Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil-helix-coiled-coil-helix domain-containing protein 1

Gene

CHCHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Alternative name(s):
28S ribosomal protein S37, mitochondrial
Short name:
MRP-S37
Mitochondrial small ribosomal subunit protein mS371 Publication
Nuclear protein C2360
Gene namesi
Name:CHCHD1
Synonyms:C10orf34, MRPS37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000172586.7
HGNCiHGNC:23518 CHCHD1
MIMi608842 gene
neXtProtiNX_Q96BP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172586
PharmGKBiPA134964437

Polymorphism and mutation databases

BioMutaiCHCHD1
DMDMi62510504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291581 – 118Coiled-coil-helix-coiled-coil-helix domain-containing protein 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 76PROSITE-ProRule annotation
Disulfide bondi55 ↔ 66PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96BP2
MaxQBiQ96BP2
PaxDbiQ96BP2
PeptideAtlasiQ96BP2
PRIDEiQ96BP2
ProteomicsDBi76095

PTM databases

iPTMnetiQ96BP2
PhosphoSitePlusiQ96BP2

Expressioni

Gene expression databases

BgeeiENSG00000172586
CleanExiHS_CHCHD1
ExpressionAtlasiQ96BP2 baseline and differential
GenevisibleiQ96BP2 HS

Organism-specific databases

HPAiHPA039046

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-5454898,EBI-6164309From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi125612, 10 interactors
IntActiQ96BP2, 5 interactors
MINTiQ96BP2
STRINGi9606.ENSP00000361923

Structurei

3D structure databases

ProteinModelPortaliQ96BP2
SMRiQ96BP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 84CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 55Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi66 – 76Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4695 Eukaryota
ENOG410Y5R6 LUCA
GeneTreeiENSGT00390000007683
HOGENOMiHOG000247034
HOVERGENiHBG050935
InParanoidiQ96BP2
OMAiFPNKPHL
OrthoDBiEOG091G0YBP
PhylomeDBiQ96BP2
TreeFamiTF314650

Family and domain databases

InterProiView protein in InterPro
IPR010625 CHCH
IPR033620 CHCHD1
IPR009069 Cys_alpha_HP_mot_SF
PANTHERiPTHR31278 PTHR31278, 1 hit
PfamiView protein in Pfam
PF06747 CHCH, 1 hit
SUPFAMiSSF47072 SSF47072, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Q96BP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS
60 70 80 90 100
VMMACWKQNE FRDDACRKEI QGFLDCAARA QEARKMRSIQ ETLGESGSLL
110
PNKLNKLLQR FPNKPYLS
Length:118
Mass (Da):13,475
Last modified:December 1, 2001 - v1
Checksum:i98AA1C38045A1C7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015387 mRNA Translation: AAH15387.1
BC020852 mRNA Translation: AAH20852.1
CCDSiCCDS7334.1
RefSeqiNP_976043.1, NM_203298.2
UniGeneiHs.181174

Genome annotation databases

EnsembliENST00000372833; ENSP00000361923; ENSG00000172586
GeneIDi118487
KEGGihsa:118487
UCSCiuc001jvc.5 human

Similar proteinsi

Entry informationi

Entry nameiCHCH1_HUMAN
AccessioniPrimary (citable) accession number: Q96BP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health