ZBTB8A

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	282 – 304	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	310 – 333	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 8A Alternative name(s): BTB/POZ and zinc-finger domain-containing factor BTB/POZ and zinc-finger domains factor on chromosome 1 Short name: BOZ-F1
Gene namesⁱ	Name:ZBTB8A Synonyms:BOZF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160062.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24172 ZBTB8A
neXtProtⁱ	NX_Q96BR9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	653121
PharmGKBⁱ	PA164727627

Polymorphism and mutation databases

BioMutaⁱ	ZBTB8A
DMDMⁱ	251765171

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000378508	1 – 441	Zinc finger and BTB domain-containing protein 8AAdd BLAST		441

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	161	PhosphoserineCombined sources	1
Modified residueⁱ	167	PhosphoserineCombined sources	1
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	191	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	199	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	437	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96BR9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96BR9
PaxDbⁱ	Q96BR9
PeptideAtlas More...PeptideAtlasⁱ	Q96BR9
PRIDEⁱ	Q96BR9
ProteomicsDBⁱ	76104 76105 [Q96BR9-2]

PTM databases

iPTMnetⁱ	Q96BR9
PhosphoSitePlusⁱ	Q96BR9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160062 Expressed in 95 organ(s), highest expression level in heart
ExpressionAtlasⁱ	Q96BR9 baseline and differential
Genevisibleⁱ	Q96BR9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031768 HPA031769 HPA031770

HPAⁱ

HPA031768
HPA031769
HPA031770

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	A8K932	3	EBI-742740,EBI-10174671
	Q9NWJ2	3	EBI-742740,EBI-10315029
AEN	Q8WTP8	3	EBI-742740,EBI-8637627
AP1M1	Q9BXS5	6	EBI-742740,EBI-541426
ARMCX1	Q9P291	5	EBI-742740,EBI-2843626
BAZ2B	Q9UIF8-2	3	EBI-742740,EBI-10321972
BYSL	Q13895	7	EBI-742740,EBI-358049
CDKL3	Q8IVW4	5	EBI-742740,EBI-3919850
DDX6	P26196	5	EBI-742740,EBI-351257
EIF1AD	Q8N9N8	5	EBI-742740,EBI-750700
FAM161A	Q3B820	5	EBI-742740,EBI-719941
GPATCH2L	Q9NWQ4	3	EBI-742740,EBI-5666657
HEL-S-61	V9HW29	3	EBI-742740,EBI-10330057
KAT5	Q92993	4	EBI-742740,EBI-399080
KIFC3	Q9BVG8	3	EBI-742740,EBI-2125614
MFAP1	P55081	3	EBI-742740,EBI-1048159
PIAS2	O75928	3	EBI-742740,EBI-348555
PRKAA2	P54646	3	EBI-742740,EBI-1383852
PSMC1	P62191	3	EBI-742740,EBI-357598
RAD23A	P54725	5	EBI-742740,EBI-746453
RPL9P9	P32969	5	EBI-742740,EBI-358122
SDCBP	O00560	5	EBI-742740,EBI-727004
SYT6	Q5T7P8-2	3	EBI-742740,EBI-10246152
TNIP3	Q96KP6	3	EBI-742740,EBI-2509913
TRIM41	Q8WV44	3	EBI-742740,EBI-725997
UBE2I	Q7KZS0	3	EBI-742740,EBI-10180829
WDYHV1	Q96HA8	3	EBI-742740,EBI-741158
YES1	P07947	5	EBI-742740,EBI-515331
ZBTB24	O43167	5	EBI-742740,EBI-744471
ZBTB48	P10074	6	EBI-742740,EBI-744864
ZBTB49	Q6ZSB9	5	EBI-742740,EBI-2859943
ZCCHC10	Q8TBK6	3	EBI-742740,EBI-597063
ZGPAT	A0A0S2Z6H0	3	EBI-742740,EBI-16428984
ZGPAT	Q8N5A5	3	EBI-742740,EBI-3439227
ZMAT2	Q96NC0	3	EBI-742740,EBI-2682299
ZNF138	P52744-2	3	EBI-742740,EBI-10213071
ZNF276	Q8N554	6	EBI-742740,EBI-750821
ZNF276	Q8N554-2	3	EBI-742740,EBI-10265849
ZNF408	Q9H9D4	3	EBI-742740,EBI-347633
ZNF417	Q8TAU3	5	EBI-742740,EBI-740727
ZNF509	Q32MK9	3	EBI-742740,EBI-10239929
ZNF587	Q96SQ5	5	EBI-742740,EBI-6427977

Protein-protein interaction databases

BioGridⁱ	575543, 70 interactors
IntActⁱ	Q96BR9, 79 interactors
STRINGⁱ	9606.ENSP00000362609

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96BR9
SMRⁱ	Q96BR9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	BTBPROSITE-ProRule annotationAdd BLAST		69

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	429 – 435	Poly-Glu		7

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	282 – 304	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	310 – 333	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000124661
InParanoidⁱ	Q96BR9
KEGG Orthology (KO) More...KOⁱ	K10495
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05WK
PhylomeDBⁱ	Q96BR9
TreeFamⁱ	TF330979

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96BR9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK 
        60         70         80         90        100
MLLSQNSKET SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS 
       110        120        130        140        150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDA NSNGVERSSF 
       160        170        180        190        200
YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW NKYNYHPASQ KNTQQPLAKH 
       210        220        230        240        250
EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV SQSEEQAQID 
       260        270        280        290        300
AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH 
       310        320        330        340        350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL 
       360        370        380        390        400
TGQVVQEGTR RYRLCNECLA EFGIDSLPID LEAEQHLMSP SDGDKDSRWH 
       410        420        430        440 
LSEDENRSYV EIVEDGSGDL VIQQVDDSEE EEEKEIKPNI R

Length:441

Mass (Da):50,141

Last modified:July 7, 2009 - v2

Checksum:ⁱ8A4A7B30C1E8C018

GO

Isoform 2 (identifier: Q96BR9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
332-441: IHQACKLICR...EEKEIKPNIR → MEIRIPD

« Hide

        10         20         30         40         50
MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK 
        60         70         80         90        100
MLLSQNSKET SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS 
       110        120        130        140        150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDA NSNGVERSSF 
       160        170        180        190        200
YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW NKYNYHPASQ KNTQQPLAKH 
       210        220        230        240        250
EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV SQSEEQAQID 
       260        270        280        290        300
AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH 
       310        320        330 
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TMEIRIPD

Show »

Length:338

Mass (Da):38,344

Checksum:ⁱ4306E1988E6E55C0

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D3DPQ1	D3DPQ1_HUMAN		HCG39683, isoform CRA_a HCG39683, isoform CRA_a (Zinc finger and BTB domain-containing protein 8A)	ZBTB8A hCG_39683	340	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	206	S → G in AAH15067 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_058085	418	G → A3 PublicationsCorresponds to variant dbSNP:rs704886Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037597	332 – 441	IHQAC…KPNIR → MEIRIPD in isoform 2. 1 PublicationAdd BLAST		110

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF548353 mRNA Translation: AAN40800.1 AY157873 mRNA Translation: AAN77376.1 AK074546 mRNA Translation: BAC11050.1 AL033529 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07521.1 CH471059 Genomic DNA Translation: EAX07522.1 BC015067 mRNA Translation: AAH15067.1 BC015239 mRNA Translation: AAH15239.1 BC029654 mRNA Translation: AAH29654.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30664.1 [Q96BR9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035531.2, NM_001040441.2 NP_001278425.1, NM_001291496.1
UniGeneⁱ	Hs.546479

Genome annotation databases

Ensemblⁱ	ENST00000373510; ENSP00000362609; ENSG00000160062
GeneIDⁱ	653121
KEGGⁱ	hsa:653121
UCSC genome browser More...UCSCⁱ	uc001bvn.4 human [Q96BR9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96BR9	Zinc finger and BTB domain-containing protein 8A		BOVIN		441	UniRef90_Q96BR9
Zinc finger and BTB domain-containing protein 8A		HETGA		447
ZBTB8A		CEREH		441
ZBTB8A isoform 1		PANTR		441
Zinc finger and BTB domain containing 8A		PANPA		441
+88
Q96BR9-2	HCG39683, isoform CRA_a		HUMAN		340	UniRef90_D3DPQ1
Zinc finger and BTB domain containing 8A		NOMLE		340
ZBTB8A isoform 2		PONAB		340
UPI000A3581EE		HETGA		354
UPI00045E54FB		CHLSB		340
+5

Protein	Similar proteins		Species	Score	Length	Source
Q96BR9	Zinc finger and BTB domain-containing protein 8A		BOVIN		441	UniRef50_Q96BR9
Zinc finger and BTB domain-containing protein 8A		RAT		441
Zinc finger and BTB domain-containing protein 8A		MOUSE		434
Histone-binding protein RBBP7	)	HUMAN		425
Histone-binding protein RBBP7		MACFA		425
+210
Q96BR9-2	HCG39683, isoform CRA_a		HUMAN		340	UniRef50_D3DPQ1
Zinc finger and BTB domain containing 8A		NOMLE		340
ZBTB8A isoform 2		PONAB		340
Uncharacterized protein		NEOLE		347
Zinc finger and BTB domain containing 8A		AOTNA		307
+11

Entry informationⁱ

Entry nameⁱ	ZBT8A_HUMAN
Accessionⁱ	Q96BR9Primary (citable) accession number: Q96BR9 Secondary accession number(s): Q8IUL5 , Q8IWR9, Q8N2Y5, Q96BX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
	Last sequence update:	July 7, 2009
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96BR9 (ZBT8A_HUMAN)

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Zinc finger and BTB domain-containing protein 8A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ