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Protein

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

PPWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638).2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Activity regulationi

Inhibited by cyclosporin A (CsA).1 Publication

GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BRENDAi5.2.1.8 2681
ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkiQ96BP3

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1Curated (EC:5.2.1.81 Publication)
Alternative name(s):
Spliceosome-associated cyclophilin1 Publication
Gene namesi
Name:PPWD1Imported
Synonyms:KIAA0073Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113593.11
HGNCiHGNC:28954 PPWD1
neXtProtiNX_Q96BP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23398
OpenTargetsiENSG00000113593
PharmGKBiPA142671149

Polymorphism and mutation databases

BioMutaiPPWD1
DMDMi74760739

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002403062 – 646Peptidylprolyl isomerase domain and WD repeat-containing protein 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96BP3
MaxQBiQ96BP3
PaxDbiQ96BP3
PeptideAtlasiQ96BP3
PRIDEiQ96BP3
ProteomicsDBi76096

PTM databases

iPTMnetiQ96BP3
PhosphoSitePlusiQ96BP3

Expressioni

Gene expression databases

BgeeiENSG00000113593 Expressed in 222 organ(s), highest expression level in corpus callosum
CleanExiHS_PPWD1
ExpressionAtlasiQ96BP3 baseline and differential
GenevisibleiQ96BP3 HS

Organism-specific databases

HPAiHPA019353
HPA019360

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Protein-protein interaction databases

BioGridi116971, 20 interactors
CORUMiQ96BP3
IntActiQ96BP3, 6 interactors
STRINGi9606.ENSP00000261308

Structurei

Secondary structure

1646
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ96BP3
SMRiQ96BP3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96BP3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 118WD 1Add BLAST39
Repeati124 – 162WD 2Add BLAST39
Repeati168 – 208WD 3Add BLAST41
Repeati213 – 252WD 4Add BLAST40
Repeati271 – 309WD 5Add BLAST39
Repeati345 – 386WD 6Add BLAST42
Repeati401 – 453WD 7Add BLAST53
Domaini490 – 645PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 17Poly-Arg6

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0882 Eukaryota
ENOG410XQB4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000213214
HOVERGENiHBG079869
InParanoidiQ96BP3
KOiK12736
OMAiLPHEKLY
OrthoDBiEOG091G03B9
PhylomeDBiQ96BP3
TreeFamiTF105686

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50891 SSF50891, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96BP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW
60 70 80 90 100
VGPLPVEATL AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK
110 120 130 140 150
TDFIITASHD GHVKFWKKIE EGIEFVKHFR SHLGVIESIA VSSEGALFCS
160 170 180 190 200
VGDDKAMKVF DVVNFDMINM LKLGYFPGQC EWIYCPGDAI SSVAASEKST
210 220 230 240 250
GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR LNPVYKAVVS SDKSGMIEYW
260 270 280 290 300
TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSVCFSP DGKKIATIGS
310 320 330 340 350
DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL
360 370 380 390 400
EKVDAVRLIN IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV
410 420 430 440 450
MQLALFQGIA KKHRAATTIE MKASENPVLQ NIQADPTIVC TSFKKNRFYM
460 470 480 490 500
FTKREPEDTK SADSDRDVFN EKPSKEEVMA ATQAEGPKRV SDSAIIHTSM
510 520 530 540 550
GDIHTKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF MIQTGDPTGT
560 570 580 590 600
GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP
610 620 630 640
WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK
Length:646
Mass (Da):73,575
Last modified:December 1, 2001 - v1
Checksum:i4DEFA1C78F914430
GO
Isoform 2 (identifier: Q96BP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):55,700
Checksum:iD82E40743B31C263
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7P7F5H7P7_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
616Annotation score:
D6R9Q1D6R9Q1_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
241Annotation score:
D6RD43D6RD43_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
107Annotation score:
H0Y8N5H0Y8N5_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
132Annotation score:
D6RDA4D6RDA4_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
84Annotation score:
D6RHV0D6RHV0_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
108Annotation score:
D6RB19D6RB19_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
107Annotation score:
D6RA12D6RA12_HUMAN
Peptidylprolyl isomerase domain and...
PPWD1
68Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552661 – 156Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301654 mRNA Translation: BAG63131.1
AC008560 Genomic DNA No translation available.
BC015385 mRNA Translation: AAH15385.1
D38552 mRNA Translation: BAA07555.1
CCDSiCCDS3985.1 [Q96BP3-1]
CCDS64162.1 [Q96BP3-2]
RefSeqiNP_001265855.1, NM_001278926.1
NP_001265856.1, NM_001278927.1
NP_001265858.1, NM_001278929.1 [Q96BP3-2]
NP_056157.1, NM_015342.3 [Q96BP3-1]
UniGeneiHs.121432

Genome annotation databases

EnsembliENST00000261308; ENSP00000261308; ENSG00000113593 [Q96BP3-1]
ENST00000538977; ENSP00000444496; ENSG00000113593 [Q96BP3-2]
GeneIDi23398
KEGGihsa:23398
UCSCiuc003jtv.6 human [Q96BP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301654 mRNA Translation: BAG63131.1
AC008560 Genomic DNA No translation available.
BC015385 mRNA Translation: AAH15385.1
D38552 mRNA Translation: BAA07555.1
CCDSiCCDS3985.1 [Q96BP3-1]
CCDS64162.1 [Q96BP3-2]
RefSeqiNP_001265855.1, NM_001278926.1
NP_001265856.1, NM_001278927.1
NP_001265858.1, NM_001278929.1 [Q96BP3-2]
NP_056157.1, NM_015342.3 [Q96BP3-1]
UniGeneiHs.121432

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2NX-ray1.65A/B/C473-646[»]
5YZGelectron microscopy4.1021-646[»]
ProteinModelPortaliQ96BP3
SMRiQ96BP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116971, 20 interactors
CORUMiQ96BP3
IntActiQ96BP3, 6 interactors
STRINGi9606.ENSP00000261308

PTM databases

iPTMnetiQ96BP3
PhosphoSitePlusiQ96BP3

Polymorphism and mutation databases

BioMutaiPPWD1
DMDMi74760739

Proteomic databases

EPDiQ96BP3
MaxQBiQ96BP3
PaxDbiQ96BP3
PeptideAtlasiQ96BP3
PRIDEiQ96BP3
ProteomicsDBi76096

Protocols and materials databases

DNASUi23398
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261308; ENSP00000261308; ENSG00000113593 [Q96BP3-1]
ENST00000538977; ENSP00000444496; ENSG00000113593 [Q96BP3-2]
GeneIDi23398
KEGGihsa:23398
UCSCiuc003jtv.6 human [Q96BP3-1]

Organism-specific databases

CTDi23398
DisGeNETi23398
EuPathDBiHostDB:ENSG00000113593.11
GeneCardsiPPWD1
HGNCiHGNC:28954 PPWD1
HPAiHPA019353
HPA019360
neXtProtiNX_Q96BP3
OpenTargetsiENSG00000113593
PharmGKBiPA142671149
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0882 Eukaryota
ENOG410XQB4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000213214
HOVERGENiHBG079869
InParanoidiQ96BP3
KOiK12736
OMAiLPHEKLY
OrthoDBiEOG091G03B9
PhylomeDBiQ96BP3
TreeFamiTF105686

Enzyme and pathway databases

BRENDAi5.2.1.8 2681
ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SignaLinkiQ96BP3

Miscellaneous databases

ChiTaRSiPPWD1 human
EvolutionaryTraceiQ96BP3
GenomeRNAii23398
PROiPR:Q96BP3

Gene expression databases

BgeeiENSG00000113593 Expressed in 222 organ(s), highest expression level in corpus callosum
CleanExiHS_PPWD1
ExpressionAtlasiQ96BP3 baseline and differential
GenevisibleiQ96BP3 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50891 SSF50891, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPWD1_HUMAN
AccessioniPrimary (citable) accession number: Q96BP3
Secondary accession number(s): B4DWR9, Q15002, Q7KZ89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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