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Protein

Zinc finger protein 775

Gene

ZNF775

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 129C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri135 – 157C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 775
Gene namesi
Name:ZNF775
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000196456.9
HGNCiHGNC:28501 ZNF775
neXtProtiNX_Q96BV0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196456
PharmGKBiPA162410371

Polymorphism and mutation databases

BioMutaiZNF775
DMDMi74760747

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804411 – 537Zinc finger protein 775Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki533Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96BV0
PaxDbiQ96BV0
PeptideAtlasiQ96BV0
PRIDEiQ96BV0
ProteomicsDBi76118

PTM databases

iPTMnetiQ96BV0
PhosphoSitePlusiQ96BV0

Expressioni

Gene expression databases

BgeeiENSG00000196456
CleanExiHS_ZNF775
ExpressionAtlasiQ96BV0 baseline and differential
GenevisibleiQ96BV0 HS

Interactioni

Protein-protein interaction databases

BioGridi130261, 7 interactors
IntActiQ96BV0, 16 interactors
MINTiQ96BV0
STRINGi9606.ENSP00000330838

Structurei

3D structure databases

ProteinModelPortaliQ96BV0
SMRiQ96BV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 129C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri135 – 157C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129964
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96BV0
OMAiEWAWLGL
OrthoDBiEOG091G02KC
PhylomeDBiQ96BV0
TreeFamiTF350922

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q96BV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGLAGNGT GAGLVMKVKQ EKPERLLQTL APQAMLVEKD KENIFQQHRG
60 70 80 90 100
LPPRQTMGRP RALGGQEESG SPRWAPPTEQ DAGLAGRAPG SASGPLSPSL
110 120 130 140 150
SSGEGHFVCL DCGKRFSWWS SLKIHQRTHT GEKPYLCGKC GKSFSQKPNL
160 170 180 190 200
ARHQRHHTGE RPFCCPECAR RFSQKQHLLK HQKTHSRPAT HSCPECERCF
210 220 230 240 250
RHQVGLRIHQ RAHARDRQGS RAGLHELIQD AAARRACRLQ PGPPRGRPEW
260 270 280 290 300
AWLGLCQGWW GQPGARAAVS GPEGPGEPRQ FICNECGKSF TWWSSLNIHQ
310 320 330 340 350
RIHTGERPYA CPECGRRFSQ KPNLTRHLRN HTGERPHPCP HCGRGFRQKQ
360 370 380 390 400
HLLKHLRTHL PGAQAAPCPS CGKSCRSRAA LRAHQRAHAV AEPAVPAGEP
410 420 430 440 450
GDQPQAEAIP GLAARPRSSQ RSPGARDTLW GRGQAGLAGP GEPRQFICNE
460 470 480 490 500
CGKSFSWWSA LTIHQRIHTG ERPYPCPECG RRFSQKPNLT RHRRNHTGER
510 520 530
PYLCPACGRG FSQKQHLLKH QRVHRAAPAC SPKEEAR
Length:537
Mass (Da):59,752
Last modified:March 1, 2004 - v2
Checksum:iBC34D5E1E3ED0BB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059937428T → A. Corresponds to variant dbSNP:rs13225910Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015152 mRNA Translation: AAH15152.2
CCDSiCCDS43678.1
RefSeqiNP_775951.2, NM_173680.3
UniGeneiHs.655734

Genome annotation databases

EnsembliENST00000329630; ENSP00000330838; ENSG00000196456
GeneIDi285971
KEGGihsa:285971
UCSCiuc003whf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN775_HUMAN
AccessioniPrimary (citable) accession number: Q96BV0
Secondary accession number(s): Q8IY24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2004
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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