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Protein

Claudin-23

Gene

CLDN23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Protein family/group databases

TCDBi1.H.1.1.4 the claudin tight junction (claudin1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-23
Gene namesi
Name:CLDN23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000253958.1
HGNCiHGNC:17591 CLDN23
MIMi609203 gene
neXtProtiNX_Q96B33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 81ExtracellularSequence analysisAdd BLAST57
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 110CytoplasmicSequence analysis8
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 160ExtracellularSequence analysisAdd BLAST29
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 292CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi137075
OpenTargetsiENSG00000253958
PharmGKBiPA134961253

Polymorphism and mutation databases

BioMutaiCLDN23
DMDMi47605532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447871 – 292Claudin-23Add BLAST292

Proteomic databases

EPDiQ96B33
PaxDbiQ96B33
PeptideAtlasiQ96B33
PRIDEiQ96B33
ProteomicsDBi76039

PTM databases

iPTMnetiQ96B33
PhosphoSitePlusiQ96B33
SwissPalmiQ96B33

Expressioni

Tissue specificityi

Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.1 Publication

Gene expression databases

BgeeiENSG00000253958 Expressed in 142 organ(s), highest expression level in vagina
CleanExiHS_CLDN23
GenevisibleiQ96B33 HS

Organism-specific databases

HPAiHPA070578

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96B33, 1 interactor
STRINGi9606.ENSP00000428780

Structurei

3D structure databases

ProteinModelPortaliQ96B33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ5H Eukaryota
ENOG4111S3E LUCA
GeneTreeiENSGT00390000006975
HOGENOMiHOG000111788
HOVERGENiHBG050988
InParanoidiQ96B33
KOiK06087
OMAiRERECGQ
OrthoDBiEOG091G0O8D
PhylomeDBiQ96B33
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q96B33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW
60 70 80 90 100
DMCREQSSRE RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL
110 120 130 140 150
GVRCWQDEPN FVLAGLSGVV LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS
160 170 180 190 200
PVTVQVSYSL VLGYLGSCLL LLGGFSLALS FAPWCDERCR RRRKGPSAGP
210 220 230 240 250
RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK PKPKVGFPMP
260 270 280 290
RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL
Length:292
Mass (Da):31,915
Last modified:May 24, 2004 - v2
Checksum:iD383B139905B8884
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059219210V → M. Corresponds to variant dbSNP:rs12548737Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125148 mRNA Translation: AAI25149.1
BC125149 mRNA Translation: AAI25150.1
CCDSiCCDS55195.1
RefSeqiNP_919260.2, NM_194284.2
UniGeneiHs.183617

Genome annotation databases

EnsembliENST00000519106; ENSP00000428780; ENSG00000253958
ENST00000644143; ENSP00000495091; ENSG00000285098
GeneIDi137075
KEGGihsa:137075
UCSCiuc003wsi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125148 mRNA Translation: AAI25149.1
BC125149 mRNA Translation: AAI25150.1
CCDSiCCDS55195.1
RefSeqiNP_919260.2, NM_194284.2
UniGeneiHs.183617

3D structure databases

ProteinModelPortaliQ96B33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96B33, 1 interactor
STRINGi9606.ENSP00000428780

Protein family/group databases

TCDBi1.H.1.1.4 the claudin tight junction (claudin1) family

PTM databases

iPTMnetiQ96B33
PhosphoSitePlusiQ96B33
SwissPalmiQ96B33

Polymorphism and mutation databases

BioMutaiCLDN23
DMDMi47605532

Proteomic databases

EPDiQ96B33
PaxDbiQ96B33
PeptideAtlasiQ96B33
PRIDEiQ96B33
ProteomicsDBi76039

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519106; ENSP00000428780; ENSG00000253958
ENST00000644143; ENSP00000495091; ENSG00000285098
GeneIDi137075
KEGGihsa:137075
UCSCiuc003wsi.4 human

Organism-specific databases

CTDi137075
DisGeNETi137075
EuPathDBiHostDB:ENSG00000253958.1
GeneCardsiCLDN23
HGNCiHGNC:17591 CLDN23
HPAiHPA070578
MIMi609203 gene
neXtProtiNX_Q96B33
OpenTargetsiENSG00000253958
PharmGKBiPA134961253
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ5H Eukaryota
ENOG4111S3E LUCA
GeneTreeiENSGT00390000006975
HOGENOMiHOG000111788
HOVERGENiHBG050988
InParanoidiQ96B33
KOiK06087
OMAiRERECGQ
OrthoDBiEOG091G0O8D
PhylomeDBiQ96B33
TreeFamiTF331936

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions

Miscellaneous databases

GenomeRNAii137075
PROiPR:Q96B33
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253958 Expressed in 142 organ(s), highest expression level in vagina
CleanExiHS_CLDN23
GenevisibleiQ96B33 HS

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLD23_HUMAN
AccessioniPrimary (citable) accession number: Q96B33
Secondary accession number(s): Q08AJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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