UniProtKB - Q96C45 (ULK4_HUMAN)

BLAST

>sp|Q96C45|ULK4_HUMAN Serine/threonine-protein kinase ULK4 OS=Homo sapiens OX=9606 GN=ULK4 PE=1 SV=2
MENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVT
FHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFC
DISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVK
GSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPI
PKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFAGADQESSVEDLSLSR
NTMECSGPQDSKELLQNSQSRQAKGHKSGQPLGHSFRLENPTEFRPKSTLEGQLNESMFL
LSSRPTPRTSTAVEVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLV
VTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWNDFLQQVCSQIDSTEKSMG
ASRAKLNLLCYLCVVAGHQEVATRLLHSPLFQLLIQHLRIAPNWDIRAKVAHVIGLLASH
TAELQENTPVVEAIVLLTELIRENFRNSKLKQCLLPTLGELIYLVATQEEKKKNPRECWA
VPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQSQGFITGEIGPILWYLFRHST
ADSLRITAVSALCRITRHSPTAFQNVIEKVGLNSVINSLASAICKVQQYMLTLFAAMLSC
GIHLQRLIQEKGFVSTIIRLLDSPSTCIRAKAFLVLLYILIYNREMLLLSCQARLVMYIE
RDSRKTTPGKEQQSGNEYLSKCLDLLICHIVQELPRILGDILNSLANVSGRKHPSTVQVK
QLKLCLPLMPVVLHLVTSQVFRPQVVTEEFLFSYGTILSHIKSVDSGETNIDGAIGLTAS
EEFIKITLSAFEAIIQYPILLKDYRSTVVDYILPPLVSLVQSQNVEWRLFSLRLLSETTS
LLVNQEFGDGKEKASVDSDSNLLALIRDVLLPQYEHILLEPDPVPAYALKLLVAMTEHNP
TFTRLVEESKLIPLIFEVTLEHQESILGNTMQSVIALLSNLVACKDSNMELLYEQGLVSH
ICNLLTETATLCLDVDNKNNNEMAAPLLFSLLDILHSMLTYTSGIVRLALQAQKSGSGED
PQAAEDLLLLNRPLTDLISLLIPLLPNEDPEIFDVSSKCLSILVQLYGGENPDSLSPENV
EIFAHLLTSKEDPKEQKLLLRILRRMITSNEKHLESLKNAGSLLRALERLAPGSGSFADS
AVAPLALEILQAVGH

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History
Entry version 139 (12 Sep 2018)
Sequence version 2 (28 Nov 2006)
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Protein

Serine/threonine-protein kinase ULK4

Gene

ULK4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule cytoskeleton organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of JNK cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of MAPK cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of neuron migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of neuron projection development
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of p38MAPK cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070
regulation of protein kinase C signaling
Source: MGI
Inferred from mutant phenotypeⁱ
- 24284070

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q96C45

SignaLinkⁱ

Q96C45

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase ULK4 (EC:2.7.11.1) Alternative name(s): Unc-51-like kinase 4
Gene namesⁱ	Name:ULK4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168038.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15784 ULK4
MIMⁱ	617010 gene
neXtProtⁱ	NX_Q96C45

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54986
Open Targets More...OpenTargetsⁱ	ENSG00000168038
PharmGKBⁱ	PA134978836

Polymorphism and mutation databases

BioMutaⁱ	ULK4
DMDMⁱ	118574241

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000260154	1 – 1275	Serine/threonine-protein kinase ULK4Add BLAST		1275

Proteomic databases

EPDⁱ	Q96C45
PaxDbⁱ	Q96C45
PeptideAtlas More...PeptideAtlasⁱ	Q96C45
PRIDEⁱ	Q96C45
ProteomicsDBⁱ	76159

PTM databases

iPTMnetⁱ	Q96C45
PhosphoSitePlusⁱ	Q96C45

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168038 Expressed in 154 organ(s), highest expression level in decidua
CleanExⁱ	HS_ULK4
ExpressionAtlasⁱ	Q96C45 baseline and differential
Genevisibleⁱ	Q96C45 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017930

HPAⁱ

HPA017930

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120321, 5 interactors
IntActⁱ	Q96C45, 1 interactor
STRINGⁱ	9606.ENSP00000301831

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96C45
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 280	Protein kinasePROSITE-ProRule annotationAdd BLAST	277
Repeatⁱ	842 – 880	HEAT 1Add BLAST	39
Repeatⁱ	926 – 964	HEAT 2Add BLAST	39
Repeatⁱ	1025 – 1063	HEAT 3Add BLAST	39
Repeatⁱ	1151 – 1189	HEAT 4Add BLAST	39
Repeatⁱ	1213 – 1253	HEAT 5Add BLAST	41

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1147 – 1150	Poly-Leu		4

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0597 Eukaryota ENOG410XRQ6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144242
HOGENOMⁱ	HOG000007938
HOVERGENⁱ	HBG094135
InParanoidⁱ	Q96C45
KEGG Orthology (KO) More...KOⁱ	K17545
OMAⁱ	CVMDICD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02A0
PhylomeDBⁱ	Q96C45
TreeFamⁱ	TF332678

Family and domain databases

Gene3Dⁱ	1.25.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 3 hits SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q96C45-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT 
        60         70         80         90        100
REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE 
       110        120        130        140        150
FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL 
       160        170        180        190        200
EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS 
       210        220        230        240        250
DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS 
       260        270        280        290        300
SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 
       310        320        330        340        350
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL 
       360        370        380        390        400
EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL 
       410        420        430        440        450
SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV 
       460        470        480        490        500
DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE 
       510        520        530        540        550
VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV 
       560        570        580        590        600
VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA 
       610        620        630        640        650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP 
       660        670        680        690        700
ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA 
       710        720        730        740        750
SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA 
       760        770        780        790        800
KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS 
       810        820        830        840        850
KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP 
       860        870        880        890        900
VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS 
       910        920        930        940        950
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF 
       960        970        980        990       1000
SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE 
      1010       1020       1030       1040       1050
PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT 
      1060       1070       1080       1090       1100
MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN 
      1110       1120       1130       1140       1150
NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL 
      1160       1170       1180       1190       1200
NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV 
      1210       1220       1230       1240       1250
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL 
      1260       1270 
APGSGSFADS AVAPLALEIL QAVGH

Length:1,275

Mass (Da):142,442

Last modified:November 28, 2006 - v2

Checksum:ⁱD3DB6795CEB1DC76

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DG77	A0A0C4DG77_HUMAN	Serine/threonine-protein kinase ULK... Serine/threonine-protein kinase ULK4	ULK4	580	Annotation score:
C9JVZ3	C9JVZ3_HUMAN	Serine/threonine-protein kinase ULK... Serine/threonine-protein kinase ULK4	ULK4	84	Annotation score:

Sequence cautionⁱ

The sequence BAA91270 differs from that shown. Reason: Frameshift at position 489.Curated

The sequence BAG52707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	388	K → E in BAA91270 (PubMed:14702039).Curated	1
Sequence conflictⁱ	553 – 580	AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794 (PubMed:15489334).CuratedAdd BLAST	28
Sequence conflictⁱ	732	G → V in BAA91270 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1024	R → S in AAH40739 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041286	18	V → A1 PublicationCorresponds to variant dbSNP:rs34538622Ensembl.	1
Natural variantⁱVAR_041287	39	K → R1 PublicationCorresponds to variant dbSNP:rs2272007EnsemblClinVar.	1
Natural variantⁱVAR_041288	139	N → K1 PublicationCorresponds to variant dbSNP:rs35833603Ensembl.	1
Natural variantⁱVAR_041289	223	S → N1 PublicationCorresponds to variant dbSNP:rs55840267Ensembl.	1
Natural variantⁱVAR_051679	224	I → V. Corresponds to variant dbSNP:rs1716975EnsemblClinVar.	1
Natural variantⁱVAR_041290	348	S → G2 PublicationsCorresponds to variant dbSNP:rs35263917Ensembl.	1
Natural variantⁱVAR_041291	415	T → M1 PublicationCorresponds to variant dbSNP:rs371185820Ensembl.	1
Natural variantⁱVAR_041292	417	S → P1 PublicationCorresponds to variant dbSNP:rs75907560Ensembl.	1
Natural variantⁱVAR_029005	542	A → T. Corresponds to variant dbSNP:rs1052501EnsemblClinVar.	1
Natural variantⁱVAR_029006	569	K → R. Corresponds to variant dbSNP:rs3774372Ensembl.	1
Natural variantⁱVAR_029007	603	L → S. Corresponds to variant dbSNP:rs17063572Ensembl.	1
Natural variantⁱVAR_029008	640	S → A. Corresponds to variant dbSNP:rs4973986EnsemblClinVar.	1
Natural variantⁱVAR_029009	715	A → T. Corresponds to variant dbSNP:rs17215589Ensembl.	1
Natural variantⁱVAR_059772	1260	S → N. Corresponds to variant dbSNP:rs12488691Ensembl.	1
Natural variantⁱVAR_051680	1261	A → V. Corresponds to variant dbSNP:rs6769117Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000581 mRNA Translation: BAA91270.1 Frameshift. AK093396 mRNA Translation: BAG52707.1 Different initiation. AK304341 mRNA Translation: BAG65186.1 AC104305 Genomic DNA No translation available. BC014794 mRNA Translation: AAH14794.1 BC040739 mRNA Translation: AAH40739.1 AL133104 mRNA Translation: CAB61411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43071.1
PIRⁱ	T42683
NCBI Reference Sequences More...RefSeqⁱ	NP_060356.2, NM_017886.3
UniGeneⁱ	Hs.656192

Genome annotation databases

Ensemblⁱ	ENST00000301831; ENSP00000301831; ENSG00000168038
GeneIDⁱ	54986
KEGGⁱ	hsa:54986
UCSC genome browser More...UCSCⁱ	uc003ckv.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96C45	Serine/threonine-protein kinase ULK4		PONAB		1275	UniRef90_Q96C45
ULK4 isoform 1		PANTR		1275
Uncharacterized protein		Cebus capucinus imitator		1275
Unc-51 like kinase 4		GORGO		1275
Uncharacterized protein		MACMU		1274
+40

Protein	Similar proteins		Species	Score	Length	Source
Q96C45	Serine/threonine-protein kinase ULK4		PONAB		1275	UniRef50_Q96C45
Uncharacterized protein		Cebus capucinus imitator		1275
Unc-51 like kinase 4		GORGO		1275
Unc-51-like kinase 4		PANTR		1275
Uncharacterized protein		PAPAN		1274
+359

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000581 mRNA Translation: BAA91270.1 Frameshift. AK093396 mRNA Translation: BAG52707.1 Different initiation. AK304341 mRNA Translation: BAG65186.1 AC104305 Genomic DNA No translation available. BC014794 mRNA Translation: AAH14794.1 BC040739 mRNA Translation: AAH40739.1 AL133104 mRNA Translation: CAB61411.1
CCDSⁱ	CCDS43071.1
PIRⁱ	T42683
RefSeqⁱ	NP_060356.2, NM_017886.3
UniGeneⁱ	Hs.656192

3D structure databases

ProteinModelPortalⁱ	Q96C45
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120321, 5 interactors
IntActⁱ	Q96C45, 1 interactor
STRINGⁱ	9606.ENSP00000301831

PTM databases

iPTMnetⁱ	Q96C45
PhosphoSitePlusⁱ	Q96C45

Polymorphism and mutation databases

BioMutaⁱ	ULK4
DMDMⁱ	118574241

Proteomic databases

EPDⁱ	Q96C45
PaxDbⁱ	Q96C45
PeptideAtlasⁱ	Q96C45
PRIDEⁱ	Q96C45
ProteomicsDBⁱ	76159

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54986
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301831; ENSP00000301831; ENSG00000168038
GeneIDⁱ	54986
KEGGⁱ	hsa:54986
UCSCⁱ	uc003ckv.5 human

Organism-specific databases

CTDⁱ	54986
DisGeNETⁱ	54986
EuPathDBⁱ	HostDB:ENSG00000168038.10
GeneCardsⁱ	ULK4
H-InvDBⁱ	HIX0021423 HIX0038398
HGNCⁱ	HGNC:15784 ULK4
HPAⁱ	HPA017930
MIMⁱ	617010 gene
neXtProtⁱ	NX_Q96C45
OpenTargetsⁱ	ENSG00000168038
PharmGKBⁱ	PA134978836
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0597 Eukaryota ENOG410XRQ6 LUCA
GeneTreeⁱ	ENSGT00910000144242
HOGENOMⁱ	HOG000007938
HOVERGENⁱ	HBG094135
InParanoidⁱ	Q96C45
KOⁱ	K17545
OMAⁱ	CVMDICD
OrthoDBⁱ	EOG091G02A0
PhylomeDBⁱ	Q96C45
TreeFamⁱ	TF332678

Enzyme and pathway databases

SignaLinkⁱ	Q96C45

SignaLinkⁱ

Q96C45

Miscellaneous databases

ChiTaRSⁱ	ULK4 human
GenomeRNAiⁱ	54986
Protein Ontology More...PROⁱ	PR:Q96C45
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168038 Expressed in 154 organ(s), highest expression level in decidua
CleanExⁱ	HS_ULK4
ExpressionAtlasⁱ	Q96C45 baseline and differential
Genevisibleⁱ	Q96C45 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 3 hits SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ULK4_HUMAN
Accessionⁱ	Q96C45Primary (citable) accession number: Q96C45 Secondary accession number(s): A6NF15 , B3KSE5, B4E2M4, Q8IW79, Q9NWV6, Q9UF96
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	November 28, 2006
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96C45 (ULK4_HUMAN)

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Serine/threonine-protein kinase ULK4

ULK4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ