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Protein

Protein CUSTOS

Gene

CUSTOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of Wnt signaling pathway during early development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CUSTOSBy similarity
Gene namesi
Name:CUSTOSBy similarity
Synonyms:C12orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000157895.11
HGNCiHGNC:25719 C12orf43
neXtProtiNX_Q96C57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64897
OpenTargetsiENSG00000157895
PharmGKBiPA143485373

Polymorphism and mutation databases

BioMutaiC12orf43
DMDMi125863775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002768501 – 262Protein CUSTOSAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96C57
MaxQBiQ96C57
PaxDbiQ96C57
PeptideAtlasiQ96C57
PRIDEiQ96C57
ProteomicsDBi76161

PTM databases

iPTMnetiQ96C57
PhosphoSitePlusiQ96C57

Expressioni

Gene expression databases

BgeeiENSG00000157895 Expressed in 206 organ(s), highest expression level in frontal cortex
CleanExiHS_C12orf43
ExpressionAtlasiQ96C57 baseline and differential
GenevisibleiQ96C57 HS

Organism-specific databases

HPAiHPA046148
HPA061739

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-11305571,EBI-710997

Protein-protein interaction databases

BioGridi122339, 20 interactors
IntActiQ96C57, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96C57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi236 – 241Nucleolar localization signal (NLS)By similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 152Poly-Ser5
Compositional biasi186 – 244Lys-richAdd BLAST59

Sequence similaritiesi

Belongs to the CUSTOS family.Curated

Phylogenomic databases

eggNOGiENOG410IYW6 Eukaryota
ENOG410YR2K LUCA
GeneTreeiENSGT00390000010771
HOGENOMiHOG000111759
HOVERGENiHBG081238
InParanoidiQ96C57
PhylomeDBiQ96C57
TreeFamiTF336221

Family and domain databases

InterProiView protein in InterPro
IPR026694 CUSTOS
PANTHERiPTHR14482 PTHR14482, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q96C57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPSGTVSD SESSNSSSDA EELERCREAA MPAWGLEQRP HVAGKPRAGA
60 70 80 90 100
ANSQLSTSQP SLRHKVNEHE QDGNELQTTP EFRAHVAKKL GALLDSFITI
110 120 130 140 150
SEAAKEPAKA KVQKVALEDD GFRLFFTSVP GGREKEESPQ PRRKRQPSSS
160 170 180 190 200
SEDSDEEWRR CREAAVSASD ILQESAIHSP GTVEKEAKKK RKLKKKAKKV
210 220 230 240 250
ASVDSAVAAT TPTSMATVQK QKSGELNGDQ VSLGTKKKKK AKKASETSPF
260
PPAKSATAIP AN
Length:262
Mass (Da):28,171
Last modified:February 6, 2007 - v2
Checksum:i443F91BC023F0DC1
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENF1E7ENF1_HUMAN
Chromosome 12 open reading frame 43
C12orf43
221Annotation score:
F5H7W8F5H7W8_HUMAN
Chromosome 12 open reading frame 43
C12orf43 hCG_27365
293Annotation score:
G5EA44G5EA44_HUMAN
Chromosome 12 open reading frame 43
C12orf43 hCG_27365
252Annotation score:
F5H3K2F5H3K2_HUMAN
Chromosome 12 open reading frame 43
C12orf43
188Annotation score:
F5H8B7F5H8B7_HUMAN
Chromosome 12 open reading frame 43
C12orf43
195Annotation score:
H0YGK4H0YGK4_HUMAN
Chromosome 12 open reading frame 43
C12orf43
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → A in BAD96350 (Ref. 2) Curated1
Sequence conflicti151S → SS in AAH14661 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03049144G → R. Corresponds to variant dbSNP:rs11537857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022510 mRNA Translation: BAB14068.1
AK222630 mRNA Translation: BAD96350.1
BC014661 mRNA Translation: AAH14661.1
CCDSiCCDS9210.1
RefSeqiNP_001273120.1, NM_001286191.1
NP_001273121.1, NM_001286192.1
NP_001273124.1, NM_001286195.1
NP_001273125.1, NM_001286196.1
NP_001273126.1, NM_001286197.1
NP_001273127.1, NM_001286198.1
NP_075046.1, NM_022895.2
UniGeneiHs.528671

Genome annotation databases

EnsembliENST00000288757; ENSP00000288757; ENSG00000157895
GeneIDi64897
KEGGihsa:64897
UCSCiuc001tzh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022510 mRNA Translation: BAB14068.1
AK222630 mRNA Translation: BAD96350.1
BC014661 mRNA Translation: AAH14661.1
CCDSiCCDS9210.1
RefSeqiNP_001273120.1, NM_001286191.1
NP_001273121.1, NM_001286192.1
NP_001273124.1, NM_001286195.1
NP_001273125.1, NM_001286196.1
NP_001273126.1, NM_001286197.1
NP_001273127.1, NM_001286198.1
NP_075046.1, NM_022895.2
UniGeneiHs.528671

3D structure databases

ProteinModelPortaliQ96C57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122339, 20 interactors
IntActiQ96C57, 2 interactors

PTM databases

iPTMnetiQ96C57
PhosphoSitePlusiQ96C57

Polymorphism and mutation databases

BioMutaiC12orf43
DMDMi125863775

Proteomic databases

EPDiQ96C57
MaxQBiQ96C57
PaxDbiQ96C57
PeptideAtlasiQ96C57
PRIDEiQ96C57
ProteomicsDBi76161

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288757; ENSP00000288757; ENSG00000157895
GeneIDi64897
KEGGihsa:64897
UCSCiuc001tzh.3 human

Organism-specific databases

CTDi64897
DisGeNETi64897
EuPathDBiHostDB:ENSG00000157895.11
GeneCardsiC12orf43
H-InvDBiHIX0011076
HGNCiHGNC:25719 C12orf43
HPAiHPA046148
HPA061739
neXtProtiNX_Q96C57
OpenTargetsiENSG00000157895
PharmGKBiPA143485373
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYW6 Eukaryota
ENOG410YR2K LUCA
GeneTreeiENSGT00390000010771
HOGENOMiHOG000111759
HOVERGENiHBG081238
InParanoidiQ96C57
PhylomeDBiQ96C57
TreeFamiTF336221

Miscellaneous databases

ChiTaRSiC12orf43 human
GeneWikiiC12orf43
GenomeRNAii64897
PROiPR:Q96C57

Gene expression databases

BgeeiENSG00000157895 Expressed in 206 organ(s), highest expression level in frontal cortex
CleanExiHS_C12orf43
ExpressionAtlasiQ96C57 baseline and differential
GenevisibleiQ96C57 HS

Family and domain databases

InterProiView protein in InterPro
IPR026694 CUSTOS
PANTHERiPTHR14482 PTHR14482, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTOS_HUMAN
AccessioniPrimary (citable) accession number: Q96C57
Secondary accession number(s): Q53HF0, Q9H9Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 10, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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