UniProtKB - Q96C45 (ULK4_HUMAN)
Protein
Serine/threonine-protein kinase ULK4
Gene
ULK4
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.1 Publication
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- microtubule cytoskeleton organization Source: MGI
- regulation of JNK cascade Source: MGI
- regulation of MAPK cascade Source: MGI
- regulation of neuron migration Source: MGI
- regulation of neuron projection development Source: MGI
- regulation of p38MAPK cascade Source: MGI
- regulation of protein kinase C signaling Source: MGI
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96C45 |
SignaLinki | Q96C45 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)Alternative name(s): Unc-51-like kinase 4 |
Gene namesi | Name:ULK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168038.10 |
HGNCi | HGNC:15784, ULK4 |
MIMi | 617010, gene |
neXtProti | NX_Q96C45 |
Pathology & Biotechi
Involvement in diseasei
Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.1 Publication
Organism-specific databases
DisGeNETi | 54986 |
OpenTargetsi | ENSG00000168038 |
PharmGKBi | PA134978836 |
Miscellaneous databases
Pharosi | Q96C45, Tbio |
Polymorphism and mutation databases
BioMutai | ULK4 |
DMDMi | 118574241 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260154 | 1 – 1275 | Serine/threonine-protein kinase ULK4Add BLAST | 1275 |
Proteomic databases
EPDi | Q96C45 |
jPOSTi | Q96C45 |
MassIVEi | Q96C45 |
PaxDbi | Q96C45 |
PeptideAtlasi | Q96C45 |
PRIDEi | Q96C45 |
ProteomicsDBi | 76159 |
PTM databases
iPTMneti | Q96C45 |
PhosphoSitePlusi | Q96C45 |
Expressioni
Tissue specificityi
Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level).1 Publication
Inductioni
Up-regulated during neuronal differentiation of neuroblastoma cells treated with all-trans or 9-cis retinoic acid.1 Publication
Gene expression databases
Bgeei | ENSG00000168038, Expressed in decidua and 172 other tissues |
ExpressionAtlasi | Q96C45, baseline and differential |
Genevisiblei | Q96C45, HS |
Organism-specific databases
HPAi | ENSG00000168038, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120321, 7 interactors |
IntActi | Q96C45, 4 interactors |
STRINGi | 9606.ENSP00000301831 |
Miscellaneous databases
RNActi | Q96C45, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96C45 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 280 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 277 | |
Repeati | 842 – 880 | HEAT 1Add BLAST | 39 | |
Repeati | 926 – 964 | HEAT 2Add BLAST | 39 | |
Repeati | 1025 – 1063 | HEAT 3Add BLAST | 39 | |
Repeati | 1151 – 1189 | HEAT 4Add BLAST | 39 | |
Repeati | 1213 – 1253 | HEAT 5Add BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1147 – 1150 | Poly-Leu | 4 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0597, Eukaryota |
GeneTreei | ENSGT00940000156541 |
HOGENOMi | CLU_002110_0_0_1 |
InParanoidi | Q96C45 |
OMAi | NWYETNN |
OrthoDBi | 219167at2759 |
PhylomeDBi | Q96C45 |
TreeFami | TF332678 |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q96C45-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT
60 70 80 90 100
REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE
110 120 130 140 150
FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL
160 170 180 190 200
EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS
210 220 230 240 250
DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS
260 270 280 290 300
SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR
310 320 330 340 350
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL
360 370 380 390 400
EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL
410 420 430 440 450
SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV
460 470 480 490 500
DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE
510 520 530 540 550
VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV
560 570 580 590 600
VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA
610 620 630 640 650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP
660 670 680 690 700
ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA
710 720 730 740 750
SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA
760 770 780 790 800
KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS
810 820 830 840 850
KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP
860 870 880 890 900
VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS
910 920 930 940 950
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF
960 970 980 990 1000
SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE
1010 1020 1030 1040 1050
PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT
1060 1070 1080 1090 1100
MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN
1110 1120 1130 1140 1150
NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL
1160 1170 1180 1190 1200
NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV
1210 1220 1230 1240 1250
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL
1260 1270
APGSGSFADS AVAPLALEIL QAVGH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG77 | A0A0C4DG77_HUMAN | Serine/threonine-protein kinase ULK... | ULK4 | 580 | Annotation score: | ||
C9JVZ3 | C9JVZ3_HUMAN | Serine/threonine-protein kinase ULK... | ULK4 | 84 | Annotation score: |
Sequence cautioni
The sequence BAA91270 differs from that shown. Reason: Frameshift.Curated
The sequence BAG52707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 388 | K → E in BAA91270 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 553 – 580 | AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794 (PubMed:15489334).CuratedAdd BLAST | 28 | |
Sequence conflicti | 732 | G → V in BAA91270 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1024 | R → S in AAH40739 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041286 | 18 | V → A1 PublicationCorresponds to variant dbSNP:rs34538622Ensembl. | 1 | |
Natural variantiVAR_041287 | 39 | K → R1 PublicationCorresponds to variant dbSNP:rs2272007EnsemblClinVar. | 1 | |
Natural variantiVAR_041288 | 139 | N → K1 PublicationCorresponds to variant dbSNP:rs35833603Ensembl. | 1 | |
Natural variantiVAR_041289 | 223 | S → N1 PublicationCorresponds to variant dbSNP:rs55840267Ensembl. | 1 | |
Natural variantiVAR_051679 | 224 | I → V. Corresponds to variant dbSNP:rs1716975EnsemblClinVar. | 1 | |
Natural variantiVAR_041290 | 348 | S → G2 PublicationsCorresponds to variant dbSNP:rs35263917Ensembl. | 1 | |
Natural variantiVAR_041291 | 415 | T → M1 PublicationCorresponds to variant dbSNP:rs371185820Ensembl. | 1 | |
Natural variantiVAR_041292 | 417 | S → P1 PublicationCorresponds to variant dbSNP:rs75907560Ensembl. | 1 | |
Natural variantiVAR_029005 | 542 | A → T. Corresponds to variant dbSNP:rs1052501EnsemblClinVar. | 1 | |
Natural variantiVAR_029006 | 569 | K → R. Corresponds to variant dbSNP:rs3774372Ensembl. | 1 | |
Natural variantiVAR_029007 | 603 | L → S. Corresponds to variant dbSNP:rs17063572Ensembl. | 1 | |
Natural variantiVAR_029008 | 640 | S → A. Corresponds to variant dbSNP:rs4973986EnsemblClinVar. | 1 | |
Natural variantiVAR_029009 | 715 | A → T. Corresponds to variant dbSNP:rs17215589Ensembl. | 1 | |
Natural variantiVAR_059772 | 1260 | S → N. Corresponds to variant dbSNP:rs12488691Ensembl. | 1 | |
Natural variantiVAR_051680 | 1261 | A → V. Corresponds to variant dbSNP:rs6769117Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000581 mRNA Translation: BAA91270.1 Frameshift. AK093396 mRNA Translation: BAG52707.1 Different initiation. AK304341 mRNA Translation: BAG65186.1 AC104305 Genomic DNA No translation available. BC014794 mRNA Translation: AAH14794.1 BC040739 mRNA Translation: AAH40739.1 AL133104 mRNA Translation: CAB61411.1 |
CCDSi | CCDS43071.1 |
PIRi | T42683 |
RefSeqi | NP_060356.2, NM_017886.3 |
Genome annotation databases
Ensembli | ENST00000301831; ENSP00000301831; ENSG00000168038 |
GeneIDi | 54986 |
KEGGi | hsa:54986 |
UCSCi | uc003ckv.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000581 mRNA Translation: BAA91270.1 Frameshift. AK093396 mRNA Translation: BAG52707.1 Different initiation. AK304341 mRNA Translation: BAG65186.1 AC104305 Genomic DNA No translation available. BC014794 mRNA Translation: AAH14794.1 BC040739 mRNA Translation: AAH40739.1 AL133104 mRNA Translation: CAB61411.1 |
CCDSi | CCDS43071.1 |
PIRi | T42683 |
RefSeqi | NP_060356.2, NM_017886.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6TSZ | X-ray | 1.90 | U | 2-288 | [»] | |
6U5L | X-ray | 1.75 | A | 1-285 | [»] | |
SMRi | Q96C45 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120321, 7 interactors |
IntActi | Q96C45, 4 interactors |
STRINGi | 9606.ENSP00000301831 |
PTM databases
iPTMneti | Q96C45 |
PhosphoSitePlusi | Q96C45 |
Polymorphism and mutation databases
BioMutai | ULK4 |
DMDMi | 118574241 |
Proteomic databases
EPDi | Q96C45 |
jPOSTi | Q96C45 |
MassIVEi | Q96C45 |
PaxDbi | Q96C45 |
PeptideAtlasi | Q96C45 |
PRIDEi | Q96C45 |
ProteomicsDBi | 76159 |
Protocols and materials databases
Antibodypediai | 6576, 99 antibodies |
DNASUi | 54986 |
Genome annotation databases
Ensembli | ENST00000301831; ENSP00000301831; ENSG00000168038 |
GeneIDi | 54986 |
KEGGi | hsa:54986 |
UCSCi | uc003ckv.5, human |
Organism-specific databases
CTDi | 54986 |
DisGeNETi | 54986 |
EuPathDBi | HostDB:ENSG00000168038.10 |
GeneCardsi | ULK4 |
HGNCi | HGNC:15784, ULK4 |
HPAi | ENSG00000168038, Low tissue specificity |
MIMi | 617010, gene |
neXtProti | NX_Q96C45 |
OpenTargetsi | ENSG00000168038 |
PharmGKBi | PA134978836 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0597, Eukaryota |
GeneTreei | ENSGT00940000156541 |
HOGENOMi | CLU_002110_0_0_1 |
InParanoidi | Q96C45 |
OMAi | NWYETNN |
OrthoDBi | 219167at2759 |
PhylomeDBi | Q96C45 |
TreeFami | TF332678 |
Enzyme and pathway databases
PathwayCommonsi | Q96C45 |
SignaLinki | Q96C45 |
Miscellaneous databases
BioGRID-ORCSi | 54986, 4 hits in 873 CRISPR screens |
ChiTaRSi | ULK4, human |
GenomeRNAii | 54986 |
Pharosi | Q96C45, Tbio |
PROi | PR:Q96C45 |
RNActi | Q96C45, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168038, Expressed in decidua and 172 other tissues |
ExpressionAtlasi | Q96C45, baseline and differential |
Genevisiblei | Q96C45, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ULK4_HUMAN | |
Accessioni | Q96C45Primary (citable) accession number: Q96C45 Secondary accession number(s): A6NF15 Q9UF96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index