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Entry version 158 (22 Apr 2020)
Sequence version 2 (20 Jun 2002)
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Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene

PINX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96BK5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PIN2/TERF1-interacting telomerase inhibitor 1
Alternative name(s):
Liver-related putative tumor suppressor
Pin2-interacting protein X1
Protein 67-11-3
TRF1-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PINX1
Synonyms:LPTL, LPTS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30046 PINX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606505 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96BK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi291L → A: Abolishes interaction with TERF1. 1 Publication1
Mutagenesisi293P → A: Does not affect interaction with TERF1. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
54984

Open Targets

More...
OpenTargetsi
ENSG00000254093

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165585852

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96BK5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PINX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21542178

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584431 – 328PIN2/TERF1-interacting telomerase inhibitor 1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei270PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96BK5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96BK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96BK5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96BK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96BK5

PeptideAtlas

More...
PeptideAtlasi
Q96BK5

PRoteomics IDEntifications database

More...
PRIDEi
Q96BK5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76086 [Q96BK5-1]
76087 [Q96BK5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96BK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96BK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000254093 Expressed in quadriceps femoris and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96BK5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96BK5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000254093 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120319, 51 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q96BK5

Protein interaction database and analysis system

More...
IntActi
Q96BK5, 36 interactors

Molecular INTeraction database

More...
MINTi
Q96BK5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318966

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96BK5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 72G-patchPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni254 – 328Telomerase inhibitory domain (TID)Add BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi287 – 297TBMAdd BLAST11

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.1 Publication
The TBM domain mediates interaction with TERF1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PINX1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2809 Eukaryota
ENOG4111IXK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00450000040279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047471_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96BK5

KEGG Orthology (KO)

More...
KOi
K11135

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPNNTKW

Database of Orthologous Groups

More...
OrthoDBi
1577610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96BK5

TreeFam database of animal gene trees

More...
TreeFami
TF321918

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01585 G-patch, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96BK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEQ
60 70 80 90 100
GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT
110 120 130 140 150
DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR
160 170 180 190 200
QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS
210 220 230 240 250
DISETQVERK RGKKRNKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA
260 270 280 290 300
KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK
310 320
KLQKPVEIAE DATLEETLVK KKKKKDSK
Length:328
Mass (Da):37,035
Last modified:June 20, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA298B31AEA6D18E1
GO
Isoform 2 (identifier: Q96BK5-2) [UniParc]FASTAAdd to basket
Also known as: PINY1

The sequence of this isoform differs from the canonical sequence as follows:
     133-174: KDLSSRSKTD...PEENETTTTS → RCQSLHSRGE...EQAPGSSSRV
     175-328: Missing.

Show »
Length:174
Mass (Da):19,714
Checksum:iC569D5959A04362C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGR1E5RGR1_HUMAN
PIN2/TERF1-interacting telomerase i...
PINX1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJG9E5RJG9_HUMAN
PIN2/TERF1-interacting telomerase i...
PINX1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBF0H0YBF0_HUMAN
PIN2/TERF1-interacting telomerase i...
PINX1
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50Q → H in AAH15479 (PubMed:15489334).Curated1
Sequence conflicti185 – 186RM → PV in AAK31790 (PubMed:11701125).Curated2
Sequence conflicti204E → V in CAC51436 (Ref. 3) Curated1
Sequence conflicti205T → A in AAS19507 (Ref. 6) Curated1
Sequence conflicti259E → K in AAK31790 (PubMed:11701125).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054024206Q → H. Corresponds to variant dbSNP:rs35530857Ensembl.1
Natural variantiVAR_054025215R → I1 PublicationCorresponds to variant dbSNP:rs17855458Ensembl.1
Natural variantiVAR_054026220T → A. Corresponds to variant dbSNP:rs17711777Ensembl.1
Natural variantiVAR_054027254S → C1 PublicationCorresponds to variant dbSNP:rs1078543Ensembl.1
Natural variantiVAR_054028315E → A. Corresponds to variant dbSNP:rs34656824Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003945133 – 174KDLSS…TTTTS → RCQSLHSRGERNHDNQRLHH PGVLCQADGSTEEQAPGSSS RV in isoform 2. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_003946175 – 328Missing in isoform 2. 2 PublicationsAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF205718 mRNA Translation: AAG18009.1
AY029161 mRNA Translation: AAK31790.1
AJ344104 mRNA Translation: CAC51436.1
AF418553 mRNA Translation: AAN31333.1
AY238941 mRNA Translation: AAP37006.1
AY523566 mRNA Translation: AAS19507.1
AK000572 mRNA Translation: BAA91263.1
AK313715 mRNA Translation: BAG36458.1
CH471157 Genomic DNA Translation: EAW65596.1
BC015479 mRNA Translation: AAH15479.1
BC093762 mRNA Translation: AAH93762.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47801.1 [Q96BK5-1]
CCDS64825.1 [Q96BK5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001271285.1, NM_001284356.1 [Q96BK5-2]
NP_060354.4, NM_017884.5 [Q96BK5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314787; ENSP00000318966; ENSG00000254093 [Q96BK5-1]
ENST00000519088; ENSP00000428853; ENSG00000254093 [Q96BK5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54984

UCSC genome browser

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UCSCi
uc003wth.4 human [Q96BK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205718 mRNA Translation: AAG18009.1
AY029161 mRNA Translation: AAK31790.1
AJ344104 mRNA Translation: CAC51436.1
AF418553 mRNA Translation: AAN31333.1
AY238941 mRNA Translation: AAP37006.1
AY523566 mRNA Translation: AAS19507.1
AK000572 mRNA Translation: BAA91263.1
AK313715 mRNA Translation: BAG36458.1
CH471157 Genomic DNA Translation: EAW65596.1
BC015479 mRNA Translation: AAH15479.1
BC093762 mRNA Translation: AAH93762.1
CCDSiCCDS47801.1 [Q96BK5-1]
CCDS64825.1 [Q96BK5-2]
RefSeqiNP_001271285.1, NM_001284356.1 [Q96BK5-2]
NP_060354.4, NM_017884.5 [Q96BK5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120319, 51 interactors
ELMiQ96BK5
IntActiQ96BK5, 36 interactors
MINTiQ96BK5
STRINGi9606.ENSP00000318966

PTM databases

iPTMnetiQ96BK5
PhosphoSitePlusiQ96BK5

Polymorphism and mutation databases

BioMutaiPINX1
DMDMi21542178

Proteomic databases

EPDiQ96BK5
jPOSTiQ96BK5
MassIVEiQ96BK5
MaxQBiQ96BK5
PaxDbiQ96BK5
PeptideAtlasiQ96BK5
PRIDEiQ96BK5
ProteomicsDBi76086 [Q96BK5-1]
76087 [Q96BK5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
54507 229 antibodies

Genome annotation databases

EnsembliENST00000314787; ENSP00000318966; ENSG00000254093 [Q96BK5-1]
ENST00000519088; ENSP00000428853; ENSG00000254093 [Q96BK5-2]
GeneIDi54984
KEGGihsa:54984
UCSCiuc003wth.4 human [Q96BK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54984
DisGeNETi54984

GeneCards: human genes, protein and diseases

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GeneCardsi
PINX1
HGNCiHGNC:30046 PINX1
HPAiENSG00000254093 Low tissue specificity
MIMi606505 gene
neXtProtiNX_Q96BK5
OpenTargetsiENSG00000254093
PharmGKBiPA165585852

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2809 Eukaryota
ENOG4111IXK LUCA
GeneTreeiENSGT00450000040279
HOGENOMiCLU_047471_0_0_1
InParanoidiQ96BK5
KOiK11135
OMAiDPNNTKW
OrthoDBi1577610at2759
PhylomeDBiQ96BK5
TreeFamiTF321918

Enzyme and pathway databases

SIGNORiQ96BK5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PINX1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PINX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54984
PharosiQ96BK5 Tbio

Protein Ontology

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PROi
PR:Q96BK5
RNActiQ96BK5 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000254093 Expressed in quadriceps femoris and 192 other tissues
ExpressionAtlasiQ96BK5 baseline and differential
GenevisibleiQ96BK5 HS

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPINX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BK5
Secondary accession number(s): B2R9B1
, Q548A5, Q6QWG9, Q7Z7J8, Q96QD7, Q9HBU7, Q9NWW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: April 22, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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