UniProtKB - Q96C90 (PP14B_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 14B
Gene
PPP1R14B
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).By similarity
GO - Molecular functioni
- protein serine/threonine phosphatase inhibitor activity Source: GO_Central
GO - Biological processi
- innate immune response Source: GO_Central
- regulation of phosphorylation Source: InterPro
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q96C90 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 14BAlternative name(s): Phospholipase C-beta-3 neighbouring gene protein |
Gene namesi | Name:PPP1R14B Synonyms:PLCB3N, PNG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9057, PPP1R14B |
MIMi | 601140, gene |
neXtProti | NX_Q96C90 |
VEuPathDBi | HostDB:ENSG00000173457.10 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 26472 |
OpenTargetsi | ENSG00000173457 |
PharmGKBi | PA33624 |
Miscellaneous databases
Pharosi | Q96C90, Tbio |
Genetic variation databases
BioMutai | PPP1R14B |
DMDMi | 55583975 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000071490 | 2 – 147 | Protein phosphatase 1 regulatory subunit 14BAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 29 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96C90 |
jPOSTi | Q96C90 |
MassIVEi | Q96C90 |
MaxQBi | Q96C90 |
PaxDbi | Q96C90 |
PeptideAtlasi | Q96C90 |
PRIDEi | Q96C90 |
ProteomicsDBi | 76165 |
TopDownProteomicsi | Q96C90 |
PTM databases
iPTMneti | Q96C90 |
PhosphoSitePlusi | Q96C90 |
Expressioni
Tissue specificityi
Ubiquitous. Expressed at low levels.1 Publication
Gene expression databases
Bgeei | ENSG00000173457, Expressed in cortical plate and 117 other tissues |
ExpressionAtlasi | Q96C90, baseline and differential |
Genevisiblei | Q96C90, HS |
Organism-specific databases
HPAi | ENSG00000173457, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117696, 8 interactors |
IntActi | Q96C90, 4 interactors |
MINTi | Q96C90 |
STRINGi | 9606.ENSP00000310117 |
Miscellaneous databases
RNActi | Q96C90, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 61 – 103 | Sequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the PP1 inhibitor family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0824, Eukaryota |
GeneTreei | ENSGT00950000182985 |
HOGENOMi | CLU_114155_1_0_1 |
InParanoidi | Q96C90 |
OMAi | TQLYDCQ |
OrthoDBi | 1492626at2759 |
PhylomeDBi | Q96C90 |
TreeFami | TF105546 |
Family and domain databases
Gene3Di | 1.10.150.220, 1 hit |
InterProi | View protein in InterPro IPR008025, CPI-17 IPR036658, CPI-17_sf |
PANTHERi | PTHR16188, PTHR16188, 1 hit |
Pfami | View protein in Pfam PF05361, PP1_inhibitor, 1 hit |
SUPFAMi | SSF81790, SSF81790, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q96C90-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV
60 70 80 90 100
RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL
110 120 130 140
LDMESDDARA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GXC4 | F5GXC4_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R14B | 45 | Annotation score: | ||
F5H2U0 | F5H2U0_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R14B | 72 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT009914 mRNA Translation: AAP88916.1 BC014522 mRNA Translation: AAH14522.3 BC094817 mRNA Translation: AAH94817.1 |
CCDSi | CCDS31596.1 |
RefSeqi | NP_619634.1, NM_138689.2 |
Genome annotation databases
Ensembli | ENST00000309318; ENSP00000310117; ENSG00000173457 |
GeneIDi | 26472 |
KEGGi | hsa:26472 |
UCSCi | uc001nza.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT009914 mRNA Translation: AAP88916.1 BC014522 mRNA Translation: AAH14522.3 BC094817 mRNA Translation: AAH94817.1 |
CCDSi | CCDS31596.1 |
RefSeqi | NP_619634.1, NM_138689.2 |
3D structure databases
SMRi | Q96C90 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117696, 8 interactors |
IntActi | Q96C90, 4 interactors |
MINTi | Q96C90 |
STRINGi | 9606.ENSP00000310117 |
PTM databases
iPTMneti | Q96C90 |
PhosphoSitePlusi | Q96C90 |
Genetic variation databases
BioMutai | PPP1R14B |
DMDMi | 55583975 |
Proteomic databases
EPDi | Q96C90 |
jPOSTi | Q96C90 |
MassIVEi | Q96C90 |
MaxQBi | Q96C90 |
PaxDbi | Q96C90 |
PeptideAtlasi | Q96C90 |
PRIDEi | Q96C90 |
ProteomicsDBi | 76165 |
TopDownProteomicsi | Q96C90 |
Protocols and materials databases
Antibodypediai | 43962, 47 antibodies |
DNASUi | 26472 |
Genome annotation databases
Ensembli | ENST00000309318; ENSP00000310117; ENSG00000173457 |
GeneIDi | 26472 |
KEGGi | hsa:26472 |
UCSCi | uc001nza.4, human |
Organism-specific databases
CTDi | 26472 |
DisGeNETi | 26472 |
GeneCardsi | PPP1R14B |
HGNCi | HGNC:9057, PPP1R14B |
HPAi | ENSG00000173457, Low tissue specificity |
MIMi | 601140, gene |
neXtProti | NX_Q96C90 |
OpenTargetsi | ENSG00000173457 |
PharmGKBi | PA33624 |
VEuPathDBi | HostDB:ENSG00000173457.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0824, Eukaryota |
GeneTreei | ENSGT00950000182985 |
HOGENOMi | CLU_114155_1_0_1 |
InParanoidi | Q96C90 |
OMAi | TQLYDCQ |
OrthoDBi | 1492626at2759 |
PhylomeDBi | Q96C90 |
TreeFami | TF105546 |
Enzyme and pathway databases
PathwayCommonsi | Q96C90 |
Miscellaneous databases
BioGRID-ORCSi | 26472, 113 hits in 855 CRISPR screens |
ChiTaRSi | PPP1R14B, human |
GeneWikii | PPP1R14B |
GenomeRNAii | 26472 |
Pharosi | Q96C90, Tbio |
PROi | PR:Q96C90 |
RNActi | Q96C90, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173457, Expressed in cortical plate and 117 other tissues |
ExpressionAtlasi | Q96C90, baseline and differential |
Genevisiblei | Q96C90, HS |
Family and domain databases
Gene3Di | 1.10.150.220, 1 hit |
InterProi | View protein in InterPro IPR008025, CPI-17 IPR036658, CPI-17_sf |
PANTHERi | PTHR16188, PTHR16188, 1 hit |
Pfami | View protein in Pfam PF05361, PP1_inhibitor, 1 hit |
SUPFAMi | SSF81790, SSF81790, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP14B_HUMAN | |
Accessioni | Q96C90Primary (citable) accession number: Q96C90 Secondary accession number(s): Q504S7, Q7KZD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 9, 2004 |
Last sequence update: | November 9, 2004 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM