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Entry version 143 (23 Feb 2022)
Sequence version 1 (01 Dec 2001)
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Protein

Modulator of apoptosis 1

Gene

MOAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Retrotransposon-derived protein that forms virion-like capsids (By similarity).

Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525).

Required for death receptor-dependent apoptosis (PubMed:11060313).

When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439).

Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314).

Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215).

By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Autophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96BY2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96BY2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Modulator of apoptosis 11 Publication
Short name:
MAP-11 Publication
Short name:
MAP11 Publication
Alternative name(s):
Paraneoplastic antigen Ma41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOAP11 PublicationImported
Synonyms:PNMA41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16658, MOAP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609485, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96BY2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000165943

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49 – 52YRLL → ARLA: Abolished interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. 1 Publication4
Mutagenesisi89 – 92WRVI → ARVA: Does not affect interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. 1 Publication4
Mutagenesisi120 – 127Missing : Abrogates interaction with BAX, resulting in a nonapoptotic protein. 1 Publication8
Mutagenesisi120L → E: Weakened interaction with BAX, resulting in a nonapoptotic protein. 1 Publication1
Mutagenesisi125 – 127GHE → VLA: Abrogates interaction with BAX, resulting in a nonapoptotic protein. 1 Publication3
Mutagenesisi161 – 166KYKKLR → AYAALA: No effect on RASSF1-binding. 1 Publication6
Mutagenesisi162 – 165YKKL → AKKA: Does not affect interaction with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. 1 Publication4
Mutagenesisi178 – 180EEE → AAA: No effect on RASSF1-binding; interacts with BAX in the absence of RASSF1. 3
Mutagenesisi202 – 205KRRR → AAAA: Loss of RASSF1-binding; interacts with BAX in the absence of RASSF1. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
64112

Open Targets

More...
OpenTargetsi
ENSG00000165943

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908381

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96BY2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MOAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37999755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001552051 – 351Modulator of apoptosis 1Add BLAST351

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96BY2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96BY2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96BY2

PeptideAtlas

More...
PeptideAtlasi
Q96BY2

PRoteomics IDEntifications database

More...
PRIDEi
Q96BY2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76126

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96BY2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96BY2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with high levels in heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165943, Expressed in parietal lobe and 247 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96BY2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165943, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:15949439). Under normal circumstances, held in an inactive conformation by an intramolecular interaction (PubMed:15949439).

Interacts with BAX (PubMed:11060313, PubMed:16199525). Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX (PubMed:15949439). Binds also to BCL2 and BCLX (PubMed:11060313). Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (PubMed:15949439).

Interacts with TRIM39 (PubMed:19100260).

Interacts with RASSF6 (By similarity).

Interacts with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C (PubMed:33783314). Does not interact with ATG8 proteins GABARAPL1, GABARAPL2 and GABARAP (PubMed:33783314).

Interacts with SQSTM1; promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1 (PubMed:33393215).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122069, 37 interactors

Database of interacting proteins

More...
DIPi
DIP-49959N

Protein interaction database and analysis system

More...
IntActi
Q96BY2, 31 interactors

Molecular INTeraction database

More...
MINTi
Q96BY2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000451594

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96BY2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 127BH3-like1 Publication8
Regioni202 – 205RASSF1-binding1 Publication4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi49 – 52LIR1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA)subdomain of gag.1 Publication
The BH3-like domain is required for association with BAX and for mediating apoptosis (PubMed:11060313). The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction (PubMed:11060313).1 Publication
The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins MAP1LC3A, MAP1LC3B and MAP1LC3C.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SAVD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234522

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014694_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96BY2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMIPEIR

Database of Orthologous Groups

More...
OrthoDBi
820525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96BY2

TreeFam database of animal gene trees

More...
TreeFami
TF335054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026523, PNMA

The PANTHER Classification System

More...
PANTHERi
PTHR23095, PTHR23095, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14893, PNMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96BY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR
60 70 80 90 100
LLGRMFRRDE NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN
110 120 130 140 150
TFLSRLNEFL AGEGMTVGEL SRALGHENGS LDPEQGMIPE MWAPMLAQAL
160 170 180 190 200
EALQPALQCL KYKKLRVFSG RESPEPGEEE FGRWMFHTTQ MIKAWQVPDV
210 220 230 240 250
EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV FGVTDNPREL
260 270 280 290 300
QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA
310 320 330 340 350
GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF

T
Length:351
Mass (Da):39,513
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5310142AC02B563C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14788 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244T → A in BAB14788 (PubMed:14702039).Curated1
Sequence conflicti258Y → H in BAB14788 (PubMed:14702039).Curated1
Sequence conflicti259Q → H in AAG31786 (PubMed:11060313).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF305550 mRNA Translation: AAG31786.1
AK024029 mRNA Translation: BAB14788.1 Sequence problems.
AK315522 mRNA Translation: BAG37903.1
CH471061 Genomic DNA Translation: EAW81516.1
BC015044 mRNA Translation: AAH15044.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9908.1

NCBI Reference Sequences

More...
RefSeqi
NP_071434.2, NM_022151.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298894; ENSP00000298894; ENSG00000165943
ENST00000556883; ENSP00000451594; ENSG00000165943
ENST00000616515; ENSP00000482284; ENSG00000278268
ENST00000627896; ENSP00000486260; ENSG00000278268

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64112

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000298894.5; ENSP00000298894.4; NM_022151.5; NP_071434.2

UCSC genome browser

More...
UCSCi
uc001ybj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305550 mRNA Translation: AAG31786.1
AK024029 mRNA Translation: BAB14788.1 Sequence problems.
AK315522 mRNA Translation: BAG37903.1
CH471061 Genomic DNA Translation: EAW81516.1
BC015044 mRNA Translation: AAH15044.1
CCDSiCCDS9908.1
RefSeqiNP_071434.2, NM_022151.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7LGCX-ray1.85A/B242-351[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122069, 37 interactors
DIPiDIP-49959N
IntActiQ96BY2, 31 interactors
MINTiQ96BY2
STRINGi9606.ENSP00000451594

PTM databases

iPTMnetiQ96BY2
PhosphoSitePlusiQ96BY2

Genetic variation databases

BioMutaiMOAP1
DMDMi37999755

Proteomic databases

MassIVEiQ96BY2
MaxQBiQ96BY2
PaxDbiQ96BY2
PeptideAtlasiQ96BY2
PRIDEiQ96BY2
ProteomicsDBi76126

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22, 318 antibodies from 30 providers

The DNASU plasmid repository

More...
DNASUi
64112

Genome annotation databases

EnsembliENST00000298894; ENSP00000298894; ENSG00000165943
ENST00000556883; ENSP00000451594; ENSG00000165943
ENST00000616515; ENSP00000482284; ENSG00000278268
ENST00000627896; ENSP00000486260; ENSG00000278268
GeneIDi64112
KEGGihsa:64112
MANE-SelectiENST00000298894.5; ENSP00000298894.4; NM_022151.5; NP_071434.2
UCSCiuc001ybj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64112
DisGeNETi64112

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MOAP1
HGNCiHGNC:16658, MOAP1
HPAiENSG00000165943, Low tissue specificity
MIMi609485, gene
neXtProtiNX_Q96BY2
OpenTargetsiENSG00000165943
PharmGKBiPA134908381
VEuPathDBiHostDB:ENSG00000165943

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SAVD, Eukaryota
GeneTreeiENSGT01030000234522
HOGENOMiCLU_014694_0_0_1
InParanoidiQ96BY2
OMAiGMIPEIR
OrthoDBi820525at2759
PhylomeDBiQ96BY2
TreeFamiTF335054

Enzyme and pathway databases

PathwayCommonsiQ96BY2
SignaLinkiQ96BY2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64112, 10 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MOAP1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MOAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64112
PharosiQ96BY2, Tbio

Protein Ontology

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PROi
PR:Q96BY2
RNActiQ96BY2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165943, Expressed in parietal lobe and 247 other tissues
GenevisibleiQ96BY2, HS

Family and domain databases

InterProiView protein in InterPro
IPR026523, PNMA
PANTHERiPTHR23095, PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893, PNMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BY2
Secondary accession number(s): B2RDF6, Q9H833, Q9HAS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: December 1, 2001
Last modified: February 23, 2022
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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