C18orf25

Functionⁱ

GO - Molecular functionⁱ

ubiquitin protein ligase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
protein polyubiquitination Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uncharacterized protein C18orf25 Alternative name(s): ARKadia-like protein 11 Publication
Gene namesⁱ	Name:C18orf25Imported Synonyms:ARKL11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152242.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28172 C18orf25
neXtProtⁱ	NX_Q96B23

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000152242
PharmGKBⁱ	PA134919240

Polymorphism and mutation databases

BioMutaⁱ	C18orf25
DMDMⁱ	209572602

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079312	1 – 404	Uncharacterized protein C18orf25Add BLAST		404

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	66	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	145	PhosphoserineCombined sources	1
Modified residueⁱ	147	PhosphoserineBy similarity	1
Modified residueⁱ	327	PhosphoserineCombined sources	1
Modified residueⁱ	328	PhosphoserineCombined sources	1
Modified residueⁱ	330	PhosphoserineCombined sources	1
Modified residueⁱ	347	Omega-N-methylarginineCombined sources	1
Cross-linkⁱ	358	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96B23
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96B23
PaxDbⁱ	Q96B23
PeptideAtlas More...PeptideAtlasⁱ	Q96B23
PRIDEⁱ	Q96B23
ProteomicsDBⁱ	76036 76037 [Q96B23-2]

PTM databases

iPTMnetⁱ	Q96B23
PhosphoSitePlusⁱ	Q96B23

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152242 Expressed in 215 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_C18orf25
ExpressionAtlasⁱ	Q96B23 baseline and differential
Genevisibleⁱ	Q96B23 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051314 HPA065021

HPAⁱ

HPA051314
HPA065021

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	G2XKQ0	5	EBI-742108,EBI-10175576
SUMO1	P63165	5	EBI-742108,EBI-80140

Protein-protein interaction databases

BioGridⁱ	127053, 51 interactors
IntActⁱ	Q96B23, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q96B23
STRINGⁱ	9606.ENSP00000282059

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96B23
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	175 – 200	Sequence analysisAdd BLAST		26

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IKCJ Eukaryota ENOG410Z94Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016167
HOVERGENⁱ	HBG056975
InParanoidⁱ	Q96B23
OMAⁱ	YDMSDTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09FS
PhylomeDBⁱ	Q96B23
TreeFamⁱ	TF351299

Family and domain databases

InterProⁱ	View protein in InterPro IPR029306 RNF111_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15303 RNF111_N, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q96B23-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST 
        60         70         80         90        100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS 
       110        120        130        140        150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS 
       160        170        180        190        200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL 
       210        220        230        240        250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG PPVVAHYDMS 
       260        270        280        290        300
DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG 
       310        320        330        340        350
HLDPGFLASD KTSAGNAPLN EEINIASSDS EVEIVGVQEH ARCVHPRGGV 
       360        370        380        390        400
IQSVSSWKHG SGTQYVSTRQ TQSWTAVTPQ QTWASPAEVV DLTLDEDSRR 

KYLL

Length:404

Mass (Da):43,395

Last modified:March 28, 2018 - v3

Checksum:ⁱ9A3DC655FE41BA7E

GO

Isoform 2 (identifier: Q96B23-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
239-299: Missing.

« Hide

        10         20         30         40         50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST 
        60         70         80         90        100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS 
       110        120        130        140        150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS 
       160        170        180        190        200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL 
       210        220        230        240        250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPGH LDPGFLASDK 
       260        270        280        290        300
TSAGNAPLNE EINIASSDSE VEIVGVQEHA RCVHPRGGVI QSVSSWKHGS 
       310        320        330        340 
GTQYVSTRQT QSWTAVTPQQ TWASPAEVVD LTLDEDSRRK YLL

Show »

Length:343

Mass (Da):37,048

Checksum:ⁱ85FBC054A3358B4E

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A087WVF1	A0A087WVF1_HUMAN	Uncharacterized protein C18orf25 Uncharacterized protein C18orf25	C18orf25	275	Annotation score:
K7ER64	K7ER64_HUMAN	Uncharacterized protein C18orf25 Uncharacterized protein C18orf25	C18orf25	103	Annotation score:
K7EQH1	K7EQH1_HUMAN	Uncharacterized protein C18orf25 Uncharacterized protein C18orf25	C18orf25	146	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	233	I → V in CAD89920 (PubMed:17974005).Curated		1
Sequence conflictⁱ	316	N → S in CAE45812 (PubMed:17974005).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_080245	314	Missing 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014753	239 – 299	Missing in isoform 2. 3 PublicationsAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BK005125 mRNA Translation: DAA05329.1 AK289738 mRNA Translation: BAF82427.1 AK292981 mRNA Translation: BAF85670.1 AL713661 mRNA Translation: CAD28470.1 AL832027 mRNA Translation: CAD89920.1 BX640683 mRNA Translation: CAE45812.1 AC021763 Genomic DNA No translation available. AC118647 Genomic DNA No translation available. KF573673 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01472.1 CH471088 Genomic DNA Translation: EAX01473.1 BC016149 mRNA Translation: AAH16149.1 BC084579 mRNA Translation: AAH84579.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42430.1 [Q96B23-1] CCDS42431.1 [Q96B23-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001008240.1, NM_001008239.2 [Q96B23-2] NP_659492.1, NM_145055.3 [Q96B23-1] XP_011524124.1, XM_011525822.1 [Q96B23-1] XP_016881044.1, XM_017025555.1 [Q96B23-2]
UniGeneⁱ	Hs.116486

Genome annotation databases

Ensemblⁱ	ENST00000615052; ENSP00000481626; ENSG00000152242 [Q96B23-1] ENST00000619301; ENSP00000480074; ENSG00000152242 [Q96B23-2]
GeneIDⁱ	147339
KEGGⁱ	hsa:147339
UCSC genome browser More...UCSCⁱ	uc032hdb.2 human uc032hdc.2 human [Q96B23-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q96B23	C18orf25 isoform 4		PANTR		404	UniRef100_Q96B23
Uncharacterized protein C18orf25 (Fragment)		HUMAN		146
C18orf25 isoform 6 (Fragment)		PONAB		146
C18orf25 isoform 2 (Fragment)		PANTR		146
Uncharacterized protein C18orf25 (Fragment)		HUMAN		103
+2
Q96B23-2	C18orf25 isoform 5		PANTR		343	UniRef100_K7CYA9
C18orf25 isoform 2		PONAB		343
Chromosome 18 open reading frame 25		CERAT		343
Chromosome 18 open reading frame 25		MANLE		343
Chromosome 18 open reading frame 25		NOMLE		343

Protein	Similar proteins		Species	Score	Length	Source
Q96B23	C18orf25 isoform 4		PANTR		404	UniRef90_Q96B23
Uncharacterized protein C18orf25 (Fragment)		HUMAN		146
C18orf25 isoform 6 (Fragment)		PONAB		146
uncharacterized protein C18orf25 homolog isoform X1		TURTR		472
Uncharacterized protein (Fragment)		MUSPF		112
+108
Q96B23-2	Chromosome 18 open reading frame 25		CANLF		343	UniRef90_J9NX44
uncharacterized protein C18orf25 homolog isoform X3		TURTR		411
Chromosome 18 open reading frame 25		FELCA		345
Chromosome 18 open reading frame 25		ICTTR		343
Chromosome 18 open reading frame 25		CALJA		343
+93

Protein	Similar proteins		Species	Score	Length	Source
Q96B23	C18orf25 isoform 4		PANTR		404	UniRef50_Q96B23
Uncharacterized protein C18orf25 (Fragment)		HUMAN		146
C18orf25 isoform 6 (Fragment)		PONAB		146
uncharacterized protein C18orf25 homolog isoform X1		TURTR		472
Uncharacterized protein (Fragment)		MUSPF		112
+156
Q96B23-2	Chromosome 18 open reading frame 25		XENTR		408	UniRef50_F6XKS4
Uncharacterized protein C18orf25		CALAN		407
Uncharacterized protein C18orf25		rifleman		405
Uncharacterized protein C18orf25 (Fragment)		ANTCR		345
Uncharacterized protein C18orf25		TINGU		407
+144

Entry informationⁱ

Entry nameⁱ	CR025_HUMAN
Accessionⁱ	Q96B23Primary (citable) accession number: Q96B23 Secondary accession number(s): A8K123 Q8TCQ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	March 28, 2018
	Last modified:	September 12, 2018
	This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96B23 (CR025_HUMAN)

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Uncharacterized protein C18orf25

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ