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Protein

Zinc finger and BTB domain-containing protein 9

Gene

ZBTB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri411 – 433C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 9
Gene namesi
Name:ZBTB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000213588.5
HGNCiHGNC:28323 ZBTB9
neXtProtiNX_Q96C00

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221504
OpenTargetsiENSG00000213588
PharmGKBiPA134895172

Polymorphism and mutation databases

BioMutaiZBTB9
DMDMi46577533

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477231 – 473Zinc finger and BTB domain-containing protein 9Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki307Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96C00
MaxQBiQ96C00
PaxDbiQ96C00
PeptideAtlasiQ96C00
PRIDEiQ96C00
ProteomicsDBi76137

PTM databases

iPTMnetiQ96C00
PhosphoSitePlusiQ96C00

Expressioni

Gene expression databases

BgeeiENSG00000213588 Expressed in 94 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZBTB9
ExpressionAtlasiQ96C00 baseline
GenevisibleiQ96C00 HS

Organism-specific databases

HPAiHPA036767

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi128736, 44 interactors
IntActiQ96C00, 35 interactors
STRINGi9606.ENSP00000378503

Structurei

3D structure databases

ProteinModelPortaliQ96C00
SMRiQ96C00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 112BTBPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 280Pro-richAdd BLAST46
Compositional biasi298 – 389Gly-richAdd BLAST92

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri411 – 433C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231208
HOVERGENiHBG101113
InParanoidiQ96C00
KOiK10496
OMAiKVFYIKQ
OrthoDBiEOG091G07XH
PhylomeDBiQ96C00

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96C00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV
60 70 80 90 100
SLLVQGRELR AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL
110 120 130 140 150
QLIYSGRLRL PLDALPAHLL VASGLQMWQV VDQCSEILRE LETSGGGISA
160 170 180 190 200
RGGNSYHALL STTSSTGGWC IRSSPFQTPV QSSASTESPA STESPVGGEG
210 220 230 240 250
SELGEVLQIQ VEEEEEEEED DDDEDQGSAT LSQTPQPQRV SGVFPRPHGP
260 270 280 290 300
HPLPMTATPR KLPEGESAPL ELPAPPALPP KIFYIKQEPF EPKEEISGSG
310 320 330 340 350
TQPGGAKEET KVFSGGDTEG NGELGFLLPS GPGPTSGGGG PSWKPVDLHG
360 370 380 390 400
NEILSGGGGP GGAGQAVHGP VKLGGTPPAD GKRFGCLCGK RFAVKPKRDR
410 420 430 440 450
HIMLTFSLRP FGCGICNKRF KLKHHLTEHM KTHAGALHAC PHCGRRFRVH
460 470
ACFLRHRDLC KGQGWATAHW TYK
Length:473
Mass (Da):50,602
Last modified:December 1, 2001 - v1
Checksum:i2BC8041790090FD9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1K1A0A087X1K1_HUMAN
Zinc finger and BTB domain-containi...
ZBTB9
138Annotation score:
A0A087X1Z5A0A087X1Z5_HUMAN
Zinc finger and BTB domain-containi...
ZBTB9
79Annotation score:
A0A087WTT7A0A087WTT7_HUMAN
Zinc finger and BTB domain-containi...
ZBTB9
116Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061981274A → G. Corresponds to variant dbSNP:rs9469425Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA Translation: BAG53637.1
BX088650 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03739.1
BC014978 mRNA Translation: AAH14978.1
CCDSiCCDS4780.1
RefSeqiNP_689948.1, NM_152735.3
UniGeneiHs.591805

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588
ENST00000414934; ENSP00000413557; ENSG00000236515
GeneIDi221504
KEGGihsa:221504
UCSCiuc003oeq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA Translation: BAG53637.1
BX088650 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03739.1
BC014978 mRNA Translation: AAH14978.1
CCDSiCCDS4780.1
RefSeqiNP_689948.1, NM_152735.3
UniGeneiHs.591805

3D structure databases

ProteinModelPortaliQ96C00
SMRiQ96C00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128736, 44 interactors
IntActiQ96C00, 35 interactors
STRINGi9606.ENSP00000378503

PTM databases

iPTMnetiQ96C00
PhosphoSitePlusiQ96C00

Polymorphism and mutation databases

BioMutaiZBTB9
DMDMi46577533

Proteomic databases

EPDiQ96C00
MaxQBiQ96C00
PaxDbiQ96C00
PeptideAtlasiQ96C00
PRIDEiQ96C00
ProteomicsDBi76137

Protocols and materials databases

DNASUi221504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588
ENST00000414934; ENSP00000413557; ENSG00000236515
GeneIDi221504
KEGGihsa:221504
UCSCiuc003oeq.4 human

Organism-specific databases

CTDi221504
DisGeNETi221504
EuPathDBiHostDB:ENSG00000213588.5
GeneCardsiZBTB9
HGNCiHGNC:28323 ZBTB9
HPAiHPA036767
neXtProtiNX_Q96C00
OpenTargetsiENSG00000213588
PharmGKBiPA134895172
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231208
HOVERGENiHBG101113
InParanoidiQ96C00
KOiK10496
OMAiKVFYIKQ
OrthoDBiEOG091G07XH
PhylomeDBiQ96C00

Miscellaneous databases

GenomeRNAii221504
PROiPR:Q96C00

Gene expression databases

BgeeiENSG00000213588 Expressed in 94 organ(s), highest expression level in adenohypophysis
CleanExiHS_ZBTB9
ExpressionAtlasiQ96C00 baseline
GenevisibleiQ96C00 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB9_HUMAN
AccessioniPrimary (citable) accession number: Q96C00
Secondary accession number(s): A2AB19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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