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Protein

Protein FAM3D

Gene

FAM3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • negative regulation of insulin secretion Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3D
Gene namesi
Name:FAM3D
ORF Names:UNQ567/PRO1130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000198643.6
HGNCiHGNC:18665 FAM3D
MIMi608619 gene
neXtProtiNX_Q96BQ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi131177
OpenTargetsiENSG00000198643
PharmGKBiPA38628

Polymorphism and mutation databases

BioMutaiFAM3D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000875426 – 224Protein FAM3DAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 83By similarity
Disulfide bondi61 ↔ 218By similarity
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96BQ1
PeptideAtlasiQ96BQ1
PRIDEiQ96BQ1
ProteomicsDBi76097

PTM databases

iPTMnetiQ96BQ1
PhosphoSitePlusiQ96BQ1

Expressioni

Tissue specificityi

Abundantly expressed in placenta and weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiENSG00000198643
CleanExiHS_FAM3D
ExpressionAtlasiQ96BQ1 baseline and differential
GenevisibleiQ96BQ1 HS

Organism-specific databases

HPAiHPA013844

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126274, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ96BQ1
SMRiQ96BQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJP8 Eukaryota
ENOG410Y9GG LUCA
GeneTreeiENSGT00530000063020
HOGENOMiHOG000285992
HOVERGENiHBG051544
InParanoidiQ96BQ1
OMAiVVGPSMC
OrthoDBiEOG091G0IGX
PhylomeDBiQ96BQ1
TreeFamiTF353414

Family and domain databases

InterProiView protein in InterPro
IPR039220 FAM3
IPR039240 FAM3D
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF9 PTHR14592:SF9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSGVLRLL ALIFAIVTTW MFIRSYMSFS MKTIRLPRWL AASPTKEIQV
60 70 80 90 100
KKYKCGLIKP CPANYFAFKI CSGAANVVGP TMCFEDRMIM SPVKNNVGRG
110 120 130 140 150
LNIALVNGTT GAVLGQKAFD MYSGDVMHLV KFLKEIPGGA LVLVASYDDP
160 170 180 190 200
GTKMNDESRK LFSDLGSSYA KQLGFRDSWV FIGAKDLRGK SPFEQFLKNS
210 220
PDTNKYEGWP ELLEMEGCMP PKPF
Length:224
Mass (Da):24,963
Last modified:December 1, 2001 - v1
Checksum:i153E81C21F193551
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05308760P → S. Corresponds to variant dbSNP:rs17059569Ensembl.1
Natural variantiVAR_053088118A → S. Corresponds to variant dbSNP:rs33966924Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494381 mRNA Translation: AAM94282.1
AY358677 mRNA Translation: AAQ89040.1
AK127546 mRNA Translation: BAG54521.1
CH471055 Genomic DNA Translation: EAW65382.1
BC015359 mRNA Translation: AAH15359.1
CCDSiCCDS2893.1
RefSeqiNP_620160.1, NM_138805.2
XP_005264919.1, XM_005264862.4
XP_006713028.1, XM_006712965.3
XP_011531653.1, XM_011533351.2
UniGeneiHs.61265

Genome annotation databases

EnsembliENST00000358781; ENSP00000351632; ENSG00000198643
GeneIDi131177
KEGGihsa:131177
UCSCiuc003dkq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFAM3D_HUMAN
AccessioniPrimary (citable) accession number: Q96BQ1
Secondary accession number(s): Q547G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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