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Entry version 157 (07 Oct 2020)
Sequence version 3 (26 May 2009)
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Protein

Solute carrier family 22 member 18

Gene

SLC22A18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.1 Publication

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Symport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96BI1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-549127, Organic cation transport
R-HSA-5619066, Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.2.53, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 18
Alternative name(s):
Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein
Efflux transporter-like protein
Imprinted multi-membrane-spanning polyspecific transporter-related protein 1
Organic cation transporter-like protein 2
Short name:
ORCTL-2
Solute carrier family 22 member 1-like
Tumor-suppressing STF cDNA 5 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein
p45-Beckwith-Wiedemann region 1 A
Short name:
p45-BWR1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A18
Synonyms:BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000110628.13

Human Gene Nomenclature Database

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HGNCi
HGNC:10964, SLC22A18

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602631, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96BI1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lung cancer (LNCR)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Related information in OMIM
Rhabdomyosarcoma, embryonal, 1 (RMSE1)
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Related information in OMIM

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5002

MalaCards human disease database

More...
MalaCardsi
SLC22A18
MIMi114480, phenotype
211980, phenotype
268210, phenotype

Open Targets

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OpenTargetsi
ENSG00000110628

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99757, Embryonal rhabdomyosarcoma
227535, Hereditary breast cancer

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35846

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96BI1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC22A18

Domain mapping of disease mutations (DMDM)

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DMDMi
238054368

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205091 – 424Solute carrier family 22 member 18Add BLAST424

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96BI1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96BI1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96BI1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96BI1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96BI1

PeptideAtlas

More...
PeptideAtlasi
Q96BI1

PRoteomics IDEntifications database

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PRIDEi
Q96BI1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76077

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96BI1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96BI1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110628, Expressed in mucosa of transverse colon and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96BI1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96BI1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110628, Tissue enhanced (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNF167.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111044, 31 interactors

Protein interaction database and analysis system

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IntActi
Q96BI1, 34 interactors

Molecular INTeraction database

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MINTi
Q96BI1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369948

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96BI1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT94, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000160333

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001265_10_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96BI1

KEGG Orthology (KO)

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KOi
K08214

Identification of Orthologs from Complete Genome Data

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OMAi
HPAMLFI

Database of Orthologous Groups

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OrthoDBi
1090653at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96BI1

TreeFam database of animal gene trees

More...
TreeFami
TF352510

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR001958, Tet-R_TetA/multi-R_MdtG

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01035, TCRTETA

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96BI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL
60 70 80 90 100
SRKLGLDSIA FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL
110 120 130 140 150
ALYLLLAAAS SPALPGVYLL FASRLPGALM HTLPAAQMVI TDLSAPEERP
160 170 180 190 200
AALGRLGLCF GVGVILGSLL GGTLVSAYGI QCPAILAALA TLLGAVLSFT
210 220 230 240 250
CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV PRIFLVKVAS
260 270 280 290 300
NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS
310 320 330 340 350
HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD
360 370 380 390 400
SMLIKAVSTS DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ
410 420
VAINTLVLLV LWRKPMPQRK DKVR
Length:424
Mass (Da):44,846
Last modified:May 26, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EFD5F902A77A6E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRM7E9PRM7_HUMAN
Solute carrier family 22 member 18
SLC22A18
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A024RCG2A0A024RCG2_HUMAN
Solute carrier family 22 (Organic c...
SLC22A18 hCG_16433
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWM3A0A0J9YWM3_HUMAN
Solute carrier family 22 member 18
SLC22A18
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMN7E9PMN7_HUMAN
Solute carrier family 22 member 18
SLC22A18
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXN9A0A0J9YXN9_HUMAN
Solute carrier family 22 member 18
SLC22A18
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB82727 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA32779 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84D → N in AAC17492 (PubMed:9520460).Curated1
Sequence conflicti227D → E in AAB82727 (PubMed:9499412).Curated1
Sequence conflicti227D → E in AAC23505 (Ref. 6) Curated1
Sequence conflicti230A → G in AAB82727 (PubMed:9499412).Curated1
Sequence conflicti230A → G in AAC23505 (Ref. 6) Curated1
Sequence conflicti242R → K in AAB82727 (PubMed:9499412).Curated1
Sequence conflicti242R → K in AAC23505 (Ref. 6) Curated1
Sequence conflicti275Q → K in AAB82727 (PubMed:9499412).Curated1
Sequence conflicti275Q → K in AAC23505 (Ref. 6) Curated1
Sequence conflicti307L → M in AAC04787 (PubMed:9570947).Curated1
Sequence conflicti309R → G in AAB82727 (PubMed:9499412).Curated1
Sequence conflicti309R → G in AAC23505 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0554066A → T1 PublicationCorresponds to variant dbSNP:rs1048046Ensembl.1
Natural variantiVAR_05540712R → Q4 PublicationsCorresponds to variant dbSNP:rs1048047Ensembl.1
Natural variantiVAR_02406186R → C in a rhabdomyosarcoma sample. 1 Publication1
Natural variantiVAR_024062233S → F in lung cancer; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121909071EnsemblClinVar.1
Natural variantiVAR_024063309R → Q1 PublicationCorresponds to variant dbSNP:rs141165353Ensembl.1
Natural variantiVAR_055408324W → C. Corresponds to variant dbSNP:rs1129782Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF059663 mRNA Translation: AAC14725.1
AB012083 mRNA Translation: BAA32779.1 Different initiation.
AF037064 mRNA Translation: AAC04787.1
AF028738 mRNA Translation: AAB82727.1 Different initiation.
AF030302 mRNA Translation: AAC17492.1
AF070479 mRNA Translation: AAC23505.1
BC015571 mRNA Translation: AAH15571.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7740.1

NCBI Reference Sequences

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RefSeqi
NP_001302430.1, NM_001315501.1
NP_001302431.1, NM_001315502.1
NP_002546.3, NM_002555.5
NP_899056.2, NM_183233.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347936; ENSP00000307859; ENSG00000110628
ENST00000380574; ENSP00000369948; ENSG00000110628
ENST00000649076; ENSP00000497561; ENSG00000110628

Database of genes from NCBI RefSeq genomes

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GeneIDi
5002

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5002

UCSC genome browser

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UCSCi
uc001lwx.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059663 mRNA Translation: AAC14725.1
AB012083 mRNA Translation: BAA32779.1 Different initiation.
AF037064 mRNA Translation: AAC04787.1
AF028738 mRNA Translation: AAB82727.1 Different initiation.
AF030302 mRNA Translation: AAC17492.1
AF070479 mRNA Translation: AAC23505.1
BC015571 mRNA Translation: AAH15571.1
CCDSiCCDS7740.1
RefSeqiNP_001302430.1, NM_001315501.1
NP_001302431.1, NM_001315502.1
NP_002546.3, NM_002555.5
NP_899056.2, NM_183233.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi111044, 31 interactors
IntActiQ96BI1, 34 interactors
MINTiQ96BI1
STRINGi9606.ENSP00000369948

Protein family/group databases

TCDBi2.A.1.2.53, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ96BI1
PhosphoSitePlusiQ96BI1

Polymorphism and mutation databases

BioMutaiSLC22A18
DMDMi238054368

Proteomic databases

EPDiQ96BI1
jPOSTiQ96BI1
MassIVEiQ96BI1
MaxQBiQ96BI1
PaxDbiQ96BI1
PeptideAtlasiQ96BI1
PRIDEiQ96BI1
ProteomicsDBi76077

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23193, 132 antibodies

The DNASU plasmid repository

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DNASUi
5002

Genome annotation databases

EnsembliENST00000347936; ENSP00000307859; ENSG00000110628
ENST00000380574; ENSP00000369948; ENSG00000110628
ENST00000649076; ENSP00000497561; ENSG00000110628
GeneIDi5002
KEGGihsa:5002
UCSCiuc001lwx.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5002
DisGeNETi5002
EuPathDBiHostDB:ENSG00000110628.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A18
HGNCiHGNC:10964, SLC22A18
HPAiENSG00000110628, Tissue enhanced (intestine, liver)
MalaCardsiSLC22A18
MIMi114480, phenotype
211980, phenotype
268210, phenotype
602631, gene
neXtProtiNX_Q96BI1
OpenTargetsiENSG00000110628
Orphaneti99757, Embryonal rhabdomyosarcoma
227535, Hereditary breast cancer
PharmGKBiPA35846

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QT94, Eukaryota
GeneTreeiENSGT00940000160333
HOGENOMiCLU_001265_10_1_1
InParanoidiQ96BI1
KOiK08214
OMAiHPAMLFI
OrthoDBi1090653at2759
PhylomeDBiQ96BI1
TreeFamiTF352510

Enzyme and pathway databases

PathwayCommonsiQ96BI1
ReactomeiR-HSA-549127, Organic cation transport
R-HSA-5619066, Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5002, 4 hits in 886 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC22A18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5002
PharosiQ96BI1, Tbio

Protein Ontology

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PROi
PR:Q96BI1
RNActiQ96BI1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110628, Expressed in mucosa of transverse colon and 186 other tissues
ExpressionAtlasiQ96BI1, baseline and differential
GenevisibleiQ96BI1, HS

Family and domain databases

InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR001958, Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
PRINTSiPR01035, TCRTETA
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22AI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BI1
Secondary accession number(s): O14906
, O43562, O60485, O60680, Q7LDS5, Q7LGF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 26, 2009
Last modified: October 7, 2020
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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