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Entry version 112 (26 Feb 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Coiled-coil domain-containing protein 127

Gene

CCDC127

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 127
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC127
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30520 CCDC127

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96BQ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
133957

Open Targets

More...
OpenTargetsi
ENSG00000164366

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96BQ5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC127

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002637501 – 260Coiled-coil domain-containing protein 127Add BLAST260

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96BQ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96BQ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96BQ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96BQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96BQ5

PeptideAtlas

More...
PeptideAtlasi
Q96BQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q96BQ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76099

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96BQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96BQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164366 Expressed in quadriceps femoris and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96BQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96BQ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045052

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126379, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q96BQ5, 9 interactors

Molecular INTeraction database

More...
MINTi
Q96BQ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296824

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96BQ5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96BQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 135Sequence analysisAdd BLAST87

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE2N Eukaryota
ENOG410ZQ95 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008818

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072814_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96BQ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YCGDVWN

Database of Orthologous Groups

More...
OrthoDBi
1623075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96BQ5

TreeFam database of animal gene trees

More...
TreeFami
TF331099

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034607 CCDC127

The PANTHER Classification System

More...
PANTHERi
PTHR31958 PTHR31958, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96BQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNLNDPPNW NIRPNSRADG GDGSRWNYAL LVPMLGLAAF RWIWSRESQK
60 70 80 90 100
EVEKEREAYR RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA
110 120 130 140 150
SYREALISQG RKLVEEKKLL EQERAQVMQE KRQVQPLRSA YLSCLQREEN
160 170 180 190 200
WQRRARLLLK EFEAVLTERQ NIYCSLFLPR SKRLEIEKSL LVRASVDPVA
210 220 230 240 250
ADLEMAAGLT DIFQHDTYCG DVWNTNKRQN GRLMWLYLKY WELVVELKKF
260
KRVEEAILEK
Length:260
Mass (Da):30,834
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA395FB63A94824
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9R2D6R9R2_HUMAN
Coiled-coil domain-containing prote...
CCDC127
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05073760R → H. Corresponds to variant dbSNP:rs11557427Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098567 mRNA Translation: BAC05336.1
BC015349 mRNA Translation: AAH15349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3852.1

NCBI Reference Sequences

More...
RefSeqi
NP_660308.1, NM_145265.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296824; ENSP00000296824; ENSG00000164366

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
133957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:133957

UCSC genome browser

More...
UCSCi
uc003jam.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098567 mRNA Translation: BAC05336.1
BC015349 mRNA Translation: AAH15349.1
CCDSiCCDS3852.1
RefSeqiNP_660308.1, NM_145265.2

3D structure databases

SMRiQ96BQ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126379, 12 interactors
IntActiQ96BQ5, 9 interactors
MINTiQ96BQ5
STRINGi9606.ENSP00000296824

PTM databases

iPTMnetiQ96BQ5
PhosphoSitePlusiQ96BQ5

Polymorphism and mutation databases

BioMutaiCCDC127
DMDMi74731264

Proteomic databases

EPDiQ96BQ5
jPOSTiQ96BQ5
MassIVEiQ96BQ5
MaxQBiQ96BQ5
PaxDbiQ96BQ5
PeptideAtlasiQ96BQ5
PRIDEiQ96BQ5
ProteomicsDBi76099

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
133957

Genome annotation databases

EnsembliENST00000296824; ENSP00000296824; ENSG00000164366
GeneIDi133957
KEGGihsa:133957
UCSCiuc003jam.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
133957
DisGeNETi133957

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC127
HGNCiHGNC:30520 CCDC127
HPAiHPA045052
neXtProtiNX_Q96BQ5
OpenTargetsiENSG00000164366
PharmGKBiPA162381297

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE2N Eukaryota
ENOG410ZQ95 LUCA
GeneTreeiENSGT00390000008818
HOGENOMiCLU_072814_0_0_1
InParanoidiQ96BQ5
OMAiYCGDVWN
OrthoDBi1623075at2759
PhylomeDBiQ96BQ5
TreeFamiTF331099

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC127 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
133957
PharosiQ96BQ5 Tdark

Protein Ontology

More...
PROi
PR:Q96BQ5
RNActiQ96BQ5 protein

Gene expression databases

BgeeiENSG00000164366 Expressed in quadriceps femoris and 208 other tissues
ExpressionAtlasiQ96BQ5 baseline and differential
GenevisibleiQ96BQ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR034607 CCDC127
PANTHERiPTHR31958 PTHR31958, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC127_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: February 26, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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