UniProtKB - Q96C24 (SYTL4_HUMAN)
Protein
Synaptotagmin-like protein 4
Gene
SYTL4
Organism
Homo sapiens (Human)
Status
Functioni
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 63 – 105 | FYVE-typeAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- neurexin family protein binding Source: UniProtKB
- phospholipid binding Source: UniProtKB
- small GTPase binding Source: InterPro
GO - Biological processi
- exocytosis Source: GO_Central
- intracellular protein transport Source: InterPro
- lysosome localization Source: UniProtKB
- multivesicular body sorting pathway Source: UniProtKB
- negative regulation of insulin secretion Source: Ensembl
- plasma membrane repair Source: UniProtKB
- platelet degranulation Source: Reactome
- positive regulation of exocytosis Source: UniProtKB
- positive regulation of protein secretion Source: UniProtKB
- regulation of plasma membrane repair Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96C24 |
Reactomei | R-HSA-114608, Platelet degranulation |
Protein family/group databases
TCDBi | 9.A.57.1.8, the extended-synaptotagmin (e-syt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-like protein 4Alternative name(s): Exophilin-2 Granuphilin |
Gene namesi | Name:SYTL4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15588, SYTL4 |
MIMi | 300723, gene |
neXtProti | NX_Q96C24 |
VEuPathDBi | HostDB:ENSG00000102362.15 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
- secretory vesicle membrane By similarity; Peripheral membrane protein By similarity
Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).By similarity
Endosome
- endosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- exocytic vesicle Source: GO_Central
- extrinsic component of membrane Source: UniProtKB
- platelet alpha granule membrane Source: Reactome
- transport vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 94121 |
OpenTargetsi | ENSG00000102362 |
PharmGKBi | PA37987 |
Miscellaneous databases
Pharosi | Q96C24, Tbio |
Chemistry databases
DrugBanki | DB00071, Insulin pork |
Genetic variation databases
BioMutai | SYTL4 |
DMDMi | 317373281 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190216 | 1 – 671 | Synaptotagmin-like protein 4Add BLAST | 671 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 201 | PhosphoserineBy similarity | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 274 | PhosphoserineCombined sources | 1 | |
Modified residuei | 289 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96C24 |
jPOSTi | Q96C24 |
MassIVEi | Q96C24 |
MaxQBi | Q96C24 |
PaxDbi | Q96C24 |
PeptideAtlasi | Q96C24 |
PRIDEi | Q96C24 |
ProteomicsDBi | 76152 [Q96C24-1] 76153 [Q96C24-2] |
PTM databases
iPTMneti | Q96C24 |
PhosphoSitePlusi | Q96C24 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102362, Expressed in left ovary and 191 other tissues |
ExpressionAtlasi | Q96C24, baseline and differential |
Genevisiblei | Q96C24, HS |
Organism-specific databases
HPAi | ENSG00000102362, Tissue enhanced (endometrium, ovary, pituitary gland) |
Interactioni
Subunit structurei
Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B.
Interacts with MYO5A (By similarity).
By similarityBinary interactionsi
Hide detailsQ96C24
GO - Molecular functioni
- neurexin family protein binding Source: UniProtKB
- small GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 125120, 43 interactors |
IntActi | Q96C24, 32 interactors |
STRINGi | 9606.ENSP00000362080 |
Miscellaneous databases
RNActi | Q96C24, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q96C24 |
SMRi | Q96C24 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96C24 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 122 | RabBDPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 356 – 478 | C2 1PROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 507 – 633 | C2 2PROSITE-ProRule annotationAdd BLAST | 127 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 305 – 311 | Poly-Glu | 7 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 63 – 105 | FYVE-typeAdd BLAST | 43 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000159060 |
HOGENOMi | CLU_002711_5_0_1 |
InParanoidi | Q96C24 |
OMAi | KKRTGDW |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q96C24 |
TreeFami | TF341184 |
Family and domain databases
CDDi | cd04029, C2A_SLP-4_5, 1 hit cd04020, C2B_SLP_1-2-3-4, 1 hit cd15764, FYVE_Slp4, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR044134, FYVE_Slp4 IPR010911, Rab_BD IPR037303, SLP-4/5_C2A IPR001565, Synaptotagmin IPR043567, SYTL1-5_C2B IPR028694, SYTL4 IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF4, PTHR45716:SF4, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
PRINTSi | PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG
60 70 80 90 100
AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW
110 120 130 140 150
RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE
160 170 180 190 200
TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE
210 220 230 240 250
SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF
260 270 280 290 300
VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL
310 320 330 340 350
NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD
360 370 380 390 400
FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY
410 420 430 440 450
LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG
460 470 480 490 500
RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV
510 520 530 540 550
VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF
560 570 580 590 600
VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT
610 620 630 640 650
VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP
660 670
GSWAEGTLQL RSSMAKQKLG L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | L → P in CAI46126 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 160 | T → A in BAC04287 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 251 | V → A in CAI46126 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 287 | S → G in BAC04287 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016076 | 420 | I → V3 PublicationsCorresponds to variant dbSNP:rs2022039Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015237 | 336 – 657 | Missing in isoform 2. 1 PublicationAdd BLAST | 322 | |
Alternative sequenceiVSP_015238 | 658 – 671 | LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094110 mRNA Translation: BAC04287.1 BX537410 mRNA Translation: CAD97652.1 AL832596 mRNA Translation: CAI46126.1 BC014913 mRNA Translation: AAH14913.1 Z73900, AL391688 Genomic DNA Translation: CAI42004.1 Z73900, AL391688 Genomic DNA Translation: CAI42005.1 |
CCDSi | CCDS14472.1 [Q96C24-1] |
RefSeqi | NP_001123368.1, NM_001129896.2 [Q96C24-1] NP_001167539.1, NM_001174068.1 [Q96C24-1] NP_542775.2, NM_080737.2 [Q96C24-1] XP_005262286.1, XM_005262229.2 XP_011529370.1, XM_011531068.2 XP_016885460.1, XM_017029971.1 |
Genome annotation databases
Ensembli | ENST00000263033; ENSP00000263033; ENSG00000102362 [Q96C24-1] ENST00000276141; ENSP00000276141; ENSG00000102362 [Q96C24-1] ENST00000372981; ENSP00000362072; ENSG00000102362 [Q96C24-2] ENST00000372989; ENSP00000362080; ENSG00000102362 [Q96C24-1] |
GeneIDi | 94121 |
KEGGi | hsa:94121 |
UCSCi | uc004egd.6, human [Q96C24-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094110 mRNA Translation: BAC04287.1 BX537410 mRNA Translation: CAD97652.1 AL832596 mRNA Translation: CAI46126.1 BC014913 mRNA Translation: AAH14913.1 Z73900, AL391688 Genomic DNA Translation: CAI42004.1 Z73900, AL391688 Genomic DNA Translation: CAI42005.1 |
CCDSi | CCDS14472.1 [Q96C24-1] |
RefSeqi | NP_001123368.1, NM_001129896.2 [Q96C24-1] NP_001167539.1, NM_001174068.1 [Q96C24-1] NP_542775.2, NM_080737.2 [Q96C24-1] XP_005262286.1, XM_005262229.2 XP_011529370.1, XM_011531068.2 XP_016885460.1, XM_017029971.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CSZ | NMR | - | A | 43-105 | [»] | |
3FDW | X-ray | 2.20 | A/B | 352-488 | [»] | |
5X6T | NMR | - | A | 59-111 | [»] | |
BMRBi | Q96C24 | |||||
SMRi | Q96C24 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125120, 43 interactors |
IntActi | Q96C24, 32 interactors |
STRINGi | 9606.ENSP00000362080 |
Chemistry databases
DrugBanki | DB00071, Insulin pork |
Protein family/group databases
TCDBi | 9.A.57.1.8, the extended-synaptotagmin (e-syt) family |
PTM databases
iPTMneti | Q96C24 |
PhosphoSitePlusi | Q96C24 |
Genetic variation databases
BioMutai | SYTL4 |
DMDMi | 317373281 |
Proteomic databases
EPDi | Q96C24 |
jPOSTi | Q96C24 |
MassIVEi | Q96C24 |
MaxQBi | Q96C24 |
PaxDbi | Q96C24 |
PeptideAtlasi | Q96C24 |
PRIDEi | Q96C24 |
ProteomicsDBi | 76152 [Q96C24-1] 76153 [Q96C24-2] |
Protocols and materials databases
Antibodypediai | 28523, 171 antibodies |
DNASUi | 94121 |
Genome annotation databases
Ensembli | ENST00000263033; ENSP00000263033; ENSG00000102362 [Q96C24-1] ENST00000276141; ENSP00000276141; ENSG00000102362 [Q96C24-1] ENST00000372981; ENSP00000362072; ENSG00000102362 [Q96C24-2] ENST00000372989; ENSP00000362080; ENSG00000102362 [Q96C24-1] |
GeneIDi | 94121 |
KEGGi | hsa:94121 |
UCSCi | uc004egd.6, human [Q96C24-1] |
Organism-specific databases
CTDi | 94121 |
DisGeNETi | 94121 |
GeneCardsi | SYTL4 |
HGNCi | HGNC:15588, SYTL4 |
HPAi | ENSG00000102362, Tissue enhanced (endometrium, ovary, pituitary gland) |
MIMi | 300723, gene |
neXtProti | NX_Q96C24 |
OpenTargetsi | ENSG00000102362 |
PharmGKBi | PA37987 |
VEuPathDBi | HostDB:ENSG00000102362.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000159060 |
HOGENOMi | CLU_002711_5_0_1 |
InParanoidi | Q96C24 |
OMAi | KKRTGDW |
OrthoDBi | 916843at2759 |
PhylomeDBi | Q96C24 |
TreeFami | TF341184 |
Enzyme and pathway databases
PathwayCommonsi | Q96C24 |
Reactomei | R-HSA-114608, Platelet degranulation |
Miscellaneous databases
BioGRID-ORCSi | 94121, 8 hits in 633 CRISPR screens |
ChiTaRSi | SYTL4, human |
EvolutionaryTracei | Q96C24 |
GeneWikii | SYTL4 |
GenomeRNAii | 94121 |
Pharosi | Q96C24, Tbio |
PROi | PR:Q96C24 |
RNActi | Q96C24, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102362, Expressed in left ovary and 191 other tissues |
ExpressionAtlasi | Q96C24, baseline and differential |
Genevisiblei | Q96C24, HS |
Family and domain databases
CDDi | cd04029, C2A_SLP-4_5, 1 hit cd04020, C2B_SLP_1-2-3-4, 1 hit cd15764, FYVE_Slp4, 1 hit |
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR044134, FYVE_Slp4 IPR010911, Rab_BD IPR037303, SLP-4/5_C2A IPR001565, Synaptotagmin IPR043567, SYTL1-5_C2B IPR028694, SYTL4 IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45716:SF4, PTHR45716:SF4, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
PRINTSi | PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYTL4_HUMAN | |
Accessioni | Q96C24Primary (citable) accession number: Q96C24 Secondary accession number(s): Q5H9J3 Q9H4R1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references