UniProtKB - Q96B21 (TM45B_HUMAN)
Protein
Transmembrane protein 45B
Gene
TMEM45B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 45B |
Gene namesi | Name:TMEM45B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151715.7 |
HGNCi | HGNC:25194, TMEM45B |
neXtProti | NX_Q96B21 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 47 – 67 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 120224 |
OpenTargetsi | ENSG00000151715 |
PharmGKBi | PA134909603 |
Miscellaneous databases
Pharosi | Q96B21, Tdark |
Polymorphism and mutation databases
BioMutai | TMEM45B |
DMDMi | 74731190 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271199 | 1 – 275 | Transmembrane protein 45BAdd BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 270 | PhosphoserineBy similarity | 1 | |
Modified residuei | 272 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q96B21 |
MassIVEi | Q96B21 |
MaxQBi | Q96B21 |
PaxDbi | Q96B21 |
PeptideAtlasi | Q96B21 |
PRIDEi | Q96B21 |
ProteomicsDBi | 76035 |
PTM databases
iPTMneti | Q96B21 |
PhosphoSitePlusi | Q96B21 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151715, Expressed in colonic mucosa and 155 other tissues |
Genevisiblei | Q96B21, HS |
Organism-specific databases
HPAi | ENSG00000151715, Tissue enhanced (intestine) |
Interactioni
Binary interactionsi
Hide detailsQ96B21
Protein-protein interaction databases
BioGRIDi | 125675, 44 interactors |
IntActi | Q96B21, 40 interactors |
STRINGi | 9606.ENSP00000281441 |
Miscellaneous databases
RNActi | Q96B21, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM45 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QU0J, Eukaryota |
GeneTreei | ENSGT00940000157181 |
HOGENOMi | CLU_059568_0_0_1 |
InParanoidi | Q96B21 |
OMAi | GIMVEQF |
OrthoDBi | 1297629at2759 |
PhylomeDBi | Q96B21 |
TreeFami | TF328673 |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 IPR042127, TMEM45 |
PANTHERi | PTHR16007, PTHR16007, 1 hit |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96B21-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA
60 70 80 90 100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG
110 120 130 140 150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL
160 170 180 190 200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG
210 220 230 240 250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG
260 270
EIIGIQKLNS DDTYQTALLS GSDEE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029866 | 59 | T → I. Corresponds to variant dbSNP:rs558813Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098106 mRNA Translation: BAC05235.1 AK290283 mRNA Translation: BAF82972.1 AK292058 mRNA Translation: BAF84747.1 BC016153 mRNA Translation: AAH16153.1 |
CCDSi | CCDS8482.1 |
RefSeqi | NP_001318139.1, NM_001331210.1 NP_001318140.1, NM_001331211.1 NP_001318141.1, NM_001331212.1 NP_620143.1, NM_138788.4 XP_016872677.1, XM_017017188.1 XP_016872678.1, XM_017017189.1 |
Genome annotation databases
Ensembli | ENST00000281441; ENSP00000281441; ENSG00000151715 ENST00000524567; ENSP00000436293; ENSG00000151715 |
GeneIDi | 120224 |
KEGGi | hsa:120224 |
UCSCi | uc001qfe.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK098106 mRNA Translation: BAC05235.1 AK290283 mRNA Translation: BAF82972.1 AK292058 mRNA Translation: BAF84747.1 BC016153 mRNA Translation: AAH16153.1 |
CCDSi | CCDS8482.1 |
RefSeqi | NP_001318139.1, NM_001331210.1 NP_001318140.1, NM_001331211.1 NP_001318141.1, NM_001331212.1 NP_620143.1, NM_138788.4 XP_016872677.1, XM_017017188.1 XP_016872678.1, XM_017017189.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125675, 44 interactors |
IntActi | Q96B21, 40 interactors |
STRINGi | 9606.ENSP00000281441 |
PTM databases
iPTMneti | Q96B21 |
PhosphoSitePlusi | Q96B21 |
Polymorphism and mutation databases
BioMutai | TMEM45B |
DMDMi | 74731190 |
Proteomic databases
jPOSTi | Q96B21 |
MassIVEi | Q96B21 |
MaxQBi | Q96B21 |
PaxDbi | Q96B21 |
PeptideAtlasi | Q96B21 |
PRIDEi | Q96B21 |
ProteomicsDBi | 76035 |
Protocols and materials databases
Antibodypediai | 19209, 8 antibodies |
DNASUi | 120224 |
Genome annotation databases
Ensembli | ENST00000281441; ENSP00000281441; ENSG00000151715 ENST00000524567; ENSP00000436293; ENSG00000151715 |
GeneIDi | 120224 |
KEGGi | hsa:120224 |
UCSCi | uc001qfe.2, human |
Organism-specific databases
CTDi | 120224 |
DisGeNETi | 120224 |
EuPathDBi | HostDB:ENSG00000151715.7 |
GeneCardsi | TMEM45B |
HGNCi | HGNC:25194, TMEM45B |
HPAi | ENSG00000151715, Tissue enhanced (intestine) |
neXtProti | NX_Q96B21 |
OpenTargetsi | ENSG00000151715 |
PharmGKBi | PA134909603 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU0J, Eukaryota |
GeneTreei | ENSGT00940000157181 |
HOGENOMi | CLU_059568_0_0_1 |
InParanoidi | Q96B21 |
OMAi | GIMVEQF |
OrthoDBi | 1297629at2759 |
PhylomeDBi | Q96B21 |
TreeFami | TF328673 |
Enzyme and pathway databases
PathwayCommonsi | Q96B21 |
Miscellaneous databases
BioGRID-ORCSi | 120224, 3 hits in 842 CRISPR screens |
ChiTaRSi | TMEM45B, human |
GenomeRNAii | 120224 |
Pharosi | Q96B21, Tdark |
PROi | PR:Q96B21 |
RNActi | Q96B21, protein |
Gene expression databases
Bgeei | ENSG00000151715, Expressed in colonic mucosa and 155 other tissues |
Genevisiblei | Q96B21, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006904, DUF716 IPR042127, TMEM45 |
PANTHERi | PTHR16007, PTHR16007, 1 hit |
Pfami | View protein in Pfam PF04819, DUF716, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM45B_HUMAN | |
Accessioni | Q96B21Primary (citable) accession number: Q96B21 Secondary accession number(s): A8K2L8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations