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UniProtKB - Q96B49 (TOM6_HUMAN)
Protein
Mitochondrial import receptor subunit TOM6 homolog
Gene
TOMM6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- protein insertion into mitochondrial outer membrane Source: ComplexPortal
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96B49 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-5205685, PINK1-PRKN Mediated Mitophagy |
SignaLinki | Q96B49 |
SIGNORi | Q96B49 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial import receptor subunit TOM6 homologAlternative name(s): Overexpressed breast tumor protein Translocase of outer membrane 6 kDa subunit homolog |
Gene namesi | Name:TOMM6 Synonyms:OBTP, TOM6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34528, TOMM6 |
MIMi | 616168, gene |
neXtProti | NX_Q96B49 |
VEuPathDBi | HostDB:ENSG00000214736 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 1 Publication
Mitochondrion
- mitochondrial outer membrane Source: Reactome
- mitochondrial outer membrane translocase complex Source: ComplexPortal
- mitochondrion Source: HPA
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 100188893 |
PharmGKBi | PA164726679 |
Miscellaneous databases
Pharosi | Q96B49, Tbio |
Genetic variation databases
BioMutai | TOMM6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000302856 | 2 – 74 | Mitochondrial import receptor subunit TOM6 homologAdd BLAST | 73 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q96B49 |
jPOSTi | Q96B49 |
MassIVEi | Q96B49 |
MaxQBi | Q96B49 |
PaxDbi | Q96B49 |
PeptideAtlasi | Q96B49 |
PRIDEi | Q96B49 |
ProteomicsDBi | 76045 |
TopDownProteomicsi | Q96B49 |
PTM databases
iPTMneti | Q96B49 |
PhosphoSitePlusi | Q96B49 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214736, Expressed in left adrenal gland and 118 other tissues |
Genevisiblei | Q96B49, HS |
Organism-specific databases
HPAi | ENSG00000214736, Low tissue specificity |
Interactioni
Subunit structurei
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
1 PublicationBinary interactionsi
Q96B49
Protein-protein interaction databases
BioGRIDi | 937002, 38 interactors |
ComplexPortali | CPX-6121, TOM40 mitochondrial outer membrane translocase complex |
CORUMi | Q96B49 |
IntActi | Q96B49, 14 interactors |
MINTi | Q96B49 |
STRINGi | 9606.ENSP00000381859 |
Miscellaneous databases
RNActi | Q96B49, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q96B49 |
SMRi | Q96B49 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the Tom6 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S9AX, Eukaryota |
GeneTreei | ENSGT00390000002376 |
HOGENOMi | CLU_2687147_0_0_1 |
InParanoidi | Q96B49 |
OMAi | VMEWISS |
OrthoDBi | 1571629at2759 |
PhylomeDBi | Q96B49 |
TreeFami | TF330716 |
Family and domain databases
InterProi | View protein in InterPro IPR029182, TOMM6 |
PANTHERi | PTHR15527, PTHR15527, 1 hit |
Pfami | View protein in Pfam PF15184, TOM6p, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q96B49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG
60 70
LFAAGVWLAR NLSDIDLMAP QPGV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | E → K in AAF25683 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB435319 mRNA Translation: BAG30996.1 AF216754 mRNA Translation: AAF25683.1 AL365205 Genomic DNA No translation available. BC015975 mRNA Translation: AAH15975.1 BC018624 mRNA Translation: AAH18624.1 BC022274 mRNA Translation: AAH22274.1 |
CCDSi | CCDS47424.1 |
RefSeqi | NP_001127965.1, NM_001134493.1 |
Genome annotation databases
Ensembli | ENST00000398881.4; ENSP00000381856.3; ENSG00000214736.8 ENST00000398884.7; ENSP00000381859.3; ENSG00000214736.8 |
GeneIDi | 100188893 |
KEGGi | hsa:100188893 |
MANE-Selecti | ENST00000398881.4; ENSP00000381856.3; NM_001382294.1; NP_001369223.1 |
UCSCi | uc011dug.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB435319 mRNA Translation: BAG30996.1 AF216754 mRNA Translation: AAF25683.1 AL365205 Genomic DNA No translation available. BC015975 mRNA Translation: AAH15975.1 BC018624 mRNA Translation: AAH18624.1 BC022274 mRNA Translation: AAH22274.1 |
CCDSi | CCDS47424.1 |
RefSeqi | NP_001127965.1, NM_001134493.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7CK6 | electron microscopy | 3.40 | E/F | 1-74 | [»] | |
7CP9 | electron microscopy | 3.00 | C/D | 1-74 | [»] | |
AlphaFoldDBi | Q96B49 | |||||
SMRi | Q96B49 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 937002, 38 interactors |
ComplexPortali | CPX-6121, TOM40 mitochondrial outer membrane translocase complex |
CORUMi | Q96B49 |
IntActi | Q96B49, 14 interactors |
MINTi | Q96B49 |
STRINGi | 9606.ENSP00000381859 |
PTM databases
iPTMneti | Q96B49 |
PhosphoSitePlusi | Q96B49 |
Genetic variation databases
BioMutai | TOMM6 |
Proteomic databases
EPDi | Q96B49 |
jPOSTi | Q96B49 |
MassIVEi | Q96B49 |
MaxQBi | Q96B49 |
PaxDbi | Q96B49 |
PeptideAtlasi | Q96B49 |
PRIDEi | Q96B49 |
ProteomicsDBi | 76045 |
TopDownProteomicsi | Q96B49 |
Protocols and materials databases
Antibodypediai | 1581, 75 antibodies from 19 providers |
DNASUi | 100188893 |
Genome annotation databases
Ensembli | ENST00000398881.4; ENSP00000381856.3; ENSG00000214736.8 ENST00000398884.7; ENSP00000381859.3; ENSG00000214736.8 |
GeneIDi | 100188893 |
KEGGi | hsa:100188893 |
MANE-Selecti | ENST00000398881.4; ENSP00000381856.3; NM_001382294.1; NP_001369223.1 |
UCSCi | uc011dug.2, human |
Organism-specific databases
CTDi | 100188893 |
DisGeNETi | 100188893 |
GeneCardsi | TOMM6 |
HGNCi | HGNC:34528, TOMM6 |
HPAi | ENSG00000214736, Low tissue specificity |
MIMi | 616168, gene |
neXtProti | NX_Q96B49 |
PharmGKBi | PA164726679 |
VEuPathDBi | HostDB:ENSG00000214736 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9AX, Eukaryota |
GeneTreei | ENSGT00390000002376 |
HOGENOMi | CLU_2687147_0_0_1 |
InParanoidi | Q96B49 |
OMAi | VMEWISS |
OrthoDBi | 1571629at2759 |
PhylomeDBi | Q96B49 |
TreeFami | TF330716 |
Enzyme and pathway databases
PathwayCommonsi | Q96B49 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-5205685, PINK1-PRKN Mediated Mitophagy |
SignaLinki | Q96B49 |
SIGNORi | Q96B49 |
Miscellaneous databases
BioGRID-ORCSi | 100188893, 14 hits in 1039 CRISPR screens |
ChiTaRSi | TOMM6, human |
GenomeRNAii | 100188893 |
Pharosi | Q96B49, Tbio |
PROi | PR:Q96B49 |
RNActi | Q96B49, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000214736, Expressed in left adrenal gland and 118 other tissues |
Genevisiblei | Q96B49, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029182, TOMM6 |
PANTHERi | PTHR15527, PTHR15527, 1 hit |
Pfami | View protein in Pfam PF15184, TOM6p, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TOM6_HUMAN | |
Accessioni | Q96B49Primary (citable) accession number: Q96B49 Secondary accession number(s): B2DG15, Q9UH52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families