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Protein

Zinc finger protein 524

Gene

ZNF524

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi51 – 63A.T hookAdd BLAST13
Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 524
Gene namesi
Name:ZNF524
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171443.6
HGNCiHGNC:28322 ZNF524
neXtProtiNX_Q96C55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981576

Polymorphism and mutation databases

BioMutaiZNF524
DMDMi74760750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345791 – 264Zinc finger protein 524Add BLAST264

Proteomic databases

EPDiQ96C55
MaxQBiQ96C55
PaxDbiQ96C55
PeptideAtlasiQ96C55
PRIDEiQ96C55
ProteomicsDBi76160

PTM databases

iPTMnetiQ96C55
PhosphoSitePlusiQ96C55

Expressioni

Gene expression databases

BgeeiENSG00000171443 Expressed in 116 organ(s), highest expression level in body of pancreas
CleanExiHS_ZNF524
ExpressionAtlasiQ96C55 baseline and differential
GenevisibleiQ96C55 HS

Organism-specific databases

HPAiHPA050981

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZC4H2Q9NQZ63EBI-10283126,EBI-747993

Protein-protein interaction databases

BioGridi127090, 10 interactors
IntActiQ96C55, 19 interactors
STRINGi9606.ENSP00000301073

Structurei

3D structure databases

ProteinModelPortaliQ96C55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149029
HOGENOMiHOG000059663
HOVERGENiHBG079385
InParanoidiQ96C55
OMAiPPWDDEG
OrthoDBiEOG091G0MXV
PhylomeDBiQ96C55
TreeFamiTF338348

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96C55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTPSPDPLP SPLPGEEEKP LALSPPVPRG RRGRRPGGAT SSNRTLKASL
60 70 80 90 100
PRKRGRPPKS GQEPPLVQVQ GVTAPVGSSG GSDLLLIDDQ GVPYTVSEGS
110 120 130 140 150
AAGPEGSGPR KAPHFCPVCL RAFPYLSDLE RHSISHSELK PHQCKVCGKT
160 170 180 190 200
FKRSSHLRRH CNIHAGLRPF RCPLCPRRFR EAGELAHHHR VHSGERPYQC
210 220 230 240 250
PICRLRFTEA NTLRRHAKRK HPEAMGVPLC APDPGSEPPW DEEGIPATAG
260
AEEEEETEGK GEPA
Length:264
Mass (Da):28,709
Last modified:December 1, 2001 - v1
Checksum:iB248388F26BBB487
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EP10K7EP10_HUMAN
Zinc finger protein 524
ZNF524
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51P → H in AAH67748 (PubMed:15489334).Curated1
Sequence conflicti176P → T in AAH67748 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007396 mRNA Translation: AAH07396.2
BC014666 mRNA Translation: AAH14666.1
BC067748 mRNA Translation: AAH67748.1
CCDSiCCDS12929.1
RefSeqiNP_694951.1, NM_153219.3
UniGeneiHs.440291

Genome annotation databases

EnsembliENST00000301073; ENSP00000301073; ENSG00000171443
ENST00000591046; ENSP00000466907; ENSG00000171443
GeneIDi147807
KEGGihsa:147807
UCSCiuc002qlk.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007396 mRNA Translation: AAH07396.2
BC014666 mRNA Translation: AAH14666.1
BC067748 mRNA Translation: AAH67748.1
CCDSiCCDS12929.1
RefSeqiNP_694951.1, NM_153219.3
UniGeneiHs.440291

3D structure databases

ProteinModelPortaliQ96C55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127090, 10 interactors
IntActiQ96C55, 19 interactors
STRINGi9606.ENSP00000301073

PTM databases

iPTMnetiQ96C55
PhosphoSitePlusiQ96C55

Polymorphism and mutation databases

BioMutaiZNF524
DMDMi74760750

Proteomic databases

EPDiQ96C55
MaxQBiQ96C55
PaxDbiQ96C55
PeptideAtlasiQ96C55
PRIDEiQ96C55
ProteomicsDBi76160

Protocols and materials databases

DNASUi147807
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301073; ENSP00000301073; ENSG00000171443
ENST00000591046; ENSP00000466907; ENSG00000171443
GeneIDi147807
KEGGihsa:147807
UCSCiuc002qlk.2 human

Organism-specific databases

CTDi147807
EuPathDBiHostDB:ENSG00000171443.6
GeneCardsiZNF524
HGNCiHGNC:28322 ZNF524
HPAiHPA050981
neXtProtiNX_Q96C55
PharmGKBiPA134981576
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149029
HOGENOMiHOG000059663
HOVERGENiHBG079385
InParanoidiQ96C55
OMAiPPWDDEG
OrthoDBiEOG091G0MXV
PhylomeDBiQ96C55
TreeFamiTF338348

Miscellaneous databases

GenomeRNAii147807
PROiPR:Q96C55

Gene expression databases

BgeeiENSG00000171443 Expressed in 116 organ(s), highest expression level in body of pancreas
CleanExiHS_ZNF524
ExpressionAtlasiQ96C55 baseline and differential
GenevisibleiQ96C55 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN524_HUMAN
AccessioniPrimary (citable) accession number: Q96C55
Secondary accession number(s): Q6NW31, Q96IL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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