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UniProtKB - Q96C24 (SYTL4_HUMAN)

Entry version 184 (07 Apr 2021)
Sequence version 2 (11 Jan 2011)
Previous versions | rss
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Protein

Synaptotagmin-like protein 4

Gene

SYTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri63 – 105FYVE-typeAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96C24

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.57.1.8, the extended-synaptotagmin (e-syt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-like protein 4
Alternative name(s):
Exophilin-2
Granuphilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYTL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15588, SYTL4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300723, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96C24

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000102362.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		94121

Open Targets

More...OpenTargetsi		ENSG00000102362

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37987

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96C24, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00071, Insulin pork

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYTL4

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902161 – 671Synaptotagmin-like protein 4Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei201PhosphoserineBy similarity1
Modified residuei204PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96C24

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96C24

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96C24

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96C24

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96C24

PeptideAtlas

More...PeptideAtlasi		Q96C24

PRoteomics IDEntifications database

More...PRIDEi		Q96C24

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76152 [Q96C24-1]
76153 [Q96C24-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96C24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96C24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102362, Expressed in left ovary and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96C24, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96C24, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102362, Tissue enhanced (endometrium, ovary, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B.

Interacts with MYO5A (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125120, 43 interactors

Protein interaction database and analysis system

More...IntActi		Q96C24, 32 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362080

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96C24, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q96C24

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96C24

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96C24

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 122RabBDPROSITE-ProRule annotationAdd BLAST119
Domaini356 – 478C2 1PROSITE-ProRule annotationAdd BLAST123
Domaini507 – 633C2 2PROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi305 – 311Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 105FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002711_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96C24

Identification of Orthologs from Complete Genome Data

More...OMAi		KKRTGDW

Database of Orthologous Groups

More...OrthoDBi		916843at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96C24

TreeFam database of animal gene trees

More...TreeFami		TF341184

Family and domain databases

Conserved Domains Database

More...CDDi		cd04029, C2A_SLP-4_5, 1 hit
cd04020, C2B_SLP_1-2-3-4, 1 hit
cd15764, FYVE_Slp4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR044134, FYVE_Slp4
IPR010911, Rab_BD
IPR037303, SLP-4/5_C2A
IPR001565, Synaptotagmin
IPR043567, SYTL1-5_C2B
IPR028694, SYTL4
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR45716:SF4, PTHR45716:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00399, SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG 
        60         70         80         90        100
AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW 
       110        120        130        140        150
RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE 
       160        170        180        190        200
TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE 
       210        220        230        240        250
SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF 
       260        270        280        290        300
VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL 
       310        320        330        340        350
NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD 
       360        370        380        390        400
FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY 
       410        420        430        440        450
LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG 
       460        470        480        490        500
RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV 
       510        520        530        540        550
VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF 
       560        570        580        590        600
VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT 
       610        620        630        640        650
VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP 
       660        670 
GSWAEGTLQL RSSMAKQKLG L
Length:671
Mass (Da):76,024
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04152119330EAB84
GO
Isoform 2 (identifier: Q96C24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-657: Missing.
     658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

Note: May be due to an intron retention.Curated
Show »
Length:349
Mass (Da):39,813
Checksum:i815C9B7DC933119E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44L → P in CAI46126 (PubMed:17974005).Curated1
Sequence conflicti160T → A in BAC04287 (PubMed:14702039).Curated1
Sequence conflicti251V → A in CAI46126 (PubMed:17974005).Curated1
Sequence conflicti287S → G in BAC04287 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016076420I → V3 PublicationsCorresponds to variant dbSNP:rs2022039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015237336 – 657Missing in isoform 2. 1 PublicationAdd BLAST322
Alternative sequenceiVSP_015238658 – 671LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK094110 mRNA Translation: BAC04287.1
BX537410 mRNA Translation: CAD97652.1
AL832596 mRNA Translation: CAI46126.1
BC014913 mRNA Translation: AAH14913.1
Z73900, AL391688 Genomic DNA Translation: CAI42004.1
Z73900, AL391688 Genomic DNA Translation: CAI42005.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14472.1 [Q96C24-1]

NCBI Reference Sequences

More...RefSeqi		NP_001123368.1, NM_001129896.2 [Q96C24-1]
NP_001167539.1, NM_001174068.1 [Q96C24-1]
NP_542775.2, NM_080737.2 [Q96C24-1]
XP_005262286.1, XM_005262229.2
XP_011529370.1, XM_011531068.2
XP_016885460.1, XM_017029971.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263033; ENSP00000263033; ENSG00000102362 [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362 [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362 [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362 [Q96C24-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		94121

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:94121

UCSC genome browser

More...UCSCi		uc004egd.6, human [Q96C24-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094110 mRNA Translation: BAC04287.1
BX537410 mRNA Translation: CAD97652.1
AL832596 mRNA Translation: CAI46126.1
BC014913 mRNA Translation: AAH14913.1
Z73900, AL391688 Genomic DNA Translation: CAI42004.1
Z73900, AL391688 Genomic DNA Translation: CAI42005.1
CCDSiCCDS14472.1 [Q96C24-1]
RefSeqiNP_001123368.1, NM_001129896.2 [Q96C24-1]
NP_001167539.1, NM_001174068.1 [Q96C24-1]
NP_542775.2, NM_080737.2 [Q96C24-1]
XP_005262286.1, XM_005262229.2
XP_011529370.1, XM_011531068.2
XP_016885460.1, XM_017029971.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSZNMR-A43-105[»]
3FDWX-ray2.20A/B352-488[»]
5X6TNMR-A59-111[»]
BMRBiQ96C24
SMRiQ96C24
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125120, 43 interactors
IntActiQ96C24, 32 interactors
STRINGi9606.ENSP00000362080

Chemistry databases

DrugBankiDB00071, Insulin pork

Protein family/group databases

TCDBi9.A.57.1.8, the extended-synaptotagmin (e-syt) family

PTM databases

iPTMnetiQ96C24
PhosphoSitePlusiQ96C24

Genetic variation databases

BioMutaiSYTL4
DMDMi317373281

Proteomic databases

EPDiQ96C24
jPOSTiQ96C24
MassIVEiQ96C24
MaxQBiQ96C24
PaxDbiQ96C24
PeptideAtlasiQ96C24
PRIDEiQ96C24
ProteomicsDBi76152 [Q96C24-1]
76153 [Q96C24-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28523, 171 antibodies

The DNASU plasmid repository

More...DNASUi		94121

Genome annotation databases

EnsembliENST00000263033; ENSP00000263033; ENSG00000102362 [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362 [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362 [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362 [Q96C24-1]
GeneIDi94121
KEGGihsa:94121
UCSCiuc004egd.6, human [Q96C24-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		94121
DisGeNETi94121

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYTL4
HGNCiHGNC:15588, SYTL4
HPAiENSG00000102362, Tissue enhanced (endometrium, ovary, pituitary gland)
MIMi300723, gene
neXtProtiNX_Q96C24
OpenTargetsiENSG00000102362
PharmGKBiPA37987
VEuPathDBiHostDB:ENSG00000102362.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000159060
HOGENOMiCLU_002711_5_0_1
InParanoidiQ96C24
OMAiKKRTGDW
OrthoDBi916843at2759
PhylomeDBiQ96C24
TreeFamiTF341184

Enzyme and pathway databases

PathwayCommonsiQ96C24
ReactomeiR-HSA-114608, Platelet degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		94121, 8 hits in 633 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYTL4, human
EvolutionaryTraceiQ96C24

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SYTL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		94121
PharosiQ96C24, Tbio

Protein Ontology

More...PROi		PR:Q96C24
RNActiQ96C24, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102362, Expressed in left ovary and 191 other tissues
ExpressionAtlasiQ96C24, baseline and differential
GenevisibleiQ96C24, HS

Family and domain databases

CDDicd04029, C2A_SLP-4_5, 1 hit
cd04020, C2B_SLP_1-2-3-4, 1 hit
cd15764, FYVE_Slp4, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR044134, FYVE_Slp4
IPR010911, Rab_BD
IPR037303, SLP-4/5_C2A
IPR001565, Synaptotagmin
IPR043567, SYTL1-5_C2B
IPR028694, SYTL4
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45716:SF4, PTHR45716:SF4, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PRINTSiPR00399, SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96C24
Secondary accession number(s): Q5H9J3
, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: April 7, 2021
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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