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UniProtKB - Q96BR9 (ZBT8A_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 8A
Gene
ZBTB8A
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 282 – 304 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 333 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- transcription cis-regulatory region binding Source: ARUK-UCL
- transcription coactivator binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96BR9 |
SignaLinki | Q96BR9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 8AAlternative name(s): BTB/POZ and zinc-finger domain-containing factor BTB/POZ and zinc-finger domains factor on chromosome 1 Short name: BOZ-F1 |
Gene namesi | Name:ZBTB8A Synonyms:BOZF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24172, ZBTB8A |
MIMi | 618742, gene |
neXtProti | NX_Q96BR9 |
VEuPathDBi | HostDB:ENSG00000160062 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
PharmGKBi | PA164727627 |
Miscellaneous databases
Pharosi | Q96BR9, Tdark |
Genetic variation databases
BioMutai | ZBTB8A |
DMDMi | 251765171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000378508 | 1 – 441 | Zinc finger and BTB domain-containing protein 8AAdd BLAST | 441 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 191 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 199 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 437 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96BR9 |
jPOSTi | Q96BR9 |
MassIVEi | Q96BR9 |
MaxQBi | Q96BR9 |
PaxDbi | Q96BR9 |
PeptideAtlasi | Q96BR9 |
PRIDEi | Q96BR9 |
ProteomicsDBi | 76104 [Q96BR9-1] 76105 [Q96BR9-2] |
PTM databases
iPTMneti | Q96BR9 |
PhosphoSitePlusi | Q96BR9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160062, Expressed in cortical plate and 116 other tissues |
ExpressionAtlasi | Q96BR9, baseline and differential |
Genevisiblei | Q96BR9, HS |
Organism-specific databases
HPAi | ENSG00000160062, Low tissue specificity |
Interactioni
Binary interactionsi
Q96BR9
GO - Molecular functioni
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
- transcription coactivator binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 575543, 94 interactors |
IntActi | Q96BR9, 80 interactors |
STRINGi | 9606.ENSP00000362609 |
Miscellaneous databases
RNActi | Q96BR9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 92 | BTBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 143 – 251 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 196 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 211 – 235 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 236 – 250 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 282 – 304 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 333 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_022356_1_1_1 |
InParanoidi | Q96BR9 |
OrthoDBi | 755439at2759 |
PhylomeDBi | Q96BR9 |
TreeFami | TF330979 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96BR9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK
60 70 80 90 100
MLLSQNSKET SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS
110 120 130 140 150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDA NSNGVERSSF
160 170 180 190 200
YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW NKYNYHPASQ KNTQQPLAKH
210 220 230 240 250
EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV SQSEEQAQID
260 270 280 290 300
AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH
310 320 330 340 350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL
360 370 380 390 400
TGQVVQEGTR RYRLCNECLA EFGIDSLPID LEAEQHLMSP SDGDKDSRWH
410 420 430 440
LSEDENRSYV EIVEDGSADL VIQQVDDSEE EEEKEIKPNI R
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3DPQ1 | D3DPQ1_HUMAN | HCG39683, isoform CRA_a | ZBTB8A hCG_39683 | 340 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 206 | S → G in AAH15067 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058085 | 418 | A → G1 PublicationCorresponds to variant dbSNP:rs704886Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037597 | 332 – 441 | IHQAC…KPNIR → MEIRIPD in isoform 2. 1 PublicationAdd BLAST | 110 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF548353 mRNA Translation: AAN40800.1 AY157873 mRNA Translation: AAN77376.1 AK074546 mRNA Translation: BAC11050.1 AL033529 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07521.1 CH471059 Genomic DNA Translation: EAX07522.1 BC015067 mRNA Translation: AAH15067.1 BC015239 mRNA Translation: AAH15239.1 BC029654 mRNA Translation: AAH29654.1 |
CCDSi | CCDS30664.1 [Q96BR9-1] |
RefSeqi | NP_001035531.2, NM_001040441.2 NP_001278425.1, NM_001291496.1 |
Genome annotation databases
Ensembli | ENST00000373510; ENSP00000362609; ENSG00000160062 |
GeneIDi | 653121 |
KEGGi | hsa:653121 |
MANE-Selecti | ENST00000373510.9; ENSP00000362609.3; NM_001040441.3; NP_001035531.2 |
UCSCi | uc001bvn.4, human [Q96BR9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF548353 mRNA Translation: AAN40800.1 AY157873 mRNA Translation: AAN77376.1 AK074546 mRNA Translation: BAC11050.1 AL033529 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07521.1 CH471059 Genomic DNA Translation: EAX07522.1 BC015067 mRNA Translation: AAH15067.1 BC015239 mRNA Translation: AAH15239.1 BC029654 mRNA Translation: AAH29654.1 |
CCDSi | CCDS30664.1 [Q96BR9-1] |
RefSeqi | NP_001035531.2, NM_001040441.2 NP_001278425.1, NM_001291496.1 |
3D structure databases
SMRi | Q96BR9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 575543, 94 interactors |
IntActi | Q96BR9, 80 interactors |
STRINGi | 9606.ENSP00000362609 |
PTM databases
iPTMneti | Q96BR9 |
PhosphoSitePlusi | Q96BR9 |
Genetic variation databases
BioMutai | ZBTB8A |
DMDMi | 251765171 |
Proteomic databases
EPDi | Q96BR9 |
jPOSTi | Q96BR9 |
MassIVEi | Q96BR9 |
MaxQBi | Q96BR9 |
PaxDbi | Q96BR9 |
PeptideAtlasi | Q96BR9 |
PRIDEi | Q96BR9 |
ProteomicsDBi | 76104 [Q96BR9-1] 76105 [Q96BR9-2] |
Protocols and materials databases
Antibodypediai | 31329, 83 antibodies from 22 providers |
DNASUi | 653121 |
Genome annotation databases
Ensembli | ENST00000373510; ENSP00000362609; ENSG00000160062 |
GeneIDi | 653121 |
KEGGi | hsa:653121 |
MANE-Selecti | ENST00000373510.9; ENSP00000362609.3; NM_001040441.3; NP_001035531.2 |
UCSCi | uc001bvn.4, human [Q96BR9-1] |
Organism-specific databases
CTDi | 653121 |
GeneCardsi | ZBTB8A |
HGNCi | HGNC:24172, ZBTB8A |
HPAi | ENSG00000160062, Low tissue specificity |
MIMi | 618742, gene |
neXtProti | NX_Q96BR9 |
PharmGKBi | PA164727627 |
VEuPathDBi | HostDB:ENSG00000160062 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_022356_1_1_1 |
InParanoidi | Q96BR9 |
OrthoDBi | 755439at2759 |
PhylomeDBi | Q96BR9 |
TreeFami | TF330979 |
Enzyme and pathway databases
PathwayCommonsi | Q96BR9 |
SignaLinki | Q96BR9 |
Miscellaneous databases
BioGRID-ORCSi | 653121, 5 hits in 1099 CRISPR screens |
ChiTaRSi | ZBTB8A, human |
GenomeRNAii | 653121 |
Pharosi | Q96BR9, Tdark |
PROi | PR:Q96BR9 |
RNActi | Q96BR9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160062, Expressed in cortical plate and 116 other tissues |
ExpressionAtlasi | Q96BR9, baseline and differential |
Genevisiblei | Q96BR9, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT8A_HUMAN | |
Accessioni | Q96BR9Primary (citable) accession number: Q96BR9 Secondary accession number(s): Q8IUL5 Q96BX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 7, 2009 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot