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UniProtKB - Q96AY3 (FKB10_HUMAN)

Entry version 183 (10 Feb 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

FKBP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PPIases accelerate the folding of proteins during protein synthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi510 – 5211PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi555 – 5662PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96AY3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
Short name:
PPIase FKBP10
Alternative name(s):
65 kDa FK506-binding protein
Short name:
65 kDa FKBP
Short name:
FKBP-65
FK506-binding protein 10
Short name:
FKBP-10
Immunophilin FKBP65
Rotamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKBP10
Synonyms:FKBP65
ORF Names:PSEC0056
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18169, FKBP10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607063, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96AY3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141756.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Osteogenesis imperfecta 11 (OI11)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063601107 – 117Missing in OI11. Add BLAST11
Bruck syndrome 1 (BRKS1)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069902113E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar.1
Natural variantiVAR_069903115R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar.1
Natural variantiVAR_069904136P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl.1

Keywords - Diseasei

Disease variant, Osteogenesis imperfecta

Organism-specific databases

DisGeNET

More...DisGeNETi		60681

MalaCards human disease database

More...MalaCardsi		FKBP10
MIMi259450, phenotype
610968, phenotype

Open Targets

More...OpenTargetsi		ENSG00000141756

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2771, Bruck syndrome
1149, Kuskokwim syndrome
216812, Osteogenesis imperfecta type 3
216820, Osteogenesis imperfecta type 4

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28152

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96AY3, Tbio

Chemistry databases

DrugCentral

More...DrugCentrali		Q96AY3

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FKBP10

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396594

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002551727 – 582Peptidyl-prolyl cis-trans isomerase FKBP10Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated and phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96AY3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96AY3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96AY3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96AY3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96AY3

PeptideAtlas

More...PeptideAtlasi		Q96AY3

PRoteomics IDEntifications database

More...PRIDEi		Q96AY3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76020 [Q96AY3-1]
80989

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q96AY3-1 [Q96AY3-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1597, 12 N-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96AY3, 7 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96AY3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q96AY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96AY3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96AY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141756, Expressed in stromal cell of endometrium and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96AY3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96AY3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141756, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121955, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q96AY3

Protein interaction database and analysis system

More...IntActi		Q96AY3, 16 interactors

Molecular INTeraction database

More...MINTi		Q96AY3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000317232

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96AY3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96AY3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 150PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini174 – 262PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST89
Domaini286 – 374PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST89
Domaini399 – 486PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST88
Domaini497 – 532EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini542 – 577EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi579 – 582Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0549, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156331

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034907_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96AY3

Database of Orthologous Groups

More...OrthoDBi		1507309at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96AY3

TreeFam database of animal gene trees

More...TreeFami		TF105296

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR001179, PPIase_FKBP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00254, FKBP_C, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS00014, ER_TARGET, 1 hit
PS50059, FKBP_PPIASE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH 
        60         70         80         90        100
IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT 
       110        120        130        140        150
GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW 
       160        170        180        190        200
NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT 
       210        220        230        240        250
YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA 
       260        270        280        290        300
SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG 
       310        320        330        340        350
TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG 
       360        370        380        390        400
ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD 
       410        420        430        440        450
FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE 
       460        470        480        490        500
RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD 
       510        520        530        540        550
PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM 
       560        570        580 
FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
Length:582
Mass (Da):64,245
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98257459158407C2
GO
Isoform 2 (identifier: Q96AY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-177: Missing.
     184-212: TLLDGTSFDTSYSKGGTYDTYVGSGWLIK → SLMDGTLFDSSYSRNHTYNTYIGQGYIIP
     219-303: LGMCPGERRK...NGSLMDGTLF → QGACMGERRR...VKWASHADPQ
     304-354: Missing.

Show »
Length:355
Mass (Da):38,950
Checksum:iDBECF4B8618BF54F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y827H0Y827_HUMAN
Peptidylprolyl isomerase
FKBP10
386Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELI6K7ELI6_HUMAN
Peptidylprolyl isomerase
FKBP10
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM43K7EM43_HUMAN
Peptidylprolyl isomerase
FKBP10
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPC3C9JPC3_HUMAN
Peptidylprolyl isomerase
FKBP10
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESG6K7ESG6_HUMAN
Peptidylprolyl isomerase
FKBP10
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15220 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD97695 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190S → F in BAB20974 (PubMed:16303743).Curated1
Sequence conflicti456V → L in CAD97695 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063601107 – 117Missing in OI11. Add BLAST11
Natural variantiVAR_069902113E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar.1
Natural variantiVAR_069903115R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar.1
Natural variantiVAR_069904136P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl.1
Natural variantiVAR_050625197K → R. Corresponds to variant dbSNP:rs34764749EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564252 – 177Missing in isoform 2. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_056426184 – 212TLLDG…GWLIK → SLMDGTLFDSSYSRNHTYNT YIGQGYIIP in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056427219 – 303LGMCP…DGTLF → QGACMGERRRITIPPHLAYG ENGTDSIGFLQGSAPLRPFR SGEGQPSLGREGGYGKTEPA YPQDPAVLGASVSSPVKWAS HADPQ in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_056428304 – 354Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF337909 mRNA Translation: AAM15770.1
AK025694 mRNA Translation: BAB15220.1 Different initiation.
AK025874 mRNA Translation: BAB15266.1
AB045981 mRNA Translation: BAB20974.1
BX537452 mRNA Translation: CAD97695.1 Different initiation.
AL133116 mRNA Translation: CAB61418.1
AC091172 Genomic DNA No translation available.
BC016467 mRNA Translation: AAH16467.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11409.1 [Q96AY3-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T42709

NCBI Reference Sequences

More...RefSeqi		NP_068758.3, NM_021939.3 [Q96AY3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		60681

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:60681

UCSC genome browser

More...UCSCi		uc002hxv.3, human [Q96AY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Osteogenesis imperfecta variant database

Peptidyl-prolyl cis-trans isomerase FKBP10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337909 mRNA Translation: AAM15770.1
AK025694 mRNA Translation: BAB15220.1 Different initiation.
AK025874 mRNA Translation: BAB15266.1
AB045981 mRNA Translation: BAB20974.1
BX537452 mRNA Translation: CAD97695.1 Different initiation.
AL133116 mRNA Translation: CAB61418.1
AC091172 Genomic DNA No translation available.
BC016467 mRNA Translation: AAH16467.1
CCDSiCCDS11409.1 [Q96AY3-1]
PIRiT42709
RefSeqiNP_068758.3, NM_021939.3 [Q96AY3-1]

3D structure databases

SMRiQ96AY3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121955, 52 interactors
CORUMiQ96AY3
IntActiQ96AY3, 16 interactors
MINTiQ96AY3
STRINGi9606.ENSP00000317232

Chemistry databases

DrugCentraliQ96AY3

PTM databases

GlyConnecti1597, 12 N-Linked glycans (6 sites)
GlyGeniQ96AY3, 7 sites, 1 N-linked glycan (1 site)
iPTMnetiQ96AY3
MetOSiteiQ96AY3
PhosphoSitePlusiQ96AY3
SwissPalmiQ96AY3

Genetic variation databases

BioMutaiFKBP10
DMDMi23396594

Proteomic databases

EPDiQ96AY3
jPOSTiQ96AY3
MassIVEiQ96AY3
MaxQBiQ96AY3
PaxDbiQ96AY3
PeptideAtlasiQ96AY3
PRIDEiQ96AY3
ProteomicsDBi76020 [Q96AY3-1]
80989
TopDownProteomicsiQ96AY3-1 [Q96AY3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28953, 261 antibodies

The DNASU plasmid repository

More...DNASUi		60681

Genome annotation databases

EnsembliENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1]
GeneIDi60681
KEGGihsa:60681
UCSCiuc002hxv.3, human [Q96AY3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		60681
DisGeNETi60681

GeneCards: human genes, protein and diseases

More...GeneCardsi		FKBP10
HGNCiHGNC:18169, FKBP10
HPAiENSG00000141756, Low tissue specificity
MalaCardsiFKBP10
MIMi259450, phenotype
607063, gene
610968, phenotype
neXtProtiNX_Q96AY3
OpenTargetsiENSG00000141756
Orphaneti2771, Bruck syndrome
1149, Kuskokwim syndrome
216812, Osteogenesis imperfecta type 3
216820, Osteogenesis imperfecta type 4
PharmGKBiPA28152
VEuPathDBiHostDB:ENSG00000141756.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0549, Eukaryota
GeneTreeiENSGT00940000156331
HOGENOMiCLU_034907_0_0_1
InParanoidiQ96AY3
OrthoDBi1507309at2759
PhylomeDBiQ96AY3
TreeFamiTF105296

Enzyme and pathway databases

PathwayCommonsiQ96AY3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		60681, 8 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FKBP10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		60681
PharosiQ96AY3, Tbio

Protein Ontology

More...PROi		PR:Q96AY3
RNActiQ96AY3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141756, Expressed in stromal cell of endometrium and 156 other tissues
ExpressionAtlasiQ96AY3, baseline and differential
GenevisibleiQ96AY3, HS

Family and domain databases

CDDicd00051, EFh, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR001179, PPIase_FKBP_dom
PfamiView protein in Pfam
PF13202, EF-hand_5, 2 hits
PF00254, FKBP_C, 4 hits
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS00014, ER_TARGET, 1 hit
PS50059, FKBP_PPIASE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKB10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AY3
Secondary accession number(s): Q7Z3R4
, Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: February 10, 2021
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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