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UniProtKB - Q96B96 (LDAF1_HUMAN)

Entry version 141 (25 May 2022)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein

Lipid droplet assembly factor 1

Gene

LDAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (PubMed:31708432).

In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (PubMed:31708432).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • lipid droplet formation Source: UniProtKB
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96B96

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96B96

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipid droplet assembly factor 11 Publication
Alternative name(s):
Promethin2 Publications
Transmembrane protein 159
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LDAF1Imported
Synonyms:TMEM159
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 16, Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30136, LDAF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611304, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96B96

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000011638

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43Cytoplasmic1 PublicationAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 61HelicalSequence analysisAdd BLAST18
Topological domaini62 – 67Lumenal1 Publication6
Transmembranei68 – 87HelicalSequence analysisAdd BLAST20
Topological domaini88 – 93Cytoplasmic1 Publication6
Transmembranei94 – 110HelicalSequence analysisAdd BLAST17
Topological domaini111 – 116Lumenal1 Publication6
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 161Cytoplasmic1 PublicationAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57146

Open Targets

More...OpenTargetsi		ENSG00000011638

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145147935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96B96, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM159

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104024

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002795351 – 161Lipid droplet assembly factor 1Add BLAST161

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96B96

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96B96

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96B96

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96B96

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96B96

PeptideAtlas

More...PeptideAtlasi		Q96B96

PRoteomics IDEntifications database

More...PRIDEi		Q96B96

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3940
76056 [Q96B96-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96B96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96B96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011638, Expressed in muscle of leg and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96B96, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96B96, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011638, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform 1 and isoform 3 of BSCL2/seipin to form an oligomeric complex.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121403, 65 interactors

Protein interaction database and analysis system

More...IntActi		Q96B96, 15 interactors

Molecular INTeraction database

More...MINTi		Q96B96

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000233047

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96B96, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96B96

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96B96

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDAF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S3TB, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006420

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96B96

Identification of Orthologs from Complete Genome Data

More...OMAi		FMNSRVG

Database of Orthologous Groups

More...OrthoDBi		1492988at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96B96

TreeFam database of animal gene trees

More...TreeFami		TF335782

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029709, LDAF1

The PANTHER Classification System

More...PANTHERi		PTHR14275, PTHR14275, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96B96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKEEPQSIS RDLQELQKKL SLLIDSFQNN SKVVAFMKSP VGQYLDSHPF 
        60         70         80         90        100
LAFTLLVFIV MSAVPVGFFL LIVVLTTLAA LLGVIILEGL VISVGGFSLL 
       110        120        130        140        150
CILCGLGFVS LAMSGMMIAS YVVVSSLISC WFSPRPLTQQ NTSCDFLPAM 
       160 
KSAEFEGLYQ E
Length:161
Mass (Da):17,522
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i196B502EE203BA7E
GO
Isoform 2 (identifier: Q96B96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: N → NSKLPQHSRISLDSDDGVSRLGSAG

Show »
Length:185
Mass (Da):19,987
Checksum:iEEFAD1983E8DED04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L288I3L288_HUMAN
Lipid droplet assembly factor 1
LDAF1 LOC57146, hCG_38247
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI23I3NI23_HUMAN
Lipid droplet assembly factor 1
LDAF1
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L319I3L319_HUMAN
Lipid droplet assembly factor 1
LDAF1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI21I3NI21_HUMAN
Lipid droplet assembly factor 1
LDAF1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05776597F → L. Corresponds to variant dbSNP:rs35345508Ensembl.1
Natural variantiVAR_030923107G → S1 PublicationCorresponds to variant dbSNP:rs1046480Ensembl.1
Natural variantiVAR_030924154E → D2 PublicationsCorresponds to variant dbSNP:rs1063087Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05607830N → NSKLPQHSRISLDSDDGVSR LGSAG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY212918 mRNA Translation: AAO52682.1
AK074667 mRNA Translation: BAC11122.1
AK293557 mRNA Translation: BAG57032.1
AF001550 Genomic DNA Translation: AAB67598.1
AC008551 Genomic DNA No translation available.
BC015812 mRNA Translation: AAH15812.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10595.1 [Q96B96-1]
CCDS76841.1 [Q96B96-2]

NCBI Reference Sequences

More...RefSeqi		NP_001288698.1, NM_001301769.1 [Q96B96-1]
NP_001288700.1, NM_001301771.1 [Q96B96-1]
NP_001288702.1, NM_001301773.1
NP_001288703.1, NM_001301774.1
NP_001288704.1, NM_001301775.1 [Q96B96-2]
NP_065155.3, NM_020422.5 [Q96B96-1]
XP_005255496.1, XM_005255439.4 [Q96B96-2]
XP_006721129.1, XM_006721066.2 [Q96B96-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000233047.9; ENSP00000233047.4; ENSG00000011638.11
ENST00000261388.7; ENSP00000261388.3; ENSG00000011638.11
ENST00000451578.6; ENSP00000409879.2; ENSG00000011638.11 [Q96B96-2]
ENST00000572599.5; ENSP00000460687.1; ENSG00000011638.11
ENST00000638934.1; ENSP00000492501.1; ENSG00000283997.1
ENST00000639177.1; ENSP00000492842.1; ENSG00000283997.1 [Q96B96-2]
ENST00000640188.1; ENSP00000491056.1; ENSG00000283997.1
ENST00000640514.1; ENSP00000492164.1; ENSG00000283997.1

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57146

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000233047.9; ENSP00000233047.4; NM_001301771.2; NP_001288700.1

UCSC genome browser

More...UCSCi		uc002dif.5, human [Q96B96-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212918 mRNA Translation: AAO52682.1
AK074667 mRNA Translation: BAC11122.1
AK293557 mRNA Translation: BAG57032.1
AF001550 Genomic DNA Translation: AAB67598.1
AC008551 Genomic DNA No translation available.
BC015812 mRNA Translation: AAH15812.1
CCDSiCCDS10595.1 [Q96B96-1]
CCDS76841.1 [Q96B96-2]
RefSeqiNP_001288698.1, NM_001301769.1 [Q96B96-1]
NP_001288700.1, NM_001301771.1 [Q96B96-1]
NP_001288702.1, NM_001301773.1
NP_001288703.1, NM_001301774.1
NP_001288704.1, NM_001301775.1 [Q96B96-2]
NP_065155.3, NM_020422.5 [Q96B96-1]
XP_005255496.1, XM_005255439.4 [Q96B96-2]
XP_006721129.1, XM_006721066.2 [Q96B96-2]

3D structure databases

AlphaFoldDBiQ96B96
SMRiQ96B96
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121403, 65 interactors
IntActiQ96B96, 15 interactors
MINTiQ96B96
STRINGi9606.ENSP00000233047

PTM databases

iPTMnetiQ96B96
PhosphoSitePlusiQ96B96

Genetic variation databases

BioMutaiTMEM159
DMDMi313104024

Proteomic databases

EPDiQ96B96
jPOSTiQ96B96
MassIVEiQ96B96
MaxQBiQ96B96
PaxDbiQ96B96
PeptideAtlasiQ96B96
PRIDEiQ96B96
ProteomicsDBi3940
76056 [Q96B96-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3080, 36 antibodies from 11 providers

The DNASU plasmid repository

More...DNASUi		57146

Genome annotation databases

EnsembliENST00000233047.9; ENSP00000233047.4; ENSG00000011638.11
ENST00000261388.7; ENSP00000261388.3; ENSG00000011638.11
ENST00000451578.6; ENSP00000409879.2; ENSG00000011638.11 [Q96B96-2]
ENST00000572599.5; ENSP00000460687.1; ENSG00000011638.11
ENST00000638934.1; ENSP00000492501.1; ENSG00000283997.1
ENST00000639177.1; ENSP00000492842.1; ENSG00000283997.1 [Q96B96-2]
ENST00000640188.1; ENSP00000491056.1; ENSG00000283997.1
ENST00000640514.1; ENSP00000492164.1; ENSG00000283997.1
GeneIDi57146
KEGGihsa:57146
MANE-SelectiENST00000233047.9; ENSP00000233047.4; NM_001301771.2; NP_001288700.1
UCSCiuc002dif.5, human [Q96B96-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57146
DisGeNETi57146

GeneCards: human genes, protein and diseases

More...GeneCardsi		LDAF1
HGNCiHGNC:30136, LDAF1
HPAiENSG00000011638, Tissue enhanced (skeletal)
MIMi611304, gene
neXtProtiNX_Q96B96
OpenTargetsiENSG00000011638
PharmGKBiPA145147935
VEuPathDBiHostDB:ENSG00000011638

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S3TB, Eukaryota
GeneTreeiENSGT00390000006420
InParanoidiQ96B96
OMAiFMNSRVG
OrthoDBi1492988at2759
PhylomeDBiQ96B96
TreeFamiTF335782

Enzyme and pathway databases

PathwayCommonsiQ96B96
SignaLinkiQ96B96

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57146, 10 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM159, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57146
PharosiQ96B96, Tdark

Protein Ontology

More...PROi		PR:Q96B96
RNActiQ96B96, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011638, Expressed in muscle of leg and 210 other tissues
ExpressionAtlasiQ96B96, baseline and differential
GenevisibleiQ96B96, HS

Family and domain databases

InterProiView protein in InterPro
IPR029709, LDAF1
PANTHERiPTHR14275, PTHR14275, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLDAF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B96
Secondary accession number(s): A6NMA9, B4DEC1, O00323
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 30, 2010
Last modified: May 25, 2022
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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