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Protein

RUN domain-containing protein 1

Gene

RUNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RUN domain-containing protein 1
Gene namesi
Name:RUNDC1
ORF Names:LP5161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198863.7
HGNCiHGNC:25418 RUNDC1
neXtProtiNX_Q96C34

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198863
PharmGKBiPA134956633

Polymorphism and mutation databases

BioMutaiRUNDC1
DMDMi296452974

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845111 – 613RUN domain-containing protein 1Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphothreonineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei497PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96C34
MaxQBiQ96C34
PaxDbiQ96C34
PeptideAtlasiQ96C34
PRIDEiQ96C34
ProteomicsDBi76156
76157 [Q96C34-2]

PTM databases

iPTMnetiQ96C34
PhosphoSitePlusiQ96C34

Expressioni

Gene expression databases

BgeeiENSG00000198863 Expressed in 189 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_RUNDC1
ExpressionAtlasiQ96C34 baseline and differential
GenevisibleiQ96C34 HS

Organism-specific databases

HPAiHPA023726

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127025, 5 interactors
STRINGi9606.ENSP00000354622

Structurei

3D structure databases

ProteinModelPortaliQ96C34
SMRiQ96C34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini421 – 602RUNPROSITE-ProRule annotationAdd BLAST182

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili160 – 235Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 30Poly-Glu7

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3759 Eukaryota
ENOG410XQKK LUCA
GeneTreeiENSGT00390000007311
HOGENOMiHOG000018481
HOVERGENiHBG063773
InParanoidiQ96C34
OMAiAIHMVLT
OrthoDBiEOG091G0627
PhylomeDBiQ96C34
TreeFamiTF105949

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96C34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVEAAAEP VTVVAAVGPK AKDEEEEEEE PLPPCEAVRW APVGAVAEAR
60 70 80 90 100
PGATAFLEEA TAEEPGAAPG SPPDSPGRTL RRLRAERRRL DSALLALSSH
110 120 130 140 150
FAQVQFRLRQ VVRGAPAEQQ RLLRELEDFA FRGCPHVLGY EGPGDPASDE
160 170 180 190 200
GDGLPGDRPW LRGEDQSEQE KQERLETQRE KQKELILQLK TQLDDLETFA
210 220 230 240 250
YQEGSYDSLP QSVVLERQRV IIDELIKKLD MNLNEDISSL STEELRQRVD
260 270 280 290 300
AAVAQIVNPA RVKEQLVEQL KTQIRDLEMF INFIQDEVGS PLQTGGGHCE
310 320 330 340 350
CKAGGKTGNG CSRTGSSRTP PGNSKTKAED VKKVRETGLH LMRRALAVLQ
360 370 380 390 400
IFAVSQFGCA TGQIPPTLWQ RVQADRDYSP LLKRLEVSVD RVKQLALRQQ
410 420 430 440 450
PHDHVITSAN LQDLSLGGKD ELTMAVRKEL TVAVRDLLAH GLYASSPGMS
460 470 480 490 500
LVMAPIACLL PAFSSAPEAM HPWELFVKYY HAKNGRAYVE SPARKLSQSF
510 520 530 540 550
ALPVTGGTVV TPKQSLLTAI HMVLTEHDPF KRSADSELKA LVCMALNEQR
560 570 580 590 600
LVSWVNLICK SGSLIEPHYQ PWSYMAHTGF ESALNLLSRL SSLKFSLPVD
610
LAVRQLKNIK DAF
Length:613
Mass (Da):67,643
Last modified:May 18, 2010 - v3
Checksum:i27DA61C05ADFE3EE
GO
Isoform 2 (identifier: Q96C34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-286: Missing.

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):67,528
Checksum:i38023DF1B42D304B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQS2K7EQS2_HUMAN
RUN domain-containing protein 1
RUNDC1
263Annotation score:

Sequence cautioni

The sequence AAH14873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAO86728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166Q → QGL in AAO86728 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0317604V → I1 PublicationCorresponds to variant dbSNP:rs17853899Ensembl.1
Natural variantiVAR_031761160W → R3 PublicationsCorresponds to variant dbSNP:rs1708875Ensembl.1
Natural variantiVAR_031762397L → M1 PublicationCorresponds to variant dbSNP:rs17857183Ensembl.1
Natural variantiVAR_051328566E → K. Corresponds to variant dbSNP:rs3744241Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024551286Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA No translation available.
BC014873 mRNA Translation: AAH14873.1 Different initiation.
BC039247 mRNA Translation: AAH39247.1
AL831813 mRNA Translation: CAD38528.1
AY189284 mRNA Translation: AAO86728.1 Different initiation.
CCDSiCCDS11448.1 [Q96C34-1]
UniGeneiHs.632255
Hs.634952

Genome annotation databases

EnsembliENST00000361677; ENSP00000354622; ENSG00000198863 [Q96C34-1]
UCSCiuc002ici.1 human [Q96C34-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA No translation available.
BC014873 mRNA Translation: AAH14873.1 Different initiation.
BC039247 mRNA Translation: AAH39247.1
AL831813 mRNA Translation: CAD38528.1
AY189284 mRNA Translation: AAO86728.1 Different initiation.
CCDSiCCDS11448.1 [Q96C34-1]
UniGeneiHs.632255
Hs.634952

3D structure databases

ProteinModelPortaliQ96C34
SMRiQ96C34
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127025, 5 interactors
STRINGi9606.ENSP00000354622

PTM databases

iPTMnetiQ96C34
PhosphoSitePlusiQ96C34

Polymorphism and mutation databases

BioMutaiRUNDC1
DMDMi296452974

Proteomic databases

EPDiQ96C34
MaxQBiQ96C34
PaxDbiQ96C34
PeptideAtlasiQ96C34
PRIDEiQ96C34
ProteomicsDBi76156
76157 [Q96C34-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361677; ENSP00000354622; ENSG00000198863 [Q96C34-1]
UCSCiuc002ici.1 human [Q96C34-1]

Organism-specific databases

EuPathDBiHostDB:ENSG00000198863.7
GeneCardsiRUNDC1
H-InvDBiHIX0020512
HGNCiHGNC:25418 RUNDC1
HPAiHPA023726
neXtProtiNX_Q96C34
OpenTargetsiENSG00000198863
PharmGKBiPA134956633
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3759 Eukaryota
ENOG410XQKK LUCA
GeneTreeiENSGT00390000007311
HOGENOMiHOG000018481
HOVERGENiHBG063773
InParanoidiQ96C34
OMAiAIHMVLT
OrthoDBiEOG091G0627
PhylomeDBiQ96C34
TreeFamiTF105949

Miscellaneous databases

ChiTaRSiRUNDC1 human
GenomeRNAii146923
PROiPR:Q96C34

Gene expression databases

BgeeiENSG00000198863 Expressed in 189 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_RUNDC1
ExpressionAtlasiQ96C34 baseline and differential
GenevisibleiQ96C34 HS

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUND1_HUMAN
AccessioniPrimary (citable) accession number: Q96C34
Secondary accession number(s): Q6Y2K8, Q8IXT9, Q8N3W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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