LENG1

Functionⁱ

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukocyte receptor cluster member 1
Gene namesⁱ	Name:LENG1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105617.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15502 LENG1
neXtProtⁱ	NX_Q96BZ8

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134904804

PharmGKBⁱ

PA134904804

Polymorphism and mutation databases

BioMutaⁱ	LENG1
DMDMⁱ	74731296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000254627	1 – 264	Leukocyte receptor cluster member 1Add BLAST		264

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	59	PhosphoserineCombined sources		1
Modified residueⁱ	245	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96BZ8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96BZ8
PaxDbⁱ	Q96BZ8
PeptideAtlas More...PeptideAtlasⁱ	Q96BZ8
PRIDEⁱ	Q96BZ8
ProteomicsDBⁱ	76133

PTM databases

iPTMnetⁱ	Q96BZ8
PhosphoSitePlusⁱ	Q96BZ8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105617 Expressed in 179 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_LENG1
Genevisibleⁱ	Q96BZ8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043541

HPAⁱ

HPA043541

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BANP	Q8N9N5	3	EBI-726510,EBI-744695
CALCOCO2	Q13137	3	EBI-726510,EBI-739580
CARD9	Q9H257	3	EBI-726510,EBI-751319
CCDC102B	Q68D86	3	EBI-726510,EBI-10171570
CCDC136	Q96JN2-2	3	EBI-726510,EBI-10171416
CCDC155	Q8N6L0	3	EBI-726510,EBI-749265
CCDC57	Q2TAC2	3	EBI-726510,EBI-2808286
CDR2	Q01850	5	EBI-726510,EBI-1181367
CEP57L1	Q8IYX8-2	3	EBI-726510,EBI-10181988
CEP70	Q8NHQ1	5	EBI-726510,EBI-739624
FSD2	A1L4K1	5	EBI-726510,EBI-5661036
GOLGA2	Q08379	7	EBI-726510,EBI-618309
KIFC3	Q9BVG8	3	EBI-726510,EBI-2125614
KRT31	Q15323	5	EBI-726510,EBI-948001
KRT40	Q6A162	5	EBI-726510,EBI-10171697
LDOC1	O95751	5	EBI-726510,EBI-740738
MID2	Q9UJV3-2	5	EBI-726510,EBI-10172526
MTUS2	Q5JR59	3	EBI-726510,EBI-742948
NAB2	Q15742	5	EBI-726510,EBI-8641936
NECAB2	Q7Z6G3-2	3	EBI-726510,EBI-10172876
PAK5	Q9P286	3	EBI-726510,EBI-741896
PDE4DIP	Q5VU43	3	EBI-726510,EBI-1105124
ROPN1	Q9HAT0	5	EBI-726510,EBI-1378139
SPERT	Q8NA61	3	EBI-726510,EBI-741724
STX11	O75558	3	EBI-726510,EBI-714135
TCF4	P15884	3	EBI-726510,EBI-533224
TFIP11	Q9UBB9	3	EBI-726510,EBI-1105213
TMEM239	Q8WW34	3	EBI-726510,EBI-9675724
TRIM27	P14373	3	EBI-726510,EBI-719493
TRIM54	Q9BYV2	5	EBI-726510,EBI-2130429
USHBP1	Q8N6Y0	3	EBI-726510,EBI-739895

Protein-protein interaction databases

BioGridⁱ	122582, 52 interactors
IntActⁱ	Q96BZ8, 84 interactors
Molecular INTeraction database More...MINTⁱ	Q96BZ8
STRINGⁱ	9606.ENSP00000222224

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96BZ8
SMRⁱ	Q96BZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	16 – 46	Sequence analysisAdd BLAST	31
Coiled coilⁱ	89 – 115	Sequence analysisAdd BLAST	27
Coiled coilⁱ	196 – 222	Sequence analysisAdd BLAST	27

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410J0Q4 Eukaryota ENOG4111NQR LUCA
HOGENOMⁱ	HOG000006930
HOVERGENⁱ	HBG060372
InParanoidⁱ	Q96BZ8
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RX6
PhylomeDBⁱ	Q96BZ8
TreeFamⁱ	TF317830

Family and domain databases

InterProⁱ	View protein in InterPro IPR019339 CIR_N_dom IPR039875 LENG1-like
PANTHERⁱ	PTHR22093 PTHR22093, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10197 Cir_N, 1 hit
SMARTⁱ	View protein in SMART SM01083 Cir_N, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96BZ8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL 
        60         70         80         90        100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK 
       110        120        130        140        150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI 
       160        170        180        190        200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR 
       210        220        230        240        250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ 
       260 
LARRPRQQDP HLTH

Length:264

Mass (Da):30,529

Last modified:December 1, 2001 - v1

Checksum:ⁱ25516678771B31F7

GO

Sequence cautionⁱ

The sequence AAG01393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051090	97	E → K. Corresponds to variant dbSNP:rs35089861Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014986 mRNA Translation: AAH14986.1 AF211966 mRNA Translation: AAG01393.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12881.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077292.2, NM_024316.2
UniGeneⁱ	Hs.590974

Genome annotation databases

Ensemblⁱ	ENST00000222224; ENSP00000222224; ENSG00000105617 ENST00000610998; ENSP00000481386; ENSG00000276959 ENST00000613622; ENSP00000478485; ENSG00000278516 ENST00000616103; ENSP00000481252; ENSG00000277808
GeneIDⁱ	79165
KEGGⁱ	hsa:79165
UCSC genome browser More...UCSCⁱ	uc002qdm.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96BZ8	Leukocyte receptor cluster member 1		SAIBB		265	UniRef90_Q96BZ8
Uncharacterized protein		AOTNA		265
Leukocyte receptor cluster member 1 (Predicted)		CALJA		264
Uncharacterized protein		Cebus capucinus imitator		264
Leukocyte receptor cluster member 1		PONAB		264
+18

Protein	Similar proteins		Species	Score	Length	Source
Q96BZ8	Leukocyte receptor cluster member 1 homolog		MOUSE		261	UniRef50_Q96BZ8
Leukocyte receptor cluster member 1 homolog		BOVIN		263
Leukocyte receptor cluster member 1		SAIBB		265
Uncharacterized protein		AOTNA		265
LENG1 isoform 1		PONAB		264
+150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014986 mRNA Translation: AAH14986.1 AF211966 mRNA Translation: AAG01393.1 Different initiation.
CCDSⁱ	CCDS12881.1
RefSeqⁱ	NP_077292.2, NM_024316.2
UniGeneⁱ	Hs.590974

3D structure databases

ProteinModelPortalⁱ	Q96BZ8
SMRⁱ	Q96BZ8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122582, 52 interactors
IntActⁱ	Q96BZ8, 84 interactors
MINTⁱ	Q96BZ8
STRINGⁱ	9606.ENSP00000222224

PTM databases

iPTMnetⁱ	Q96BZ8
PhosphoSitePlusⁱ	Q96BZ8

Polymorphism and mutation databases

BioMutaⁱ	LENG1
DMDMⁱ	74731296

Proteomic databases

EPDⁱ	Q96BZ8
MaxQBⁱ	Q96BZ8
PaxDbⁱ	Q96BZ8
PeptideAtlasⁱ	Q96BZ8
PRIDEⁱ	Q96BZ8
ProteomicsDBⁱ	76133

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79165
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000222224; ENSP00000222224; ENSG00000105617 ENST00000610998; ENSP00000481386; ENSG00000276959 ENST00000613622; ENSP00000478485; ENSG00000278516 ENST00000616103; ENSP00000481252; ENSG00000277808
GeneIDⁱ	79165
KEGGⁱ	hsa:79165
UCSCⁱ	uc002qdm.4 human

Organism-specific databases

CTDⁱ	79165
EuPathDBⁱ	HostDB:ENSG00000105617.3
GeneCardsⁱ	LENG1
HGNCⁱ	HGNC:15502 LENG1
HPAⁱ	HPA043541
neXtProtⁱ	NX_Q96BZ8
PharmGKBⁱ	PA134904804
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0Q4 Eukaryota ENOG4111NQR LUCA
HOGENOMⁱ	HOG000006930
HOVERGENⁱ	HBG060372
InParanoidⁱ	Q96BZ8
OrthoDBⁱ	EOG091G0RX6
PhylomeDBⁱ	Q96BZ8
TreeFamⁱ	TF317830

Miscellaneous databases

GenomeRNAiⁱ	79165
Protein Ontology More...PROⁱ	PR:Q96BZ8

Gene expression databases

Bgeeⁱ	ENSG00000105617 Expressed in 179 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_LENG1
Genevisibleⁱ	Q96BZ8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019339 CIR_N_dom IPR039875 LENG1-like
PANTHERⁱ	PTHR22093 PTHR22093, 1 hit
Pfamⁱ	View protein in Pfam PF10197 Cir_N, 1 hit
SMARTⁱ	View protein in SMART SM01083 Cir_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LENG1_HUMAN
Accessionⁱ	Q96BZ8Primary (citable) accession number: Q96BZ8 Secondary accession number(s): Q9HCU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q96BZ8 (LENG1_HUMAN)

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Leukocyte receptor cluster member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ