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Entry version 154 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Integrator complex subunit 12

Gene

INTS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144).

Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96CB8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505, RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96CB8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS12
Synonyms:PHF22
ORF Names:SBBI22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25067, INTS12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611355, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96CB8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000138785.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57117

Open Targets

More...
OpenTargetsi
ENSG00000138785

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96CB8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INTS12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73621394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593121 – 462Integrator complex subunit 12Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128PhosphoserineCombined sources1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96CB8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96CB8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96CB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96CB8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96CB8

PeptideAtlas

More...
PeptideAtlasi
Q96CB8

PRoteomics IDEntifications database

More...
PRIDEi
Q96CB8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76174

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96CB8, 3 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96CB8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96CB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138785, Expressed in myocardium and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96CB8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96CB8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138785, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121381, 57 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96CB8

Database of interacting proteins

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DIPi
DIP-48479N

Protein interaction database and analysis system

More...
IntActi
Q96CB8, 37 interactors

Molecular INTeraction database

More...
MINTi
Q96CB8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415433

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96CB8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96CB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 132DisorderedSequence analysisAdd BLAST91
Regioni301 – 462DisorderedSequence analysisAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 87Polar residuesSequence analysisAdd BLAST33
Compositional biasi88 – 123Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi301 – 356Polar residuesSequence analysisAdd BLAST56
Compositional biasi371 – 445Polar residuesSequence analysisAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 215PHD-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4323, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033336_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96CB8

Identification of Orthologs from Complete Genome Data

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OMAi
NSPDKEP

Database of Orthologous Groups

More...
OrthoDBi
1631937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96CB8

TreeFam database of animal gene trees

More...
TreeFami
TF106418

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15501, PHD_Int12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039053, Int12
IPR039054, Int12_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR13415:SF4, PTHR13415:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628, PHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249, PHD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96CB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS
60 70 80 90 100
QKDVEPPKIS STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP
110 120 130 140 150
ADKMKSDITE GVDIPKKPRL EKPETQSSPI TVQSSKDLPM ADLSSFEETS
160 170 180 190 200
ADDFAMEMGL ACVVCRQMMV ASGNQLVECQ ECHNLYHRDC HKPQVTDKEA
210 220 230 240 250
NDPRLVWYCA RCTRQMKRMA QKTQKPPQKP APAVVSVTPA VKDPLVKKPE
260 270 280 290 300
TKLKQETTFL AFKRTEVKTS TVISGNSSSA SVSSSVTSGL TGWAAFAAKT
310 320 330 340 350
SSAGPSTAKL SSTTQNNTGK PATSSANQKP VGLTGLATSS KGGIGSKIGS
360 370 380 390 400
NNSTTPTVPL KPPPPLTLGK TGLSRSVSCD NVSKVGLPSP SSLVPGSSSQ
410 420 430 440 450
LSGNGNSGTS GPSGSTTSKT TSESSSSPSA SLKGPTSQES QLNAMKRLQM
460
VKKKAAQKKL KK
Length:462
Mass (Da):48,808
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AEF952044A3E951
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXN4A0A087WXN4_HUMAN
Integrator complex subunit 12
INTS12
444Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGI3E9PGI3_HUMAN
Integrator complex subunit 12
INTS12
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDP3C9JDP3_HUMAN
Integrator complex subunit 12
INTS12
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0M6C9J0M6_HUMAN
Integrator complex subunit 12
INTS12
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GX90A0A1B0GX90_HUMAN
Integrator complex subunit 12
INTS12
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9W3D6R9W3_HUMAN
Integrator complex subunit 12
INTS12
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9Y5D6R9Y5_HUMAN
Integrator complex subunit 12
INTS12
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF99604 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049629323T → A. Corresponds to variant dbSNP:rs34567094Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF242524 mRNA Translation: AAF99604.1 Frameshift.
AK314939 mRNA Translation: BAG37445.1
CH471057 Genomic DNA Translation: EAX06189.1
BC014442 mRNA Translation: AAH14442.1
BK005729 mRNA Translation: DAA05729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3671.1

NCBI Reference Sequences

More...
RefSeqi
NP_001135943.1, NM_001142471.1
NP_065128.2, NM_020395.3
XP_005263205.1, XM_005263148.4
XP_011530445.1, XM_011532143.2
XP_011530447.1, XM_011532145.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340139; ENSP00000340737; ENSG00000138785
ENST00000394735; ENSP00000378221; ENSG00000138785
ENST00000451321; ENSP00000415433; ENSG00000138785

Database of genes from NCBI RefSeq genomes

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GeneIDi
57117

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57117

UCSC genome browser

More...
UCSCi
uc003hxw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242524 mRNA Translation: AAF99604.1 Frameshift.
AK314939 mRNA Translation: BAG37445.1
CH471057 Genomic DNA Translation: EAX06189.1
BC014442 mRNA Translation: AAH14442.1
BK005729 mRNA Translation: DAA05729.1
CCDSiCCDS3671.1
RefSeqiNP_001135943.1, NM_001142471.1
NP_065128.2, NM_020395.3
XP_005263205.1, XM_005263148.4
XP_011530445.1, XM_011532143.2
XP_011530447.1, XM_011532145.2

3D structure databases

SMRiQ96CB8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121381, 57 interactors
CORUMiQ96CB8
DIPiDIP-48479N
IntActiQ96CB8, 37 interactors
MINTiQ96CB8
STRINGi9606.ENSP00000415433

PTM databases

GlyGeniQ96CB8, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetiQ96CB8
PhosphoSitePlusiQ96CB8

Genetic variation databases

BioMutaiINTS12
DMDMi73621394

Proteomic databases

EPDiQ96CB8
jPOSTiQ96CB8
MassIVEiQ96CB8
MaxQBiQ96CB8
PaxDbiQ96CB8
PeptideAtlasiQ96CB8
PRIDEiQ96CB8
ProteomicsDBi76174

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26162, 75 antibodies

The DNASU plasmid repository

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DNASUi
57117

Genome annotation databases

EnsembliENST00000340139; ENSP00000340737; ENSG00000138785
ENST00000394735; ENSP00000378221; ENSG00000138785
ENST00000451321; ENSP00000415433; ENSG00000138785
GeneIDi57117
KEGGihsa:57117
UCSCiuc003hxw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57117
DisGeNETi57117

GeneCards: human genes, protein and diseases

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GeneCardsi
INTS12
HGNCiHGNC:25067, INTS12
HPAiENSG00000138785, Low tissue specificity
MIMi611355, gene
neXtProtiNX_Q96CB8
OpenTargetsiENSG00000138785
PharmGKBiPA142671177
VEuPathDBiHostDB:ENSG00000138785.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4323, Eukaryota
GeneTreeiENSGT00390000005218
HOGENOMiCLU_033336_0_0_1
InParanoidiQ96CB8
OMAiNSPDKEP
OrthoDBi1631937at2759
PhylomeDBiQ96CB8
TreeFamiTF106418

Enzyme and pathway databases

PathwayCommonsiQ96CB8
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes
SIGNORiQ96CB8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57117, 333 hits in 1011 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
INTS12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57117
PharosiQ96CB8, Tbio

Protein Ontology

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PROi
PR:Q96CB8
RNActiQ96CB8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000138785, Expressed in myocardium and 236 other tissues
ExpressionAtlasiQ96CB8, baseline and differential
GenevisibleiQ96CB8, HS

Family and domain databases

CDDicd15501, PHD_Int12, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039053, Int12
IPR039054, Int12_PHD
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR13415:SF4, PTHR13415:SF4, 1 hit
PfamiView protein in Pfam
PF00628, PHD, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96CB8
Secondary accession number(s): B2RC48, Q3B6Z3, Q9HD71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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