TMEM45B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 45B
Gene namesⁱ	Name:TMEM45B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151715.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25194 TMEM45B
neXtProtⁱ	NX_Q96B21

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	7 – 27	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	47 – 67	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	116 – 136	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	146 – 166	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	180 – 200	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	212 – 232	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	120224
Open Targets More...OpenTargetsⁱ	ENSG00000151715
PharmGKBⁱ	PA134909603

Polymorphism and mutation databases

BioMutaⁱ	TMEM45B
DMDMⁱ	74731190

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271199	1 – 275	Transmembrane protein 45BAdd BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	270	PhosphoserineBy similarity		1
Modified residueⁱ	272	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96B21
PaxDbⁱ	Q96B21
PeptideAtlas More...PeptideAtlasⁱ	Q96B21
PRIDEⁱ	Q96B21
ProteomicsDBⁱ	76035

PTM databases

iPTMnetⁱ	Q96B21
PhosphoSitePlusⁱ	Q96B21

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151715
CleanExⁱ	HS_TMEM45B
Genevisibleⁱ	Q96B21 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015878

HPAⁱ

HPA015878

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	125675, 6 interactors
IntActⁱ	Q96B21, 38 interactors
STRINGⁱ	9606.ENSP00000281441

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96B21
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM45 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IG9I Eukaryota ENOG410ZTA1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063088
HOGENOMⁱ	HOG000136727
HOVERGENⁱ	HBG008722
InParanoidⁱ	Q96B21
OMAⁱ	LTYLVTH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GQ9
PhylomeDBⁱ	Q96B21
TreeFamⁱ	TF328673

Family and domain databases

InterProⁱ	View protein in InterPro IPR006904 DUF716_TMEM45
PANTHERⁱ	PTHR16007 PTHR16007, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04819 DUF716, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96B21-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA 
        60         70         80         90        100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG 
       110        120        130        140        150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL 
       160        170        180        190        200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG 
       210        220        230        240        250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG 
       260        270 
EIIGIQKLNS DDTYQTALLS GSDEE

Length:275

Mass (Da):31,826

Last modified:December 1, 2001 - v1

Checksum:ⁱDB8514C1E5005216

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029866	59	T → I. Corresponds to variant dbSNP:rs558813Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098106 mRNA Translation: BAC05235.1 AK290283 mRNA Translation: BAF82972.1 AK292058 mRNA Translation: BAF84747.1 BC016153 mRNA Translation: AAH16153.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8482.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001318139.1, NM_001331210.1 NP_001318140.1, NM_001331211.1 NP_001318141.1, NM_001331212.1 NP_620143.1, NM_138788.4 XP_016872677.1, XM_017017188.1 XP_016872678.1, XM_017017189.1
UniGeneⁱ	Hs.504301

Genome annotation databases

Ensemblⁱ	ENST00000281441; ENSP00000281441; ENSG00000151715 ENST00000524567; ENSP00000436293; ENSG00000151715
GeneIDⁱ	120224
KEGGⁱ	hsa:120224
UCSC genome browser More...UCSCⁱ	uc001qfe.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q96B21	UPI00080A6FCF		Cebus capucinus imitator		288
Transmembrane protein 45B		SAIBB		276
Transmembrane protein 45B		AOTNA		276
Transmembrane protein 45B, isoform CRA_b		HUMAN		275
TMEM45B isoform 1		PANTR		275
+20

Protein	Similar proteins		Species	Score	Length
Q96B21	UPI00080A6FCF		Cebus capucinus imitator		288
Transmembrane protein 45B		SAIBB		276
Transmembrane protein 45B		AOTNA		276
Transmembrane protein 45B		RHIRO		275
Transmembrane protein 45B, isoform CRA_b		HUMAN		275
+225

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK098106 mRNA Translation: BAC05235.1 AK290283 mRNA Translation: BAF82972.1 AK292058 mRNA Translation: BAF84747.1 BC016153 mRNA Translation: AAH16153.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8482.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001318139.1, NM_001331210.1 NP_001318140.1, NM_001331211.1 NP_001318141.1, NM_001331212.1 NP_620143.1, NM_138788.4 XP_016872677.1, XM_017017188.1 XP_016872678.1, XM_017017189.1
UniGeneⁱ	Hs.504301

3D structure databases

ProteinModelPortalⁱ	Q96B21
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125675, 6 interactors
IntActⁱ	Q96B21, 38 interactors
STRINGⁱ	9606.ENSP00000281441

PTM databases

iPTMnetⁱ	Q96B21
PhosphoSitePlusⁱ	Q96B21

Polymorphism and mutation databases

BioMutaⁱ	TMEM45B
DMDMⁱ	74731190

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96B21
PaxDbⁱ	Q96B21
PeptideAtlas More...PeptideAtlasⁱ	Q96B21
PRIDEⁱ	Q96B21
ProteomicsDBⁱ	76035

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	120224
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000281441; ENSP00000281441; ENSG00000151715 ENST00000524567; ENSP00000436293; ENSG00000151715
GeneIDⁱ	120224
KEGGⁱ	hsa:120224
UCSC genome browser More...UCSCⁱ	uc001qfe.2 human

Organism-specific databases

CTDⁱ	120224
DisGeNET More...DisGeNETⁱ	120224
EuPathDBⁱ	HostDB:ENSG00000151715.7
GeneCardsⁱ	TMEM45B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25194 TMEM45B
Human Protein Atlas More...HPAⁱ	HPA015878
neXtProtⁱ	NX_Q96B21
Open Targets More...OpenTargetsⁱ	ENSG00000151715
PharmGKBⁱ	PA134909603
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IG9I Eukaryota ENOG410ZTA1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063088
HOGENOMⁱ	HOG000136727
HOVERGENⁱ	HBG008722
InParanoidⁱ	Q96B21
OMAⁱ	LTYLVTH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GQ9
PhylomeDBⁱ	Q96B21
TreeFamⁱ	TF328673

Miscellaneous databases

GenomeRNAiⁱ	120224
Protein Ontology More...PROⁱ	PR:Q96B21

Gene expression databases

Bgeeⁱ	ENSG00000151715
CleanExⁱ	HS_TMEM45B
Genevisibleⁱ	Q96B21 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006904 DUF716_TMEM45
PANTHERⁱ	PTHR16007 PTHR16007, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04819 DUF716, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM45B_HUMAN
Accessionⁱ	Q96B21Primary (citable) accession number: Q96B21 Secondary accession number(s): A8K2L8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	December 1, 2001
	Last modified:	July 18, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q96B21 (TM45B_HUMAN)

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Transmembrane protein 45B

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ