UniProtKB - Q96BJ3 (AIDA_HUMAN)
Protein
Axin interactor, dorsalization-associated protein
Gene
AIDA
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).By similarity
GO - Molecular functioni
- phosphatidylinositol binding Source: GO_Central
- protein domain specific binding Source: Ensembl
GO - Biological processi
- determination of ventral identity Source: GO_Central
- dorsal/ventral pattern formation Source: UniProtKB
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of JUN kinase activity Source: MGI
- negative regulation of protein-containing complex assembly Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q96BJ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Axin interactor, dorsalization-associated proteinAlternative name(s): Axin interaction partner and dorsalization antagonist |
Gene namesi | Name:AIDA Synonyms:C1orf80 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186063.12 |
HGNCi | HGNC:25761, AIDA |
MIMi | 612375, gene |
neXtProti | NX_Q96BJ3 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 64853 |
OpenTargetsi | ENSG00000186063 |
PharmGKBi | PA162376104 |
Miscellaneous databases
Pharosi | Q96BJ3, Tbio |
Polymorphism and mutation databases
BioMutai | AIDA |
DMDMi | 74751770 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305277 | 1 – 306 | Axin interactor, dorsalization-associated proteinAdd BLAST | 306 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 144 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96BJ3 |
jPOSTi | Q96BJ3 |
MassIVEi | Q96BJ3 |
MaxQBi | Q96BJ3 |
PaxDbi | Q96BJ3 |
PeptideAtlasi | Q96BJ3 |
PRIDEi | Q96BJ3 |
ProteomicsDBi | 76080 [Q96BJ3-1] 76081 [Q96BJ3-2] 76082 [Q96BJ3-3] |
PTM databases
iPTMneti | Q96BJ3 |
PhosphoSitePlusi | Q96BJ3 |
SwissPalmi | Q96BJ3 |
Expressioni
Tissue specificityi
Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000186063, Expressed in layer of synovial tissue and 224 other tissues |
Genevisiblei | Q96BJ3, HS |
Organism-specific databases
HPAi | ENSG00000186063, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with AXIN1.
By similarityBinary interactionsi
Hide detailsQ96BJ3
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 122326, 19 interactors |
IntActi | Q96BJ3, 20 interactors |
MINTi | Q96BJ3 |
STRINGi | 9606.ENSP00000339161 |
Miscellaneous databases
RNActi | Q96BJ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 157 – 304 | C2 Aida-typePROSITE-ProRule annotationAdd BLAST | 148 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 221 | Axin-bindingBy similarityAdd BLAST | 68 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 27 – 62 | Sequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QSD5, Eukaryota |
GeneTreei | ENSGT00390000016465 |
HOGENOMi | CLU_064322_0_0_1 |
InParanoidi | Q96BJ3 |
OMAi | KLHAAWC |
OrthoDBi | 1196787at2759 |
PhylomeDBi | Q96BJ3 |
TreeFami | TF328541 |
Family and domain databases
Gene3Di | 1.20.120.360, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR025939, Aida_C IPR023421, AIDA_N IPR036818, AIDA_N_sf IPR035892, C2_domain_sf |
Pfami | View protein in Pfam PF14186, Aida_C2, 1 hit PF08910, Aida_N, 1 hit |
SUPFAMi | SSF109779, SSF109779, 1 hit |
PROSITEi | View protein in PROSITE PS51911, C2_AIDA, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96BJ3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH
60 70 80 90 100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN
110 120 130 140 150
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA
160 170 180 190 200
RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID
210 220 230 240 250
LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK
260 270 280 290 300
RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH
QTLHKE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | E → G in BAB14281 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028322 | 1 – 165 | Missing in isoform 2. 1 PublicationAdd BLAST | 165 | |
Alternative sequenceiVSP_034661 | 155 – 236 | Missing in isoform 3. CuratedAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022868 mRNA Translation: BAB14281.1 AK289865 mRNA Translation: BAF82554.1 AL392172 Genomic DNA No translation available. AL592148 Genomic DNA No translation available. BC015535 mRNA Translation: AAH15535.1 BC043142 mRNA Translation: AAH43142.1 BC067805 mRNA Translation: AAH67805.1 AL833718 mRNA Translation: CAH56257.1 |
CCDSi | CCDS1533.1 [Q96BJ3-1] |
RefSeqi | NP_073742.2, NM_022831.2 [Q96BJ3-1] |
Genome annotation databases
Ensembli | ENST00000340020; ENSP00000339161; ENSG00000186063 [Q96BJ3-1] ENST00000355727; ENSP00000347964; ENSG00000186063 [Q96BJ3-3] |
GeneIDi | 64853 |
KEGGi | hsa:64853 |
UCSCi | uc001hnn.4, human [Q96BJ3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022868 mRNA Translation: BAB14281.1 AK289865 mRNA Translation: BAF82554.1 AL392172 Genomic DNA No translation available. AL592148 Genomic DNA No translation available. BC015535 mRNA Translation: AAH15535.1 BC043142 mRNA Translation: AAH43142.1 BC067805 mRNA Translation: AAH67805.1 AL833718 mRNA Translation: CAH56257.1 |
CCDSi | CCDS1533.1 [Q96BJ3-1] |
RefSeqi | NP_073742.2, NM_022831.2 [Q96BJ3-1] |
3D structure databases
BMRBi | Q96BJ3 |
SMRi | Q96BJ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122326, 19 interactors |
IntActi | Q96BJ3, 20 interactors |
MINTi | Q96BJ3 |
STRINGi | 9606.ENSP00000339161 |
PTM databases
iPTMneti | Q96BJ3 |
PhosphoSitePlusi | Q96BJ3 |
SwissPalmi | Q96BJ3 |
Polymorphism and mutation databases
BioMutai | AIDA |
DMDMi | 74751770 |
Proteomic databases
EPDi | Q96BJ3 |
jPOSTi | Q96BJ3 |
MassIVEi | Q96BJ3 |
MaxQBi | Q96BJ3 |
PaxDbi | Q96BJ3 |
PeptideAtlasi | Q96BJ3 |
PRIDEi | Q96BJ3 |
ProteomicsDBi | 76080 [Q96BJ3-1] 76081 [Q96BJ3-2] 76082 [Q96BJ3-3] |
Protocols and materials databases
Antibodypediai | 34630, 127 antibodies |
Genome annotation databases
Ensembli | ENST00000340020; ENSP00000339161; ENSG00000186063 [Q96BJ3-1] ENST00000355727; ENSP00000347964; ENSG00000186063 [Q96BJ3-3] |
GeneIDi | 64853 |
KEGGi | hsa:64853 |
UCSCi | uc001hnn.4, human [Q96BJ3-1] |
Organism-specific databases
CTDi | 64853 |
DisGeNETi | 64853 |
EuPathDBi | HostDB:ENSG00000186063.12 |
GeneCardsi | AIDA |
HGNCi | HGNC:25761, AIDA |
HPAi | ENSG00000186063, Low tissue specificity |
MIMi | 612375, gene |
neXtProti | NX_Q96BJ3 |
OpenTargetsi | ENSG00000186063 |
PharmGKBi | PA162376104 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSD5, Eukaryota |
GeneTreei | ENSGT00390000016465 |
HOGENOMi | CLU_064322_0_0_1 |
InParanoidi | Q96BJ3 |
OMAi | KLHAAWC |
OrthoDBi | 1196787at2759 |
PhylomeDBi | Q96BJ3 |
TreeFami | TF328541 |
Enzyme and pathway databases
PathwayCommonsi | Q96BJ3 |
Miscellaneous databases
BioGRID-ORCSi | 64853, 31 hits in 820 CRISPR screens |
ChiTaRSi | AIDA, human |
GenomeRNAii | 64853 |
Pharosi | Q96BJ3, Tbio |
PROi | PR:Q96BJ3 |
RNActi | Q96BJ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186063, Expressed in layer of synovial tissue and 224 other tissues |
Genevisiblei | Q96BJ3, HS |
Family and domain databases
Gene3Di | 1.20.120.360, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR025939, Aida_C IPR023421, AIDA_N IPR036818, AIDA_N_sf IPR035892, C2_domain_sf |
Pfami | View protein in Pfam PF14186, Aida_C2, 1 hit PF08910, Aida_N, 1 hit |
SUPFAMi | SSF109779, SSF109779, 1 hit |
PROSITEi | View protein in PROSITE PS51911, C2_AIDA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AIDA_HUMAN | |
Accessioni | Q96BJ3Primary (citable) accession number: Q96BJ3 Secondary accession number(s): A8K1F0 Q9H9E8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM