UniProtKB - Q96BF3 (TMIG2_HUMAN)
Protein
Transmembrane and immunoglobulin domain-containing protein 2
Gene
TMIGD2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.2 Publications
GO - Molecular functioni
- coreceptor activity Source: UniProtKB
GO - Biological processi
- immune response Source: GO_Central
- immunoglobulin production Source: GO_Central
- positive regulation of activated T cell proliferation Source: UniProtKB
- positive regulation of angiogenesis Source: CACAO
- positive regulation of cytokine production Source: UniProtKB
- T cell costimulation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q96BF3 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane and immunoglobulin domain-containing protein 2Alternative name(s): CD28 homolog Immunoglobulin and proline-rich receptor 1 Short name: IGPR-1 |
Gene namesi | Name:TMIGD2 Synonyms:CD28H, IGPR1 ORF Names:UNQ3059/PRO9879 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167664.8 |
HGNCi | HGNC:28324, TMIGD2 |
MIMi | 614715, gene |
neXtProti | NX_Q96BF3 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 150 | ExtracellularSequence analysisAdd BLAST | 128 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 282 | CytoplasmicSequence analysisAdd BLAST | 111 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 192 | Y → F: Partial loss of phosphorylation; when associated with F-197. Complete loss of phosphorylation; when associated with F-222. 1 Publication | 1 | |
Mutagenesisi | 197 | Y → F: Partial loss of phosphorylation; when associated with F-192 or with F-222. 1 Publication | 1 | |
Mutagenesisi | 222 | Y → F: Partial loss of phosphorylation; when tested individually or when associated with F-197. Complete loss of phosphorylation; when associated with F-192. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 126259 |
OpenTargetsi | ENSG00000167664 |
PharmGKBi | PA145148047 |
Miscellaneous databases
Pharosi | Q96BF3, Tbio |
Polymorphism and mutation databases
BioMutai | TMIGD2 |
DMDMi | 125991218 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000275870 | 23 – 282 | Transmembrane and immunoglobulin domain-containing protein 2Add BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 112 | PROSITE-ProRule annotation | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 192 | PhosphotyrosineCurated | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 222 | PhosphotyrosineCurated | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q96BF3 |
PaxDbi | Q96BF3 |
PeptideAtlasi | Q96BF3 |
PRIDEi | Q96BF3 |
ProteomicsDBi | 76072 [Q96BF3-1] 76073 [Q96BF3-2] |
PTM databases
GlyGeni | Q96BF3, 3 sites |
iPTMneti | Q96BF3 |
PhosphoSitePlusi | Q96BF3 |
SwissPalmi | Q96BF3 |
Expressioni
Tissue specificityi
Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double-negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).2 Publications
Developmental stagei
Repetitive stimulation of naive T-cells, including with IL2 and antibodies against CD3 and CD28 or repetitive antigenic exposure, leads to progressive and irreversible loss of expression.1 Publication
Gene expression databases
Bgeei | ENSG00000167664, Expressed in quadriceps femoris and 203 other tissues |
ExpressionAtlasi | Q96BF3, baseline and differential |
Genevisiblei | Q96BF3, HS |
Organism-specific databases
HPAi | ENSG00000167664, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
May form homophilic interactions that could regulate cell-cell interaction.
Interacts with CACNB2, DST, MIA and NCKIPSD.
Interacts with HHLA2.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 125971, 1 interactor |
STRINGi | 9606.ENSP00000301272 |
Miscellaneous databases
RNActi | Q96BF3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 129 | Ig-likeAdd BLAST | 107 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 227 – 277 | Pro-richAdd BLAST | 51 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SX6X, Eukaryota |
GeneTreei | ENSGT00390000007100 |
HOGENOMi | CLU_1008198_0_0_1 |
InParanoidi | Q96BF3 |
OMAi | CWAAVEI |
OrthoDBi | 1383523at2759 |
PhylomeDBi | Q96BF3 |
TreeFami | TF341425 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96BF3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSPGMVLGL LVQIWALQEA SSLSVQQGPN LLQVRQGSQA TLVCQVDQAT
60 70 80 90 100
AWERLRVKWT KDGAILCQPY ITNGSLSLGV CGPQGRLSWQ APSHLTLQLD
110 120 130 140 150
PVSLNHSGAY VCWAAVEIPE LEEAEGNITR LFVDPDDPTQ NRNRIASFPG
160 170 180 190 200
FLFVLLGVGS MGVAAIVWGA WFWGRRSCQQ RDSGNSPGNA FYSNVLYRPR
210 220 230 240 250
GAPKKSEDCS GEGKDQRGQS IYSTSFPQPA PRQPHLASRP CPSPRPCPSP
260 270 280
RPGHPVSMVR VSPRPSPTQQ PRPKGFPKVG EE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J2A9 | A0A0B4J2A9_HUMAN | Transmembrane and immunoglobulin do... | TMIGD2 | 162 | Annotation score: | ||
A0A0B4J2B0 | A0A0B4J2B0_HUMAN | Transmembrane and immunoglobulin do... | TMIGD2 | 110 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061328 | 168 | W → L. Corresponds to variant dbSNP:rs58237134Ensembl. | 1 | |
Natural variantiVAR_030469 | 202 | A → P1 PublicationCorresponds to variant dbSNP:rs28477168Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022967 | 186 – 189 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358964 mRNA Translation: AAQ89323.1 BC015655 mRNA Translation: AAH15655.1 |
CCDSi | CCDS12126.1 [Q96BF3-1] CCDS59334.1 [Q96BF3-2] |
RefSeqi | NP_001162597.1, NM_001169126.1 [Q96BF3-2] NP_001295161.1, NM_001308232.1 NP_653216.2, NM_144615.2 [Q96BF3-1] |
Genome annotation databases
Ensembli | ENST00000301272; ENSP00000301272; ENSG00000167664 [Q96BF3-1] ENST00000595645; ENSP00000470561; ENSG00000167664 [Q96BF3-2] |
GeneIDi | 126259 |
KEGGi | hsa:126259 |
UCSCi | uc002lzx.3, human [Q96BF3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358964 mRNA Translation: AAQ89323.1 BC015655 mRNA Translation: AAH15655.1 |
CCDSi | CCDS12126.1 [Q96BF3-1] CCDS59334.1 [Q96BF3-2] |
RefSeqi | NP_001162597.1, NM_001169126.1 [Q96BF3-2] NP_001295161.1, NM_001308232.1 NP_653216.2, NM_144615.2 [Q96BF3-1] |
3D structure databases
SMRi | Q96BF3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125971, 1 interactor |
STRINGi | 9606.ENSP00000301272 |
PTM databases
GlyGeni | Q96BF3, 3 sites |
iPTMneti | Q96BF3 |
PhosphoSitePlusi | Q96BF3 |
SwissPalmi | Q96BF3 |
Polymorphism and mutation databases
BioMutai | TMIGD2 |
DMDMi | 125991218 |
Proteomic databases
MassIVEi | Q96BF3 |
PaxDbi | Q96BF3 |
PeptideAtlasi | Q96BF3 |
PRIDEi | Q96BF3 |
ProteomicsDBi | 76072 [Q96BF3-1] 76073 [Q96BF3-2] |
Protocols and materials databases
ABCDi | Q96BF3, 15 sequenced antibodies |
Antibodypediai | 2599, 213 antibodies |
Genome annotation databases
Ensembli | ENST00000301272; ENSP00000301272; ENSG00000167664 [Q96BF3-1] ENST00000595645; ENSP00000470561; ENSG00000167664 [Q96BF3-2] |
GeneIDi | 126259 |
KEGGi | hsa:126259 |
UCSCi | uc002lzx.3, human [Q96BF3-1] |
Organism-specific databases
CTDi | 126259 |
DisGeNETi | 126259 |
EuPathDBi | HostDB:ENSG00000167664.8 |
GeneCardsi | TMIGD2 |
HGNCi | HGNC:28324, TMIGD2 |
HPAi | ENSG00000167664, Group enriched (blood, lymphoid tissue) |
MIMi | 614715, gene |
neXtProti | NX_Q96BF3 |
OpenTargetsi | ENSG00000167664 |
PharmGKBi | PA145148047 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SX6X, Eukaryota |
GeneTreei | ENSGT00390000007100 |
HOGENOMi | CLU_1008198_0_0_1 |
InParanoidi | Q96BF3 |
OMAi | CWAAVEI |
OrthoDBi | 1383523at2759 |
PhylomeDBi | Q96BF3 |
TreeFami | TF341425 |
Enzyme and pathway databases
PathwayCommonsi | Q96BF3 |
Miscellaneous databases
BioGRID-ORCSi | 126259, 12 hits in 842 CRISPR screens |
GenomeRNAii | 126259 |
Pharosi | Q96BF3, Tbio |
PROi | PR:Q96BF3 |
RNActi | Q96BF3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167664, Expressed in quadriceps femoris and 203 other tissues |
ExpressionAtlasi | Q96BF3, baseline and differential |
Genevisiblei | Q96BF3, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMIG2_HUMAN | |
Accessioni | Q96BF3Primary (citable) accession number: Q96BF3 Secondary accession number(s): Q6UW59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations