UniProtKB - Q96B23 (CR025_HUMAN)
Protein
Uncharacterized protein C18orf25
Gene
C18orf25
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96B23 |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized protein C18orf25Alternative name(s): ARKadia-like protein 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28172, C18orf25 |
neXtProti | NX_Q96B23 |
VEuPathDBi | HostDB:ENSG00000152242.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 147339 |
OpenTargetsi | ENSG00000152242 |
PharmGKBi | PA134919240 |
Miscellaneous databases
Pharosi | Q96B23, Tdark |
Genetic variation databases
BioMutai | C18orf25 |
DMDMi | 209572602 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079312 | 1 – 404 | Uncharacterized protein C18orf25Add BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 145 | PhosphoserineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineBy similarity | 1 | |
Modified residuei | 327 | PhosphoserineCombined sources | 1 | |
Modified residuei | 328 | PhosphoserineCombined sources | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 347 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 358 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96B23 |
jPOSTi | Q96B23 |
MassIVEi | Q96B23 |
MaxQBi | Q96B23 |
PaxDbi | Q96B23 |
PeptideAtlasi | Q96B23 |
PRIDEi | Q96B23 |
ProteomicsDBi | 76036 [Q96B23-1] 76037 [Q96B23-2] |
PTM databases
iPTMneti | Q96B23 |
PhosphoSitePlusi | Q96B23 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152242, Expressed in buccal mucosa cell and 228 other tissues |
ExpressionAtlasi | Q96B23, baseline and differential |
Genevisiblei | Q96B23, HS |
Organism-specific databases
HPAi | ENSG00000152242, Tissue enhanced (esophagus) |
Interactioni
Binary interactionsi
Hide detailsQ96B23
Protein-protein interaction databases
BioGRIDi | 127053, 64 interactors |
IntActi | Q96B23, 38 interactors |
MINTi | Q96B23 |
STRINGi | 9606.ENSP00000481626 |
Miscellaneous databases
RNActi | Q96B23, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 175 – 200 | Sequence analysisAdd BLAST | 26 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QUC3, Eukaryota |
GeneTreei | ENSGT00390000016167 |
HOGENOMi | CLU_056953_0_0_1 |
InParanoidi | Q96B23 |
OMAi | ATWRTSE |
OrthoDBi | 1237164at2759 |
PhylomeDBi | Q96B23 |
TreeFami | TF351299 |
Family and domain databases
InterProi | View protein in InterPro IPR029306, RNF111_N |
Pfami | View protein in Pfam PF15303, RNF111_N, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96B23-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST
60 70 80 90 100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS
110 120 130 140 150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS
160 170 180 190 200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL
210 220 230 240 250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG PPVVAHYDMS
260 270 280 290 300
DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
310 320 330 340 350
HLDPGFLASD KTSAGNAPLN EEINIASSDS EVEIVGVQEH ARCVHPRGGV
360 370 380 390 400
IQSVSSWKHG SGTQYVSTRQ TQSWTAVTPQ QTWASPAEVV DLTLDEDSRR
KYLL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQH1 | K7EQH1_HUMAN | Uncharacterized protein C18orf25 | C18orf25 | 146 | Annotation score: | ||
A0A087WVF1 | A0A087WVF1_HUMAN | Uncharacterized protein C18orf25 | C18orf25 | 275 | Annotation score: | ||
K7ER64 | K7ER64_HUMAN | Uncharacterized protein C18orf25 | C18orf25 | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 233 | I → V in CAD89920 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 316 | N → S in CAE45812 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080245 | 314 | Missing 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014753 | 239 – 299 | Missing in isoform 2. 3 PublicationsAdd BLAST | 61 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BK005125 mRNA Translation: DAA05329.1 AK289738 mRNA Translation: BAF82427.1 AK292981 mRNA Translation: BAF85670.1 AL713661 mRNA Translation: CAD28470.1 AL832027 mRNA Translation: CAD89920.1 BX640683 mRNA Translation: CAE45812.1 AC021763 Genomic DNA No translation available. AC118647 Genomic DNA No translation available. KF573673 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01472.1 CH471088 Genomic DNA Translation: EAX01473.1 BC016149 mRNA Translation: AAH16149.1 BC084579 mRNA Translation: AAH84579.1 |
CCDSi | CCDS42430.1 [Q96B23-1] CCDS42431.1 [Q96B23-2] |
RefSeqi | NP_001008240.1, NM_001008239.2 [Q96B23-2] NP_659492.1, NM_145055.3 [Q96B23-1] XP_011524124.1, XM_011525822.1 [Q96B23-1] XP_016881044.1, XM_017025555.1 [Q96B23-2] |
Genome annotation databases
Ensembli | ENST00000615052; ENSP00000481626; ENSG00000152242 [Q96B23-1] ENST00000619301; ENSP00000480074; ENSG00000152242 [Q96B23-2] |
GeneIDi | 147339 |
KEGGi | hsa:147339 |
UCSCi | uc032hdb.2, human uc032hdc.2, human [Q96B23-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BK005125 mRNA Translation: DAA05329.1 AK289738 mRNA Translation: BAF82427.1 AK292981 mRNA Translation: BAF85670.1 AL713661 mRNA Translation: CAD28470.1 AL832027 mRNA Translation: CAD89920.1 BX640683 mRNA Translation: CAE45812.1 AC021763 Genomic DNA No translation available. AC118647 Genomic DNA No translation available. KF573673 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01472.1 CH471088 Genomic DNA Translation: EAX01473.1 BC016149 mRNA Translation: AAH16149.1 BC084579 mRNA Translation: AAH84579.1 |
CCDSi | CCDS42430.1 [Q96B23-1] CCDS42431.1 [Q96B23-2] |
RefSeqi | NP_001008240.1, NM_001008239.2 [Q96B23-2] NP_659492.1, NM_145055.3 [Q96B23-1] XP_011524124.1, XM_011525822.1 [Q96B23-1] XP_016881044.1, XM_017025555.1 [Q96B23-2] |
3D structure databases
SMRi | Q96B23 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127053, 64 interactors |
IntActi | Q96B23, 38 interactors |
MINTi | Q96B23 |
STRINGi | 9606.ENSP00000481626 |
PTM databases
iPTMneti | Q96B23 |
PhosphoSitePlusi | Q96B23 |
Genetic variation databases
BioMutai | C18orf25 |
DMDMi | 209572602 |
Proteomic databases
EPDi | Q96B23 |
jPOSTi | Q96B23 |
MassIVEi | Q96B23 |
MaxQBi | Q96B23 |
PaxDbi | Q96B23 |
PeptideAtlasi | Q96B23 |
PRIDEi | Q96B23 |
ProteomicsDBi | 76036 [Q96B23-1] 76037 [Q96B23-2] |
Protocols and materials databases
Antibodypediai | 22461, 111 antibodies |
DNASUi | 147339 |
Genome annotation databases
Ensembli | ENST00000615052; ENSP00000481626; ENSG00000152242 [Q96B23-1] ENST00000619301; ENSP00000480074; ENSG00000152242 [Q96B23-2] |
GeneIDi | 147339 |
KEGGi | hsa:147339 |
UCSCi | uc032hdb.2, human uc032hdc.2, human [Q96B23-1] |
Organism-specific databases
CTDi | 147339 |
DisGeNETi | 147339 |
GeneCardsi | C18orf25 |
HGNCi | HGNC:28172, C18orf25 |
HPAi | ENSG00000152242, Tissue enhanced (esophagus) |
neXtProti | NX_Q96B23 |
OpenTargetsi | ENSG00000152242 |
PharmGKBi | PA134919240 |
VEuPathDBi | HostDB:ENSG00000152242.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUC3, Eukaryota |
GeneTreei | ENSGT00390000016167 |
HOGENOMi | CLU_056953_0_0_1 |
InParanoidi | Q96B23 |
OMAi | ATWRTSE |
OrthoDBi | 1237164at2759 |
PhylomeDBi | Q96B23 |
TreeFami | TF351299 |
Enzyme and pathway databases
PathwayCommonsi | Q96B23 |
Miscellaneous databases
BioGRID-ORCSi | 147339, 5 hits in 970 CRISPR screens |
ChiTaRSi | C18orf25, human |
GenomeRNAii | 147339 |
Pharosi | Q96B23, Tdark |
PROi | PR:Q96B23 |
RNActi | Q96B23, protein |
Gene expression databases
Bgeei | ENSG00000152242, Expressed in buccal mucosa cell and 228 other tissues |
ExpressionAtlasi | Q96B23, baseline and differential |
Genevisiblei | Q96B23, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029306, RNF111_N |
Pfami | View protein in Pfam PF15303, RNF111_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CR025_HUMAN | |
Accessioni | Q96B23Primary (citable) accession number: Q96B23 Secondary accession number(s): A8K123 Q8TCQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | March 28, 2018 | |
Last modified: | April 7, 2021 | |
This is version 136 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants