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Entry version 165 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 1

Gene

CREB3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).By similarity3 Publications
(Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processHost-virus interaction, Transcription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96BA8

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8874211, CREB3 factors activate genes

SIGNOR Signaling Network Open Resource

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SIGNORi
Q96BA8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 1
Short name:
cAMP-responsive element-binding protein 3-like protein 1
Alternative name(s):
Old astrocyte specifically-induced substance
Short name:
OASIS
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CREB3L1
Synonyms:OASIS
ORF Names:PSEC0238
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157613.10

Human Gene Nomenclature Database

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HGNCi
HGNC:18856, CREB3L1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616215, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96BA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 374CytoplasmicSequence analysisAdd BLAST374
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei375 – 395Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini396 – 519LumenalSequence analysisAdd BLAST124

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteogenesis imperfecta 16 (OI16)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry. OI16 affected patients show a genomic deletion encompassing CREB3L1 and the first exon of DGKZ. The absence of this exon does not affect all DGKZ isoforms, some are still produced at normal level. It cannot be ruled out that DGKZ could contribute to the phenotype, but in view of its role in bone formation, CREB3L1 is a strong OI16-causing candidate (PubMed:24079343). This hypothesis is corroborated by the observation of CREB3L1 knockout mice which exhibit features reminiscent of severe human osteogenesis imperfecta.1 Publication
Disease descriptionAn autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI16 is a severe form.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi392P → A: Abolishes proteolytic cleavage by S2P; when associated with A-395. 1 Publication1
Mutagenesisi392P → L: Abolishes proteolytic cleavage by S2P. 1 Publication1
Mutagenesisi395P → A: Abolishes proteolytic cleavage by S2P; when associated with A-392. 1 Publication1
Mutagenesisi423R → A: Abolishes proteolytic cleavage by S1P. 2 Publications1
Mutagenesisi426L → V: Abolishes proteolytic cleavage by S1P. 1 Publication1

Keywords - Diseasei

Osteogenesis imperfecta

Organism-specific databases

DisGeNET

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DisGeNETi
90993

MalaCards human disease database

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MalaCardsi
CREB3L1
MIMi616229, phenotype

Open Targets

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OpenTargetsi
ENSG00000157613

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
79105, Myxofibrosarcoma
216812, Osteogenesis imperfecta type 3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134960108

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q96BA8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CREB3L1

Domain mapping of disease mutations (DMDM)

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DMDMi
74751763

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880641 – 519Cyclic AMP-responsive element-binding protein 3-like protein 1Add BLAST519
ChainiPRO_00002962061 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). RIP is induced by TGFB1 and ceramide (PubMed:25310401, PubMed:27499293).4 Publications
N-glycosylated.By similarity
Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L1 is stabilized.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei426 – 427Cleavage; by S1PBy similarity2

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96BA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96BA8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96BA8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96BA8

PeptideAtlas

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PeptideAtlasi
Q96BA8

PRoteomics IDEntifications database

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PRIDEi
Q96BA8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76059 [Q96BA8-1]
76060 [Q96BA8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q96BA8, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96BA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96BA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several tissues, with highest levels in pancreas and prostate. Expressed at relatively lower levels in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000157613, Expressed in pancreas and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96BA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96BA8, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000157613, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD4, the interaction takes place upon TGFB1 induction and SMAD4 acts as CREB3L1 coactivator to induce the expression of genes involved in assembly of collagen extracellular matrix.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96BA8
With#Exp.IntAct
ADAM33 [Q08AM2]3EBI-6942903,EBI-10225815
ADGRE2 [Q9UHX3]3EBI-6942903,EBI-11277970
ADIPOQ [Q15848]3EBI-6942903,EBI-10827839
AGPAT3 [Q9NRZ7]3EBI-6942903,EBI-2803601
AGPAT4 [Q9NRZ5]3EBI-6942903,EBI-1754287
AGPAT5 [Q9NUQ2]3EBI-6942903,EBI-6916385
ALG8 [Q9BVK2]3EBI-6942903,EBI-3921603
ANKRD46 - isoform 1 [Q86W74-2]3EBI-6942903,EBI-12109402
AOC3 [Q16853]3EBI-6942903,EBI-3921628
APOD [P05090]3EBI-6942903,EBI-715495
AQP10 [Q96PS8]3EBI-6942903,EBI-12820279
AQP2 [P41181]3EBI-6942903,EBI-12701138
ARV1 [Q9H2C2]3EBI-6942903,EBI-11724186
ASGR1 [P07306]3EBI-6942903,EBI-1172335
BET1 [O15155]3EBI-6942903,EBI-749204
BMP10 [O95393]3EBI-6942903,EBI-3922513
BNIP3 [Q12983]3EBI-6942903,EBI-749464
BRICD5 - isoform 2 [Q6PL45-2]3EBI-6942903,EBI-12244618
C11orf24 [Q96F05]3EBI-6942903,EBI-2836238
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-6942903,EBI-12003442
C5 [P01031]3EBI-6942903,EBI-8558308
CCL4L2 [Q8NHW4]3EBI-6942903,EBI-10271156
CD53 [P19397]5EBI-6942903,EBI-6657396
CD72 [P21854]5EBI-6942903,EBI-307924
CD99L2 [A0A0S2Z5R8]3EBI-6942903,EBI-16434925
CFHR5 [Q9BXR6]6EBI-6942903,EBI-11579371
CIAO2A [Q9H5X1]5EBI-6942903,EBI-752069
CLN6 [Q9NWW5]5EBI-6942903,EBI-6165897
CMTM3 [Q96MX0]3EBI-6942903,EBI-7247651
CMTM7 [Q96FZ5]3EBI-6942903,EBI-2807956
CNIH2 [Q6PI25]3EBI-6942903,EBI-12815321
COL8A2 [Q4VAQ0]3EBI-6942903,EBI-10241815
COMT [P21964]3EBI-6942903,EBI-372265
COX20 [Q5RI15]3EBI-6942903,EBI-2834035
CSGALNACT2 [Q8N6G5]3EBI-6942903,EBI-10267100
CTXN3 [Q4LDR2]3EBI-6942903,EBI-12019274
CYB561D2 [O14569]3EBI-6942903,EBI-717654
CYP4F2 [P78329]3EBI-6942903,EBI-1752413
DOLK [Q9UPQ8]3EBI-6942903,EBI-8645574
EBP [Q15125]5EBI-6942903,EBI-3915253
EMP3 [P54852]3EBI-6942903,EBI-3907816
ENTPD3 - isoform 2 [O75355-2]3EBI-6942903,EBI-12279764
ERG28 [Q9UKR5]3EBI-6942903,EBI-711490
ERMP1 [Q7Z2K6]3EBI-6942903,EBI-10976398
FA2H [Q7L5A8]3EBI-6942903,EBI-11337888
FAM3C [Q92520]4EBI-6942903,EBI-2876774
FAXDC2 [Q96IV6]3EBI-6942903,EBI-12142299
FETUB [Q9UGM5]3EBI-6942903,EBI-13049494
FXYD3 - isoform 3 [Q14802-3]3EBI-6942903,EBI-12175685
FXYD6 [Q9H0Q3]6EBI-6942903,EBI-713304
GAST [P01350]5EBI-6942903,EBI-3436637
GIMAP1 [Q8WWP7]3EBI-6942903,EBI-11991950
GIMAP5 [Q96F15]3EBI-6942903,EBI-6166686
GOLT1B [Q9Y3E0]3EBI-6942903,EBI-4402607
GOSR2 [O14653]5EBI-6942903,EBI-4401517
GPR151 [Q8TDV0]3EBI-6942903,EBI-11955647
GPR25 [O00155]7EBI-6942903,EBI-10178951
GPR37L1 [O60883]3EBI-6942903,EBI-2927498
HACD2 [Q6Y1H2]3EBI-6942903,EBI-530257
IL1RL1 - isoform B [Q01638-2]3EBI-6942903,EBI-12838366
INSIG2 [Q9Y5U4]3EBI-6942903,EBI-8503746
ITGAM [P11215]3EBI-6942903,EBI-2568251
JAGN1 [Q8N5M9]3EBI-6942903,EBI-10266796
KCNK1 [O00180]5EBI-6942903,EBI-3914675
LEPROTL1 [O95214]3EBI-6942903,EBI-750776
LHFPL5 [Q8TAF8]3EBI-6942903,EBI-2820517
LPAR3 [Q9UBY5]5EBI-6942903,EBI-12033434
LTC4S [Q16873]5EBI-6942903,EBI-12241118
MAL [P21145]3EBI-6942903,EBI-3932027
MAL2 [Q969L2]3EBI-6942903,EBI-944295
MALL [Q13021]3EBI-6942903,EBI-750078
MAN2B2 [Q9Y2E5]3EBI-6942903,EBI-12243024
MARCHF2 [Q9P0N8]3EBI-6942903,EBI-10317612
MFSD5 [Q6N075]6EBI-6942903,EBI-3920969
MGAM [O43451]3EBI-6942903,EBI-2829774
MGST2 [Q99735]3EBI-6942903,EBI-11324706
MGST3 [O14880]3EBI-6942903,EBI-724754
MMD2 - isoform 2 [Q8IY49-2]3EBI-6942903,EBI-13349813
MS4A1 [P11836]3EBI-6942903,EBI-2808234
MS4A13 [Q5J8X5]3EBI-6942903,EBI-12070086
NAPB [Q9H115]3EBI-6942903,EBI-3921185
NAT8 [Q9UHE5]3EBI-6942903,EBI-2863634
NEU1 [Q99519]5EBI-6942903,EBI-721517
NINJ1 [Q92982]3EBI-6942903,EBI-2802124
NINJ2 [Q9NZG7]3EBI-6942903,EBI-10317425
NRM [Q8IXM6]3EBI-6942903,EBI-10262547
NSG1 [P42857]3EBI-6942903,EBI-6380741
OLFM4 [Q6UX06]3EBI-6942903,EBI-2804156
OR10AG1 [Q8NH19]3EBI-6942903,EBI-13339917
ORMDL1 [Q9P0S3]3EBI-6942903,EBI-1054848
ORMDL2 [Q53FV1]3EBI-6942903,EBI-11075081
PAQR6 [Q6TCH4]3EBI-6942903,EBI-17265310
PEX16 [Q9Y5Y5]3EBI-6942903,EBI-981985
PGAP2 [E9PRZ2]3EBI-6942903,EBI-16438210
PGAP2 [Q9UHJ9]3EBI-6942903,EBI-10321427
PGAP2 - isoform 5 [Q9UHJ9-5]6EBI-6942903,EBI-12092917
PGRMC1 [Q6IB11]3EBI-6942903,EBI-10249941
PLN [P26678]3EBI-6942903,EBI-692836
PLP1 [P60201]3EBI-6942903,EBI-8653150
PLP1 - isoform DM-20 [P60201-2]16EBI-6942903,EBI-12188331
PLP2 [Q04941]3EBI-6942903,EBI-608347
PLPP4 [Q5VZY2]3EBI-6942903,EBI-10485931
PLPP6 [Q8IY26]5EBI-6942903,EBI-11721828
PLPPR2 [Q96GM1]3EBI-6942903,EBI-12955265
PMP22 [Q01453]3EBI-6942903,EBI-2845982
PPGB [Q59EV6]3EBI-6942903,EBI-14210385
PRKAB2 [O43741]4EBI-6942903,EBI-1053424
PTPN9 [P43378]3EBI-6942903,EBI-742898
RFT1 [Q96AA3]3EBI-6942903,EBI-6269616
RHBDD1 [Q8TEB9]3EBI-6942903,EBI-9916444
RHD - isoform 2 [Q02161-2]3EBI-6942903,EBI-17249212
RNASE10 [Q5GAN6]3EBI-6942903,EBI-12423312
RUNX1T1 - isoform 4 [Q06455-4]3EBI-6942903,EBI-10224192
RUSF1 [Q96GQ5]3EBI-6942903,EBI-8636004
SACM1L [Q9NTJ5]6EBI-6942903,EBI-3917235
SCARF1 [Q14162]3EBI-6942903,EBI-12056025
SCD [O00767]3EBI-6942903,EBI-2684237
SCGB1D1 [O95968]3EBI-6942903,EBI-12825395
SEC22A [Q96IW7]3EBI-6942903,EBI-8652744
SEC22B [O75396]3EBI-6942903,EBI-1058865
SEC61G [P60059]5EBI-6942903,EBI-4402709
SEMA4G - isoform 2 [Q9NTN9-2]5EBI-6942903,EBI-12913124
SFXN5 [Q8TD22]3EBI-6942903,EBI-17274136
SLC13A2 [Q13183]3EBI-6942903,EBI-17460043
SLC13A3 [Q8WWT9]3EBI-6942903,EBI-12938720
SLC16A13 [Q7RTY0]3EBI-6942903,EBI-12243266
SLC2A3 [P11169]3EBI-6942903,EBI-725116
SLC30A8 [Q8IWU4]9EBI-6942903,EBI-10262251
SLC35A4 [Q96G79]3EBI-6942903,EBI-12363689
SLC35B1 [P78383]3EBI-6942903,EBI-12147661
SLC35B2 [Q8TB61]5EBI-6942903,EBI-1054782
SLC35B4 [Q969S0]8EBI-6942903,EBI-10281213
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-6942903,EBI-17295964
SLC39A2 [Q9NP94]3EBI-6942903,EBI-12898013
SLC39A9 [Q9NUM3]3EBI-6942903,EBI-2823239
SLC52A1 [Q9NWF4]3EBI-6942903,EBI-12904614
SLC7A1 [P30825]5EBI-6942903,EBI-4289564
SMCO4 [Q9NRQ5]3EBI-6942903,EBI-8640191
SMIM1 [B2RUZ4]3EBI-6942903,EBI-12188413
SPOCK1 [Q08629]3EBI-6942903,EBI-2682560
SQLE [Q14534]3EBI-6942903,EBI-3905171
STX3 [Q13277]3EBI-6942903,EBI-1394295
STX7 [O15400]5EBI-6942903,EBI-3221827
STX8 [Q9UNK0]5EBI-6942903,EBI-727240
SYNGR1 - isoform 1B [O43759-2]3EBI-6942903,EBI-12187159
SYNJ2BP [P57105]3EBI-6942903,EBI-1049004
TECR [Q9NZ01]3EBI-6942903,EBI-2877718
TEX264 [Q9Y6I9]3EBI-6942903,EBI-10329860
TFRC [P02786]3EBI-6942903,EBI-355727
TIMM23 [O14925]3EBI-6942903,EBI-1047996
TIMMDC1 [Q9NPL8]3EBI-6942903,EBI-6268651
TLCD1 [Q96CP7]3EBI-6942903,EBI-11337932
TMBIM6 [P55061]3EBI-6942903,EBI-1045825
TMEM11 [P17152]6EBI-6942903,EBI-723946
TMEM120B [A0PK00]5EBI-6942903,EBI-10171534
TMEM147 [Q9BVK8]9EBI-6942903,EBI-348587
TMEM14A [Q9Y6G1]5EBI-6942903,EBI-2800360
TMEM14B [Q9NUH8]3EBI-6942903,EBI-8638294
TMEM14C [Q9P0S9]5EBI-6942903,EBI-2339195
TMEM189-UBE2V1 [I3L0A0]3EBI-6942903,EBI-12213001
TMEM19 [Q96HH6]3EBI-6942903,EBI-741829
TMEM203 [Q969S6]3EBI-6942903,EBI-12274070
TMEM208 [Q9BTX3]3EBI-6942903,EBI-12876824
TMEM218 [A2RU14]7EBI-6942903,EBI-10173151
TMEM222 [Q9H0R3]3EBI-6942903,EBI-347385
TMEM229B [Q8NBD8]3EBI-6942903,EBI-12195227
TMEM234 [Q8WY98]3EBI-6942903,EBI-8642211
TMEM239 - isoform 2 [Q8WW34-2]3EBI-6942903,EBI-11528917
TMEM50B [P56557]3EBI-6942903,EBI-12366453
TMEM86A [Q8N2M4]3EBI-6942903,EBI-12015604
TNF [P01375]3EBI-6942903,EBI-359977
TNFRSF10C [O14798]3EBI-6942903,EBI-717441
TNMD - isoform 2 [Q9H2S6-2]3EBI-6942903,EBI-12003398
TRAM1L1 [Q8N609]3EBI-6942903,EBI-11996766
TSPAN2 [O60636]3EBI-6942903,EBI-3914288
TSPO [P30536]7EBI-6942903,EBI-6623146
TSPO2 [Q5TGU0]5EBI-6942903,EBI-12195249
UBIAD1 [Q9Y5Z9]3EBI-6942903,EBI-2819725
UNC93B1 [Q9H1C4]3EBI-6942903,EBI-4401271
VAMP1 - isoform 2 [P23763-3]3EBI-6942903,EBI-12097582
VAMP2 [P63027]3EBI-6942903,EBI-520113
VKORC1 [Q9BQB6]3EBI-6942903,EBI-6256462
WFDC2 [Q14508]3EBI-6942903,EBI-723529
YIPF6 [Q96EC8]3EBI-6942903,EBI-751210
ZDHHC15 [Q96MV8]5EBI-6942903,EBI-12837904
ZDHHC22 [Q8N966]3EBI-6942903,EBI-10268111
ZFPL1 [O95159]5EBI-6942903,EBI-718439

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124786, 243 interactors

Protein interaction database and analysis system

More...
IntActi
Q96BA8, 194 interactors

Molecular INTeraction database

More...
MINTi
Q96BA8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481956

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96BA8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96BA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini290 – 353bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60Required for transcriptional activationAdd BLAST60
Regioni292 – 321Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni332 – 353Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi392 – 395S2P recognition1 Publication4
Motifi423 – 426S1P recognition1 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 154Poly-Ala9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0709, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037638_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96BA8

KEGG Orthology (KO)

More...
KOi
K09048

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMPCLPE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96BA8

TreeFam database of animal gene trees

More...
TreeFami
TF316079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004827, bZIP
IPR001630, Leuzip_CREB
IPR029805, OASIS

The PANTHER Classification System

More...
PANTHERi
PTHR46004:SF1, PTHR46004:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00170, bZIP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00041, LEUZIPPRCREB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00338, BRLZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96BA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAVLEPFPA DRLFPGSSFL DLGDLNESDF LNNAHFPEHL DHFTENMEDF
60 70 80 90 100
SNDLFSSFFD DPVLDEKSPL LDMELDSPTP GIQAEHSYSL SGDSAPQSPL
110 120 130 140 150
VPIKMEDTTQ DAEHGAWALG HKLCSIMVKQ EQSPELPVDP LAAPSAMAAA
160 170 180 190 200
AAMATTPLLG LSPLSRLPIP HQAPGEMTQL PVIKAEPLEV NQFLKVTPED
210 220 230 240 250
LVQMPPTPPS SHGSDSDGSQ SPRSLPPSSP VRPMARSSTA ISTSPLLTAP
260 270 280 290 300
HKLQGTSGPL LLTEEEKRTL IAEGYPIPTK LPLTKAEEKA LKRVRRKIKN
310 320 330 340 350
KISAQESRRK KKEYVECLEK KVETFTSENN ELWKKVETLE NANRTLLQQL
360 370 380 390 400
QKLQTLVTNK ISRPYKMAAT QTGTCLMVAA LCFVLVLGSL VPCLPEFSSG
410 420 430 440 450
SQTVKEDPLA ADGVYTASQM PSRSLLFYDD GAGLWEDGRS TLLPMEPPDG
460 470 480 490 500
WEINPGGPAE QRPRDHLQHD HLDSTHETTK YLSEAWPKDG GNGTSPDFSH
510
SKEWFHDRDL GPNTTIKLS
Length:519
Mass (Da):57,005
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD08133CD8B02A3AC
GO
Isoform 2 (identifier: Q96BA8-2) [UniParc]FASTAAdd to basket
Also known as: OASISv1

The sequence of this isoform differs from the canonical sequence as follows:
     111-198: Missing.

Show »
Length:431
Mass (Da):47,783
Checksum:i7DD049831DE6024C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK33E9PK33_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEU7H0YEU7_HUMAN
Cyclic AMP-responsive element-bindi...
CREB3L1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11681 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249A → P in AAH14097 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032392411A → T. Corresponds to variant dbSNP:rs35652107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025632111 – 198Missing in isoform 2. CuratedAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB063321 mRNA Translation: BAC01278.1
BC014097 mRNA Translation: AAH14097.1
BC015781 mRNA Translation: AAH15781.1
AK075538 mRNA Translation: BAC11681.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53620.1 [Q96BA8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_443086.1, NM_052854.3 [Q96BA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000621158; ENSP00000481956; ENSG00000157613 [Q96BA8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90993

UCSC genome browser

More...
UCSCi
uc021qik.3, human [Q96BA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063321 mRNA Translation: BAC01278.1
BC014097 mRNA Translation: AAH14097.1
BC015781 mRNA Translation: AAH15781.1
AK075538 mRNA Translation: BAC11681.1 Different initiation.
CCDSiCCDS53620.1 [Q96BA8-1]
RefSeqiNP_443086.1, NM_052854.3 [Q96BA8-1]

3D structure databases

SMRiQ96BA8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124786, 243 interactors
IntActiQ96BA8, 194 interactors
MINTiQ96BA8
STRINGi9606.ENSP00000481956

PTM databases

GlyGeniQ96BA8, 2 sites
iPTMnetiQ96BA8
PhosphoSitePlusiQ96BA8

Polymorphism and mutation databases

BioMutaiCREB3L1
DMDMi74751763

Proteomic databases

jPOSTiQ96BA8
MassIVEiQ96BA8
MaxQBiQ96BA8
PaxDbiQ96BA8
PeptideAtlasiQ96BA8
PRIDEiQ96BA8
ProteomicsDBi76059 [Q96BA8-1]
76060 [Q96BA8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6395, 268 antibodies

The DNASU plasmid repository

More...
DNASUi
90993

Genome annotation databases

EnsembliENST00000621158; ENSP00000481956; ENSG00000157613 [Q96BA8-1]
GeneIDi90993
KEGGihsa:90993
UCSCiuc021qik.3, human [Q96BA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90993
DisGeNETi90993
EuPathDBiHostDB:ENSG00000157613.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CREB3L1
HGNCiHGNC:18856, CREB3L1
HPAiENSG00000157613, Tissue enhanced (pancreas)
MalaCardsiCREB3L1
MIMi616215, gene
616229, phenotype
neXtProtiNX_Q96BA8
OpenTargetsiENSG00000157613
Orphaneti79105, Myxofibrosarcoma
216812, Osteogenesis imperfecta type 3
PharmGKBiPA134960108

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0709, Eukaryota
GeneTreeiENSGT00940000159848
HOGENOMiCLU_037638_1_0_1
InParanoidiQ96BA8
KOiK09048
OMAiLMPCLPE
PhylomeDBiQ96BA8
TreeFamiTF316079

Enzyme and pathway databases

PathwayCommonsiQ96BA8
ReactomeiR-HSA-8874211, CREB3 factors activate genes
SIGNORiQ96BA8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
90993, 6 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CREB3L1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90993
PharosiQ96BA8, Tbio

Protein Ontology

More...
PROi
PR:Q96BA8
RNActiQ96BA8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157613, Expressed in pancreas and 197 other tissues
ExpressionAtlasiQ96BA8, baseline and differential
GenevisibleiQ96BA8, HS

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR001630, Leuzip_CREB
IPR029805, OASIS
PANTHERiPTHR46004:SF1, PTHR46004:SF1, 1 hit
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
PRINTSiPR00041, LEUZIPPRCREB
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR3L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96BA8
Secondary accession number(s): Q8N2D5, Q96CP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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