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UniProtKB - Q96C45 (ULK4_HUMAN)

Entry version 158 (29 Sep 2021)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
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Protein

Serine/threonine-protein kinase ULK4

Gene

ULK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96C45

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96C45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)
Alternative name(s):
Unc-51-like kinase 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ULK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15784, ULK4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617010, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96C45

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168038

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		54986

Open Targets

More...OpenTargetsi		ENSG00000168038

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134978836

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96C45, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ULK4

Domain mapping of disease mutations (DMDM)

More...DMDMi		118574241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002601541 – 1275Serine/threonine-protein kinase ULK4Add BLAST1275

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96C45

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96C45

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96C45

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96C45

PeptideAtlas

More...PeptideAtlasi		Q96C45

PRoteomics IDEntifications database

More...PRIDEi		Q96C45

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96C45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96C45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during neuronal differentiation of neuroblastoma cells treated with all-trans or 9-cis retinoic acid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168038, Expressed in decidua and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96C45, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96C45, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168038, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120321, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q96C45, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301831

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96C45, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96C45

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 280Protein kinasePROSITE-ProRule annotationAdd BLAST277
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati842 – 880HEAT 1Add BLAST39
Repeati926 – 964HEAT 2Add BLAST39
Repeati1025 – 1063HEAT 3Add BLAST39
Repeati1151 – 1189HEAT 4Add BLAST39
Repeati1213 – 1253HEAT 5Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni299 – 350DisorderedSequence analysisAdd BLAST52
Regioni364 – 392DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi299 – 326Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002110_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96C45

Identification of Orthologs from Complete Genome Data

More...OMAi		NWYETNN

Database of Orthologous Groups

More...OrthoDBi		219167at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96C45

TreeFam database of animal gene trees

More...TreeFami		TF332678

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96C45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT 
        60         70         80         90        100
REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE 
       110        120        130        140        150
FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL 
       160        170        180        190        200
EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS 
       210        220        230        240        250
DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS 
       260        270        280        290        300
SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 
       310        320        330        340        350
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL 
       360        370        380        390        400
EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL 
       410        420        430        440        450
SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV 
       460        470        480        490        500
DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE 
       510        520        530        540        550
VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV 
       560        570        580        590        600
VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA 
       610        620        630        640        650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP 
       660        670        680        690        700
ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA 
       710        720        730        740        750
SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA 
       760        770        780        790        800
KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS 
       810        820        830        840        850
KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP 
       860        870        880        890        900
VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS 
       910        920        930        940        950
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF 
       960        970        980        990       1000
SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE 
      1010       1020       1030       1040       1050
PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT 
      1060       1070       1080       1090       1100
MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN 
      1110       1120       1130       1140       1150
NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL 
      1160       1170       1180       1190       1200
NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV 
      1210       1220       1230       1240       1250
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL 
      1260       1270 
APGSGSFADS AVAPLALEIL QAVGH
Length:1,275
Mass (Da):142,442
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3DB6795CEB1DC76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG77A0A0C4DG77_HUMAN
Serine/threonine-protein kinase ULK...
ULK4
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVZ3C9JVZ3_HUMAN
Serine/threonine-protein kinase ULK...
ULK4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91270 differs from that shown. Reason: Frameshift.Curated
The sequence BAG52707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti388K → E in BAA91270 (PubMed:14702039).Curated1
Sequence conflicti553 – 580AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794 (PubMed:15489334).CuratedAdd BLAST28
Sequence conflicti732G → V in BAA91270 (PubMed:14702039).Curated1
Sequence conflicti1024R → S in AAH40739 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04128618V → A1 PublicationCorresponds to variant dbSNP:rs34538622Ensembl.1
Natural variantiVAR_04128739K → R1 PublicationCorresponds to variant dbSNP:rs2272007EnsemblClinVar.1
Natural variantiVAR_041288139N → K1 PublicationCorresponds to variant dbSNP:rs35833603Ensembl.1
Natural variantiVAR_041289223S → N1 PublicationCorresponds to variant dbSNP:rs55840267Ensembl.1
Natural variantiVAR_051679224I → V. Corresponds to variant dbSNP:rs1716975EnsemblClinVar.1
Natural variantiVAR_041290348S → G2 PublicationsCorresponds to variant dbSNP:rs35263917Ensembl.1
Natural variantiVAR_041291415T → M1 PublicationCorresponds to variant dbSNP:rs371185820Ensembl.1
Natural variantiVAR_041292417S → P1 PublicationCorresponds to variant dbSNP:rs75907560Ensembl.1
Natural variantiVAR_029005542A → T. Corresponds to variant dbSNP:rs1052501EnsemblClinVar.1
Natural variantiVAR_029006569K → R. Corresponds to variant dbSNP:rs3774372Ensembl.1
Natural variantiVAR_029007603L → S. Corresponds to variant dbSNP:rs17063572Ensembl.1
Natural variantiVAR_029008640S → A. Corresponds to variant dbSNP:rs4973986EnsemblClinVar.1
Natural variantiVAR_029009715A → T. Corresponds to variant dbSNP:rs17215589Ensembl.1
Natural variantiVAR_0597721260S → N. Corresponds to variant dbSNP:rs12488691Ensembl.1
Natural variantiVAR_0516801261A → V. Corresponds to variant dbSNP:rs6769117Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000581 mRNA Translation: BAA91270.1 Frameshift.
AK093396 mRNA Translation: BAG52707.1 Different initiation.
AK304341 mRNA Translation: BAG65186.1
AC104305 Genomic DNA No translation available.
BC014794 mRNA Translation: AAH14794.1
BC040739 mRNA Translation: AAH40739.1
AL133104 mRNA Translation: CAB61411.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43071.1

Protein sequence database of the Protein Information Resource

More...PIRi		T42683

NCBI Reference Sequences

More...RefSeqi		NP_060356.2, NM_017886.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301831; ENSP00000301831; ENSG00000168038

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54986

UCSC genome browser

More...UCSCi		uc003ckv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000581 mRNA Translation: BAA91270.1 Frameshift.
AK093396 mRNA Translation: BAG52707.1 Different initiation.
AK304341 mRNA Translation: BAG65186.1
AC104305 Genomic DNA No translation available.
BC014794 mRNA Translation: AAH14794.1
BC040739 mRNA Translation: AAH40739.1
AL133104 mRNA Translation: CAB61411.1
CCDSiCCDS43071.1
PIRiT42683
RefSeqiNP_060356.2, NM_017886.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6TSZX-ray1.90U2-288[»]
6U5LX-ray1.75A1-285[»]
SMRiQ96C45
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120321, 8 interactors
IntActiQ96C45, 4 interactors
STRINGi9606.ENSP00000301831

PTM databases

iPTMnetiQ96C45
PhosphoSitePlusiQ96C45

Genetic variation databases

BioMutaiULK4
DMDMi118574241

Proteomic databases

EPDiQ96C45
jPOSTiQ96C45
MassIVEiQ96C45
PaxDbiQ96C45
PeptideAtlasiQ96C45
PRIDEiQ96C45
ProteomicsDBi76159

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6576, 109 antibodies

The DNASU plasmid repository

More...DNASUi		54986

Genome annotation databases

EnsembliENST00000301831; ENSP00000301831; ENSG00000168038
GeneIDi54986
KEGGihsa:54986
UCSCiuc003ckv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54986
DisGeNETi54986

GeneCards: human genes, protein and diseases

More...GeneCardsi		ULK4
HGNCiHGNC:15784, ULK4
HPAiENSG00000168038, Low tissue specificity
MIMi617010, gene
neXtProtiNX_Q96C45
OpenTargetsiENSG00000168038
PharmGKBiPA134978836
VEuPathDBiHostDB:ENSG00000168038

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0597, Eukaryota
GeneTreeiENSGT00940000156541
HOGENOMiCLU_002110_0_0_1
InParanoidiQ96C45
OMAiNWYETNN
OrthoDBi219167at2759
PhylomeDBiQ96C45
TreeFamiTF332678

Enzyme and pathway databases

PathwayCommonsiQ96C45
SignaLinkiQ96C45

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54986, 5 hits in 1043 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ULK4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54986
PharosiQ96C45, Tbio

Protein Ontology

More...PROi		PR:Q96C45
RNActiQ96C45, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168038, Expressed in decidua and 173 other tissues
ExpressionAtlasiQ96C45, baseline and differential
GenevisibleiQ96C45, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiULK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96C45
Secondary accession number(s): A6NF15
, B3KSE5, B4E2M4, Q8IW79, Q9NWV6, Q9UF96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 29, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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