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Entry version 128 (17 Jun 2020)
Sequence version 2 (18 May 2010)
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Protein

Leukocyte receptor cluster member 9

Gene

LENG9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri40 – 67C3H1-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte receptor cluster member 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LENG9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16306 LENG9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96B70

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134975056

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96B70 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LENG9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434565

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002636881 – 501Leukocyte receptor cluster member 9Add BLAST501

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96B70

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96B70

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96B70

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96B70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96B70

PeptideAtlas

More...
PeptideAtlasi
Q96B70

PRoteomics IDEntifications database

More...
PRIDEi
Q96B70

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76052

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96B70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96B70

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125106, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96B70, 3 interactors

Molecular INTeraction database

More...
MINTi
Q96B70

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479355

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96B70 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96B70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 67C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWVT Eukaryota
ENOG4111GEQ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96B70

Database of Orthologous Groups

More...
OrthoDBi
1210602at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96B70

TreeFam database of animal gene trees

More...
TreeFami
TF329287

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009097 Cyclic_Pdiesterase
IPR019510 Kinase-A_anchor_nucl_local_sig
IPR042653 Leng9
IPR040459 MJ1316
IPR000571 Znf_CCCH

The PANTHER Classification System

More...
PANTHERi
PTHR46729 PTHR46729, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10469 AKAP7_NLS, 1 hit
PF04457 MJ1316, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55144 SSF55144, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96B70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRPPCGAT SSARRACQFP APMAAAREPE LPQEAPATEP APPPACRFFL
60 70 80 90 100
EGRCRFGARC RQPHPGAPAP PGREAQPEAG AKKPPLRTAA DVIQRIRWDP
110 120 130 140 150
RLDPADFSVG YVDRFLGVRE EPFSAFCWDQ PLAALGPGVL AVPQHRVRFF
160 170 180 190 200
RFHGRLVWDR ASRTDLVFGS GSAAGRGPTI LDAPNTEGAH GAEGAEWTLA
210 220 230 240 250
GTGQEAQAAP KRGSTRPLCT GHQEPGVEEP GELEAAQERA LGTAADLGTL
260 270 280 290 300
APRGRLAGVT EEALKPTAAT RTTLLGGKEA QALGVPGGSA ETTEAEWGPA
310 320 330 340 350
AWPEDKRARL SVAAPCQPRP THFVALMVTE PGLQAEVTKA QEYLVHVAPH
360 370 380 390 400
CANFLVPSQN LHLTLALLRL AGAGEEAAAI GALRRALLAP GLNAPPRLSF
410 420 430 440 450
RKLVLLGPHV LCAPPSPTLE SMAQVLSQRL EAEGLSTLQS PGQLHPHLTV
460 470 480 490 500
AKVPHGSQVH LPKLEFTLSQ EVGCQPLQTL WLCRIGRTGG PFQPLAEIRL

E
Length:501
Mass (Da):53,167
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AF04904A6518554
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVD1A0A087WVD1_HUMAN
Leukocyte receptor cluster member 9
LENG9
478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15921 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029602153H → R. Corresponds to variant dbSNP:rs10406453Ensembl.1
Natural variantiVAR_029603499R → P. Corresponds to variant dbSNP:rs10423424Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008746 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72251.1
BC015921 mRNA Translation: AAH15921.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_945339.2, NM_198988.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000614111; ENSP00000483600; ENSG00000274495
ENST00000622419; ENSP00000477636; ENSG00000273574

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94059

UCSC genome browser

More...
UCSCi
uc032jrx.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008746 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72251.1
BC015921 mRNA Translation: AAH15921.1 Different initiation.
RefSeqiNP_945339.2, NM_198988.1

3D structure databases

SMRiQ96B70
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125106, 3 interactors
IntActiQ96B70, 3 interactors
MINTiQ96B70
STRINGi9606.ENSP00000479355

PTM databases

iPTMnetiQ96B70
PhosphoSitePlusiQ96B70

Polymorphism and mutation databases

BioMutaiLENG9
DMDMi296434565

Proteomic databases

EPDiQ96B70
jPOSTiQ96B70
MassIVEiQ96B70
MaxQBiQ96B70
PaxDbiQ96B70
PeptideAtlasiQ96B70
PRIDEiQ96B70
ProteomicsDBi76052

Genome annotation databases

EnsembliENST00000614111; ENSP00000483600; ENSG00000274495
ENST00000622419; ENSP00000477636; ENSG00000273574
GeneIDi94059
KEGGihsa:94059
UCSCiuc032jrx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94059

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LENG9
HGNCiHGNC:16306 LENG9
neXtProtiNX_Q96B70
PharmGKBiPA134975056

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWVT Eukaryota
ENOG4111GEQ LUCA
InParanoidiQ96B70
OrthoDBi1210602at2759
PhylomeDBiQ96B70
TreeFamiTF329287

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94059 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LENG9 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94059
PharosiQ96B70 Tdark

Protein Ontology

More...
PROi
PR:Q96B70
RNActiQ96B70 protein

Family and domain databases

InterProiView protein in InterPro
IPR009097 Cyclic_Pdiesterase
IPR019510 Kinase-A_anchor_nucl_local_sig
IPR042653 Leng9
IPR040459 MJ1316
IPR000571 Znf_CCCH
PANTHERiPTHR46729 PTHR46729, 1 hit
PfamiView protein in Pfam
PF10469 AKAP7_NLS, 1 hit
PF04457 MJ1316, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF55144 SSF55144, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLENG9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B70
Secondary accession number(s): B2VAM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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