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Protein

Transmembrane protein 18

Gene

TMEM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Protein family/group databases

TCDBi9.B.228.1.1 the tmem18 (tmem18) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 18
Gene namesi
Name:TMEM18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000151353.14
HGNCiHGNC:25257 TMEM18
MIMi613220 gene
neXtProtiNX_Q96B42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25Perinuclear spaceSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 52NuclearSequence analysis6
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 91Perinuclear spaceSequence analysisAdd BLAST18
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 140NuclearSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi129787
OpenTargetsiENSG00000151353
PharmGKBiPA134873089

Polymorphism and mutation databases

BioMutaiTMEM18
DMDMi121944491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843691 – 140Transmembrane protein 18Add BLAST140

Proteomic databases

PaxDbiQ96B42
PeptideAtlasiQ96B42
PRIDEiQ96B42
ProteomicsDBi76042
76043 [Q96B42-2]

PTM databases

iPTMnetiQ96B42
PhosphoSitePlusiQ96B42

Expressioni

Gene expression databases

BgeeiENSG00000151353 Expressed in 200 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TMEM18
ExpressionAtlasiQ96B42 baseline and differential
GenevisibleiQ96B42 HS

Organism-specific databases

HPAiHPA040233

Interactioni

Subunit structurei

Forms homooligomers, independently of the DNA-binding domain.1 Publication

Protein-protein interaction databases

IntActiQ96B42, 2 interactors
STRINGi9606.ENSP00000281017

Structurei

3D structure databases

ProteinModelPortaliQ96B42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 140DNA-bindingAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 140Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 138Nuclear localization signal9

Sequence similaritiesi

Belongs to the TMEM18 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZTN Eukaryota
ENOG41125VK LUCA
GeneTreeiENSGT00390000015191
HOGENOMiHOG000230683
HOVERGENiHBG104687
InParanoidiQ96B42
KOiK22145
OMAiVIMWVRK
PhylomeDBiQ96B42
TreeFamiTF324883

Family and domain databases

InterProiView protein in InterPro
IPR026721 TMEM18
PfamiView protein in Pfam
PF14770 TMEM18, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96B42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSAFSVSSF PVSIPAVLTQ TDWTEPWLMG LATFHALCVL LTCLSSRSYR
60 70 80 90 100
LQIGHFLCLV ILVYCAEYIN EAAAMNWRLF SKYQYFDSRG MFISIVFSAP
110 120 130 140
LLVNAMIIVV MWVWKTLNVM TDLKNAQERR KEKKRRRKED
Length:140
Mass (Da):16,265
Last modified:November 8, 2005 - v2
Checksum:iFDE25DA6B7CCC2BC
GO
Isoform 2 (identifier: Q96B42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-19: PSAFSVSSFPVSIPAVLT → LSGYL

Show »
Length:127
Mass (Da):15,011
Checksum:i25B6D00BD1183F58
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MBX8B5MBX8_HUMAN
Transmembrane protein 18
TMEM18
143Annotation score:
F8WBA6F8WBA6_HUMAN
Transmembrane protein 18
TMEM18
66Annotation score:
F8WEA7F8WEA7_HUMAN
Transmembrane protein 18
TMEM18
59Annotation score:

Sequence cautioni

The sequence CAB70668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244692 – 19PSAFS…PAVLT → LSGYL in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137269 mRNA Translation: CAB70668.1 Different initiation.
AC092159 Genomic DNA Translation: AAY14770.1
CH471053 Genomic DNA Translation: EAX01100.1
CH471053 Genomic DNA Translation: EAX01101.1
BC016010 mRNA Translation: AAH16010.2
BC032379 mRNA Translation: AAH32379.1
CCDSiCCDS33141.1 [Q96B42-1]
CCDS86815.1 [Q96B42-2]
PIRiT46342
RefSeqiNP_690047.2, NM_152834.2 [Q96B42-1]
UniGeneiHs.43899
Hs.6729

Genome annotation databases

EnsembliENST00000281017; ENSP00000281017; ENSG00000151353 [Q96B42-1]
ENST00000355654; ENSP00000347874; ENSG00000151353 [Q96B42-2]
GeneIDi129787
KEGGihsa:129787
UCSCiuc002qwl.4 human [Q96B42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137269 mRNA Translation: CAB70668.1 Different initiation.
AC092159 Genomic DNA Translation: AAY14770.1
CH471053 Genomic DNA Translation: EAX01100.1
CH471053 Genomic DNA Translation: EAX01101.1
BC016010 mRNA Translation: AAH16010.2
BC032379 mRNA Translation: AAH32379.1
CCDSiCCDS33141.1 [Q96B42-1]
CCDS86815.1 [Q96B42-2]
PIRiT46342
RefSeqiNP_690047.2, NM_152834.2 [Q96B42-1]
UniGeneiHs.43899
Hs.6729

3D structure databases

ProteinModelPortaliQ96B42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96B42, 2 interactors
STRINGi9606.ENSP00000281017

Protein family/group databases

TCDBi9.B.228.1.1 the tmem18 (tmem18) family

PTM databases

iPTMnetiQ96B42
PhosphoSitePlusiQ96B42

Polymorphism and mutation databases

BioMutaiTMEM18
DMDMi121944491

Proteomic databases

PaxDbiQ96B42
PeptideAtlasiQ96B42
PRIDEiQ96B42
ProteomicsDBi76042
76043 [Q96B42-2]

Protocols and materials databases

DNASUi129787
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281017; ENSP00000281017; ENSG00000151353 [Q96B42-1]
ENST00000355654; ENSP00000347874; ENSG00000151353 [Q96B42-2]
GeneIDi129787
KEGGihsa:129787
UCSCiuc002qwl.4 human [Q96B42-1]

Organism-specific databases

CTDi129787
DisGeNETi129787
EuPathDBiHostDB:ENSG00000151353.14
GeneCardsiTMEM18
HGNCiHGNC:25257 TMEM18
HPAiHPA040233
MIMi613220 gene
neXtProtiNX_Q96B42
OpenTargetsiENSG00000151353
PharmGKBiPA134873089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZTN Eukaryota
ENOG41125VK LUCA
GeneTreeiENSGT00390000015191
HOGENOMiHOG000230683
HOVERGENiHBG104687
InParanoidiQ96B42
KOiK22145
OMAiVIMWVRK
PhylomeDBiQ96B42
TreeFamiTF324883

Miscellaneous databases

GeneWikiiTMEM18
GenomeRNAii129787
PROiPR:Q96B42
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151353 Expressed in 200 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TMEM18
ExpressionAtlasiQ96B42 baseline and differential
GenevisibleiQ96B42 HS

Family and domain databases

InterProiView protein in InterPro
IPR026721 TMEM18
PfamiView protein in Pfam
PF14770 TMEM18, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM18_HUMAN
AccessioniPrimary (citable) accession number: Q96B42
Secondary accession number(s): D6W4X9, Q8N5H2, Q9NTH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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