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Protein

Tetratricopeptide repeat protein 28

Gene

TTC28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of mitotic cell cycle Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 28
Short name:
TPR repeat protein 28
Alternative name(s):
TPR repeat-containing big gene cloned at Keio
Gene namesi
Name:TTC28
Synonyms:KIAA1043, TPRBK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100154.14
HGNCiHGNC:29179 TTC28
MIMi615098 gene
neXtProtiNX_Q96AY4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi23331
OpenTargetsiENSG00000100154
PharmGKBiPA145147752

Polymorphism and mutation databases

BioMutaiTTC28
DMDMi218512146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064271 – 2481Tetratricopeptide repeat protein 28Add BLAST2481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei1590PhosphoserineBy similarity1
Modified residuei2104PhosphoserineCombined sources1
Modified residuei2224PhosphoserineCombined sources1
Modified residuei2251PhosphoserineCombined sources1
Modified residuei2393PhosphoserineCombined sources1
Modified residuei2398PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96AY4
PaxDbiQ96AY4
PeptideAtlasiQ96AY4
PRIDEiQ96AY4
ProteomicsDBi76021

PTM databases

iPTMnetiQ96AY4
PhosphoSitePlusiQ96AY4

Expressioni

Tissue specificityi

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000100154
CleanExiHS_TTC28
ExpressionAtlasiQ96AY4 baseline and differential
GenevisibleiQ96AY4 HS

Organism-specific databases

HPAiHPA003099

Interactioni

Subunit structurei

Interacts with AURKB.1 Publication

GO - Molecular functioni

  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116918, 37 interactors
IntActiQ96AY4, 8 interactors
STRINGi9606.ENSP00000381003

Structurei

3D structure databases

ProteinModelPortaliQ96AY4
SMRiQ96AY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 91TPR 1Add BLAST34
Repeati93 – 125TPR 2Add BLAST33
Repeati126 – 159TPR 3Add BLAST34
Repeati196 – 229TPR 4Add BLAST34
Repeati234 – 267TPR 5Add BLAST34
Repeati274 – 307TPR 6Add BLAST34
Repeati314 – 347TPR 7Add BLAST34
Repeati354 – 387TPR 8Add BLAST34
Repeati394 – 427TPR 9Add BLAST34
Repeati434 – 467TPR 10Add BLAST34
Repeati474 – 507TPR 11Add BLAST34
Repeati514 – 547TPR 12Add BLAST34
Repeati554 – 587TPR 13Add BLAST34
Repeati594 – 627TPR 14Add BLAST34
Repeati634 – 667TPR 15Add BLAST34
Repeati674 – 707TPR 16Add BLAST34
Repeati714 – 747TPR 17Add BLAST34
Repeati754 – 787TPR 18Add BLAST34
Repeati794 – 827TPR 19Add BLAST34
Repeati834 – 867TPR 20Add BLAST34
Repeati877 – 910TPR 21Add BLAST34
Repeati917 – 950TPR 22Add BLAST34
Repeati957 – 990TPR 23Add BLAST34
Repeati997 – 1030TPR 24Add BLAST34
Repeati1037 – 1070TPR 25Add BLAST34
Repeati1077 – 1110TPR 26Add BLAST34
Repeati1117 – 1150TPR 27Add BLAST34
Repeati1169 – 1202TPR 28Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1948 – 2006Ser-richAdd BLAST59
Compositional biasi2201 – 2335Ser-richAdd BLAST135

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1130 Eukaryota
COG0457 LUCA
COG4995 LUCA
ENOG410XP6N LUCA
GeneTreeiENSGT00530000063126
HOVERGENiHBG052194
InParanoidiQ96AY4
OMAiTSMAAVI
OrthoDBiEOG091G04C9
PhylomeDBiQ96AY4
TreeFamiTF328344

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR024983 CHAT_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF12770 CHAT, 1 hit
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 25 hits
SUPFAMiSSF48452 SSF48452, 7 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 25 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q96AY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG
60 70 80 90 100
PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA
110 120 130 140 150
AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA
160 170 180 190 200
SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS
210 220 230 240 250
VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT
260 270 280 290 300
EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
310 320 330 340 350
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE
360 370 380 390 400
LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL
410 420 430 440 450
GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL
460 470 480 490 500
ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH
510 520 530 540 550
LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR
560 570 580 590 600
ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
610 620 630 640 650
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY
660 670 680 690 700
QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL
710 720 730 740 750
LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR
760 770 780 790 800
RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL
810 820 830 840 850
AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM
860 870 880 890 900
EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY
910 920 930 940 950
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL
960 970 980 990 1000
GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA
1010 1020 1030 1040 1050
CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL
1060 1070 1080 1090 1100
GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL
1110 1120 1130 1140 1150
QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI
1160 1170 1180 1190 1200
RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
1210 1220 1230 1240 1250
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL
1260 1270 1280 1290 1300
LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR
1310 1320 1330 1340 1350
EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV
1360 1370 1380 1390 1400
RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL
1410 1420 1430 1440 1450
IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF
1460 1470 1480 1490 1500
GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL
1510 1520 1530 1540 1550
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS
1560 1570 1580 1590 1600
WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP
1610 1620 1630 1640 1650
LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA
1660 1670 1680 1690 1700
QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS
1710 1720 1730 1740 1750
HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE
1760 1770 1780 1790 1800
KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP
1810 1820 1830 1840 1850
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS
1860 1870 1880 1890 1900
RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA
1910 1920 1930 1940 1950
ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD
1960 1970 1980 1990 2000
SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS
2010 2020 2030 2040 2050
SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN
2060 2070 2080 2090 2100
KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK
2110 2120 2130 2140 2150
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ
2160 2170 2180 2190 2200
EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP
2210 2220 2230 2240 2250
SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS
2260 2270 2280 2290 2300
SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS
2310 2320 2330 2340 2350
KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI
2360 2370 2380 2390 2400
DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR
2410 2420 2430 2440 2450
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP
2460 2470 2480
PATAPARPLR LPSGNGYKFL SPGRFFPSSK C
Length:2,481
Mass (Da):270,884
Last modified:December 16, 2008 - v4
Checksum:iD646D744EBFCFE35
GO

Sequence cautioni

The sequence AAH16465 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB62963 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB62964 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB665284 mRNA Translation: BAM66822.1
AL008724 Genomic DNA Translation: CAB62963.1 Sequence problems.
AL008724 Genomic DNA Translation: CAB62964.1 Sequence problems.
AL121825 Genomic DNA No translation available.
AL023281 Genomic DNA No translation available.
AL050313 Genomic DNA No translation available.
AL035453 Genomic DNA No translation available.
AL035397 Genomic DNA No translation available.
AL033538 Genomic DNA No translation available.
ES313581 mRNA No translation available.
BU584912 mRNA No translation available.
AB028966 mRNA Translation: BAA82995.3
BC016465 mRNA Translation: AAH16465.1 Different initiation.
AL080174 mRNA Translation: CAB45760.2
AL137328 mRNA Translation: CAB70697.1
CCDSiCCDS46678.1
PIRiT12496
RefSeqiNP_001138890.1, NM_001145418.1
UniGeneiHs.387856

Genome annotation databases

EnsembliENST00000397906; ENSP00000381003; ENSG00000100154
GeneIDi23331
KEGGihsa:23331
UCSCiuc003adp.4 human

Similar proteinsi

Entry informationi

Entry nameiTTC28_HUMAN
AccessioniPrimary (citable) accession number: Q96AY4
Secondary accession number(s): K7ZRV2
, O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 16, 2008
Last modified: June 20, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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