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Entry version 133 (07 Apr 2021)
Sequence version 2 (13 Feb 2019)
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Protein

BLOC-1-related complex subunit 7

Gene

BORCS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.1 Publication

Miscellaneous

Diaskedin is from the ancient Greek diaskedazo, meaning to disperse.1 Publication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96B45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BLOC-1-related complex subunit 7Curated
Alternative name(s):
Diaskedin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BORCS7Imported
Synonyms:C10orf32Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23516, BORCS7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616600, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96B45

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166275.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
119032

Open Targets

More...
OpenTargetsi
ENSG00000166275

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928831

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96B45, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BORCS7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897871 – 106BLOC-1-related complex subunit 7Add BLAST106

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96B45

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96B45

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96B45

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96B45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96B45

PeptideAtlas

More...
PeptideAtlasi
Q96B45

PRoteomics IDEntifications database

More...
PRIDEi
Q96B45

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76044

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96B45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96B45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166275, Expressed in metanephros and 216 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96B45, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166275, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125633, 20 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5029, BORC complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96B45

Protein interaction database and analysis system

More...
IntActi
Q96B45, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342331

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96B45, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BORCS7 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S2QS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_150749_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96B45

Identification of Orthologs from Complete Genome Data

More...
OMAi
NFAQQEH

Database of Orthologous Groups

More...
OrthoDBi
1626208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96B45

TreeFam database of animal gene trees

More...
TreeFami
TF314767

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032143, BORCS7

The PANTHER Classification System

More...
PANTHERi
PTHR31397, PTHR31397, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16088, BORCS7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96B45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMATGTPESQ ARFGQSVKGL LTEKVTTCGT DVIALTKQVL KGSRSSELLG
60 70 80 90 100
QAARNMVLQE DAILHSEDSL RKMAIITTHL QYQQEAIQKN VEQSSDLQDQ

LNHLLK
Length:106
Mass (Da):11,695
Last modified:February 13, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i134926BED02C85CF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15994 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG34685 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAI46115 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098071 mRNA Translation: BAG53576.1
AK311742 mRNA Translation: BAG34685.1 Different initiation.
AL832477 mRNA Translation: CAI46115.1 Different initiation.
AL358790 Genomic DNA No translation available.
BC015994 mRNA Translation: AAH15994.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7542.2

NCBI Reference Sequences

More...
RefSeqi
NP_001129672.1, NM_001136200.1
NP_653192.2, NM_144591.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339834; ENSP00000342331; ENSG00000166275
ENST00000369883; ENSP00000358899; ENSG00000166275

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
119032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:119032

UCSC genome browser

More...
UCSCi
uc001kwh.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098071 mRNA Translation: BAG53576.1
AK311742 mRNA Translation: BAG34685.1 Different initiation.
AL832477 mRNA Translation: CAI46115.1 Different initiation.
AL358790 Genomic DNA No translation available.
BC015994 mRNA Translation: AAH15994.1 Different initiation.
CCDSiCCDS7542.2
RefSeqiNP_001129672.1, NM_001136200.1
NP_653192.2, NM_144591.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125633, 20 interactors
ComplexPortaliCPX-5029, BORC complex
CORUMiQ96B45
IntActiQ96B45, 6 interactors
STRINGi9606.ENSP00000342331

PTM databases

iPTMnetiQ96B45
PhosphoSitePlusiQ96B45

Genetic variation databases

BioMutaiBORCS7

Proteomic databases

EPDiQ96B45
jPOSTiQ96B45
MassIVEiQ96B45
MaxQBiQ96B45
PaxDbiQ96B45
PeptideAtlasiQ96B45
PRIDEiQ96B45
ProteomicsDBi76044

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48493, 62 antibodies

The DNASU plasmid repository

More...
DNASUi
119032

Genome annotation databases

EnsembliENST00000339834; ENSP00000342331; ENSG00000166275
ENST00000369883; ENSP00000358899; ENSG00000166275
GeneIDi119032
KEGGihsa:119032
UCSCiuc001kwh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
119032
DisGeNETi119032

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BORCS7
HGNCiHGNC:23516, BORCS7
HPAiENSG00000166275, Low tissue specificity
MIMi616600, gene
neXtProtiNX_Q96B45
OpenTargetsiENSG00000166275
PharmGKBiPA134928831
VEuPathDBiHostDB:ENSG00000166275.15

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S2QS, Eukaryota
GeneTreeiENSGT00390000015849
HOGENOMiCLU_150749_1_0_1
InParanoidiQ96B45
OMAiNFAQQEH
OrthoDBi1626208at2759
PhylomeDBiQ96B45
TreeFamiTF314767

Enzyme and pathway databases

PathwayCommonsiQ96B45

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
119032, 16 hits in 973 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
119032
PharosiQ96B45, Tdark

Protein Ontology

More...
PROi
PR:Q96B45
RNActiQ96B45, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166275, Expressed in metanephros and 216 other tissues
GenevisibleiQ96B45, HS

Family and domain databases

InterProiView protein in InterPro
IPR032143, BORCS7
PANTHERiPTHR31397, PTHR31397, 1 hit
PfamiView protein in Pfam
PF16088, BORCS7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBORC7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B45
Secondary accession number(s): B2R488, B3KUW4, C9K0X3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 13, 2019
Last modified: April 7, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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