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UniProtKB - Q96BR9 (ZBT8A_HUMAN)

Entry version 179 (23 Feb 2022)
Sequence version 3 (23 Feb 2022)
Previous versions | rss
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Protein

Zinc finger and BTB domain-containing protein 8A

Gene

ZBTB8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96BR9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96BR9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8A
Alternative name(s):
BTB/POZ and zinc-finger domain-containing factor
BTB/POZ and zinc-finger domains factor on chromosome 1
Short name:
BOZ-F1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB8A
Synonyms:BOZF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24172, ZBTB8A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618742, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96BR9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160062

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164727627

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96BR9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZBTB8A

Domain mapping of disease mutations (DMDM)

More...DMDMi		251765171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003785081 – 441Zinc finger and BTB domain-containing protein 8AAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96BR9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96BR9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96BR9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96BR9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96BR9

PeptideAtlas

More...PeptideAtlasi		Q96BR9

PRoteomics IDEntifications database

More...PRIDEi		Q96BR9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76104 [Q96BR9-1]
76105 [Q96BR9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96BR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96BR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160062, Expressed in cortical plate and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96BR9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96BR9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160062, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96BR9
With#Exp.IntAct
ACOT12 [Q8WYK0]4EBI-742740,EBI-11954993
AEN [Q8WTP8]3EBI-742740,EBI-8637627
AP1M1 [Q9BXS5]7EBI-742740,EBI-541426
ARMC7 [Q9H6L4]3EBI-742740,EBI-742909
ARMCX1 [Q9P291]6EBI-742740,EBI-2843626
BAZ2B - isoform 2 [Q9UIF8-2]3EBI-742740,EBI-10321972
BLK [P51451]3EBI-742740,EBI-2105445
BYSL [Q13895]8EBI-742740,EBI-358049
CBX8 [Q9HC52]3EBI-742740,EBI-712912
CDC37 [Q16543]3EBI-742740,EBI-295634
CDKL3 [Q8IVW4]6EBI-742740,EBI-3919850
CSNK1D [P48730]3EBI-742740,EBI-751621
CWF19L2 [Q2TBE0]3EBI-742740,EBI-5453285
DDX6 [P26196]6EBI-742740,EBI-351257
DVL3 [Q92997]3EBI-742740,EBI-739789
EHHADH [Q08426]3EBI-742740,EBI-2339219
EIF1AD [Q8N9N8]6EBI-742740,EBI-750700
FAM161A [Q3B820]6EBI-742740,EBI-719941
FAM90A1 [Q86YD7]3EBI-742740,EBI-6658203
GPATCH2L [Q9NWQ4]3EBI-742740,EBI-5666657
hCG_1987119 [A0A024R8L2]3EBI-742740,EBI-14103818
HEL-S-61 [V9HW29]3EBI-742740,EBI-10330057
HIC2 [Q96JB3]5EBI-742740,EBI-726282
JRK - isoform 2 [O75564-2]3EBI-742740,EBI-17181882
KAT5 [Q92993]4EBI-742740,EBI-399080
KIF5B [P33176]3EBI-742740,EBI-355878
KIF9 [Q9HAQ2]3EBI-742740,EBI-8472129
KIFC3 [Q9BVG8]3EBI-742740,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-742740,EBI-14069005
LGALS14 [Q8TCE9]3EBI-742740,EBI-10274069
MFAP1 [P55081]3EBI-742740,EBI-1048159
MRPL11 [Q9Y3B7]3EBI-742740,EBI-5453723
NTAQ1 [Q96HA8]3EBI-742740,EBI-741158
PIAS2 [O75928]3EBI-742740,EBI-348555
PRKAA2 [P54646]3EBI-742740,EBI-1383852
PRR34 [Q9NV39]3EBI-742740,EBI-11959565
PSMC1 [P62191]3EBI-742740,EBI-357598
RAD23A [P54725]6EBI-742740,EBI-746453
RPL9 [P32969]6EBI-742740,EBI-358122
SDCBP [O00560]6EBI-742740,EBI-727004
SYT6 - isoform 2 [Q5T7P8-2]3EBI-742740,EBI-10246152
TCEA2 [Q15560]3EBI-742740,EBI-710310
TNIP3 [Q96KP6]3EBI-742740,EBI-2509913
TRIM41 [Q8WV44]4EBI-742740,EBI-725997
UBE2I [Q7KZS0]3EBI-742740,EBI-10180829
YES1 [P07947]6EBI-742740,EBI-515331
ZBTB17 [Q13105]3EBI-742740,EBI-372156
ZBTB24 [O43167]6EBI-742740,EBI-744471
ZBTB48 [P10074]7EBI-742740,EBI-744864
ZBTB49 [Q6ZSB9]6EBI-742740,EBI-2859943
ZCCHC10 [Q8TBK6]3EBI-742740,EBI-597063
ZGPAT [A0A0S2Z6H0]3EBI-742740,EBI-16428984
ZGPAT [Q8N5A5]3EBI-742740,EBI-3439227
ZMAT2 [Q96NC0]3EBI-742740,EBI-2682299
ZNF138 [P52744]3EBI-742740,EBI-10746567
ZNF138 - isoform 2 [P52744-2]3EBI-742740,EBI-10213071
ZNF250 - isoform 3 [P15622-3]3EBI-742740,EBI-10177272
ZNF276 [Q8N554]7EBI-742740,EBI-750821
ZNF276 - isoform 2 [Q8N554-2]3EBI-742740,EBI-10265849
ZNF329 [Q86UD4]3EBI-742740,EBI-7233259
ZNF35 [P13682]3EBI-742740,EBI-11041653
ZNF408 [Q9H9D4]4EBI-742740,EBI-347633
ZNF417 [Q8TAU3]6EBI-742740,EBI-740727
ZNF438 [Q7Z4V0]3EBI-742740,EBI-11962468
ZNF497 [Q6ZNH5]3EBI-742740,EBI-10486136
ZNF509 [Q32MK9]3EBI-742740,EBI-10239929
ZNF572 [Q7Z3I7]3EBI-742740,EBI-10172590
ZNF587 [Q96SQ5]6EBI-742740,EBI-6427977
ZNF648 [Q5T619]3EBI-742740,EBI-11985915
ZNF837 [Q96EG3]3EBI-742740,EBI-11962574
A8K9323EBI-742740,EBI-10174671
Q9NWJ23EBI-742740,EBI-10315029

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		575543, 94 interactors

Protein interaction database and analysis system

More...IntActi		Q96BR9, 80 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362609

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96BR9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96BR9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 251DisorderedSequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 196Polar residuesSequence analysisAdd BLAST54
Compositional biasi211 – 235Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi236 – 250Polar residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022356_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96BR9

Database of Orthologous Groups

More...OrthoDBi		755439at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96BR9

TreeFam database of animal gene trees

More...TreeFami		TF330979

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96BR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK 
        60         70         80         90        100
MLLSQNSKET SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS 
       110        120        130        140        150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDA NSNGVERSSF 
       160        170        180        190        200
YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW NKYNYHPASQ KNTQQPLAKH 
       210        220        230        240        250
EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV SQSEEQAQID 
       260        270        280        290        300
AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH 
       310        320        330        340        350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL 
       360        370        380        390        400
TGQVVQEGTR RYRLCNECLA EFGIDSLPID LEAEQHLMSP SDGDKDSRWH 
       410        420        430        440 
LSEDENRSYV EIVEDGSADL VIQQVDDSEE EEEKEIKPNI R
Length:441
Mass (Da):50,155
Last modified:February 23, 2022 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A2C7B30C1E8C01C
GO
Isoform 2 (identifier: Q96BR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-441: IHQACKLICR...EEKEIKPNIR → MEIRIPD

Show »
Length:338
Mass (Da):38,344
Checksum:i4306E1988E6E55C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DPQ1D3DPQ1_HUMAN
HCG39683, isoform CRA_a
ZBTB8A hCG_39683
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206S → G in AAH15067 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058085418A → G1 PublicationCorresponds to variant dbSNP:rs704886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037597332 – 441IHQAC…KPNIR → MEIRIPD in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF548353 mRNA Translation: AAN40800.1
AY157873 mRNA Translation: AAN77376.1
AK074546 mRNA Translation: BAC11050.1
AL033529 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07521.1
CH471059 Genomic DNA Translation: EAX07522.1
BC015067 mRNA Translation: AAH15067.1
BC015239 mRNA Translation: AAH15239.1
BC029654 mRNA Translation: AAH29654.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30664.1 [Q96BR9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035531.2, NM_001040441.2
NP_001278425.1, NM_001291496.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373510; ENSP00000362609; ENSG00000160062

Database of genes from NCBI RefSeq genomes

More...GeneIDi		653121

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:653121

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373510.9; ENSP00000362609.3; NM_001040441.3; NP_001035531.2

UCSC genome browser

More...UCSCi		uc001bvn.4, human [Q96BR9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548353 mRNA Translation: AAN40800.1
AY157873 mRNA Translation: AAN77376.1
AK074546 mRNA Translation: BAC11050.1
AL033529 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07521.1
CH471059 Genomic DNA Translation: EAX07522.1
BC015067 mRNA Translation: AAH15067.1
BC015239 mRNA Translation: AAH15239.1
BC029654 mRNA Translation: AAH29654.1
CCDSiCCDS30664.1 [Q96BR9-1]
RefSeqiNP_001035531.2, NM_001040441.2
NP_001278425.1, NM_001291496.1

3D structure databases

SMRiQ96BR9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi575543, 94 interactors
IntActiQ96BR9, 80 interactors
STRINGi9606.ENSP00000362609

PTM databases

iPTMnetiQ96BR9
PhosphoSitePlusiQ96BR9

Genetic variation databases

BioMutaiZBTB8A
DMDMi251765171

Proteomic databases

EPDiQ96BR9
jPOSTiQ96BR9
MassIVEiQ96BR9
MaxQBiQ96BR9
PaxDbiQ96BR9
PeptideAtlasiQ96BR9
PRIDEiQ96BR9
ProteomicsDBi76104 [Q96BR9-1]
76105 [Q96BR9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31329, 83 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		653121

Genome annotation databases

EnsembliENST00000373510; ENSP00000362609; ENSG00000160062
GeneIDi653121
KEGGihsa:653121
MANE-SelectiENST00000373510.9; ENSP00000362609.3; NM_001040441.3; NP_001035531.2
UCSCiuc001bvn.4, human [Q96BR9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		653121

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZBTB8A
HGNCiHGNC:24172, ZBTB8A
HPAiENSG00000160062, Low tissue specificity
MIMi618742, gene
neXtProtiNX_Q96BR9
PharmGKBiPA164727627
VEuPathDBiHostDB:ENSG00000160062

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
HOGENOMiCLU_022356_1_1_1
InParanoidiQ96BR9
OrthoDBi755439at2759
PhylomeDBiQ96BR9
TreeFamiTF330979

Enzyme and pathway databases

PathwayCommonsiQ96BR9
SignaLinkiQ96BR9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		653121, 5 hits in 1099 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZBTB8A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		653121
PharosiQ96BR9, Tdark

Protein Ontology

More...PROi		PR:Q96BR9
RNActiQ96BR9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160062, Expressed in cortical plate and 116 other tissues
ExpressionAtlasiQ96BR9, baseline and differential
GenevisibleiQ96BR9, HS

Family and domain databases

Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 2 hits
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT8A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BR9
Secondary accession number(s): Q8IUL5
, Q8IWR9, Q8N2Y5, Q96BX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: February 23, 2022
Last modified: February 23, 2022
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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