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UniProtKB - Q96BZ8 (LENG1_HUMAN)
Protein
Leukocyte receptor cluster member 1
Gene
LENG1
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
Enzyme and pathway databases
PathwayCommonsi | Q96BZ8 |
SignaLinki | Q96BZ8 |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte receptor cluster member 1 |
Gene namesi | Name:LENG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15502, LENG1 |
neXtProti | NX_Q96BZ8 |
VEuPathDBi | HostDB:ENSG00000105617 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA134904804 |
Miscellaneous databases
Pharosi | Q96BZ8, Tdark |
Genetic variation databases
BioMutai | LENG1 |
DMDMi | 74731296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254627 | 1 – 264 | Leukocyte receptor cluster member 1Add BLAST | 264 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 59 | PhosphoserineCombined sources | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96BZ8 |
jPOSTi | Q96BZ8 |
MassIVEi | Q96BZ8 |
MaxQBi | Q96BZ8 |
PaxDbi | Q96BZ8 |
PeptideAtlasi | Q96BZ8 |
PRIDEi | Q96BZ8 |
ProteomicsDBi | 76133 |
PTM databases
GlyGeni | Q96BZ8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96BZ8 |
PhosphoSitePlusi | Q96BZ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105617, Expressed in quadriceps femoris and 194 other tissues |
Genevisiblei | Q96BZ8, HS |
Organism-specific databases
HPAi | ENSG00000105617, Low tissue specificity |
Interactioni
Binary interactionsi
Q96BZ8
Protein-protein interaction databases
BioGRIDi | 122582, 110 interactors |
IntActi | Q96BZ8, 93 interactors |
MINTi | Q96BZ8 |
STRINGi | 9606.ENSP00000222224 |
Miscellaneous databases
RNActi | Q96BZ8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 76 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 118 – 264 | DisorderedSequence analysisAdd BLAST | 147 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 16 – 46 | Sequence analysisAdd BLAST | 31 | |
Coiled coili | 89 – 115 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 196 – 222 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 133 – 147 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 148 – 214 | Basic and acidic residuesSequence analysisAdd BLAST | 67 | |
Compositional biasi | 227 – 244 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RZ97, Eukaryota |
HOGENOMi | CLU_058751_2_0_1 |
InParanoidi | Q96BZ8 |
OrthoDBi | 1518973at2759 |
PhylomeDBi | Q96BZ8 |
TreeFami | TF317830 |
Family and domain databases
InterProi | View protein in InterPro IPR019339, CIR_N_dom IPR039875, LENG1-like |
PANTHERi | PTHR22093, PTHR22093, 1 hit |
Pfami | View protein in Pfam PF10197, Cir_N, 1 hit |
SMARTi | View protein in SMART SM01083, Cir_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96BZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL
60 70 80 90 100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYKEEK
110 120 130 140 150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI
160 170 180 190 200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR
210 220 230 240 250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ
260
LARRPRQQDP HLTH
Sequence cautioni
The sequence AAG01393 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051090 | 97 | K → E. Corresponds to variant dbSNP:rs35089861Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245052 Genomic DNA No translation available. BC014986 mRNA Translation: AAH14986.1 AF211966 mRNA Translation: AAG01393.1 Different initiation. |
CCDSi | CCDS12881.1 |
RefSeqi | NP_077292.2, NM_024316.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC245052 Genomic DNA No translation available. BC014986 mRNA Translation: AAH14986.1 AF211966 mRNA Translation: AAG01393.1 Different initiation. |
CCDSi | CCDS12881.1 |
RefSeqi | NP_077292.2, NM_024316.2 |
3D structure databases
SMRi | Q96BZ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122582, 110 interactors |
IntActi | Q96BZ8, 93 interactors |
MINTi | Q96BZ8 |
STRINGi | 9606.ENSP00000222224 |
PTM databases
GlyGeni | Q96BZ8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q96BZ8 |
PhosphoSitePlusi | Q96BZ8 |
Genetic variation databases
BioMutai | LENG1 |
DMDMi | 74731296 |
Proteomic databases
EPDi | Q96BZ8 |
jPOSTi | Q96BZ8 |
MassIVEi | Q96BZ8 |
MaxQBi | Q96BZ8 |
PaxDbi | Q96BZ8 |
PeptideAtlasi | Q96BZ8 |
PRIDEi | Q96BZ8 |
ProteomicsDBi | 76133 |
Protocols and materials databases
Antibodypediai | 46337, 203 antibodies from 18 providers |
DNASUi | 79165 |
Genome annotation databases
Organism-specific databases
CTDi | 79165 |
GeneCardsi | LENG1 |
HGNCi | HGNC:15502, LENG1 |
HPAi | ENSG00000105617, Low tissue specificity |
neXtProti | NX_Q96BZ8 |
PharmGKBi | PA134904804 |
VEuPathDBi | HostDB:ENSG00000105617 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ97, Eukaryota |
HOGENOMi | CLU_058751_2_0_1 |
InParanoidi | Q96BZ8 |
OrthoDBi | 1518973at2759 |
PhylomeDBi | Q96BZ8 |
TreeFami | TF317830 |
Enzyme and pathway databases
PathwayCommonsi | Q96BZ8 |
SignaLinki | Q96BZ8 |
Miscellaneous databases
BioGRID-ORCSi | 79165, 184 hits in 1041 CRISPR screens |
ChiTaRSi | LENG1, human |
GenomeRNAii | 79165 |
Pharosi | Q96BZ8, Tdark |
PROi | PR:Q96BZ8 |
RNActi | Q96BZ8, protein |
Gene expression databases
Bgeei | ENSG00000105617, Expressed in quadriceps femoris and 194 other tissues |
Genevisiblei | Q96BZ8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019339, CIR_N_dom IPR039875, LENG1-like |
PANTHERi | PTHR22093, PTHR22093, 1 hit |
Pfami | View protein in Pfam PF10197, Cir_N, 1 hit |
SMARTi | View protein in SMART SM01083, Cir_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LENG1_HUMAN | |
Accessioni | Q96BZ8Primary (citable) accession number: Q96BZ8 Secondary accession number(s): Q9HCU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports