AIDA

Functionⁱ

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).By similarity

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dorsal/ventral pattern formation Source: UniProtKB
negative regulation of JNK cascade Source: UniProtKB
negative regulation of JUN kinase activity
Source: MGI
Inferred from direct assayⁱ
- 17681137
regulation of protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein

Molecular function

Developmental protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Axin interactor, dorsalization-associated protein Alternative name(s): Axin interaction partner and dorsalization antagonist
Gene namesⁱ	Name:AIDA Synonyms:C1orf80
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186063.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25761 AIDA
MIMⁱ	612375 gene
neXtProtⁱ	NX_Q96BJ3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64853
Open Targets More...OpenTargetsⁱ	ENSG00000186063
PharmGKBⁱ	PA162376104

Polymorphism and mutation databases

BioMutaⁱ	AIDA
DMDMⁱ	74751770

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305277	1 – 306	Axin interactor, dorsalization-associated proteinAdd BLAST		306

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	144	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96BJ3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96BJ3
PaxDbⁱ	Q96BJ3
PeptideAtlas More...PeptideAtlasⁱ	Q96BJ3
PRIDEⁱ	Q96BJ3
ProteomicsDBⁱ	76080 76081 [Q96BJ3-2] 76082 [Q96BJ3-3]

PTM databases

iPTMnetⁱ	Q96BJ3
PhosphoSitePlusⁱ	Q96BJ3
SwissPalmⁱ	Q96BJ3

Expressionⁱ

Tissue specificityⁱ

Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000186063 Expressed in 210 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_AIDA
Genevisibleⁱ	Q96BJ3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027935

HPAⁱ

HPA027935

Interactionⁱ

Subunit structureⁱ

Interacts with AXIN1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FAM118A	Q9NWS6	5	EBI-4401674,EBI-8638992
LNX1	Q8TBB1	3	EBI-4401674,EBI-739832

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122326, 14 interactors
IntActⁱ	Q96BJ3, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q96BJ3
STRINGⁱ	9606.ENSP00000339161

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96BJ3
SMRⁱ	Q96BJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	154 – 221	Axin-bindingBy similarityAdd BLAST		68

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	27 – 62	Sequence analysisAdd BLAST		36

Sequence similaritiesⁱ

Belongs to the AIDA family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IJ07 Eukaryota ENOG410YXX7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016465
HOGENOMⁱ	HOG000006666
HOVERGENⁱ	HBG057354
InParanoidⁱ	Q96BJ3
OMAⁱ	SQHNNSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GXU
PhylomeDBⁱ	Q96BJ3
TreeFamⁱ	TF328541

Family and domain databases

Gene3Dⁱ	1.20.120.360, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR025939 Aida_C IPR023421 AIDA_N IPR036818 AIDA_N_sf IPR035892 C2_domain_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14186 Aida_C2, 1 hit PF08910 Aida_N, 1 hit
SUPFAMⁱ	SSF109779 SSF109779, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q96BJ3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH 
        60         70         80         90        100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN 
       110        120        130        140        150
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA 
       160        170        180        190        200
RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID 
       210        220        230        240        250
LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK 
       260        270        280        290        300
RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH 

QTLHKE

Length:306

Mass (Da):35,023

Last modified:December 1, 2001 - v1

Checksum:ⁱ48E563CEEC398ECC

GO

Isoform 2 (identifier: Q96BJ3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-165: Missing.

« Hide

        10         20         30         40         50
MTLLTIRIEK IGLKDAGQCI DPYITVSVKD LNGIDLTPVQ DTPVASRKED 
        60         70         80         90        100
TYVHFNVDIE LQKHVEKLTK GAAIFFEFKH YKPKKRFTST KCFAFMEMDE 
       110        120        130        140 
IKPGPIVIEL YKKPTDFKRK KLQLLTKKPL YLHLHQTLHK E

Note: No experimental confirmation available.

Show »

Length:141

Mass (Da):16,444

Checksum:ⁱ7934104EAB68EED2

GO

Isoform 3 (identifier: Q96BJ3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
155-236: Missing.

« Hide

        10         20         30         40         50
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH 
        60         70         80         90        100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN 
       110        120        130        140        150
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA 
       160        170        180        190        200
RVPGAAIFFE FKHYKPKKRF TSTKCFAFME MDEIKPGPIV IELYKKPTDF 
       210        220 
KRKKLQLLTK KPLYLHLHQT LHKE

Note: No experimental confirmation available.

Show »

Length:224

Mass (Da):25,914

Checksum:ⁱFF95596B7B9C0385

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	130	E → G in BAB14281 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028322	1 – 165	Missing in isoform 2. 1 PublicationAdd BLAST		165
Alternative sequenceⁱVSP_034661	155 – 236	Missing in isoform 3. CuratedAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022868 mRNA Translation: BAB14281.1 AK289865 mRNA Translation: BAF82554.1 AL392172 Genomic DNA No translation available. AL592148 Genomic DNA No translation available. BC015535 mRNA Translation: AAH15535.1 BC043142 mRNA Translation: AAH43142.1 BC067805 mRNA Translation: AAH67805.1 AL833718 mRNA Translation: CAH56257.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1533.1 [Q96BJ3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_073742.2, NM_022831.2 [Q96BJ3-1]
UniGeneⁱ	Hs.156625 Hs.534965

Genome annotation databases

Ensemblⁱ	ENST00000340020; ENSP00000339161; ENSG00000186063 [Q96BJ3-1] ENST00000355727; ENSP00000347964; ENSG00000186063 [Q96BJ3-3]
GeneIDⁱ	64853
KEGGⁱ	hsa:64853
UCSC genome browser More...UCSCⁱ	uc001hnn.4 human [Q96BJ3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q96BJ3	Axin interactor, dorsalization-associated protein		PONAB		306	UniRef100_Q96BJ3
AIDA isoform 1		PANTR		306
Axin interactor, dorsalization-associated protein		MACMU		306
Axin interactor, dorsalization-associated protein		CALJA		306
Uncharacterized protein		SHEEP		306
+17
Q96BJ3-2	Uncharacterized protein		PANTR		141	UniRef100_G2HE81
Uncharacterized protein		COLAP		141
Uncharacterized protein		PANPA		141
axin interactor, dorsalization-associated protein isoform X2		Florida manatee		141
Uncharacterized protein		MANLE		141
+3
Q96BJ3-3	AIDA isoform 4		PANTR		224	UniRef100_A0A2I3SQL3
Axin interactor, dorsalization associated		SAIBB		224
Uncharacterized protein		MACMU		224
Uncharacterized protein		Cebus capucinus imitator		224
AIDA isoform 4		PONAB		224
+8

Protein	Similar proteins		Species	Score	Length	Source
Q96BJ3	Axin interactor, dorsalization-associated protein	)	MOUSE		305	UniRef90_Q8C4Q6
Axin interactor, dorsalization-associated protein		PONAB		306
Uncharacterized protein		MONDO		367
Axin interactor, dorsalization-associated protein		wild yak		322
Uncharacterized protein		CROHD		310
+128
Q96BJ3-2	Uncharacterized protein		PANTR		141	UniRef90_G2HE81
Uncharacterized protein		COLAP		141
Uncharacterized protein		PANPA		141
axin interactor, dorsalization-associated protein isoform X2		Florida manatee		141
Uncharacterized protein		MANLE		141
+3
Q96BJ3-3	Isoform 2 of Axin interactor, dorsalization-associated protein		MOUSE		223	UniRef90_Q8C4Q6-2
AIDA isoform 4		PANTR		224
Axin interactor, dorsalization associated		SAIBB		224
Uncharacterized protein		MACMU		224
Uncharacterized protein		Cebus capucinus imitator		224
+15

Protein	Similar proteins		Species	Score	Length	Source
Q96BJ3	Axin interactor, dorsalization-associated protein	)	MOUSE		305	UniRef50_Q8C4Q6
Axin interactor, dorsalization-associated protein		PONAB		306
Axin interactor, dorsalization-associated protein		MACFA		275
Uncharacterized protein		MONDO		367
Axin interactor, dorsalization-associated protein		wild yak		322
+216
Q96BJ3-2	Axin interactor, dorsalization-associated protein (Fragment)		FUNHE		444	UniRef50_A0A147A212
Uncharacterized protein		PANTR		141
Uncharacterized protein		COLAP		141
Uncharacterized protein		PANPA		141
axin interactor, dorsalization-associated protein isoform X2		Florida manatee		141
+7
Q96BJ3-3	Isoform 2 of Axin interactor, dorsalization-associated protein		MOUSE		223	UniRef50_Q8C4Q6-2
Uncharacterized protein		CAVPO		224
Uncharacterized protein		LOXAF		224
Uncharacterized protein		RHIBE		224
Uncharacterized protein		FELCA		224
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022868 mRNA Translation: BAB14281.1 AK289865 mRNA Translation: BAF82554.1 AL392172 Genomic DNA No translation available. AL592148 Genomic DNA No translation available. BC015535 mRNA Translation: AAH15535.1 BC043142 mRNA Translation: AAH43142.1 BC067805 mRNA Translation: AAH67805.1 AL833718 mRNA Translation: CAH56257.1
CCDSⁱ	CCDS1533.1 [Q96BJ3-1]
RefSeqⁱ	NP_073742.2, NM_022831.2 [Q96BJ3-1]
UniGeneⁱ	Hs.156625 Hs.534965

3D structure databases

ProteinModelPortalⁱ	Q96BJ3
SMRⁱ	Q96BJ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122326, 14 interactors
IntActⁱ	Q96BJ3, 13 interactors
MINTⁱ	Q96BJ3
STRINGⁱ	9606.ENSP00000339161

PTM databases

iPTMnetⁱ	Q96BJ3
PhosphoSitePlusⁱ	Q96BJ3
SwissPalmⁱ	Q96BJ3

Polymorphism and mutation databases

BioMutaⁱ	AIDA
DMDMⁱ	74751770

Proteomic databases

EPDⁱ	Q96BJ3
MaxQBⁱ	Q96BJ3
PaxDbⁱ	Q96BJ3
PeptideAtlasⁱ	Q96BJ3
PRIDEⁱ	Q96BJ3
ProteomicsDBⁱ	76080 76081 [Q96BJ3-2] 76082 [Q96BJ3-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340020; ENSP00000339161; ENSG00000186063 [Q96BJ3-1] ENST00000355727; ENSP00000347964; ENSG00000186063 [Q96BJ3-3]
GeneIDⁱ	64853
KEGGⁱ	hsa:64853
UCSCⁱ	uc001hnn.4 human [Q96BJ3-1]

Organism-specific databases

CTDⁱ	64853
DisGeNETⁱ	64853
EuPathDBⁱ	HostDB:ENSG00000186063.12
GeneCardsⁱ	AIDA
H-InvDBⁱ	HIX0001616 HIX0028617
HGNCⁱ	HGNC:25761 AIDA
HPAⁱ	HPA027935
MIMⁱ	612375 gene
neXtProtⁱ	NX_Q96BJ3
OpenTargetsⁱ	ENSG00000186063
PharmGKBⁱ	PA162376104
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ07 Eukaryota ENOG410YXX7 LUCA
GeneTreeⁱ	ENSGT00390000016465
HOGENOMⁱ	HOG000006666
HOVERGENⁱ	HBG057354
InParanoidⁱ	Q96BJ3
OMAⁱ	SQHNNSE
OrthoDBⁱ	EOG091G0GXU
PhylomeDBⁱ	Q96BJ3
TreeFamⁱ	TF328541

Miscellaneous databases

GenomeRNAiⁱ	64853
Protein Ontology More...PROⁱ	PR:Q96BJ3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186063 Expressed in 210 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_AIDA
Genevisibleⁱ	Q96BJ3 HS

Family and domain databases

Gene3Dⁱ	1.20.120.360, 1 hit 2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR025939 Aida_C IPR023421 AIDA_N IPR036818 AIDA_N_sf IPR035892 C2_domain_sf
Pfamⁱ	View protein in Pfam PF14186 Aida_C2, 1 hit PF08910 Aida_N, 1 hit
SUPFAMⁱ	SSF109779 SSF109779, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AIDA_HUMAN
Accessionⁱ	Q96BJ3Primary (citable) accession number: Q96BJ3 Secondary accession number(s): A8K1F0 , Q49A81, Q5JRA4, Q658P1, Q9H9E8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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UniProtKB - Q96BJ3 (AIDA_HUMAN)

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Axin interactor, dorsalization-associated protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ