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Protein

Zinc finger and BTB domain-containing protein 8A

Gene

ZBTB8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8A
Alternative name(s):
BTB/POZ and zinc-finger domain-containing factor
BTB/POZ and zinc-finger domains factor on chromosome 1
Short name:
BOZ-F1
Gene namesi
Name:ZBTB8A
Synonyms:BOZF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160062.14
HGNCiHGNC:24172 ZBTB8A
neXtProtiNX_Q96BR9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi653121
PharmGKBiPA164727627

Polymorphism and mutation databases

BioMutaiZBTB8A
DMDMi251765171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003785081 – 441Zinc finger and BTB domain-containing protein 8AAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96BR9
MaxQBiQ96BR9
PaxDbiQ96BR9
PeptideAtlasiQ96BR9
PRIDEiQ96BR9
ProteomicsDBi76104
76105 [Q96BR9-2]

PTM databases

iPTMnetiQ96BR9
PhosphoSitePlusiQ96BR9

Expressioni

Gene expression databases

BgeeiENSG00000160062
ExpressionAtlasiQ96BR9 baseline and differential
GenevisibleiQ96BR9 HS

Organism-specific databases

HPAiHPA031768
HPA031769
HPA031770

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-742740,EBI-10174671
Q9NWJ23EBI-742740,EBI-10315029
ADY3Q077323EBI-742740,EBI-33406From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
AENQ8WTP83EBI-742740,EBI-8637627
AP1M1Q9BXS56EBI-742740,EBI-541426
ARMCX1Q9P2915EBI-742740,EBI-2843626
BAZ2BQ9UIF8-23EBI-742740,EBI-10321972
BYSLQ138957EBI-742740,EBI-358049
CDKL3Q8IVW45EBI-742740,EBI-3919850
DDX6P261965EBI-742740,EBI-351257
DHR2P360093EBI-742740,EBI-5844From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
EIF1ADQ8N9N85EBI-742740,EBI-750700
FAA2P395183EBI-742740,EBI-10082From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
FAM161AQ3B8205EBI-742740,EBI-719941
GCD7P325023EBI-742740,EBI-6260From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GPATCH2LQ9NWQ43EBI-742740,EBI-5666657
HEL-S-61V9HW293EBI-742740,EBI-10330057
KAT5Q929934EBI-742740,EBI-399080
KIFC3Q9BVG83EBI-742740,EBI-2125614
KRR1P255863EBI-742740,EBI-21773From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
MFAP1P550813EBI-742740,EBI-1048159
PIAS2O759283EBI-742740,EBI-348555
PRKAA2P546463EBI-742740,EBI-1383852
PRP3Q033383EBI-742740,EBI-421From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PSMC1P621913EBI-742740,EBI-357598
RAD23AP547255EBI-742740,EBI-746453
RPL9P9P329695EBI-742740,EBI-358122
SDCBPO005605EBI-742740,EBI-727004
SEC24P404823EBI-742740,EBI-16592From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SGD1Q061323EBI-742740,EBI-34377From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SYT6Q5T7P8-23EBI-742740,EBI-10246152
TAE1P383403EBI-742740,EBI-21116From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TCP1P126123EBI-742740,EBI-19045From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TNIP3Q96KP63EBI-742740,EBI-2509913
TRIM41Q8WV443EBI-742740,EBI-725997
TRX3P253723EBI-742740,EBI-19616From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
UBE2IQ7KZS03EBI-742740,EBI-10180829
WDYHV1Q96HA83EBI-742740,EBI-741158
YES1P079475EBI-742740,EBI-515331
YLR108CQ122593EBI-742740,EBI-30776From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ZBTB24O431675EBI-742740,EBI-744471
ZBTB48P100746EBI-742740,EBI-744864
ZBTB49Q6ZSB95EBI-742740,EBI-2859943
ZCCHC10Q8TBK63EBI-742740,EBI-597063
ZGPATA0A0S2Z6H03EBI-742740,EBI-16428984
ZGPATQ8N5A53EBI-742740,EBI-3439227
ZMAT2Q96NC03EBI-742740,EBI-2682299
ZNF138P52744-23EBI-742740,EBI-10213071
ZNF276Q8N5546EBI-742740,EBI-750821
ZNF276Q8N554-23EBI-742740,EBI-10265849
ZNF408Q9H9D43EBI-742740,EBI-347633
ZNF417Q8TAU35EBI-742740,EBI-740727
ZNF509Q32MK93EBI-742740,EBI-10239929
ZNF587Q96SQ55EBI-742740,EBI-6427977

Protein-protein interaction databases

BioGridi575543, 70 interactors
IntActiQ96BR9, 91 interactors
STRINGi9606.ENSP00000362609

Structurei

3D structure databases

ProteinModelPortaliQ96BR9
SMRiQ96BR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi429 – 435Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000124661
InParanoidiQ96BR9
KOiK10495
OrthoDBiEOG091G05WK
PhylomeDBiQ96BR9
TreeFamiTF330979

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96BR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK
60 70 80 90 100
MLLSQNSKET SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS
110 120 130 140 150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDA NSNGVERSSF
160 170 180 190 200
YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW NKYNYHPASQ KNTQQPLAKH
210 220 230 240 250
EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV SQSEEQAQID
260 270 280 290 300
AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH
310 320 330 340 350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL
360 370 380 390 400
TGQVVQEGTR RYRLCNECLA EFGIDSLPID LEAEQHLMSP SDGDKDSRWH
410 420 430 440
LSEDENRSYV EIVEDGSGDL VIQQVDDSEE EEEKEIKPNI R
Length:441
Mass (Da):50,141
Last modified:July 7, 2009 - v2
Checksum:i8A4A7B30C1E8C018
GO
Isoform 2 (identifier: Q96BR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-441: IHQACKLICR...EEKEIKPNIR → MEIRIPD

Show »
Length:338
Mass (Da):38,344
Checksum:i4306E1988E6E55C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206S → G in AAH15067 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058085418G → A3 PublicationsCorresponds to variant dbSNP:rs704886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037597332 – 441IHQAC…KPNIR → MEIRIPD in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548353 mRNA Translation: AAN40800.1
AY157873 mRNA Translation: AAN77376.1
AK074546 mRNA Translation: BAC11050.1
AL033529 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07521.1
CH471059 Genomic DNA Translation: EAX07522.1
BC015067 mRNA Translation: AAH15067.1
BC015239 mRNA Translation: AAH15239.1
BC029654 mRNA Translation: AAH29654.1
CCDSiCCDS30664.1 [Q96BR9-1]
RefSeqiNP_001035531.2, NM_001040441.2
NP_001278425.1, NM_001291496.1
UniGeneiHs.546479

Genome annotation databases

EnsembliENST00000373510; ENSP00000362609; ENSG00000160062
GeneIDi653121
KEGGihsa:653121
UCSCiuc001bvn.4 human [Q96BR9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT8A_HUMAN
AccessioniPrimary (citable) accession number: Q96BR9
Secondary accession number(s): Q8IUL5
, Q8IWR9, Q8N2Y5, Q96BX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: July 18, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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