TOMM6

Functionⁱ

GO - Biological processⁱ

protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial import receptor subunit TOM6 homolog Alternative name(s): Overexpressed breast tumor protein Translocase of outer membrane 6 kDa subunit homolog
Gene namesⁱ	Name:TOMM6 Synonyms:OBTP, TOM6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000214736.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:34528 TOMM6
MIMⁱ	616168 gene
neXtProtⁱ	NX_Q96B49

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA164726679

PharmGKBⁱ

PA164726679

Polymorphism and mutation databases

BioMutaⁱ	TOMM6

BioMutaⁱ

TOMM6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000302856	2 – 74	Mitochondrial import receptor subunit TOM6 homologAdd BLAST		73

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q96B49
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96B49
PaxDbⁱ	Q96B49
PeptideAtlas More...PeptideAtlasⁱ	Q96B49
PRIDEⁱ	Q96B49
ProteomicsDBⁱ	76045
TopDownProteomicsⁱ	Q96B49

PTM databases

iPTMnetⁱ	Q96B49
PhosphoSitePlusⁱ	Q96B49

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000214736 Expressed in 91 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_TOMM6
Genevisibleⁱ	Q96B49 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004801

HPAⁱ

HPA004801

Interactionⁱ

Subunit structureⁱ

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CD68	P34810	4	EBI-10826510,EBI-2826276

With

Entry

#Exp.

IntAct

Notes

CD68

P34810

4

EBI-10826510,EBI-2826276

Protein-protein interaction databases

BioGridⁱ	937002, 1 interactor
CORUMⁱ	Q96B49
IntActⁱ	Q96B49, 12 interactors
STRINGⁱ	9606.ENSP00000381856

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96B49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Tom6 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410JENH Eukaryota ENOG41114XV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002376
HOGENOMⁱ	HOG000081508
HOVERGENⁱ	HBG054583
InParanoidⁱ	Q96B49
KEGG Orthology (KO) More...KOⁱ	K17772
OMAⁱ	WLRGVFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1975
PhylomeDBⁱ	Q96B49
TreeFamⁱ	TF330716

Family and domain databases

InterProⁱ	View protein in InterPro IPR029182 TOMM6
PANTHERⁱ	PTHR15527 PTHR15527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15184 TOM6p, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q96B49-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG 
        60         70 
LFAAGVWLAR NLSDIDLMAP QPGV

Length:74

Mass (Da):8,002

Last modified:December 1, 2001 - v1

Checksum:ⁱ805462C0444865FD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	16	E → K in AAF25683 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB435319 mRNA Translation: BAG30996.1 AF216754 mRNA Translation: AAF25683.1 AL365205 Genomic DNA No translation available. BC015975 mRNA Translation: AAH15975.1 BC018624 mRNA Translation: AAH18624.1 BC022274 mRNA Translation: AAH22274.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47424.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001127965.1, NM_001134493.1
UniGeneⁱ	Hs.731633

Genome annotation databases

Ensemblⁱ	ENST00000398881; ENSP00000381856; ENSG00000214736 ENST00000398884; ENSP00000381859; ENSG00000214736
GeneIDⁱ	100188893
KEGGⁱ	hsa:100188893
UCSC genome browser More...UCSCⁱ	uc011dug.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96B49	TOMM6 isoform 1		PANTR		74	UniRef100_Q96B49
Uncharacterized protein		PANPA		74

Protein	Similar proteins		Species	Score	Length	Source
Q96B49	TOMM6 isoform 1		PANTR		74	UniRef90_Q96B49
Uncharacterized protein		PANPA		74
Uncharacterized protein		CALJA		76
Over-expressed breast tumor protein (Predicted)		PAPAN		74
Mitochondrial import receptor subunit TOM6 homolog		MACMU		74
+29

Protein	Similar proteins		Species	Score	Length	Source
Q96B49	TOMM6 isoform 1		PANTR		74	UniRef50_Q96B49
Uncharacterized protein		PANPA		74
Uncharacterized protein		CALJA		76
Uncharacterized protein		MYOLU		74
Translocase of outer mitochondrial membrane 6		ICTTR		74
+79

Entry informationⁱ

Entry nameⁱ	TOM6_HUMAN
Accessionⁱ	Q96B49Primary (citable) accession number: Q96B49 Secondary accession number(s): B2DG15, Q9UH52
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96B49 (TOM6_HUMAN)

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Mitochondrial import receptor subunit TOM6 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ