG081798
InParanoidiQ96CB8
KOiK13149
OMAiSSKHGHK
OrthoDBiEOG091G0KPP
PhylomeDBiQ96CB8
TreeFamiTF106418

Family and domain databases

CDDicd15501 PHD_Int12, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039053 Int12
IPR039054 Int12_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13415 PTHR13415, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96CB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS
60 70 80 90 100
QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP
110 120 130 140 150
ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS
160 170 180 190 200
ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA
210 220 230 240 250
NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE
260 270 280 290 300
TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT
310 320 330 340 350
SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS
360 370 380 390 400
NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ
410 420 430 440 450
LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM
460
VKKKAAQKKL KK
Length:462
Mass (Da):48,808
Last modified:December 1, 2001 - v1
Checksum:i7AEF952044A3E951
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXN4A0A087WXN4_HUMAN
Integrator complex subunit 12
INTS12
444Annotation score:
C9JDP3C9JDP3_HUMAN
Integrator complex subunit 12
INTS12
88Annotation score:
E9PGI3E9PGI3_HUMAN
Integrator complex subunit 12
INTS12
159Annotation score:
C9J0M6C9J0M6_HUMAN
Integrator complex subunit 12
INTS12
131Annotation score:
D6R9W3D6R9W3_HUMAN
Integrator complex subunit 12
INTS12
57Annotation score:
A0A1B0GX90A0A1B0GX90_HUMAN
Integrator complex subunit 12
INTS12
87Annotation score:
D6R9Y5D6R9Y5_HUMAN
Integrator complex subunit 12
INTS12
18Annotation score:

Sequence cautioni

The sequence AAF99604 differs from that shown. Reason: Frameshift at position 439.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049629323T → A. Corresponds to variant dbSNP:rs34567094Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242524 mRNA Translation: AAF99604.1 Frameshift.
AK314939 mRNA Translation: BAG37445.1
CH471057 Genomic DNA Translation: EAX06189.1
BC014442 mRNA Translation: AAH14442.1
BK005729 mRNA Translation: DAA05729.1
CCDSiCCDS3671.1
RefSeqiNP_001135943.1, NM_001142471.1
NP_065128.2, NM_020395.3
XP_005263205.1, XM_005263148.4
XP_011530445.1, XM_011532143.2
XP_011530447.1, XM_011532145.2
UniGeneiHs.480454

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785
ENST00000394735; ENSP00000378221; ENSG00000138785
ENST00000451321; ENSP00000415433; ENSG00000138785
GeneIDi57117
KEGGihsa:57117
UCSCiuc003hxw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242524 mRNA Translation: AAF99604.1 Frameshift.
AK314939 mRNA Translation: BAG37445.1
CH471057 Genomic DNA Translation: EAX06189.1
BC014442 mRNA Translation: AAH14442.1
BK005729 mRNA Translation: DAA05729.1
CCDSiCCDS3671.1
RefSeqiNP_001135943.1, NM_001142471.1
NP_065128.2, NM_020395.3
XP_005263205.1, XM_005263148.4
XP_011530445.1, XM_011532143.2
XP_011530447.1, XM_011532145.2
UniGeneiHs.480454

3D structure databases

ProteinModelPortaliQ96CB8
SMRiQ96CB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121381, 44 interactors
CORUMiQ96CB8
DIPiDIP-48479N
IntActiQ96CB8, 16 interactors
MINTiQ96CB8
STRINGi9606.ENSP00000340737

PTM databases

iPTMnetiQ96CB8
PhosphoSitePlusiQ96CB8

Polymorphism and mutation databases

BioMutaiINTS12
DMDMi73621394

Proteomic databases

EPDiQ96CB8
MaxQBiQ96CB8
PaxDbiQ96CB8
PeptideAtlasiQ96CB8
PRIDEiQ96CB8
ProteomicsDBi76174

Protocols and materials databases

DNASUi57117
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785
ENST00000394735; ENSP00000378221; ENSG00000138785
ENST00000451321; ENSP00000415433; ENSG00000138785
GeneIDi57117
KEGGihsa:57117
UCSCiuc003hxw.4 human

Organism-specific databases

CTDi57117
DisGeNETi57117
EuPathDBiHostDB:ENSG00000138785.14
GeneCardsiINTS12
HGNCiHGNC:25067 INTS12
HPAiHPA035772
HPA041814
MIMi611355 gene
neXtProtiNX_Q96CB8
OpenTargetsiENSG00000138785
PharmGKBiPA142671177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000005218
HOGENOMiHOG000059634
HOVERGENiHBG081798
InParanoidiQ96CB8
KOiK13149
OMAiSSKHGHK
OrthoDBiEOG091G0KPP
PhylomeDBiQ96CB8
TreeFamiTF106418

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

GeneWikiiINTS12
GenomeRNAii57117
PROiPR:Q96CB8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138785 Expressed in 222 organ(s), highest expression level in myocardium
CleanExiHS_INTS12
ExpressionAtlasiQ96CB8 baseline and differential
GenevisibleiQ96CB8 HS

Family and domain databases

CDDicd15501 PHD_Int12, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039053 Int12
IPR039054 Int12_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13415 PTHR13415, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT12_HUMAN
AccessioniPrimary (citable) accession number: Q96CB8
Secondary accession number(s): B2RC48, Q3B6Z3, Q9HD71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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