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Protein

Baculoviral IAP repeat-containing protein 7

Gene

BIRC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.4 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124Zinc1
Metal bindingi127Zinc1
Metal bindingi144Zinc1
Metal bindingi151Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 286RING-typePROSITE-ProRule annotationAdd BLAST35

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: GO_Central
  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor, Transferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ96CA5
SIGNORiQ96CA5

Protein family/group databases

MEROPSiI32.007

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 7 (EC:2.3.2.271 Publication)
Alternative name(s):
Kidney inhibitor of apoptosis protein
Short name:
KIAP
Livin
Melanoma inhibitor of apoptosis protein
Short name:
ML-IAP
RING finger protein 50
RING-type E3 ubiquitin transferase BIRC7Curated
Cleaved into the following chain:
Baculoviral IAP repeat-containing protein 7 30kDa subunit
Short name:
Truncated livin
Short name:
p30-Livin
Short name:
tLivin
Gene namesi
Name:BIRC7
Synonyms:KIAP, LIVIN, MLIAP, RNF50
ORF Names:UNQ5800/PRO19607/PRO21344
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101197.12
HGNCiHGNC:13702 BIRC7
MIMi605737 gene
neXtProtiNX_Q96CA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87 – 88EE → AA: No change in SMAC interaction and anti-apoptotic activity. 1 Publication2
Mutagenesisi120D → A: Abolishes inhibition of caspases, SMAC binding and anti-apoptotic activity. 1 Publication1
Mutagenesisi124C → A: Abolishes inhibition of caspases and anti-apoptotic activity. 1 Publication1
Mutagenesisi138D → A: Abolishes inhibition of caspases, SMAC binding and anti-apoptotic activity. 1 Publication1

Organism-specific databases

DisGeNETi79444
OpenTargetsiENSG00000101197
PharmGKBiPA25364

Chemistry databases

ChEMBLiCHEMBL1075127
GuidetoPHARMACOLOGYi2794

Polymorphism and mutation databases

BioMutaiBIRC7
DMDMi21759008

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223621 – 298Baculoviral IAP repeat-containing protein 7Add BLAST298
ChainiPRO_000041609253 – 298Baculoviral IAP repeat-containing protein 7 30kDa subunitAdd BLAST246

Post-translational modificationi

Autoubiquitinated and undergoes proteasome-mediated degradation.
The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei52 – 53Cleavage; by CASP3 and CASP72

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96CA5
PaxDbiQ96CA5
PeptideAtlasiQ96CA5
PRIDEiQ96CA5
ProteomicsDBi76171
76172 [Q96CA5-2]

PTM databases

iPTMnetiQ96CA5
PhosphoSitePlusiQ96CA5

Miscellaneous databases

PMAP-CutDBiQ96CA5

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000101197 Expressed in 68 organ(s), highest expression level in adrenal tissue
CleanExiHS_BIRC7
ExpressionAtlasiQ96CA5 baseline and differential
GenevisibleiQ96CA5 HS

Organism-specific databases

HPAiHPA047850

Interactioni

Subunit structurei

Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122670, 33 interactors
DIPiDIP-33486N
IntActiQ96CA5, 35 interactors
MINTiQ96CA5
STRINGi9606.ENSP00000217169

Chemistry databases

BindingDBiQ96CA5

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96CA5
SMRiQ96CA5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96CA5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati90 – 155BIRAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 69Poly-Glu6

Domaini

The RING domain is essential for autoubiquitination.

Sequence similaritiesi

Belongs to the IAP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri252 – 286RING-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00500000044782
HOGENOMiHOG000232059
HOVERGENiHBG099136
InParanoidiQ96CA5
KOiK16061
OMAiRAPIRSC
OrthoDBiEOG091G0CXH
PhylomeDBiQ96CA5
TreeFamiTF105356

Family and domain databases

CDDicd00022 BIR, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00653 BIR, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 1 hit
PS50143 BIR_REPEAT_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q96CA5-1) [UniParc]FASTAAdd to basket
Also known as: Livin alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH
60 70 80 90 100
VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT
110 120 130 140 150
AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS
160 170 180 190 200
CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE
210 220 230 240 250
LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER
260 270 280 290
TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS
Length:298
Mass (Da):32,798
Last modified:July 11, 2002 - v2
Checksum:iB2EAAEE531BEC101
GO
Isoform 1 (identifier: Q96CA5-2) [UniParc]FASTAAdd to basket
Also known as: Livin beta

The sequence of this isoform differs from the canonical sequence as follows:
     216-233: Missing.

Show »
Length:280
Mass (Da):30,866
Checksum:i630BE9C0737F7952
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MTF4A8MTF4_HUMAN
Baculoviral IAP repeat-containing p...
BIRC7
193Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020253223E → Q1 PublicationCorresponds to variant dbSNP:rs1077019Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002459216 – 233Missing in isoform 1. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301009 mRNA Translation: AAG37878.1
AJ309298 Genomic DNA Translation: CAC37337.1
AJ309298 Genomic DNA Translation: CAC37338.1
AF311388 mRNA Translation: AAG33622.1
AY358835 mRNA Translation: AAQ89194.1
AY358836 mRNA Translation: AAQ89195.1
AL121827 Genomic DNA No translation available.
BC014475 mRNA Translation: AAH14475.1
CCDSiCCDS13512.1 [Q96CA5-2]
CCDS13513.1 [Q96CA5-1]
PIRiJC7568
RefSeqiNP_071444.1, NM_022161.3 [Q96CA5-2]
NP_647478.1, NM_139317.2 [Q96CA5-1]
UniGeneiHs.256126

Genome annotation databases

EnsembliENST00000217169; ENSP00000217169; ENSG00000101197 [Q96CA5-1]
ENST00000342412; ENSP00000345213; ENSG00000101197 [Q96CA5-2]
GeneIDi79444
KEGGihsa:79444
UCSCiuc002yei.5 human [Q96CA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301009 mRNA Translation: AAG37878.1
AJ309298 Genomic DNA Translation: CAC37337.1
AJ309298 Genomic DNA Translation: CAC37338.1
AF311388 mRNA Translation: AAG33622.1
AY358835 mRNA Translation: AAQ89194.1
AY358836 mRNA Translation: AAQ89195.1
AL121827 Genomic DNA No translation available.
BC014475 mRNA Translation: AAH14475.1
CCDSiCCDS13512.1 [Q96CA5-2]
CCDS13513.1 [Q96CA5-1]
PIRiJC7568
RefSeqiNP_071444.1, NM_022161.3 [Q96CA5-2]
NP_647478.1, NM_139317.2 [Q96CA5-1]
UniGeneiHs.256126

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OXNX-ray2.20A/B/C/D/E63-179[»]
1OXQX-ray2.30A/B/C/D/E63-179[»]
1OY7X-ray2.70A/B/C/D/E63-179[»]
1TW6X-ray1.71A/B63-172[»]
2I3HX-ray1.62A/B63-172[»]
2I3IX-ray2.30A/B63-172[»]
3F7GX-ray2.30A/B/C/D/E63-179[»]
3F7HX-ray1.80A/B63-172[»]
3F7IX-ray1.90A/B63-172[»]
3GT9X-ray1.70A/B63-172[»]
3GTAX-ray1.70A/B63-172[»]
3UW5X-ray1.71A/B63-159[»]
4AUQX-ray2.18B/E239-298[»]
ProteinModelPortaliQ96CA5
SMRiQ96CA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122670, 33 interactors
DIPiDIP-33486N
IntActiQ96CA5, 35 interactors
MINTiQ96CA5
STRINGi9606.ENSP00000217169

Chemistry databases

BindingDBiQ96CA5
ChEMBLiCHEMBL1075127
GuidetoPHARMACOLOGYi2794

Protein family/group databases

MEROPSiI32.007

PTM databases

iPTMnetiQ96CA5
PhosphoSitePlusiQ96CA5

Polymorphism and mutation databases

BioMutaiBIRC7
DMDMi21759008

Proteomic databases

MaxQBiQ96CA5
PaxDbiQ96CA5
PeptideAtlasiQ96CA5
PRIDEiQ96CA5
ProteomicsDBi76171
76172 [Q96CA5-2]

Protocols and materials databases

DNASUi79444
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217169; ENSP00000217169; ENSG00000101197 [Q96CA5-1]
ENST00000342412; ENSP00000345213; ENSG00000101197 [Q96CA5-2]
GeneIDi79444
KEGGihsa:79444
UCSCiuc002yei.5 human [Q96CA5-1]

Organism-specific databases

CTDi79444
DisGeNETi79444
EuPathDBiHostDB:ENSG00000101197.12
GeneCardsiBIRC7
HGNCiHGNC:13702 BIRC7
HPAiHPA047850
MIMi605737 gene
neXtProtiNX_Q96CA5
OpenTargetsiENSG00000101197
PharmGKBiPA25364
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00500000044782
HOGENOMiHOG000232059
HOVERGENiHBG099136
InParanoidiQ96CA5
KOiK16061
OMAiRAPIRSC
OrthoDBiEOG091G0CXH
PhylomeDBiQ96CA5
TreeFamiTF105356

Enzyme and pathway databases

SignaLinkiQ96CA5
SIGNORiQ96CA5

Miscellaneous databases

EvolutionaryTraceiQ96CA5
GeneWikiiBIRC7
GenomeRNAii79444
PMAP-CutDBiQ96CA5
PROiPR:Q96CA5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101197 Expressed in 68 organ(s), highest expression level in adrenal tissue
CleanExiHS_BIRC7
ExpressionAtlasiQ96CA5 baseline and differential
GenevisibleiQ96CA5 HS

Family and domain databases

CDDicd00022 BIR, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00653 BIR, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 1 hit
PS50143 BIR_REPEAT_2, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBIRC7_HUMAN
AccessioniPrimary (citable) accession number: Q96CA5
Secondary accession number(s): Q9BQV0, Q9H2A8, Q9HAP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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