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UniProtKB - Q96B01 (R51A1_HUMAN)

Entry version 156 (02 Dec 2020)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

RAD51-associated protein 1

Gene

RAD51AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801).13 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processDNA damage, DNA recombination, DNA repair, Meiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96B01

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579, Homologous DNA Pairing and Strand Exchange

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAD51-associated protein 1Curated
Short name:
HsRAD51AP11 Publication
Alternative name(s):
RAD51-interacting protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD51AP11 PublicationImported
Synonyms:PIR511 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000111247.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:16956, RAD51AP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603070, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96B01

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34 – 47KKSRT…LKQDK → AASATAPAELAQDA in K6RA; impaired DNA-binding. 1 PublicationAdd BLAST14
Mutagenesisi34 – 37KKSR → AASA in K2RA; impaired DNA-binding. 1 Publication4
Mutagenesisi44K → R: Does not affect sumoylation. 1 Publication1
Mutagenesisi150 – 153DYLD → AYLA: Abolished interaction with WDR48/UAF1. 1 Publication4
Mutagenesisi154 – 159LDKITV → ADKATA: Reduced sumoylation. Reduced ubiquitination. 1 Publication6
Mutagenesisi154 – 157LDKI → ADKA: Decreased interaction with WDR48/UAF1. 1 Publication4
Mutagenesisi156K → R: Does not affect interaction with WDR48/UAF1. 1 Publication1
Mutagenesisi157 – 159ITV → ATA: Decreased interaction with WDR48/UAF1. 1 Publication3
Mutagenesisi240K → R: Does not affect sumoylation. 1 Publication1
Mutagenesisi248 – 253KKSKSK → AASASA in K4A; reduced DNA-binding. In K7WA; strongly decreased DNA-binding; when associated with 300-A--A-304. 1 Publication6
Mutagenesisi269K → R: Strongly reduced sumoylation. Strongly reduced ubiquitination. 1 Publication1
Mutagenesisi300 – 304KKPKW → AAPAA in K3WA; reduced DNA-binding. In K7WA; strongly decreased DNA-binding; when associated with 248-A--A-253. 1 Publication5
Mutagenesisi304W → A: Abolished interaction with DMC1 without affecting interaction with RAD51. 1 Publication1
Mutagenesisi326K → R: Does not affect sumoylation. 1 Publication1
Mutagenesisi327 – 352Missing : Abolished interaction with RAD51. 1 PublicationAdd BLAST26
Mutagenesisi328 – 352Missing in mutant delta25; abolished interaction with RAD51. 1 PublicationAdd BLAST25
Mutagenesisi333R → A: Strongly decreases interaction with RAD51; when associated with Q-336, A-345 and A-346. 1 Publication1
Mutagenesisi336L → Q: Strongly decreases interaction with RAD51; when associated with A-333, A-345 and A-346. Decreased interacting with RAD51 and ability to stimulate RAD51-mediated homologous recombination. Does not affect interaction with DMC1. 3 Publications1
Mutagenesisi345 – 346LH → AA: Strongly decreases interaction with RAD51; when associated with A-333; and Q-336. 1 Publication2
Mutagenesisi346H → A: Decreased interacting with RAD51 and ability to stimulate RAD51-mediated homologous recombination. Does not affect interaction with DMC1. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		10635

Open Targets

More...OpenTargetsi		ENSG00000111247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134871784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96B01, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAD51AP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971401 – 352RAD51-associated protein 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei66PhosphothreonineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin; alternate)1 Publication
Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei280PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation with SUMO2/3 by NSMCE2/MMS21 promotes stabilization, possibly by preventing ubiquitination (PubMed:31400850). Sumoylation is required for alternative lengthening of telomeres (ALT) pathway (PubMed:31400850).1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96B01

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96B01

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96B01

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96B01

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96B01

PeptideAtlas

More...PeptideAtlasi		Q96B01

PRoteomics IDEntifications database

More...PRIDEi		Q96B01

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76027 [Q96B01-1]
76028 [Q96B01-2]
76029 [Q96B01-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q96B01-1 [Q96B01-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96B01

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96B01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and thymus (PubMed:9396801). Lower levels in colon and small intestine (PubMed:9396801). Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes (PubMed:9396801).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111247, Expressed in secondary oocyte and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96B01, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96B01, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111247, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; elongated monodisperse monomer (PubMed:17996710).

Interacts (via C-terminal region) with RAD51; the interaction is direct (PubMed:16990250, PubMed:23754376, PubMed:9396801, PubMed:17996710, PubMed:17996711, PubMed:21903585).

Interacts (via SIM motif) with WDR48/UAF1; WDR48/UAF1 and RAD51AP1 cooperate together to stimulate RAD51-mediated homologous recombination (HR) (PubMed:27463890, PubMed:27239033).

Interacts (via WVPP motif) with DMC1; the interaction is direct (PubMed:21903585, PubMed:21307306).

Interacts with PALB2 (PubMed:20871616).

Interacts with RAD52 (PubMed:31400850).

11 Publications

Does not interact with DMC1; lack of interaction is caused by the absence of the WVPP motif in this isoform.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115879, 19 interactors

Database of interacting proteins

More...DIPi		DIP-35257N

Protein interaction database and analysis system

More...IntActi		Q96B01, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000228843

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96B01, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 49Interaction with DNA1 PublicationAdd BLAST20
Regioni243 – 304Interaction with DNA1 PublicationAdd BLAST62
Regioni313 – 352Interaction with RAD514 PublicationsAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi154 – 159SIM motif2 Publications6
Motifi304 – 307WVPP motif1 Publication4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXRS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153414

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_067355_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96B01

Identification of Orthologs from Complete Genome Data

More...OMAi		KVQLPVD

Database of Orthologous Groups

More...OrthoDBi		1109145at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96B01

TreeFam database of animal gene trees

More...TreeFami		TF335955

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026632, RAD51-assoc_prot_1
IPR031419, RAD51_interact

The PANTHER Classification System

More...PANTHERi		PTHR15361:SF4, PTHR15361:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15696, RAD51_interact, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.1 Publication

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q96B01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP KELKQDKPKP 
        60         70         80         90        100
NLNNLRKEEI PVQEKTPKKR LPEGTFSIPA SAVPCTKMAL DDKLYQRDLE 
       110        120        130        140        150
VALALSVKEL PTVTTNVQNS QDKSIEKHGS SKIETMNKSP HISNCSVASD 
       160        170        180        190        200
YLDLDKITVE DDVGGVQGKR KAASKAAAQQ RKILLEGSDG DSANDTEPDF 
       210        220        230        240        250
APGEDSEDDS DFCESEDNDE DFSMRKSKVK EIKKKEVKVK SPVEKKEKKS 
       260        270        280        290        300
KSKCNALVTS VDSAPAAVKS ESQSLPKKVS LSSDTTRKPL EIRSPSAESK 
       310        320        330        340        350
KPKWVPPAAS GGSRSSSSPL VVVSVKSPNQ SLRLGLSRLA RVKPLHPNAT 

ST
Length:352
Mass (Da):38,457
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE582EE4BC459DD92
GO
Isoform 21 Publication (identifier: Q96B01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-87: Missing.

Show »
Length:335
Mass (Da):36,757
Checksum:i71BBA478F55C5D39
GO
Isoform 31 Publication (identifier: Q96B01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-307: Missing.

Show »
Length:302
Mass (Da):33,142
Checksum:iF667DBB6B8DF19E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1Y0F5H1Y0_HUMAN
RAD51-associated protein 1
RAD51AP1
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGT5H0YGT5_HUMAN
RAD51-associated protein 1
RAD51AP1
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H710F5H710_HUMAN
RAD51-associated protein 1
RAD51AP1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFK6H0YFK6_HUMAN
RAD51-associated protein 1
RAD51AP1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H031F5H031_HUMAN
RAD51-associated protein 1
RAD51AP1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4V6F5H4V6_HUMAN
RAD51-associated protein 1
RAD51AP1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05697668K → Q. Corresponds to variant dbSNP:rs34810644EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05173971 – 87Missing in isoform 2. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_051740258 – 307Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006259 mRNA Translation: AAC39554.1
AK096930 mRNA Translation: BAC04902.1
AK291948 mRNA Translation: BAF84637.1
CH471116 Genomic DNA Translation: EAW88844.1
BC006992 mRNA Translation: AAH06992.1
BC016330 mRNA Translation: AAH16330.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44805.1 [Q96B01-1]
CCDS8529.1 [Q96B01-2]

NCBI Reference Sequences

More...RefSeqi		NP_001124334.1, NM_001130862.1 [Q96B01-1]
NP_006470.1, NM_006479.4 [Q96B01-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228843; ENSP00000228843; ENSG00000111247 [Q96B01-1]
ENST00000352618; ENSP00000309479; ENSG00000111247 [Q96B01-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10635

UCSC genome browser

More...UCSCi		uc001qmu.4, human [Q96B01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006259 mRNA Translation: AAC39554.1
AK096930 mRNA Translation: BAC04902.1
AK291948 mRNA Translation: BAF84637.1
CH471116 Genomic DNA Translation: EAW88844.1
BC006992 mRNA Translation: AAH06992.1
BC016330 mRNA Translation: AAH16330.1
CCDSiCCDS44805.1 [Q96B01-1]
CCDS8529.1 [Q96B01-2]
RefSeqiNP_001124334.1, NM_001130862.1 [Q96B01-1]
NP_006470.1, NM_006479.4 [Q96B01-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115879, 19 interactors
DIPiDIP-35257N
IntActiQ96B01, 17 interactors
STRINGi9606.ENSP00000228843

PTM databases

iPTMnetiQ96B01
PhosphoSitePlusiQ96B01

Polymorphism and mutation databases

BioMutaiRAD51AP1
DMDMi68565925

Proteomic databases

EPDiQ96B01
jPOSTiQ96B01
MassIVEiQ96B01
MaxQBiQ96B01
PaxDbiQ96B01
PeptideAtlasiQ96B01
PRIDEiQ96B01
ProteomicsDBi76027 [Q96B01-1]
76028 [Q96B01-2]
76029 [Q96B01-3]
TopDownProteomicsiQ96B01-1 [Q96B01-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22279, 153 antibodies

The DNASU plasmid repository

More...DNASUi		10635

Genome annotation databases

EnsembliENST00000228843; ENSP00000228843; ENSG00000111247 [Q96B01-1]
ENST00000352618; ENSP00000309479; ENSG00000111247 [Q96B01-2]
GeneIDi10635
KEGGihsa:10635
UCSCiuc001qmu.4, human [Q96B01-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10635
DisGeNETi10635
EuPathDBiHostDB:ENSG00000111247.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAD51AP1
HGNCiHGNC:16956, RAD51AP1
HPAiENSG00000111247, Tissue enhanced (lymphoid)
MIMi603070, gene
neXtProtiNX_Q96B01
OpenTargetsiENSG00000111247
PharmGKBiPA134871784

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RXRS, Eukaryota
GeneTreeiENSGT00940000153414
HOGENOMiCLU_067355_1_0_1
InParanoidiQ96B01
OMAiKVQLPVD
OrthoDBi1109145at2759
PhylomeDBiQ96B01
TreeFamiTF335955

Enzyme and pathway databases

PathwayCommonsiQ96B01
ReactomeiR-HSA-5685942, HDR through Homologous Recombination (HRR)
R-HSA-5693554, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568, Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579, Homologous DNA Pairing and Strand Exchange

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10635, 10 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAD51AP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10635
PharosiQ96B01, Tbio

Protein Ontology

More...PROi		PR:Q96B01
RNActiQ96B01, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111247, Expressed in secondary oocyte and 185 other tissues
ExpressionAtlasiQ96B01, baseline and differential
GenevisibleiQ96B01, HS

Family and domain databases

InterProiView protein in InterPro
IPR026632, RAD51-assoc_prot_1
IPR031419, RAD51_interact
PANTHERiPTHR15361:SF4, PTHR15361:SF4, 1 hit
PfamiView protein in Pfam
PF15696, RAD51_interact, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR51A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96B01
Secondary accession number(s): A8K7D3, O43403, Q7Z779
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: December 2, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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