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Entry version 119 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 45B

Gene

TMEM45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96B21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 45B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM45B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000151715.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25194, TMEM45B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96B21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
120224

Open Targets

More...
OpenTargetsi
ENSG00000151715

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909603

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96B21, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM45B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74731190

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002711991 – 275Transmembrane protein 45BAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei270PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96B21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96B21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96B21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96B21

PeptideAtlas

More...
PeptideAtlasi
Q96B21

PRoteomics IDEntifications database

More...
PRIDEi
Q96B21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76035

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96B21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96B21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151715, Expressed in colonic mucosa and 155 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96B21, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000151715, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q96B21
With#Exp.IntAct
ANKRD46 - isoform 1 [Q86W74-2]3EBI-3923061,EBI-12109402
APOD [P05090]3EBI-3923061,EBI-715495
APOL2 [Q9BQE5]3EBI-3923061,EBI-4290634
AQP1 [P29972]3EBI-3923061,EBI-745213
BMP10 [O95393]3EBI-3923061,EBI-3922513
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-3923061,EBI-12003442
CACNG1 [Q06432]3EBI-3923061,EBI-9686780
CDS2 [O95674]3EBI-3923061,EBI-3913685
CYB561D2 [O14569]3EBI-3923061,EBI-717654
DOLK [Q9UPQ8]3EBI-3923061,EBI-8645574
FAM3C [Q92520]3EBI-3923061,EBI-2876774
FKBP8 [Q14318]3EBI-3923061,EBI-724839
GIMAP1 [Q8WWP7]3EBI-3923061,EBI-11991950
INSIG2 [Q9Y5U4]3EBI-3923061,EBI-8503746
LAT - isoform 2 [O43561-2]3EBI-3923061,EBI-8070286
NSG1 [P42857]3EBI-3923061,EBI-6380741
PLN [P26678]3EBI-3923061,EBI-692836
PLP1 - isoform DM-20 [P60201-2]3EBI-3923061,EBI-12188331
PLPP4 [Q5VZY2]3EBI-3923061,EBI-10485931
SEC22A [Q96IW7]3EBI-3923061,EBI-8652744
SEC23A [Q15436]3EBI-3923061,EBI-81088
SMAGP [Q0VAQ4]3EBI-3923061,EBI-10226799
SMIM1 [B2RUZ4]3EBI-3923061,EBI-12188413
SNORC [Q6UX34]3EBI-3923061,EBI-11957067
SYNGR1 - isoform 1B [O43759-2]3EBI-3923061,EBI-12187159
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-3923061,EBI-10694905
TMEM218 [A2RU14]3EBI-3923061,EBI-10173151
TMEM229B [Q8NBD8]3EBI-3923061,EBI-12195227
TMEM243 [Q9BU79]3EBI-3923061,EBI-12887458
TMEM254 [Q8TBM7]3EBI-3923061,EBI-11956809
TMEM60 [Q9H2L4]3EBI-3923061,EBI-2852148
TMEM97 [Q5BJF2]3EBI-3923061,EBI-12111910
TNFRSF10C [O14798]3EBI-3923061,EBI-717441
TREX1 - isoform 1 [Q9NSU2-1]3EBI-3923061,EBI-16746122
TSPAN33 [Q86UF1]3EBI-3923061,EBI-12045841
TTMP [Q5BVD1]3EBI-3923061,EBI-10243654
UPK1B [O75841]3EBI-3923061,EBI-12237619
VAMP5 [O95183]3EBI-3923061,EBI-10191195

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125675, 44 interactors

Protein interaction database and analysis system

More...
IntActi
Q96B21, 40 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000281441

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96B21, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU0J, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_059568_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96B21

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIMVEQF

Database of Orthologous Groups

More...
OrthoDBi
1297629at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96B21

TreeFam database of animal gene trees

More...
TreeFami
TF328673

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006904, DUF716
IPR042127, TMEM45

The PANTHER Classification System

More...
PANTHERi
PTHR16007, PTHR16007, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04819, DUF716, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96B21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA
60 70 80 90 100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG
110 120 130 140 150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL
160 170 180 190 200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG
210 220 230 240 250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG
260 270
EIIGIQKLNS DDTYQTALLS GSDEE
Length:275
Mass (Da):31,826
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB8514C1E5005216
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02986659T → I. Corresponds to variant dbSNP:rs558813Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098106 mRNA Translation: BAC05235.1
AK290283 mRNA Translation: BAF82972.1
AK292058 mRNA Translation: BAF84747.1
BC016153 mRNA Translation: AAH16153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8482.1

NCBI Reference Sequences

More...
RefSeqi
NP_001318139.1, NM_001331210.1
NP_001318140.1, NM_001331211.1
NP_001318141.1, NM_001331212.1
NP_620143.1, NM_138788.4
XP_016872677.1, XM_017017188.1
XP_016872678.1, XM_017017189.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281441; ENSP00000281441; ENSG00000151715
ENST00000524567; ENSP00000436293; ENSG00000151715

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
120224

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:120224

UCSC genome browser

More...
UCSCi
uc001qfe.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA Translation: BAC05235.1
AK290283 mRNA Translation: BAF82972.1
AK292058 mRNA Translation: BAF84747.1
BC016153 mRNA Translation: AAH16153.1
CCDSiCCDS8482.1
RefSeqiNP_001318139.1, NM_001331210.1
NP_001318140.1, NM_001331211.1
NP_001318141.1, NM_001331212.1
NP_620143.1, NM_138788.4
XP_016872677.1, XM_017017188.1
XP_016872678.1, XM_017017189.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125675, 44 interactors
IntActiQ96B21, 40 interactors
STRINGi9606.ENSP00000281441

PTM databases

iPTMnetiQ96B21
PhosphoSitePlusiQ96B21

Polymorphism and mutation databases

BioMutaiTMEM45B
DMDMi74731190

Proteomic databases

jPOSTiQ96B21
MassIVEiQ96B21
MaxQBiQ96B21
PaxDbiQ96B21
PeptideAtlasiQ96B21
PRIDEiQ96B21
ProteomicsDBi76035

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19209, 8 antibodies

The DNASU plasmid repository

More...
DNASUi
120224

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715
ENST00000524567; ENSP00000436293; ENSG00000151715
GeneIDi120224
KEGGihsa:120224
UCSCiuc001qfe.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
120224
DisGeNETi120224
EuPathDBiHostDB:ENSG00000151715.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM45B
HGNCiHGNC:25194, TMEM45B
HPAiENSG00000151715, Tissue enhanced (intestine)
neXtProtiNX_Q96B21
OpenTargetsiENSG00000151715
PharmGKBiPA134909603

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QU0J, Eukaryota
GeneTreeiENSGT00940000157181
HOGENOMiCLU_059568_0_0_1
InParanoidiQ96B21
OMAiGIMVEQF
OrthoDBi1297629at2759
PhylomeDBiQ96B21
TreeFamiTF328673

Enzyme and pathway databases

PathwayCommonsiQ96B21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
120224, 3 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM45B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
120224
PharosiQ96B21, Tdark

Protein Ontology

More...
PROi
PR:Q96B21
RNActiQ96B21, protein

Gene expression databases

BgeeiENSG00000151715, Expressed in colonic mucosa and 155 other tissues
GenevisibleiQ96B21, HS

Family and domain databases

InterProiView protein in InterPro
IPR006904, DUF716
IPR042127, TMEM45
PANTHERiPTHR16007, PTHR16007, 1 hit
PfamiView protein in Pfam
PF04819, DUF716, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM45B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B21
Secondary accession number(s): A8K2L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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