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Protein

Uncharacterized protein C18orf25

Gene

C18orf25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C18orf25
Alternative name(s):
ARKadia-like protein 11 Publication
Gene namesi
Name:C18orf25Imported
Synonyms:ARKL11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000152242.10
HGNCiHGNC:28172 C18orf25
neXtProtiNX_Q96B23

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152242
PharmGKBiPA134919240

Polymorphism and mutation databases

BioMutaiC18orf25
DMDMi209572602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793121 – 404Uncharacterized protein C18orf25Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei147PhosphoserineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei347Omega-N-methylarginineCombined sources1
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96B23
MaxQBiQ96B23
PaxDbiQ96B23
PeptideAtlasiQ96B23
PRIDEiQ96B23
ProteomicsDBi76036
76037 [Q96B23-2]

PTM databases

iPTMnetiQ96B23
PhosphoSitePlusiQ96B23

Expressioni

Gene expression databases

BgeeiENSG00000152242
CleanExiHS_C18orf25
ExpressionAtlasiQ96B23 baseline and differential
GenevisibleiQ96B23 HS

Organism-specific databases

HPAiHPA051314
HPA065021

Interactioni

Protein-protein interaction databases

BioGridi127053, 51 interactors
IntActiQ96B23, 7 interactors
MINTiQ96B23
STRINGi9606.ENSP00000282059

Structurei

3D structure databases

ProteinModelPortaliQ96B23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 200Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKCJ Eukaryota
ENOG410Z94Y LUCA
GeneTreeiENSGT00390000016167
HOVERGENiHBG056975
InParanoidiQ96B23
OMAiYDMSDTS
OrthoDBiEOG091G09FS
PhylomeDBiQ96B23
TreeFamiTF351299

Family and domain databases

InterProiView protein in InterPro
IPR029306 RNF111_N
PfamiView protein in Pfam
PF15303 RNF111_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96B23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST
60 70 80 90 100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS
110 120 130 140 150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS
160 170 180 190 200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL
210 220 230 240 250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG PPVVAHYDMS
260 270 280 290 300
DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
310 320 330 340 350
HLDPGFLASD KTSAGNAPLN EEINIASSDS EVEIVGVQEH ARCVHPRGGV
360 370 380 390 400
IQSVSSWKHG SGTQYVSTRQ TQSWTAVTPQ QTWASPAEVV DLTLDEDSRR

KYLL
Length:404
Mass (Da):43,395
Last modified:March 28, 2018 - v3
Checksum:i9A3DC655FE41BA7E
GO
Isoform 2 (identifier: Q96B23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-299: Missing.

Show »
Length:343
Mass (Da):37,048
Checksum:i85FBC054A3358B4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233I → V in CAD89920 (PubMed:17974005).Curated1
Sequence conflicti316N → S in CAE45812 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080245314Missing 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014753239 – 299Missing in isoform 2. 3 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005125 mRNA Translation: DAA05329.1
AK289738 mRNA Translation: BAF82427.1
AK292981 mRNA Translation: BAF85670.1
AL713661 mRNA Translation: CAD28470.1
AL832027 mRNA Translation: CAD89920.1
BX640683 mRNA Translation: CAE45812.1
AC021763 Genomic DNA No translation available.
AC118647 Genomic DNA No translation available.
KF573673 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01472.1
CH471088 Genomic DNA Translation: EAX01473.1
BC016149 mRNA Translation: AAH16149.1
BC084579 mRNA Translation: AAH84579.1
CCDSiCCDS42430.1 [Q96B23-1]
CCDS42431.1 [Q96B23-2]
RefSeqiNP_001008240.1, NM_001008239.2 [Q96B23-2]
NP_659492.1, NM_145055.3 [Q96B23-1]
XP_011524124.1, XM_011525822.1 [Q96B23-1]
XP_016881044.1, XM_017025555.1 [Q96B23-2]
UniGeneiHs.116486

Genome annotation databases

EnsembliENST00000615052; ENSP00000481626; ENSG00000152242 [Q96B23-1]
ENST00000619301; ENSP00000480074; ENSG00000152242 [Q96B23-2]
GeneIDi147339
KEGGihsa:147339
UCSCiuc032hdb.2 human
uc032hdc.2 human [Q96B23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCR025_HUMAN
AccessioniPrimary (citable) accession number: Q96B23
Secondary accession number(s): A8K123
, A8KAB6, Q5BIX2, Q5XG78, Q6N058, Q86TB5, Q8TCQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations

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