Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q96C11 (FGGY_HUMAN)

Entry version 146 (25 May 2022)
Sequence version 2 (18 Mar 2008)
Previous versions | rss
Add a publicationFeedback
Protein

FGGY carbohydrate kinase domain-containing protein

Gene

FGGY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activities. Alternatively, may play a role in regulating D-ribulose 5-phosphate recycling in the pentose phosphate pathway. Can phosphorylate ribitol with low efficiency.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=97 µM for D-ribulose1 Publication
  2. KM=1468 µM for ribitol1 Publication
  1. Vmax=5.6 µmol/min/mg enzyme toward D-ribulose1 Publication
  2. Vmax=2.4 µmol/min/mg enzyme toward ribitol1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • D-ribulokinase activity Source: SGD
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96C11

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96C11

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00246

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FGGY carbohydrate kinase domain-containing protein
Alternative name(s):
D-ribulokinase FGGY1 Publication (EC:2.7.1.471 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGGY1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25610, FGGY

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611370, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96C11

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000172456

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis (ALS)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Related information in OMIM

Keywords - Diseasei

Amyotrophic lateral sclerosis, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		55277
MIMi105400, phenotype

Open Targets

More...OpenTargetsi		ENSG00000172456

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162388453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96C11, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FGGY

Domain mapping of disease mutations (DMDM)

More...DMDMi		172045850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003264521 – 551FGGY carbohydrate kinase domain-containing proteinAdd BLAST551

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96C11

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96C11

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96C11

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96C11

PeptideAtlas

More...PeptideAtlasi		Q96C11

PRoteomics IDEntifications database

More...PRIDEi		Q96C11

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3030
76142 [Q96C11-1]
76143 [Q96C11-2]
76144 [Q96C11-3]
76145 [Q96C11-4]
82738

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96C11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96C11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172456, Expressed in right lobe of liver and 169 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96C11, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96C11, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172456, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120565, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q96C11, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360262

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96C11, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96C11

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96C11

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2517, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214434

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009281_10_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96C11

Identification of Orthologs from Complete Genome Data

More...OMAi		GHKAMWH

Database of Orthologous Groups

More...OrthoDBi		1252682at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96C11

TreeFam database of animal gene trees

More...TreeFami		TF300904

Family and domain databases

Conserved Domains Database

More...CDDi		cd07782, FGGY_YpCarbK_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043129, ATPase_NBD
IPR000577, Carb_kinase_FGGY
IPR018485, Carb_kinase_FGGY_C
IPR018484, Carb_kinase_FGGY_N
IPR006003, FGGY_RbtK-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02782, FGGY_C, 1 hit
PF00370, FGGY_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000538, GlpK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53067, SSF53067, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01315, 5C_CHO_kinase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96C11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH 
        60         70         80         90        100
HEQSSEDIWA ACCVVTKKVV QGIDLNQIRG LGFDATCSLV VLDKQFHPLP 
       110        120        130        140        150
VNQEGDSHRN VIMWLDHRAV SQVNRINETK HSVLQYVGGV MSVEMQAPKL 
       160        170        180        190        200
LWLKENLREI CWDKAGHFFD LPDFLSWKAT GVTARSLCSL VCKWTYSAEK 
       210        220        230        240        250
GWDDSFWKMI GLEDFVADNY SKIGNQVLPP GASLGNGLTP EAARDLGLLP 
       260        270        280        290        300
GIAVAASLID AHAGGLGVIG ADVRGHGLIC EGQPVTSRLA VICGTSSCHM 
       310        320        330        340        350
GISKDPIFVP GVWGPYFSAM VPGFWLNEGG QSVTGKLIDH MVQGHAAFPE 
       360        370        380        390        400
LQVKATARCQ SIYAYLNSHL DLIKKAQPVG FLTVDLHVWP DFHGNRSPLA 
       410        420        430        440        450
DLTLKGMVTG LKLSQDLDDL AILYLATVQA IALGTRFIIE AMEAAGHSIS 
       460        470        480        490        500
TLFLCGGLSK NPLFVQMHAD ITGMPVVLSQ EVESVLVGAA VLGACASGDF 
       510        520        530        540        550
ASVQEAMAKM SKVGKVVFPR LQDKKYYDKK YQVFLKLVEH QKEYLAIMND 

D
Length:551
Mass (Da):59,993
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i938946C33E6DC78F
GO
Isoform 2 (identifier: Q96C11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     359-551: Missing.

Show »
Length:246
Mass (Da):26,577
Checksum:i04D5374635B4DB01
GO
Isoform 3 (identifier: Q96C11-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:439
Mass (Da):47,706
Checksum:i6DF2354474EBE3E8
GO
Isoform 4 (identifier: Q96C11-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-407: M → MRTTGYLYIPALAALHSPSSLLSPQ

Show »
Length:575
Mass (Da):62,532
Checksum:i3F1D3C60B539B98A
GO
Isoform 5 (identifier: Q96C11-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-155: Missing.

Show »
Length:463
Mass (Da):50,035
Checksum:iC124C94AEBB4384A
GO
Isoform 6 (identifier: Q96C11-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Show »
Length:252
Mass (Da):27,502
Checksum:i287A650AB8235124
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2V1F2Z2V1_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRB9A0A0U1RRB9_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J015C9J015_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQJ1A0A0U1RQJ1_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQS3A0A0U1RQS3_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR53A0A0U1RR53_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRI8A0A0U1RRI8_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKV9J3QKV9_HUMAN
FGGY carbohydrate kinase domain-con...
FGGY
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14947 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05919343N → K. Corresponds to variant dbSNP:rs835409Ensembl.1
Natural variantiVAR_040072134L → V. Corresponds to variant dbSNP:rs11207463Ensembl.1
Natural variantiVAR_059194246L → V. Corresponds to variant dbSNP:rs11207463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545331 – 299Missing in isoform 6. 1 PublicationAdd BLAST299
Alternative sequenceiVSP_0326581 – 112Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_04533868 – 155Missing in isoform 5. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_032659359 – 551Missing in isoform 2. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_033424407M → MRTTGYLYIPALAALHSPSS LLSPQ in isoform 4. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001848 mRNA Translation: BAA91940.1
AK022237 mRNA Translation: BAB13993.1
AK054842 mRNA Translation: BAG51432.1
AK315649 mRNA Translation: BAG38015.1
AL954338 Genomic DNA No translation available.
AC093424 Genomic DNA No translation available.
AL035416 Genomic DNA No translation available.
AL390234 Genomic DNA No translation available.
AL713859 Genomic DNA No translation available.
BX119322 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06619.1
CH471059 Genomic DNA Translation: EAX06621.1
CH471059 Genomic DNA Translation: EAX06622.1
CH471059 Genomic DNA Translation: EAX06623.1
CH471059 Genomic DNA Translation: EAX06624.1
BC014947 mRNA Translation: AAH14947.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44155.1 [Q96C11-3]
CCDS58003.1 [Q96C11-5]
CCDS60155.1 [Q96C11-6]
CCDS611.2 [Q96C11-1]

NCBI Reference Sequences

More...RefSeqi		NP_001106882.1, NM_001113411.1 [Q96C11-3]
NP_001231643.1, NM_001244714.1 [Q96C11-5]
NP_001265153.1, NM_001278224.1 [Q96C11-6]
NP_060761.3, NM_018291.3 [Q96C11-1]
XP_011540032.1, XM_011541730.1 [Q96C11-3]
XP_011540033.1, XM_011541731.1 [Q96C11-3]
XP_011540034.1, XM_011541732.1
XP_011540035.1, XM_011541733.1
XP_011540037.1, XM_011541735.1
XP_016857132.1, XM_017001643.1 [Q96C11-3]
XP_016857133.1, XM_017001644.1
XP_016857134.1, XM_017001645.1 [Q96C11-1]
XP_016857135.1, XM_017001646.1 [Q96C11-1]
XP_016857136.1, XM_017001647.1
XP_016857155.1, XM_017001666.1
XP_016857156.1, XM_017001667.1
XP_016857161.1, XM_017001672.1
XP_016857162.1, XM_017001673.1 [Q96C11-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303721.12; ENSP00000305922.8; ENSG00000172456.18
ENST00000371210.1; ENSP00000360254.1; ENSG00000172456.18 [Q96C11-6]
ENST00000371212.5; ENSP00000360256.1; ENSG00000172456.18 [Q96C11-5]
ENST00000371218.8; ENSP00000360262.4; ENSG00000172456.18 [Q96C11-3]
ENST00000635156.1; ENSP00000489417.1; ENSG00000172456.18 [Q96C11-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55277

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55277

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000303721.12; ENSP00000305922.8; NM_018291.5; NP_060761.3

UCSC genome browser

More...UCSCi		uc001czi.6, human [Q96C11-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001848 mRNA Translation: BAA91940.1
AK022237 mRNA Translation: BAB13993.1
AK054842 mRNA Translation: BAG51432.1
AK315649 mRNA Translation: BAG38015.1
AL954338 Genomic DNA No translation available.
AC093424 Genomic DNA No translation available.
AL035416 Genomic DNA No translation available.
AL390234 Genomic DNA No translation available.
AL713859 Genomic DNA No translation available.
BX119322 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06619.1
CH471059 Genomic DNA Translation: EAX06621.1
CH471059 Genomic DNA Translation: EAX06622.1
CH471059 Genomic DNA Translation: EAX06623.1
CH471059 Genomic DNA Translation: EAX06624.1
BC014947 mRNA Translation: AAH14947.1 Different initiation.
CCDSiCCDS44155.1 [Q96C11-3]
CCDS58003.1 [Q96C11-5]
CCDS60155.1 [Q96C11-6]
CCDS611.2 [Q96C11-1]
RefSeqiNP_001106882.1, NM_001113411.1 [Q96C11-3]
NP_001231643.1, NM_001244714.1 [Q96C11-5]
NP_001265153.1, NM_001278224.1 [Q96C11-6]
NP_060761.3, NM_018291.3 [Q96C11-1]
XP_011540032.1, XM_011541730.1 [Q96C11-3]
XP_011540033.1, XM_011541731.1 [Q96C11-3]
XP_011540034.1, XM_011541732.1
XP_011540035.1, XM_011541733.1
XP_011540037.1, XM_011541735.1
XP_016857132.1, XM_017001643.1 [Q96C11-3]
XP_016857133.1, XM_017001644.1
XP_016857134.1, XM_017001645.1 [Q96C11-1]
XP_016857135.1, XM_017001646.1 [Q96C11-1]
XP_016857136.1, XM_017001647.1
XP_016857155.1, XM_017001666.1
XP_016857156.1, XM_017001667.1
XP_016857161.1, XM_017001672.1
XP_016857162.1, XM_017001673.1 [Q96C11-4]

3D structure databases

AlphaFoldDBiQ96C11
SMRiQ96C11
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120565, 4 interactors
IntActiQ96C11, 3 interactors
STRINGi9606.ENSP00000360262

PTM databases

iPTMnetiQ96C11
PhosphoSitePlusiQ96C11

Genetic variation databases

BioMutaiFGGY
DMDMi172045850

Proteomic databases

EPDiQ96C11
MassIVEiQ96C11
MaxQBiQ96C11
PaxDbiQ96C11
PeptideAtlasiQ96C11
PRIDEiQ96C11
ProteomicsDBi3030
76142 [Q96C11-1]
76143 [Q96C11-2]
76144 [Q96C11-3]
76145 [Q96C11-4]
82738

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33269, 118 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		55277

Genome annotation databases

EnsembliENST00000303721.12; ENSP00000305922.8; ENSG00000172456.18
ENST00000371210.1; ENSP00000360254.1; ENSG00000172456.18 [Q96C11-6]
ENST00000371212.5; ENSP00000360256.1; ENSG00000172456.18 [Q96C11-5]
ENST00000371218.8; ENSP00000360262.4; ENSG00000172456.18 [Q96C11-3]
ENST00000635156.1; ENSP00000489417.1; ENSG00000172456.18 [Q96C11-5]
GeneIDi55277
KEGGihsa:55277
MANE-SelectiENST00000303721.12; ENSP00000305922.8; NM_018291.5; NP_060761.3
UCSCiuc001czi.6, human [Q96C11-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55277
DisGeNETi55277

GeneCards: human genes, protein and diseases

More...GeneCardsi		FGGY
HGNCiHGNC:25610, FGGY
HPAiENSG00000172456, Tissue enhanced (liver)
MIMi105400, phenotype
611370, gene
neXtProtiNX_Q96C11
OpenTargetsiENSG00000172456
PharmGKBiPA162388453
VEuPathDBiHostDB:ENSG00000172456

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2517, Eukaryota
GeneTreeiENSGT01000000214434
HOGENOMiCLU_009281_10_0_1
InParanoidiQ96C11
OMAiGHKAMWH
OrthoDBi1252682at2759
PhylomeDBiQ96C11
TreeFamiTF300904

Enzyme and pathway databases

UniPathwayiUPA00246
PathwayCommonsiQ96C11
SignaLinkiQ96C11

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55277, 6 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FGGY, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55277
PharosiQ96C11, Tbio

Protein Ontology

More...PROi		PR:Q96C11
RNActiQ96C11, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172456, Expressed in right lobe of liver and 169 other tissues
ExpressionAtlasiQ96C11, baseline and differential
GenevisibleiQ96C11, HS

Family and domain databases

CDDicd07782, FGGY_YpCarbK_like, 1 hit
InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR000577, Carb_kinase_FGGY
IPR018485, Carb_kinase_FGGY_C
IPR018484, Carb_kinase_FGGY_N
IPR006003, FGGY_RbtK-like
PfamiView protein in Pfam
PF02782, FGGY_C, 1 hit
PF00370, FGGY_N, 1 hit
PIRSFiPIRSF000538, GlpK, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
TIGRFAMsiTIGR01315, 5C_CHO_kinase, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGGY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96C11
Secondary accession number(s): B1AK92
, B1AK93, B1AK94, B2RDR8, D3DQ56, Q9HA63, Q9NV20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 25, 2022
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again