UniProtKB - Q96C86 (DCPS_HUMAN)
Protein
m7GpppX diphosphatase
Gene
DCPS
Organism
Homo sapiens (Human)
Status
Functioni
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.10 Publications
Catalytic activityi
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H+ + N7-methyl-GMP4 PublicationsEC:3.6.1.594 Publications
Activity regulationi
The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 175 | Substrate2 Publications | 1 | |
Binding sitei | 185 | Substrate2 Publications | 1 | |
Binding sitei | 205 | Substrate2 Publications | 1 | |
Binding sitei | 207 | Substrate2 Publications | 1 | |
Active sitei | 277 | Nucleophile | 1 |
GO - Molecular functioni
- exoribonuclease activity Source: Reactome
- identical protein binding Source: IntAct
- m7G(5')pppN diphosphatase activity Source: UniProtKB
- RNA 7-methylguanosine cap binding Source: UniProtKB
GO - Biological processi
- cellular response to menadione Source: UniProtKB
- deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
- exonucleolytic catabolism of deadenylated mRNA Source: Reactome
- mRNA cis splicing, via spliceosome Source: UniProtKB
- negative regulation of programmed cell death Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
BRENDAi | 3.6.1.59, 2681 |
PathwayCommonsi | Q96C86 |
Reactomei | R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease |
Names & Taxonomyi
Protein namesi | Recommended name: m7GpppX diphosphatase (EC:3.6.1.59)Alternative name(s): DCS-1 Decapping scavenger enzyme Hint-related 7meGMP-directed hydrolase Histidine triad nucleotide-binding protein 5 Histidine triad protein member 5 Short name: HINT-5 Scavenger mRNA-decapping enzyme DcpS |
Gene namesi | Name:DCPS Synonyms:DCS1, HINT5 ORF Names:HSPC015 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110063.8 |
HGNCi | HGNC:29812, DCPS |
MIMi | 610534, gene |
neXtProti | NX_Q96C86 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Al-Raqad syndrome (ARS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by delayed psychomotor development, moderate to severe intellectual disability, poor or absent speech, microcephaly, congenital hypotonia, and severe growth delay.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073956 | 316 | T → M in ARS; results in a severe decrease of decapase activity. 1 PublicationCorresponds to variant dbSNP:rs137941190EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 10 – 13 | Missing : Increases cytoplasmic localization. 1 Publication | 4 | |
Mutagenesisi | 58 | R → A: Increases decapping activity to 125% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 61 | I → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 63 | F → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 83 | I → A: Strongly reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 85 | E → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 108 | F → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 110 | N → A: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 113 | Y → A: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 128 | K → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 138 | K → D: Increases decapping activity to 250% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 145 | R → A: Increases decapping activity to 180% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 146 | Q → P: Increases decapping activity to 140% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 148 | L → A: Inhibits nuclear export to the cytoplasm. 1 Publication | 1 | |
Mutagenesisi | 150 | L → A: Inhibits nuclear export to the cytoplasm. 1 Publication | 1 | |
Mutagenesisi | 175 | W → A: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 185 | E → A: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 204 | P → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 205 | D → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 206 | L → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 207 | K → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 207 | K → R: No effect. 1 Publication | 1 | |
Mutagenesisi | 217 | Y → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 217 | Y → F: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 268 | H → N: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 272 | S → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 273 | Y → A: Reduces decapping activity. 1 Publication | 1 | |
Mutagenesisi | 273 | Y → F: Activates decapping activity to 120% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 277 | H → N: Loss of decapping activity. Does not inhibit cap structure and capped RNA binding. Preferentially hydrolyzes cap structure (m7GpppG) at least 2500-fold more efficiently than capped RNA (m7Gppp-RNA). 3 Publications | 1 | |
Mutagenesisi | 279 | H → N: Loss of decapping activity. 1 Publication | 1 | |
Mutagenesisi | 294 | R → A or K: No effect. 1 Publication | 1 | |
Mutagenesisi | 322 | R → A: No effect. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 28960 |
MalaCardsi | DCPS |
MIMi | 616459, phenotype |
OpenTargetsi | ENSG00000110063 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA134863866 |
Miscellaneous databases
Pharosi | Q96C86, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1949488 |
DrugBanki | DB07644, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine DB07643, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine DB07642, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine DB03593, 7-methyl-5'-guanylic acid DB01960, 7-methyl-7,8-dihydroguanosine-5'-diphosphate DB01649, 7-methyl-GpppA DB03958, 7-methyl-guanosine-5'-triphosphate-5'-guanosine |
Polymorphism and mutation databases
BioMutai | DCPS |
DMDMi | 116241325 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000109794 | 2 – 337 | m7GpppX diphosphataseAdd BLAST | 336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineBy similarity | 1 | |
Modified residuei | 138 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 142 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96C86 |
jPOSTi | Q96C86 |
MassIVEi | Q96C86 |
MaxQBi | Q96C86 |
PaxDbi | Q96C86 |
PeptideAtlasi | Q96C86 |
PRIDEi | Q96C86 |
ProteomicsDBi | 76164 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00335385 |
PTM databases
iPTMneti | Q96C86 |
PhosphoSitePlusi | Q96C86 |
Expressioni
Tissue specificityi
Detected in liver, brain, kidney, testis and prostate.1 Publication
Inductioni
Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at protein level).2 Publications
Gene expression databases
Bgeei | ENSG00000110063, Expressed in right lobe of liver and 204 other tissues |
ExpressionAtlasi | Q96C86, baseline and differential |
Genevisiblei | Q96C86, HS |
Organism-specific databases
HPAi | ENSG00000110063, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4.
Interacts with NDOR1.
6 PublicationsBinary interactionsi
Hide detailsQ96C86
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-3917181,EBI-3917181 |
KPNA2 [P52292] | 3 | EBI-3917181,EBI-349938 |
KPNA6 [O60684] | 5 | EBI-3917181,EBI-359923 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 118787, 379 interactors |
IntActi | Q96C86, 7 interactors |
STRINGi | 9606.ENSP00000263579 |
Chemistry databases
BindingDBi | Q96C86 |
Miscellaneous databases
RNActi | Q96C86, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96C86 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96C86 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 268 – 279 | Substrate bindingAdd BLAST | 12 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 10 – 13 | nuclear localization signal (NLS) | 4 | |
Motifi | 142 – 154 | nuclear export sequence (NES)Add BLAST | 13 | |
Motifi | 275 – 279 | Histidine triad motif | 5 |
Domaini
The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity. The N-terminus is necessary but not sufficient for binding cap structures.1 Publication
Sequence similaritiesi
Belongs to the HIT family.Curated
Phylogenomic databases
eggNOGi | KOG3969, Eukaryota |
GeneTreei | ENSGT00390000003924 |
HOGENOMi | CLU_041045_2_0_1 |
InParanoidi | Q96C86 |
OMAi | FHIHVVN |
OrthoDBi | 930557at2759 |
PhylomeDBi | Q96C86 |
TreeFami | TF105622 |
Family and domain databases
Gene3Di | 3.30.200.40, 1 hit 3.30.428.10, 1 hit |
InterProi | View protein in InterPro IPR008594, DcpS/DCS2 IPR019808, Histidine_triad_CS IPR036265, HIT-like_sf IPR011145, Scavenger_mRNA_decap_enz_N |
PANTHERi | PTHR12978, PTHR12978, 1 hit |
Pfami | View protein in Pfam PF05652, DcpS, 1 hit |
PIRSFi | PIRSF028973, Scavenger_mRNA_decap_enz, 1 hit |
SUPFAMi | SSF102860, SSF102860, 1 hit SSF54197, SSF54197, 1 hit |
PROSITEi | View protein in PROSITE PS00892, HIT_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96C86-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ
60 70 80 90 100
KVLRESARDK IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG
110 120 130 140 150
SPELQLQFSN DIYSTYHLFP PRQLNDVKTT VVYPATEKHL QKYLRQDLRL
160 170 180 190 200
IRETGDDYRN ITLPHLESQS LSIQWVYNIL DKKAEADRIV FENPDPSDGF
210 220 230 240 250
VLIPDLKWNQ QQLDDLYLIA ICHRRGIRSL RDLTPEHLPL LRNILHQGQE
260 270 280 290 300
AILQRYRMKG DHLRVYLHYL PSYYHLHVHF TALGFEAPGS GVERAHLLAE
310 320 330
VIENLECDPR HYQQRTLTFA LRADDPLLKL LQEAQQS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITF0 | A0A3B3ITF0_HUMAN | DCS-1 | DCPS | 244 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | N → K in AAK91763 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027958 | 73 | G → E1 PublicationCorresponds to variant dbSNP:rs11557735Ensembl. | 1 | |
Natural variantiVAR_073956 | 316 | T → M in ARS; results in a severe decrease of decapase activity. 1 PublicationCorresponds to variant dbSNP:rs137941190EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH010984 Genomic DNA Translation: AAK91763.1 AY040771 mRNA Translation: AAK91765.1 AF532613 mRNA Translation: AAM90310.1 AY077684 mRNA Translation: AAL77216.1 AF077201 mRNA Translation: AAD26996.1 BC014532 mRNA Translation: AAH14532.1 |
CCDSi | CCDS8473.1 |
RefSeqi | NP_054745.1, NM_014026.4 |
Genome annotation databases
Ensembli | ENST00000263579; ENSP00000263579; ENSG00000110063 |
GeneIDi | 28960 |
KEGGi | hsa:28960 |
UCSCi | uc001qdp.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH010984 Genomic DNA Translation: AAK91763.1 AY040771 mRNA Translation: AAK91765.1 AF532613 mRNA Translation: AAM90310.1 AY077684 mRNA Translation: AAL77216.1 AF077201 mRNA Translation: AAD26996.1 BC014532 mRNA Translation: AAH14532.1 |
CCDSi | CCDS8473.1 |
RefSeqi | NP_054745.1, NM_014026.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ST0 | X-ray | 1.90 | A/B | 1-337 | [»] | |
1ST4 | X-ray | 2.02 | A/B | 1-337 | [»] | |
1XML | X-ray | 2.00 | A/B | 1-337 | [»] | |
1XMM | X-ray | 2.50 | A/B/C/D | 1-337 | [»] | |
3BL7 | X-ray | 2.31 | A/B | 38-337 | [»] | |
3BL9 | X-ray | 1.80 | A/B | 38-337 | [»] | |
3BLA | X-ray | 2.60 | A/B | 38-337 | [»] | |
4QDE | X-ray | 2.90 | A/B/C/D | 2-337 | [»] | |
4QDV | X-ray | 2.80 | A/B/C/D | 2-337 | [»] | |
4QEB | X-ray | 3.21 | A/B/C/D | 2-337 | [»] | |
5OSY | X-ray | 2.06 | A/B | 37-337 | [»] | |
SMRi | Q96C86 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118787, 379 interactors |
IntActi | Q96C86, 7 interactors |
STRINGi | 9606.ENSP00000263579 |
Chemistry databases
BindingDBi | Q96C86 |
ChEMBLi | CHEMBL1949488 |
DrugBanki | DB07644, 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine DB07643, 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine DB07642, 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine DB03593, 7-methyl-5'-guanylic acid DB01960, 7-methyl-7,8-dihydroguanosine-5'-diphosphate DB01649, 7-methyl-GpppA DB03958, 7-methyl-guanosine-5'-triphosphate-5'-guanosine |
PTM databases
iPTMneti | Q96C86 |
PhosphoSitePlusi | Q96C86 |
Polymorphism and mutation databases
BioMutai | DCPS |
DMDMi | 116241325 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00335385 |
Proteomic databases
EPDi | Q96C86 |
jPOSTi | Q96C86 |
MassIVEi | Q96C86 |
MaxQBi | Q96C86 |
PaxDbi | Q96C86 |
PeptideAtlasi | Q96C86 |
PRIDEi | Q96C86 |
ProteomicsDBi | 76164 |
Protocols and materials databases
Antibodypediai | 32998, 218 antibodies |
DNASUi | 28960 |
Genome annotation databases
Ensembli | ENST00000263579; ENSP00000263579; ENSG00000110063 |
GeneIDi | 28960 |
KEGGi | hsa:28960 |
UCSCi | uc001qdp.3, human |
Organism-specific databases
CTDi | 28960 |
DisGeNETi | 28960 |
EuPathDBi | HostDB:ENSG00000110063.8 |
GeneCardsi | DCPS |
HGNCi | HGNC:29812, DCPS |
HPAi | ENSG00000110063, Low tissue specificity |
MalaCardsi | DCPS |
MIMi | 610534, gene 616459, phenotype |
neXtProti | NX_Q96C86 |
OpenTargetsi | ENSG00000110063 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA134863866 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3969, Eukaryota |
GeneTreei | ENSGT00390000003924 |
HOGENOMi | CLU_041045_2_0_1 |
InParanoidi | Q96C86 |
OMAi | FHIHVVN |
OrthoDBi | 930557at2759 |
PhylomeDBi | Q96C86 |
TreeFami | TF105622 |
Enzyme and pathway databases
BRENDAi | 3.6.1.59, 2681 |
PathwayCommonsi | Q96C86 |
Reactomei | R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease |
Miscellaneous databases
BioGRID-ORCSi | 28960, 212 hits in 854 CRISPR screens |
ChiTaRSi | DCPS, human |
EvolutionaryTracei | Q96C86 |
GeneWikii | DCPS_(gene) |
GenomeRNAii | 28960 |
Pharosi | Q96C86, Tbio |
PROi | PR:Q96C86 |
RNActi | Q96C86, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110063, Expressed in right lobe of liver and 204 other tissues |
ExpressionAtlasi | Q96C86, baseline and differential |
Genevisiblei | Q96C86, HS |
Family and domain databases
Gene3Di | 3.30.200.40, 1 hit 3.30.428.10, 1 hit |
InterProi | View protein in InterPro IPR008594, DcpS/DCS2 IPR019808, Histidine_triad_CS IPR036265, HIT-like_sf IPR011145, Scavenger_mRNA_decap_enz_N |
PANTHERi | PTHR12978, PTHR12978, 1 hit |
Pfami | View protein in Pfam PF05652, DcpS, 1 hit |
PIRSFi | PIRSF028973, Scavenger_mRNA_decap_enz, 1 hit |
SUPFAMi | SSF102860, SSF102860, 1 hit SSF54197, SSF54197, 1 hit |
PROSITEi | View protein in PROSITE PS00892, HIT_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCPS_HUMAN | |
Accessioni | Q96C86Primary (citable) accession number: Q96C86 Secondary accession number(s): Q8NHL8, Q9Y2S5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations