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Protein

Tetratricopeptide repeat protein 28

Gene

TTC28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of mitotic cell cycle Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 28
Short name:
TPR repeat protein 28
Alternative name(s):
TPR repeat-containing big gene cloned at Keio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC28
Synonyms:KIAA1043, TPRBK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100154.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29179 TTC28

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615098 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96AY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23331

Open Targets

More...
OpenTargetsi
ENSG00000100154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145147752

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC28

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218512146

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001064271 – 2481Tetratricopeptide repeat protein 28Add BLAST2481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei1590PhosphoserineBy similarity1
Modified residuei2104PhosphoserineCombined sources1
Modified residuei2224PhosphoserineCombined sources1
Modified residuei2251PhosphoserineCombined sources1
Modified residuei2393PhosphoserineCombined sources1
Modified residuei2398PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96AY4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96AY4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96AY4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96AY4

PeptideAtlas

More...
PeptideAtlasi
Q96AY4

PRoteomics IDEntifications database

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PRIDEi
Q96AY4

ProteomicsDB human proteome resource

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ProteomicsDBi
76021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96AY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96AY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100154 Expressed in 222 organ(s), highest expression level in cerebral cortex

CleanEx database of gene expression profiles

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CleanExi
HS_TTC28

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96AY4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96AY4 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA003099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AURKB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116918, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q96AY4, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381003

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96AY4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati58 – 91TPR 1Add BLAST34
Repeati93 – 125TPR 2Add BLAST33
Repeati126 – 159TPR 3Add BLAST34
Repeati196 – 229TPR 4Add BLAST34
Repeati234 – 267TPR 5Add BLAST34
Repeati274 – 307TPR 6Add BLAST34
Repeati314 – 347TPR 7Add BLAST34
Repeati354 – 387TPR 8Add BLAST34
Repeati394 – 427TPR 9Add BLAST34
Repeati434 – 467TPR 10Add BLAST34
Repeati474 – 507TPR 11Add BLAST34
Repeati514 – 547TPR 12Add BLAST34
Repeati554 – 587TPR 13Add BLAST34
Repeati594 – 627TPR 14Add BLAST34
Repeati634 – 667TPR 15Add BLAST34
Repeati674 – 707TPR 16Add BLAST34
Repeati714 – 747TPR 17Add BLAST34
Repeati754 – 787TPR 18Add BLAST34
Repeati794 – 827TPR 19Add BLAST34
Repeati834 – 867TPR 20Add BLAST34
Repeati877 – 910TPR 21Add BLAST34
Repeati917 – 950TPR 22Add BLAST34
Repeati957 – 990TPR 23Add BLAST34
Repeati997 – 1030TPR 24Add BLAST34
Repeati1037 – 1070TPR 25Add BLAST34
Repeati1077 – 1110TPR 26Add BLAST34
Repeati1117 – 1150TPR 27Add BLAST34
Repeati1169 – 1202TPR 28Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1948 – 2006Ser-richAdd BLAST59
Compositional biasi2201 – 2335Ser-richAdd BLAST135

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0548 Eukaryota
KOG1130 Eukaryota
COG0457 LUCA
COG4995 LUCA
ENOG410XP6N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156428

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052194

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96AY4

Identification of Orthologs from Complete Genome Data

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OMAi
FHAARID

Database of Orthologous Groups

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OrthoDBi
733786at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96AY4

TreeFam database of animal gene trees

More...
TreeFami
TF328344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024983 CHAT_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12770 CHAT, 1 hit
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 25 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 25 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96AY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG
60 70 80 90 100
PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA
110 120 130 140 150
AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA
160 170 180 190 200
SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS
210 220 230 240 250
VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT
260 270 280 290 300
EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
310 320 330 340 350
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE
360 370 380 390 400
LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL
410 420 430 440 450
GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL
460 470 480 490 500
ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH
510 520 530 540 550
LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR
560 570 580 590 600
ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
610 620 630 640 650
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY
660 670 680 690 700
QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL
710 720 730 740 750
LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR
760 770 780 790 800
RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL
810 820 830 840 850
AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM
860 870 880 890 900
EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY
910 920 930 940 950
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL
960 970 980 990 1000
GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA
1010 1020 1030 1040 1050
CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL
1060 1070 1080 1090 1100
GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL
1110 1120 1130 1140 1150
QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI
1160 1170 1180 1190 1200
RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
1210 1220 1230 1240 1250
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL
1260 1270 1280 1290 1300
LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR
1310 1320 1330 1340 1350
EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV
1360 1370 1380 1390 1400
RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL
1410 1420 1430 1440 1450
IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF
1460 1470 1480 1490 1500
GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL
1510 1520 1530 1540 1550
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS
1560 1570 1580 1590 1600
WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP
1610 1620 1630 1640 1650
LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA
1660 1670 1680 1690 1700
QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS
1710 1720 1730 1740 1750
HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE
1760 1770 1780 1790 1800
KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP
1810 1820 1830 1840 1850
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS
1860 1870 1880 1890 1900
RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA
1910 1920 1930 1940 1950
ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD
1960 1970 1980 1990 2000
SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS
2010 2020 2030 2040 2050
SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN
2060 2070 2080 2090 2100
KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK
2110 2120 2130 2140 2150
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ
2160 2170 2180 2190 2200
EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP
2210 2220 2230 2240 2250
SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS
2260 2270 2280 2290 2300
SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS
2310 2320 2330 2340 2350
KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI
2360 2370 2380 2390 2400
DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR
2410 2420 2430 2440 2450
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP
2460 2470 2480
PATAPARPLR LPSGNGYKFL SPGRFFPSSK C
Length:2,481
Mass (Da):270,884
Last modified:December 16, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD646D744EBFCFE35
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WW06A0A087WW06_HUMAN
Tetratricopeptide repeat protein 28
TTC28
2,354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYP4B0QYP4_HUMAN
Tetratricopeptide repeat protein 28
TTC28
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYP5B0QYP5_HUMAN
Tetratricopeptide repeat protein 28
TTC28
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16465 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB62963 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB62964 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB665284 mRNA Translation: BAM66822.1
AL008724 Genomic DNA Translation: CAB62963.1 Sequence problems.
AL008724 Genomic DNA Translation: CAB62964.1 Sequence problems.
AL121825 Genomic DNA No translation available.
AL023281 Genomic DNA No translation available.
AL050313 Genomic DNA No translation available.
AL035453 Genomic DNA No translation available.
AL035397 Genomic DNA No translation available.
AL033538 Genomic DNA No translation available.
ES313581 mRNA No translation available.
BU584912 mRNA No translation available.
AB028966 mRNA Translation: BAA82995.3
BC016465 mRNA Translation: AAH16465.1 Different initiation.
AL080174 mRNA Translation: CAB45760.2
AL137328 mRNA Translation: CAB70697.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46678.1

Protein sequence database of the Protein Information Resource

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PIRi
T12496

NCBI Reference Sequences

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RefSeqi
NP_001138890.1, NM_001145418.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.387856

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397906; ENSP00000381003; ENSG00000100154

Database of genes from NCBI RefSeq genomes

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GeneIDi
23331

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23331

UCSC genome browser

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UCSCi
uc003adp.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB665284 mRNA Translation: BAM66822.1
AL008724 Genomic DNA Translation: CAB62963.1 Sequence problems.
AL008724 Genomic DNA Translation: CAB62964.1 Sequence problems.
AL121825 Genomic DNA No translation available.
AL023281 Genomic DNA No translation available.
AL050313 Genomic DNA No translation available.
AL035453 Genomic DNA No translation available.
AL035397 Genomic DNA No translation available.
AL033538 Genomic DNA No translation available.
ES313581 mRNA No translation available.
BU584912 mRNA No translation available.
AB028966 mRNA Translation: BAA82995.3
BC016465 mRNA Translation: AAH16465.1 Different initiation.
AL080174 mRNA Translation: CAB45760.2
AL137328 mRNA Translation: CAB70697.1
CCDSiCCDS46678.1
PIRiT12496
RefSeqiNP_001138890.1, NM_001145418.1
UniGeneiHs.387856

3D structure databases

ProteinModelPortaliQ96AY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116918, 37 interactors
IntActiQ96AY4, 8 interactors
STRINGi9606.ENSP00000381003

PTM databases

iPTMnetiQ96AY4
PhosphoSitePlusiQ96AY4

Polymorphism and mutation databases

BioMutaiTTC28
DMDMi218512146

Proteomic databases

EPDiQ96AY4
jPOSTiQ96AY4
MaxQBiQ96AY4
PaxDbiQ96AY4
PeptideAtlasiQ96AY4
PRIDEiQ96AY4
ProteomicsDBi76021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397906; ENSP00000381003; ENSG00000100154
GeneIDi23331
KEGGihsa:23331
UCSCiuc003adp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23331
DisGeNETi23331
EuPathDBiHostDB:ENSG00000100154.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TTC28

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0016336
HGNCiHGNC:29179 TTC28
HPAiHPA003099
MIMi615098 gene
neXtProtiNX_Q96AY4
OpenTargetsiENSG00000100154
PharmGKBiPA145147752

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1130 Eukaryota
COG0457 LUCA
COG4995 LUCA
ENOG410XP6N LUCA
GeneTreeiENSGT00940000156428
HOVERGENiHBG052194
InParanoidiQ96AY4
OMAiFHAARID
OrthoDBi733786at2759
PhylomeDBiQ96AY4
TreeFamiTF328344

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTC28 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23331

Protein Ontology

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PROi
PR:Q96AY4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100154 Expressed in 222 organ(s), highest expression level in cerebral cortex
CleanExiHS_TTC28
ExpressionAtlasiQ96AY4 baseline and differential
GenevisibleiQ96AY4 HS

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR024983 CHAT_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF12770 CHAT, 1 hit
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 25 hits
SUPFAMiSSF48452 SSF48452, 7 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 25 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AY4
Secondary accession number(s): K7ZRV2
, O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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