UniProtKB - Q96AY3 (FKB10_HUMAN)
Peptidyl-prolyl cis-trans isomerase FKBP10
FKBP10
Functioni
Catalytic activityi
- EC:5.2.1.8
Activity regulationi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 510 – 521 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 555 – 566 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- FK506 binding Source: Ensembl
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
GO - Biological processi
- aorta morphogenesis Source: Ensembl
- collagen fibril organization Source: Ensembl
- extracellular matrix assembly Source: Ensembl
- in utero embryonic development Source: Ensembl
- peptidyl-lysine hydroxylation Source: Ensembl
- wound healing Source: Ensembl
Keywordsi
Molecular function | Isomerase, Rotamase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96AY3 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)Short name: PPIase FKBP10 Alternative name(s): 65 kDa FK506-binding protein Short name: 65 kDa FKBP Short name: FKBP-65 FK506-binding protein 10 Short name: FKBP-10 Immunophilin FKBP65 Rotamase |
Gene namesi | Name:FKBP10 Synonyms:FKBP65 ORF Names:PSEC0056 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18169, FKBP10 |
MIMi | 607063, gene |
neXtProti | NX_Q96AY3 |
VEuPathDBi | HostDB:ENSG00000141756.18 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen PROSITE-ProRule annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial intermembrane space Source: Ensembl
Other locations
- membrane Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulumPathology & Biotechi
Involvement in diseasei
Osteogenesis imperfecta 11 (OI11)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063601 | 107 – 117 | Missing in OI11. Add BLAST | 11 |
Bruck syndrome 1 (BRKS1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069902 | 113 | E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar. | 1 | |
Natural variantiVAR_069903 | 115 | R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar. | 1 | |
Natural variantiVAR_069904 | 136 | P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl. | 1 |
Keywords - Diseasei
Disease variant, Osteogenesis imperfectaOrganism-specific databases
DisGeNETi | 60681 |
MalaCardsi | FKBP10 |
MIMi | 259450, phenotype 610968, phenotype |
OpenTargetsi | ENSG00000141756 |
Orphaneti | 2771, Bruck syndrome 1149, Kuskokwim syndrome 216812, Osteogenesis imperfecta type 3 216820, Osteogenesis imperfecta type 4 |
PharmGKBi | PA28152 |
Miscellaneous databases
Pharosi | Q96AY3, Tbio |
Chemistry databases
DrugCentrali | Q96AY3 |
Genetic variation databases
BioMutai | FKBP10 |
DMDMi | 23396594 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000025517 | 27 – 582 | Peptidyl-prolyl cis-trans isomerase FKBP10Add BLAST | 556 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 182 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 294 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 310 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 352 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 393 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 407 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q96AY3 |
jPOSTi | Q96AY3 |
MassIVEi | Q96AY3 |
MaxQBi | Q96AY3 |
PaxDbi | Q96AY3 |
PeptideAtlasi | Q96AY3 |
PRIDEi | Q96AY3 |
ProteomicsDBi | 76020 [Q96AY3-1] 80989 |
TopDownProteomicsi | Q96AY3-1 [Q96AY3-1] |
PTM databases
GlyConnecti | 1597, 12 N-Linked glycans (6 sites) |
GlyGeni | Q96AY3, 7 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q96AY3 |
MetOSitei | Q96AY3 |
PhosphoSitePlusi | Q96AY3 |
SwissPalmi | Q96AY3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141756, Expressed in stromal cell of endometrium and 156 other tissues |
ExpressionAtlasi | Q96AY3, baseline and differential |
Genevisiblei | Q96AY3, HS |
Organism-specific databases
HPAi | ENSG00000141756, Low tissue specificity |
Interactioni
Binary interactionsi
Q96AY3
With | #Exp. | IntAct |
---|---|---|
SPRED1 [Q7Z699] | 3 | EBI-2372475,EBI-5235340 |
Protein-protein interaction databases
BioGRIDi | 121955, 52 interactors |
CORUMi | Q96AY3 |
IntActi | Q96AY3, 16 interactors |
MINTi | Q96AY3 |
STRINGi | 9606.ENSP00000317232 |
Miscellaneous databases
RNActi | Q96AY3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 150 | PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 174 – 262 | PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 286 – 374 | PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 399 – 486 | PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 497 – 532 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 542 – 577 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 579 – 582 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG0549, Eukaryota |
GeneTreei | ENSGT00940000156331 |
HOGENOMi | CLU_034907_0_0_1 |
InParanoidi | Q96AY3 |
OrthoDBi | 1507309at2759 |
PhylomeDBi | Q96AY3 |
TreeFami | TF105296 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001179, PPIase_FKBP_dom |
Pfami | View protein in Pfam PF13202, EF-hand_5, 2 hits PF00254, FKBP_C, 4 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00014, ER_TARGET, 1 hit PS50059, FKBP_PPIASE, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH
60 70 80 90 100
IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT
110 120 130 140 150
GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW
160 170 180 190 200
NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT
210 220 230 240 250
YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA
260 270 280 290 300
SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG
310 320 330 340 350
TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG
360 370 380 390 400
ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD
410 420 430 440 450
FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE
460 470 480 490 500
RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD
510 520 530 540 550
PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM
560 570 580
FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
The sequence of this isoform differs from the canonical sequence as follows:
2-177: Missing.
184-212: TLLDGTSFDTSYSKGGTYDTYVGSGWLIK → SLMDGTLFDSSYSRNHTYNTYIGQGYIIP
219-303: LGMCPGERRK...NGSLMDGTLF → QGACMGERRR...VKWASHADPQ
304-354: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y827 | H0Y827_HUMAN | Peptidylprolyl isomerase | FKBP10 | 386 | Annotation score: | ||
K7ELI6 | K7ELI6_HUMAN | Peptidylprolyl isomerase | FKBP10 | 171 | Annotation score: | ||
K7EM43 | K7EM43_HUMAN | Peptidylprolyl isomerase | FKBP10 | 147 | Annotation score: | ||
C9JPC3 | C9JPC3_HUMAN | Peptidylprolyl isomerase | FKBP10 | 81 | Annotation score: | ||
K7ESG6 | K7ESG6_HUMAN | Peptidylprolyl isomerase | FKBP10 | 172 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | S → F in BAB20974 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 456 | V → L in CAD97695 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063601 | 107 – 117 | Missing in OI11. Add BLAST | 11 | |
Natural variantiVAR_069902 | 113 | E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar. | 1 | |
Natural variantiVAR_069903 | 115 | R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar. | 1 | |
Natural variantiVAR_069904 | 136 | P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl. | 1 | |
Natural variantiVAR_050625 | 197 | K → R. Corresponds to variant dbSNP:rs34764749EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056425 | 2 – 177 | Missing in isoform 2. 1 PublicationAdd BLAST | 176 | |
Alternative sequenceiVSP_056426 | 184 – 212 | TLLDG…GWLIK → SLMDGTLFDSSYSRNHTYNT YIGQGYIIP in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_056427 | 219 – 303 | LGMCP…DGTLF → QGACMGERRRITIPPHLAYG ENGTDSIGFLQGSAPLRPFR SGEGQPSLGREGGYGKTEPA YPQDPAVLGASVSSPVKWAS HADPQ in isoform 2. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_056428 | 304 – 354 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF337909 mRNA Translation: AAM15770.1 AK025694 mRNA Translation: BAB15220.1 Different initiation. AK025874 mRNA Translation: BAB15266.1 AB045981 mRNA Translation: BAB20974.1 BX537452 mRNA Translation: CAD97695.1 Different initiation. AL133116 mRNA Translation: CAB61418.1 AC091172 Genomic DNA No translation available. BC016467 mRNA Translation: AAH16467.1 |
CCDSi | CCDS11409.1 [Q96AY3-1] |
PIRi | T42709 |
RefSeqi | NP_068758.3, NM_021939.3 [Q96AY3-1] |
Genome annotation databases
Ensembli | ENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1] |
GeneIDi | 60681 |
KEGGi | hsa:60681 |
UCSCi | uc002hxv.3, human [Q96AY3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Osteogenesis imperfecta variant database Peptidyl-prolyl cis-trans isomerase FKBP10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF337909 mRNA Translation: AAM15770.1 AK025694 mRNA Translation: BAB15220.1 Different initiation. AK025874 mRNA Translation: BAB15266.1 AB045981 mRNA Translation: BAB20974.1 BX537452 mRNA Translation: CAD97695.1 Different initiation. AL133116 mRNA Translation: CAB61418.1 AC091172 Genomic DNA No translation available. BC016467 mRNA Translation: AAH16467.1 |
CCDSi | CCDS11409.1 [Q96AY3-1] |
PIRi | T42709 |
RefSeqi | NP_068758.3, NM_021939.3 [Q96AY3-1] |
3D structure databases
SMRi | Q96AY3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121955, 52 interactors |
CORUMi | Q96AY3 |
IntActi | Q96AY3, 16 interactors |
MINTi | Q96AY3 |
STRINGi | 9606.ENSP00000317232 |
Chemistry databases
DrugCentrali | Q96AY3 |
PTM databases
GlyConnecti | 1597, 12 N-Linked glycans (6 sites) |
GlyGeni | Q96AY3, 7 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q96AY3 |
MetOSitei | Q96AY3 |
PhosphoSitePlusi | Q96AY3 |
SwissPalmi | Q96AY3 |
Genetic variation databases
BioMutai | FKBP10 |
DMDMi | 23396594 |
Proteomic databases
EPDi | Q96AY3 |
jPOSTi | Q96AY3 |
MassIVEi | Q96AY3 |
MaxQBi | Q96AY3 |
PaxDbi | Q96AY3 |
PeptideAtlasi | Q96AY3 |
PRIDEi | Q96AY3 |
ProteomicsDBi | 76020 [Q96AY3-1] 80989 |
TopDownProteomicsi | Q96AY3-1 [Q96AY3-1] |
Protocols and materials databases
Antibodypediai | 28953, 261 antibodies |
DNASUi | 60681 |
Genome annotation databases
Ensembli | ENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1] |
GeneIDi | 60681 |
KEGGi | hsa:60681 |
UCSCi | uc002hxv.3, human [Q96AY3-1] |
Organism-specific databases
CTDi | 60681 |
DisGeNETi | 60681 |
GeneCardsi | FKBP10 |
HGNCi | HGNC:18169, FKBP10 |
HPAi | ENSG00000141756, Low tissue specificity |
MalaCardsi | FKBP10 |
MIMi | 259450, phenotype 607063, gene 610968, phenotype |
neXtProti | NX_Q96AY3 |
OpenTargetsi | ENSG00000141756 |
Orphaneti | 2771, Bruck syndrome 1149, Kuskokwim syndrome 216812, Osteogenesis imperfecta type 3 216820, Osteogenesis imperfecta type 4 |
PharmGKBi | PA28152 |
VEuPathDBi | HostDB:ENSG00000141756.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0549, Eukaryota |
GeneTreei | ENSGT00940000156331 |
HOGENOMi | CLU_034907_0_0_1 |
InParanoidi | Q96AY3 |
OrthoDBi | 1507309at2759 |
PhylomeDBi | Q96AY3 |
TreeFami | TF105296 |
Enzyme and pathway databases
PathwayCommonsi | Q96AY3 |
Miscellaneous databases
BioGRID-ORCSi | 60681, 8 hits in 874 CRISPR screens |
ChiTaRSi | FKBP10, human |
GenomeRNAii | 60681 |
Pharosi | Q96AY3, Tbio |
PROi | PR:Q96AY3 |
RNActi | Q96AY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141756, Expressed in stromal cell of endometrium and 156 other tissues |
ExpressionAtlasi | Q96AY3, baseline and differential |
Genevisiblei | Q96AY3, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001179, PPIase_FKBP_dom |
Pfami | View protein in Pfam PF13202, EF-hand_5, 2 hits PF00254, FKBP_C, 4 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00014, ER_TARGET, 1 hit PS50059, FKBP_PPIASE, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FKB10_HUMAN | |
Accessioni | Q96AY3Primary (citable) accession number: Q96AY3 Secondary accession number(s): Q7Z3R4 Q9UF89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot