Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modulator of apoptosis 1

Gene

MOAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of apoptosis 1
Short name:
MAP-1
Short name:
MAP1
Alternative name(s):
Paraneoplastic antigen Ma4
Gene namesi
Name:MOAP1
Synonyms:PNMA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165943.4
HGNCiHGNC:16658 MOAP1
MIMi609485 gene
neXtProtiNX_Q96BY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120 – 127Missing : Abrogates interaction with BAX, resulting in a nonapoptotic protein. 1 Publication8
Mutagenesisi120L → E: Weakened interaction with BAX, resulting in a nonapoptotic protein. 1 Publication1
Mutagenesisi125 – 127GHE → VLA: Abrogates interaction with BAX, resulting in a nonapoptotic protein. 1 Publication3
Mutagenesisi161 – 166KYKKLR → AYAALA: No effect on RASSF1-binding. 1 Publication6
Mutagenesisi178 – 180EEE → AAA: No effect on RASSF1-binding; interacts with BAX in the absence of RASSF1. 3
Mutagenesisi202 – 205KRRR → AAAA: Loss of RASSF1-binding; interacts with BAX in the absence of RASSF1. 1 Publication4

Organism-specific databases

DisGeNETi64112
OpenTargetsiENSG00000165943
PharmGKBiPA134908381

Polymorphism and mutation databases

BioMutaiMOAP1
DMDMi37999755

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552051 – 351Modulator of apoptosis 1Add BLAST351

Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96BY2
PaxDbiQ96BY2
PeptideAtlasiQ96BY2
PRIDEiQ96BY2
ProteomicsDBi76126

PTM databases

iPTMnetiQ96BY2
PhosphoSitePlusiQ96BY2

Expressioni

Tissue specificityi

Widely expressed, with high levels in heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000165943 Expressed in 234 organ(s), highest expression level in parietal lobe
CleanExiHS_MOAP1
GenevisibleiQ96BY2 HS

Organism-specific databases

HPAiHPA000939

Interactioni

Subunit structurei

Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39. Interacts with RASSF6 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122069, 28 interactors
DIPiDIP-49959N
IntActiQ96BY2, 21 interactors
STRINGi9606.ENSP00000298894

Structurei

3D structure databases

ProteinModelPortaliQ96BY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 127BH3-like8
Regioni202 – 205RASSF1-binding4

Domaini

The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410IIH9 Eukaryota
ENOG410YK5I LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ96BY2
OMAiIPEMWAP
OrthoDBiEOG091G0BG9
PhylomeDBiQ96BY2
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q96BY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR
60 70 80 90 100
LLGRMFRRDE NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN
110 120 130 140 150
TFLSRLNEFL AGEGMTVGEL SRALGHENGS LDPEQGMIPE MWAPMLAQAL
160 170 180 190 200
EALQPALQCL KYKKLRVFSG RESPEPGEEE FGRWMFHTTQ MIKAWQVPDV
210 220 230 240 250
EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV FGVTDNPREL
260 270 280 290 300
QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA
310 320 330 340 350
GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF

T
Length:351
Mass (Da):39,513
Last modified:December 1, 2001 - v1
Checksum:i5310142AC02B563C
GO

Sequence cautioni

The sequence BAB14788 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244T → A in BAB14788 (PubMed:14702039).Curated1
Sequence conflicti258Y → H in BAB14788 (PubMed:14702039).Curated1
Sequence conflicti259Q → H in AAG31786 (PubMed:11060313).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305550 mRNA Translation: AAG31786.1
AK024029 mRNA Translation: BAB14788.1 Sequence problems.
AK315522 mRNA Translation: BAG37903.1
CH471061 Genomic DNA Translation: EAW81516.1
BC015044 mRNA Translation: AAH15044.1
CCDSiCCDS9908.1
RefSeqiNP_071434.2, NM_022151.4
UniGeneiHs.24719

Genome annotation databases

EnsembliENST00000298894; ENSP00000298894; ENSG00000165943
ENST00000556883; ENSP00000451594; ENSG00000165943
ENST00000616515; ENSP00000482284; ENSG00000278268
ENST00000627896; ENSP00000486260; ENSG00000278268
GeneIDi64112
KEGGihsa:64112
UCSCiuc001ybj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305550 mRNA Translation: AAG31786.1
AK024029 mRNA Translation: BAB14788.1 Sequence problems.
AK315522 mRNA Translation: BAG37903.1
CH471061 Genomic DNA Translation: EAW81516.1
BC015044 mRNA Translation: AAH15044.1
CCDSiCCDS9908.1
RefSeqiNP_071434.2, NM_022151.4
UniGeneiHs.24719

3D structure databases

ProteinModelPortaliQ96BY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122069, 28 interactors
DIPiDIP-49959N
IntActiQ96BY2, 21 interactors
STRINGi9606.ENSP00000298894

PTM databases

iPTMnetiQ96BY2
PhosphoSitePlusiQ96BY2

Polymorphism and mutation databases

BioMutaiMOAP1
DMDMi37999755

Proteomic databases

MaxQBiQ96BY2
PaxDbiQ96BY2
PeptideAtlasiQ96BY2
PRIDEiQ96BY2
ProteomicsDBi76126

Protocols and materials databases

DNASUi64112
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298894; ENSP00000298894; ENSG00000165943
ENST00000556883; ENSP00000451594; ENSG00000165943
ENST00000616515; ENSP00000482284; ENSG00000278268
ENST00000627896; ENSP00000486260; ENSG00000278268
GeneIDi64112
KEGGihsa:64112
UCSCiuc001ybj.4 human

Organism-specific databases

CTDi64112
DisGeNETi64112
EuPathDBiHostDB:ENSG00000165943.4
GeneCardsiMOAP1
HGNCiHGNC:16658 MOAP1
HPAiHPA000939
MIMi609485 gene
neXtProtiNX_Q96BY2
OpenTargetsiENSG00000165943
PharmGKBiPA134908381
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIH9 Eukaryota
ENOG410YK5I LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ96BY2
OMAiIPEMWAP
OrthoDBiEOG091G0BG9
PhylomeDBiQ96BY2
TreeFamiTF335054

Miscellaneous databases

ChiTaRSiMOAP1 human
GeneWikiiMOAP1
GenomeRNAii64112
PROiPR:Q96BY2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165943 Expressed in 234 organ(s), highest expression level in parietal lobe
CleanExiHS_MOAP1
GenevisibleiQ96BY2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96BY2
Secondary accession number(s): B2RDF6, Q9H833, Q9HAS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again