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Entry version 143 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Proline-rich AKT1 substrate 1

Gene

AKT1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q96B36

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q96B36

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96B36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich AKT1 substrate 1
Alternative name(s):
40 kDa proline-rich AKT substrate
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKT1S1Imported
Synonyms:PRAS402 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28426 AKT1S1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610221 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96B36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi246T → A: Suppresses S6K1 phosphorylation by mTORC1. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84335

Open Targets

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OpenTargetsi
ENSG00000204673

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943587

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1255161

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKT1S1

Domain mapping of disease mutations (DMDM)

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DMDMi
74731194

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002534461 – 256Proline-rich AKT1 substrate 1Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51Omega-N-methylarginineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei116PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei246Phosphothreonine; by PKB/AKT1 and DYRK3Combined sources3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AKT1 (PubMed:12524439). Phosphorylation at Thr-246 by DYRK3 relieves inhibitory function on mTORC1 (PubMed:23415227).2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96B36

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96B36

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96B36

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96B36

PeptideAtlas

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PeptideAtlasi
Q96B36

PRoteomics IDEntifications database

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PRIDEi
Q96B36

ProteomicsDB human proteome resource

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ProteomicsDBi
76040
76041 [Q96B36-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96B36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96B36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204673 Expressed in 169 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96B36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96B36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB021903
HPA043590
HPA064427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Interacts directly with RPTOR. The phosphorylated form interacts with 14-3-3 proteins.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124059, 23 interactors

Protein interaction database and analysis system

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IntActi
Q96B36, 13 interactors

Molecular INTeraction database

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MINTi
Q96B36

STRING: functional protein association networks

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STRINGi
9606.ENSP00000375711

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96B36

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96B36

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 43Poly-ProSequence analysis9
Compositional biasi77 – 96Pro-richSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXEE Eukaryota
ENOG41121RI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017397

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96B36

KEGG Orthology (KO)

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KOi
K16184

Identification of Orthologs from Complete Genome Data

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OMAi
RDCEPFF

Database of Orthologous Groups

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OrthoDBi
927670at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96B36

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026682 AKT1S1

The PANTHER Classification System

More...
PANTHERi
PTHR21844 PTHR21844, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15798 PRAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q96B36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGRPEELW EAVVGAAERF RARTGTELVL LTAAPPPPPR PGPCAYAAHG
60 70 80 90 100
RGALAEAARR CLHDIALAHR AATAARPPAP PPAPQPPSPT PSPPRPTLAR
110 120 130 140 150
EDNEEDEDEP TETETSGEQL GISDNGGLFV MDEDATLQDL PPFCESDPES
160 170 180 190 200
TDDGSLSEET PAGPPTCSVP PASALPTQQY AKSLPVSVPV WGFKEKRTEA
210 220 230 240 250
RSSDEENGPP SSPDLDRIAA SMRALVLREA EDTQVFGDLP RPRLNTSDFQ

KLKRKY
Length:256
Mass (Da):27,383
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6CB195CBB54326C
GO
Isoform 21 Publication (identifier: Q96B36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:126
Mass (Da):13,807
Checksum:i2E34744BBEFEC1E9
GO
Isoform 3 (identifier: Q96B36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSFEGGDGAGPAMLATGTARM

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):29,262
Checksum:i3866EE718A29CC48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV91H9KV91_HUMAN
Proline-rich AKT1 substrate 1
AKT1S1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2V8M0R2V8_HUMAN
Proline-rich AKT1 substrate 1
AKT1S1
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00031 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108D → G in BAB70937 (PubMed:14702039).Curated1
Sequence conflicti196K → M in BAB70937 (PubMed:14702039).Curated1
Sequence conflicti233T → A in BAB70937 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02823947A → P1 PublicationCorresponds to variant dbSNP:rs17850191Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0521821 – 130Missing in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_0475361M → MSFEGGDGAGPAMLATGTAR M in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055511 mRNA Translation: BAB70937.1
AK092610 mRNA Translation: BAG52583.1
AK316603 mRNA Translation: BAG38190.1
AK226004 mRNA No translation available.
AC118341 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52570.1
CH471177 Genomic DNA Translation: EAW52568.1
BC000031 mRNA Translation: AAH00031.2 Different initiation.
BC007416 mRNA Translation: AAH07416.1
BC015562 mRNA Translation: AAH15562.1
BC016043 mRNA Translation: AAH16043.1
BC051844 mRNA Translation: AAH51844.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12784.1 [Q96B36-1]
CCDS59410.1 [Q96B36-3]

NCBI Reference Sequences

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RefSeqi
NP_001092102.1, NM_001098632.2 [Q96B36-1]
NP_001092103.1, NM_001098633.3 [Q96B36-1]
NP_001265088.1, NM_001278159.1 [Q96B36-1]
NP_001265089.1, NM_001278160.1 [Q96B36-1]
NP_115751.3, NM_032375.5 [Q96B36-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344175; ENSP00000341698; ENSG00000204673 [Q96B36-1]
ENST00000391831; ENSP00000375707; ENSG00000204673 [Q96B36-1]
ENST00000391832; ENSP00000375708; ENSG00000204673 [Q96B36-1]
ENST00000391833; ENSP00000375709; ENSG00000204673 [Q96B36-1]
ENST00000391834; ENSP00000375710; ENSG00000204673 [Q96B36-1]
ENST00000391835; ENSP00000375711; ENSG00000204673 [Q96B36-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84335

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84335

UCSC genome browser

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UCSCi
uc002pql.6 human [Q96B36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055511 mRNA Translation: BAB70937.1
AK092610 mRNA Translation: BAG52583.1
AK316603 mRNA Translation: BAG38190.1
AK226004 mRNA No translation available.
AC118341 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52570.1
CH471177 Genomic DNA Translation: EAW52568.1
BC000031 mRNA Translation: AAH00031.2 Different initiation.
BC007416 mRNA Translation: AAH07416.1
BC015562 mRNA Translation: AAH15562.1
BC016043 mRNA Translation: AAH16043.1
BC051844 mRNA Translation: AAH51844.1
CCDSiCCDS12784.1 [Q96B36-1]
CCDS59410.1 [Q96B36-3]
RefSeqiNP_001092102.1, NM_001098632.2 [Q96B36-1]
NP_001092103.1, NM_001098633.3 [Q96B36-1]
NP_001265088.1, NM_001278159.1 [Q96B36-1]
NP_001265089.1, NM_001278160.1 [Q96B36-1]
NP_115751.3, NM_032375.5 [Q96B36-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WBLX-ray3.35T124-139[»]
5WBUX-ray3.42O/P/Q/R173-256[»]
5WBYX-ray3.10O/P114-207[»]
SMRiQ96B36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124059, 23 interactors
IntActiQ96B36, 13 interactors
MINTiQ96B36
STRINGi9606.ENSP00000375711

Chemistry databases

BindingDBiQ96B36
ChEMBLiCHEMBL1255161

PTM databases

iPTMnetiQ96B36
PhosphoSitePlusiQ96B36

Polymorphism and mutation databases

BioMutaiAKT1S1
DMDMi74731194

Proteomic databases

EPDiQ96B36
jPOSTiQ96B36
MaxQBiQ96B36
PaxDbiQ96B36
PeptideAtlasiQ96B36
PRIDEiQ96B36
ProteomicsDBi76040
76041 [Q96B36-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344175; ENSP00000341698; ENSG00000204673 [Q96B36-1]
ENST00000391831; ENSP00000375707; ENSG00000204673 [Q96B36-1]
ENST00000391832; ENSP00000375708; ENSG00000204673 [Q96B36-1]
ENST00000391833; ENSP00000375709; ENSG00000204673 [Q96B36-1]
ENST00000391834; ENSP00000375710; ENSG00000204673 [Q96B36-1]
ENST00000391835; ENSP00000375711; ENSG00000204673 [Q96B36-3]
GeneIDi84335
KEGGihsa:84335
UCSCiuc002pql.6 human [Q96B36-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84335
DisGeNETi84335

GeneCards: human genes, protein and diseases

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GeneCardsi
AKT1S1
HGNCiHGNC:28426 AKT1S1
HPAiCAB021903
HPA043590
HPA064427
MIMi610221 gene
neXtProtiNX_Q96B36
OpenTargetsiENSG00000204673
PharmGKBiPA134943587

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IXEE Eukaryota
ENOG41121RI LUCA
GeneTreeiENSGT00390000017397
InParanoidiQ96B36
KOiK16184
OMAiRDCEPFF
OrthoDBi927670at2759
PhylomeDBiQ96B36

Enzyme and pathway databases

ReactomeiR-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
SABIO-RKiQ96B36
SignaLinkiQ96B36
SIGNORiQ96B36

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AKT1S1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AKT1S1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84335

Protein Ontology

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PROi
PR:Q96B36

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204673 Expressed in 169 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ96B36 baseline and differential
GenevisibleiQ96B36 HS

Family and domain databases

InterProiView protein in InterPro
IPR026682 AKT1S1
PANTHERiPTHR21844 PTHR21844, 1 hit
PfamiView protein in Pfam
PF15798 PRAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKTS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B36
Secondary accession number(s): A8MTQ1
, B2RE93, J3KPM3, Q96BI4, Q96IK7, Q96NG2, Q9BWR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: May 8, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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