Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 707

Gene

ZNF707

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 707
Gene namesi
Name:ZNF707
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000181135.15
HGNCiHGNC:27815 ZNF707
neXtProtiNX_Q96C28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181135
PharmGKBiPA142670506

Polymorphism and mutation databases

BioMutaiZNF707
DMDMi296453056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332841 – 371Zinc finger protein 707Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96C28
PaxDbiQ96C28
PeptideAtlasiQ96C28
PRIDEiQ96C28
ProteomicsDBi76154

PTM databases

iPTMnetiQ96C28
PhosphoSitePlusiQ96C28

Expressioni

Gene expression databases

BgeeiENSG00000181135 Expressed in 157 organ(s), highest expression level in right testis
CleanExiHS_ZNF707
ExpressionAtlasiQ96C28 baseline and differential
GenevisibleiQ96C28 HS

Organism-specific databases

HPAiHPA044991

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi130290, 59 interactors
IntActiQ96C28, 10 interactors
STRINGi9606.ENSP00000351482

Structurei

3D structure databases

ProteinModelPortaliQ96C28
SMRiQ96C28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150903
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96C28
KOiK09228
OMAiWAHKKTH
OrthoDBiEOG091G0P6J
PhylomeDBiQ96C28
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q96C28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMAQEPVTF RDVAIYFSRE EWACLEPSQR ALYRDVMLDN FSSVAALGFC
60 70 80 90 100
SPRPDLVSRL EQWEEPWVED RERPEFQAVQ RGPRPGARKS ADPKRPCDHP
110 120 130 140 150
AWAHKKTHVR RERAREGSSF RKGFRLDTDD GQLPRAAPER TDAKPTAFPC
160 170 180 190 200
QVLTQRCGRR PGRRERRKQR AVELSFICGT CGKALSCHSR LLAHQTVHTG
210 220 230 240 250
TKAFECPECG QTFRWASNLQ RHQKNHTREK PFCCEACGQA FSLKDRLAQH
260 270 280 290 300
RKVHTEHRPY SCGDCGKAFK QKSNLLRHQL VHTGERPFYC ADCGKAFRTK
310 320 330 340 350
ENLSHHQRVH SGEKPYTCAE CGKSFRWPKG FSIHRRLHLT KRFYECGHCG
360 370
KGFRHLGFFT RHQRTHRHGE V
Length:371
Mass (Da):43,088
Last modified:May 18, 2010 - v2
Checksum:i113B680E5296FF3B
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ46E9PJ46_HUMAN
Zinc finger protein 707
ZNF707
55Annotation score:
E9PKX4E9PKX4_HUMAN
Zinc finger protein 707
ZNF707
92Annotation score:
E9PNV7E9PNV7_HUMAN
Zinc finger protein 707
ZNF707
141Annotation score:
E9PP66E9PP66_HUMAN
Zinc finger protein 707
ZNF707
103Annotation score:
E9PQ20E9PQ20_HUMAN
Zinc finger protein 707
ZNF707
79Annotation score:
E9PPS7E9PPS7_HUMAN
Zinc finger protein 707
ZNF707
134Annotation score:
E9PHZ0E9PHZ0_HUMAN
Zinc finger protein 707
ZNF707
47Annotation score:
E9PS67E9PS67_HUMAN
Zinc finger protein 707
ZNF707
145Annotation score:
A0A2R8YE36A0A2R8YE36_HUMAN
Zinc finger protein 707
ZNF707
296Annotation score:

Sequence cautioni

The sequence AAH14894 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF83121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → V in BAF83121 (PubMed:14702039).Curated1
Sequence conflicti192L → F in BAG51493 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03359696P → H2 PublicationsCorresponds to variant dbSNP:rs6987308Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290432 mRNA Translation: BAF83121.1 Different initiation.
AK055263 mRNA Translation: BAG51493.1
AC105219 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82210.1
CH471162 Genomic DNA Translation: EAW82211.1
CH471162 Genomic DNA Translation: EAW82214.1
BC014894 mRNA Translation: AAH14894.1 Different initiation.
CCDSiCCDS47932.1
RefSeqiNP_001094068.1, NM_001100598.1
NP_001094069.1, NM_001100599.1
NP_001275734.1, NM_001288805.1
NP_001275735.1, NM_001288806.1
NP_001275736.1, NM_001288807.1
NP_001275737.1, NM_001288808.1
NP_001275738.1, NM_001288809.1
NP_776192.2, NM_173831.3
XP_011515279.1, XM_011516977.2
UniGeneiHs.521922

Genome annotation databases

EnsembliENST00000358656; ENSP00000351482; ENSG00000181135
ENST00000418203; ENSP00000413215; ENSG00000181135
ENST00000532158; ENSP00000436250; ENSG00000181135
ENST00000532205; ENSP00000436212; ENSG00000181135
ENST00000611146; ENSP00000484032; ENSG00000274352
ENST00000611844; ENSP00000481069; ENSG00000274352
ENST00000617261; ENSP00000484744; ENSG00000274352
ENST00000622212; ENSP00000481033; ENSG00000274352
GeneIDi286075
KEGGihsa:286075
UCSCiuc003yze.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290432 mRNA Translation: BAF83121.1 Different initiation.
AK055263 mRNA Translation: BAG51493.1
AC105219 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82210.1
CH471162 Genomic DNA Translation: EAW82211.1
CH471162 Genomic DNA Translation: EAW82214.1
BC014894 mRNA Translation: AAH14894.1 Different initiation.
CCDSiCCDS47932.1
RefSeqiNP_001094068.1, NM_001100598.1
NP_001094069.1, NM_001100599.1
NP_001275734.1, NM_001288805.1
NP_001275735.1, NM_001288806.1
NP_001275736.1, NM_001288807.1
NP_001275737.1, NM_001288808.1
NP_001275738.1, NM_001288809.1
NP_776192.2, NM_173831.3
XP_011515279.1, XM_011516977.2
UniGeneiHs.521922

3D structure databases

ProteinModelPortaliQ96C28
SMRiQ96C28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130290, 59 interactors
IntActiQ96C28, 10 interactors
STRINGi9606.ENSP00000351482

PTM databases

iPTMnetiQ96C28
PhosphoSitePlusiQ96C28

Polymorphism and mutation databases

BioMutaiZNF707
DMDMi296453056

Proteomic databases

EPDiQ96C28
PaxDbiQ96C28
PeptideAtlasiQ96C28
PRIDEiQ96C28
ProteomicsDBi76154

Protocols and materials databases

DNASUi286075
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358656; ENSP00000351482; ENSG00000181135
ENST00000418203; ENSP00000413215; ENSG00000181135
ENST00000532158; ENSP00000436250; ENSG00000181135
ENST00000532205; ENSP00000436212; ENSG00000181135
ENST00000611146; ENSP00000484032; ENSG00000274352
ENST00000611844; ENSP00000481069; ENSG00000274352
ENST00000617261; ENSP00000484744; ENSG00000274352
ENST00000622212; ENSP00000481033; ENSG00000274352
GeneIDi286075
KEGGihsa:286075
UCSCiuc003yze.5 human

Organism-specific databases

CTDi286075
EuPathDBiHostDB:ENSG00000181135.15
GeneCardsiZNF707
HGNCiHGNC:27815 ZNF707
HPAiHPA044991
neXtProtiNX_Q96C28
OpenTargetsiENSG00000181135
PharmGKBiPA142670506
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150903
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96C28
KOiK09228
OMAiWAHKKTH
OrthoDBiEOG091G0P6J
PhylomeDBiQ96C28
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii286075
PROiPR:Q96C28

Gene expression databases

BgeeiENSG00000181135 Expressed in 157 organ(s), highest expression level in right testis
CleanExiHS_ZNF707
ExpressionAtlasiQ96C28 baseline and differential
GenevisibleiQ96C28 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN707_HUMAN
AccessioniPrimary (citable) accession number: Q96C28
Secondary accession number(s): A8K317, B3KNY1, D3DWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again