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Protein

Transmembrane protein 186

Gene

TMEM186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 186
Gene namesi
Name:TMEM186
Synonyms:C16orf51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184857.7
HGNCiHGNC:24530 TMEM186
neXtProtiNX_Q96B77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184857
PharmGKBiPA162406190

Polymorphism and mutation databases

BioMutaiTMEM186
DMDMi74731207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794391 – 213Transmembrane protein 186Add BLAST213

Proteomic databases

EPDiQ96B77
MaxQBiQ96B77
PaxDbiQ96B77
PeptideAtlasiQ96B77
PRIDEiQ96B77
ProteomicsDBi76053

PTM databases

iPTMnetiQ96B77
PhosphoSitePlusiQ96B77

Expressioni

Gene expression databases

BgeeiENSG00000184857
CleanExiHS_TMEM186
GenevisibleiQ96B77 HS

Organism-specific databases

HPAiHPA018226
HPA063559

Interactioni

Protein-protein interaction databases

BioGridi117394, 36 interactors
IntActiQ96B77, 2 interactors
MINTiQ96B77
STRINGi9606.ENSP00000331640

Structurei

3D structure databases

ProteinModelPortaliQ96B77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM186 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZSW Eukaryota
ENOG4111SG0 LUCA
GeneTreeiENSGT00390000000087
HOGENOMiHOG000059619
HOVERGENiHBG107416
InParanoidiQ96B77
OMAiYRFDAIR
OrthoDBiEOG091G0YC4
PhylomeDBiQ96B77
TreeFamiTF326623

Family and domain databases

InterProiView protein in InterPro
IPR026571 Tmem186
PANTHERiPTHR13603 PTHR13603, 1 hit

Sequencei

Sequence statusi: Complete.

Q96B77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALLRAVRR FRGKAVWERP LHGLWCCSGQ EDPKRWVGSS SPISKEKLPN
60 70 80 90 100
AETEKFWMFY RFDAIRTFGF LSRLKLAQTA LTVVALPPGY YLYSQGLLTL
110 120 130 140 150
NTVCLMSGIS GFALTMLCWM SYFLRRLVGI LYLNESGTML RVAHLNFWGW
160 170 180 190 200
RQDTYCPMAD VIPLTETKDR PQEMFVRIQR YSGKQTFYVT LRYGRILDRE
210
RFTQVFGVHQ MLK
Length:213
Mass (Da):24,893
Last modified:December 1, 2001 - v1
Checksum:iBE993F091D8FF6F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19R → G in CAB45703 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080088 mRNA Translation: CAB45703.2
AK314404 mRNA Translation: BAG37027.1
CH471112 Genomic DNA Translation: EAW85205.1
BC015912 mRNA Translation: AAH15912.1
CCDSiCCDS10535.1
PIRiT12474
RefSeqiNP_056236.2, NM_015421.3
UniGeneiHs.513330

Genome annotation databases

EnsembliENST00000333050; ENSP00000331640; ENSG00000184857
GeneIDi25880
KEGGihsa:25880
UCSCiuc002cze.3 human

Similar proteinsi

Entry informationi

Entry nameiTM186_HUMAN
AccessioniPrimary (citable) accession number: Q96B77
Secondary accession number(s): B2RAY0, Q9Y4T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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