UniProtKB - Q96C28 (ZN707_HUMAN)
Protein
Zinc finger protein 707
Gene
ZNF707
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 198 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 288 – 310 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96C28 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 707 |
Gene namesi | Name:ZNF707 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27815, ZNF707 |
neXtProti | NX_Q96C28 |
VEuPathDBi | HostDB:ENSG00000181135.15 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000181135 |
PharmGKBi | PA142670506 |
Miscellaneous databases
Pharosi | Q96C28, Tdark |
Genetic variation databases
BioMutai | ZNF707 |
DMDMi | 296453056 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233284 | 1 – 371 | Zinc finger protein 707Add BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 144 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q96C28 |
MassIVEi | Q96C28 |
PaxDbi | Q96C28 |
PeptideAtlasi | Q96C28 |
PRIDEi | Q96C28 |
ProteomicsDBi | 76154 |
PTM databases
iPTMneti | Q96C28 |
PhosphoSitePlusi | Q96C28 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181135, Expressed in right testis and 174 other tissues |
ExpressionAtlasi | Q96C28, baseline and differential |
Genevisiblei | Q96C28, HS |
Organism-specific databases
HPAi | ENSG00000181135, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96C28
Protein-protein interaction databases
BioGRIDi | 130290, 64 interactors |
IntActi | Q96C28, 45 interactors |
STRINGi | 9606.ENSP00000436212 |
Miscellaneous databases
RNActi | Q96C28, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 198 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 288 – 310 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164666 |
HOGENOMi | CLU_002678_0_7_1 |
InParanoidi | Q96C28 |
OMAi | WDEPWVE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96C28 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q96C28-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMAQEPVTF RDVAIYFSRE EWACLEPSQR ALYRDVMLDN FSSVAALGFC
60 70 80 90 100
SPRPDLVSRL EQWEEPWVED RERPEFQAVQ RGPRPGARKS ADPKRPCDHP
110 120 130 140 150
AWAHKKTHVR RERAREGSSF RKGFRLDTDD GQLPRAAPER TDAKPTAFPC
160 170 180 190 200
QVLTQRCGRR PGRRERRKQR AVELSFICGT CGKALSCHSR LLAHQTVHTG
210 220 230 240 250
TKAFECPECG QTFRWASNLQ RHQKNHTREK PFCCEACGQA FSLKDRLAQH
260 270 280 290 300
RKVHTEHRPY SCGDCGKAFK QKSNLLRHQL VHTGERPFYC ADCGKAFRTK
310 320 330 340 350
ENLSHHQRVH SGEKPYTCAE CGKSFRWPKG FSIHRRLHLT KRFYECGHCG
360 370
KGFRHLGFFT RHQRTHRHGE V
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PNV7 | E9PNV7_HUMAN | Zinc finger protein 707 | ZNF707 | 141 | Annotation score: | ||
E9PS67 | E9PS67_HUMAN | Zinc finger protein 707 | ZNF707 | 145 | Annotation score: | ||
A0A2R8YE36 | A0A2R8YE36_HUMAN | Zinc finger protein 707 | ZNF707 | 296 | Annotation score: | ||
E9PPS7 | E9PPS7_HUMAN | Zinc finger protein 707 | ZNF707 | 134 | Annotation score: | ||
E9PKX4 | E9PKX4_HUMAN | Zinc finger protein 707 | ZNF707 | 92 | Annotation score: | ||
E9PHZ0 | E9PHZ0_HUMAN | Zinc finger protein 707 | ZNF707 | 47 | Annotation score: | ||
E9PJ46 | E9PJ46_HUMAN | Zinc finger protein 707 | ZNF707 | 55 | Annotation score: | ||
E9PQ20 | E9PQ20_HUMAN | Zinc finger protein 707 | ZNF707 | 79 | Annotation score: | ||
E9PP66 | E9PP66_HUMAN | Zinc finger protein 707 | ZNF707 | 103 | Annotation score: |
Sequence cautioni
The sequence AAH14894 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF83121 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | E → V in BAF83121 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 192 | L → F in BAG51493 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033596 | 96 | P → H2 PublicationsCorresponds to variant dbSNP:rs6987308Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290432 mRNA Translation: BAF83121.1 Different initiation. AK055263 mRNA Translation: BAG51493.1 AC105219 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82210.1 CH471162 Genomic DNA Translation: EAW82211.1 CH471162 Genomic DNA Translation: EAW82214.1 BC014894 mRNA Translation: AAH14894.1 Different initiation. |
CCDSi | CCDS47932.1 |
RefSeqi | NP_001094068.1, NM_001100598.1 NP_001094069.1, NM_001100599.1 NP_001275734.1, NM_001288805.1 NP_001275735.1, NM_001288806.1 NP_001275736.1, NM_001288807.1 NP_001275737.1, NM_001288808.1 NP_001275738.1, NM_001288809.1 NP_776192.2, NM_173831.3 XP_011515279.1, XM_011516977.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290432 mRNA Translation: BAF83121.1 Different initiation. AK055263 mRNA Translation: BAG51493.1 AC105219 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82210.1 CH471162 Genomic DNA Translation: EAW82211.1 CH471162 Genomic DNA Translation: EAW82214.1 BC014894 mRNA Translation: AAH14894.1 Different initiation. |
CCDSi | CCDS47932.1 |
RefSeqi | NP_001094068.1, NM_001100598.1 NP_001094069.1, NM_001100599.1 NP_001275734.1, NM_001288805.1 NP_001275735.1, NM_001288806.1 NP_001275736.1, NM_001288807.1 NP_001275737.1, NM_001288808.1 NP_001275738.1, NM_001288809.1 NP_776192.2, NM_173831.3 XP_011515279.1, XM_011516977.2 |
3D structure databases
SMRi | Q96C28 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130290, 64 interactors |
IntActi | Q96C28, 45 interactors |
STRINGi | 9606.ENSP00000436212 |
PTM databases
iPTMneti | Q96C28 |
PhosphoSitePlusi | Q96C28 |
Genetic variation databases
BioMutai | ZNF707 |
DMDMi | 296453056 |
Proteomic databases
EPDi | Q96C28 |
MassIVEi | Q96C28 |
PaxDbi | Q96C28 |
PeptideAtlasi | Q96C28 |
PRIDEi | Q96C28 |
ProteomicsDBi | 76154 |
Protocols and materials databases
Antibodypediai | 7422, 92 antibodies |
DNASUi | 286075 |
Genome annotation databases
Organism-specific databases
CTDi | 286075 |
GeneCardsi | ZNF707 |
HGNCi | HGNC:27815, ZNF707 |
HPAi | ENSG00000181135, Low tissue specificity |
neXtProti | NX_Q96C28 |
OpenTargetsi | ENSG00000181135 |
PharmGKBi | PA142670506 |
VEuPathDBi | HostDB:ENSG00000181135.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164666 |
HOGENOMi | CLU_002678_0_7_1 |
InParanoidi | Q96C28 |
OMAi | WDEPWVE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96C28 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q96C28 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 286075, 9 hits in 1018 CRISPR screens |
GenomeRNAii | 286075 |
Pharosi | Q96C28, Tdark |
PROi | PR:Q96C28 |
RNActi | Q96C28, protein |
Gene expression databases
Bgeei | ENSG00000181135, Expressed in right testis and 174 other tissues |
ExpressionAtlasi | Q96C28, baseline and differential |
Genevisiblei | Q96C28, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN707_HUMAN | |
Accessioni | Q96C28Primary (citable) accession number: Q96C28 Secondary accession number(s): A8K317, B3KNY1, D3DWK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families