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Protein

Cytochrome c oxidase assembly factor 7

Gene

COA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for assembly of mitochondrial respiratory chain complex I and complex IV.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 7
Alternative name(s):
Beta-lactamase hcp-like protein
Respiratory chain assembly factor 1
Sel1 repeat-containing protein 1
Gene namesi
Name:COA7
Synonyms:C1orf163, RESA1, SELRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162377.5
HGNCiHGNC:25716 COA7
MIMi615623 gene
neXtProtiNX_Q96BR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65260
MalaCardsiCOA7
OpenTargetsiENSG00000162377
PharmGKBiPA142672414

Polymorphism and mutation databases

BioMutaiSELRC1
DMDMi223590164

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002823642 – 231Cytochrome c oxidase assembly factor 7Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96BR5
MaxQBiQ96BR5
PaxDbiQ96BR5
PeptideAtlasiQ96BR5
PRIDEiQ96BR5
ProteomicsDBi76102

PTM databases

iPTMnetiQ96BR5
PhosphoSitePlusiQ96BR5

Expressioni

Gene expression databases

BgeeiENSG00000162377
CleanExiHS_C1orf163
GenevisibleiQ96BR5 HS

Organism-specific databases

HPAiHPA028154
HPA029926

Interactioni

Protein-protein interaction databases

BioGridi122417, 22 interactors
IntActiQ96BR5, 11 interactors
MINTiQ96BR5
STRINGi9606.ENSP00000360593

Structurei

3D structure databases

ProteinModelPortaliQ96BR5
SMRiQ96BR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 66Sel1-like 1Add BLAST33
Repeati68 – 104Sel1-like 2Add BLAST37
Repeati108 – 146Sel1-like 3Add BLAST39
Repeati147 – 183Sel1-like 4Add BLAST37
Repeati184 – 219Sel1-like 5Add BLAST36

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4014 Eukaryota
COG0790 LUCA
GeneTreeiENSGT00390000004835
HOVERGENiHBG107158
InParanoidiQ96BR5
KOiK18180
OMAiACFYLSG
OrthoDBiEOG091G0HCT
PhylomeDBiQ96BR5
TreeFamiTF105805

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF08238 Sel1, 4 hits
SMARTiView protein in SMART
SM00671 SEL1, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMVDFQDE EQVKSFLENM EVECNYHCYH EKDPDGCYRL VDYLEGIRKN
60 70 80 90 100
FDEAAKVLKF NCEENQHSDS CYKLGAYYVT GKGGLTQDLK AAARCFLMAC
110 120 130 140 150
EKPGKKSIAA CHNVGLLAHD GQVNEDGQPD LGKARDYYTR ACDGGYTSSC
160 170 180 190 200
FNLSAMFLQG APGFPKDMDL ACKYSMKACD LGHIWACANA SRMYKLGDGV
210 220 230
DKDEAKAEVL KNRAQQLHKE QQKGVQPLTF G
Length:231
Mass (Da):25,709
Last modified:February 10, 2009 - v2
Checksum:iDB7E2BEDCC0ECE8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77Y → H in BAB14063 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031401219K → R2 PublicationsCorresponds to variant dbSNP:rs443751Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022501 mRNA Translation: BAB14063.1
AC099784 Genomic DNA No translation available.
BC015313 mRNA Translation: AAH15313.1
CCDSiCCDS570.1
RefSeqiNP_075565.2, NM_023077.2
UniGeneiHs.349905

Genome annotation databases

EnsembliENST00000371538; ENSP00000360593; ENSG00000162377
GeneIDi65260
KEGGihsa:65260
UCSCiuc001cui.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q96BR5
Secondary accession number(s): Q0P6I7, Q9H9Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 10, 2009
Last modified: June 20, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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