UniProtKB - Q96AY3 (FKB10_HUMAN)

BLAST

>sp|Q96AY3|FKB10_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP10 OS=Homo sapiens OX=9606 GN=FKBP10 PE=1 SV=1
MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ
MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP
PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH
YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK
GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG
TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG
SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSH
DYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEV
ELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPG
QDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL

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History
Entry version 168 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

FKBP10

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityⁱ

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationⁱ

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	510 – 521	1PROSITE-ProRule annotationAdd BLAST		12
Calcium bindingⁱ	555 – 566	2PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
FK506 binding Source: Ensembl
peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, Rotamase
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8) Short name: PPIase FKBP10 Alternative name(s): 65 kDa FK506-binding protein Short name: 65 kDa FKBP Short name: FKBP-65 FK506-binding protein 10 Short name: FKBP-10 Immunophilin FKBP65 Rotamase
Gene namesⁱ	Name:FKBP10 Synonyms:FKBP65 ORF Names:PSEC0056
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141756.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18169 FKBP10
MIMⁱ	607063 gene
neXtProtⁱ	NX_Q96AY3

Keywords - Cellular componentⁱ

Endoplasmic reticulum

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Osteogenesis imperfecta 11 (OI11)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form.

Bruck syndrome 1 (BRKS1)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069902	113	E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar.	1
Natural variantⁱVAR_069903	115	R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar.	1
Natural variantⁱVAR_069904	136	P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl.	1

Keywords - Diseaseⁱ

Disease mutation, Osteogenesis imperfecta

Organism-specific databases

DisGeNET More...DisGeNETⁱ	60681
MalaCards human disease database More...MalaCardsⁱ	FKBP10
MIMⁱ	259450 phenotype 610968 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000141756
Orphanetⁱ	1149 Arthrogryposis-like syndrome 2771 Bruck syndrome 216812 Osteogenesis imperfecta type 3 216820 Osteogenesis imperfecta type 4
PharmGKBⁱ	PA28152

Polymorphism and mutation databases

BioMutaⁱ	FKBP10
DMDMⁱ	23396594

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000025517	27 – 582	Peptidyl-prolyl cis-trans isomerase FKBP10Add BLAST		556

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	70	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	182	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	294	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	310	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	352	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	393	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	407	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

Glycosylated and phosphorylated.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q96AY3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96AY3
PaxDbⁱ	Q96AY3
PeptideAtlas More...PeptideAtlasⁱ	Q96AY3
PRIDEⁱ	Q96AY3
ProteomicsDBⁱ	76020
TopDownProteomicsⁱ	Q96AY3-1 [Q96AY3-1]

PTM databases

GlyConnectⁱ	1597
iPTMnetⁱ	Q96AY3
PhosphoSitePlusⁱ	Q96AY3
SwissPalmⁱ	Q96AY3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000141756 Expressed in 137 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_FKBP10
ExpressionAtlasⁱ	Q96AY3 baseline and differential
Genevisibleⁱ	Q96AY3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051171 HPA057021

HPAⁱ

HPA051171
HPA057021

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121955, 28 interactors
IntActⁱ	Q96AY3, 7 interactors
STRINGⁱ	9606.ENSP00000317232

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96AY3
SMRⁱ	Q96AY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	62 – 150	PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	174 – 262	PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	286 – 374	PPIase FKBP-type 3PROSITE-ProRule annotationAdd BLAST	89
Domainⁱ	399 – 486	PPIase FKBP-type 4PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	497 – 532	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	542 – 577	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	579 – 582	Prevents secretion from ERPROSITE-ProRule annotation		4

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG0549 Eukaryota COG0545 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062784
HOGENOMⁱ	HOG000230960
HOVERGENⁱ	HBG051620
InParanoidⁱ	Q96AY3
KEGG Orthology (KO) More...KOⁱ	K09575
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02W1
PhylomeDBⁱ	Q96AY3
TreeFamⁱ	TF105296

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR023566 PPIase_FKBP IPR001179 PPIase_FKBP_dom
PANTHERⁱ	PTHR10516 PTHR10516, 6 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13202 EF-hand_5, 2 hits PF00254 FKBP_C, 4 hits
PIRSFⁱ	PIRSF001473 FK506-bp_FPR3, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits PS00014 ER_TARGET, 1 hit PS50059 FKBP_PPIASE, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96AY3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH 
        60         70         80         90        100
IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT 
       110        120        130        140        150
GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW 
       160        170        180        190        200
NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT 
       210        220        230        240        250
YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA 
       260        270        280        290        300
SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG 
       310        320        330        340        350
TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG 
       360        370        380        390        400
ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD 
       410        420        430        440        450
FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE 
       460        470        480        490        500
RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD 
       510        520        530        540        550
PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM 
       560        570        580 
FQNQDRNQDG KITVDELKLK SDEDEERVHE EL

Length:582

Mass (Da):64,245

Last modified:December 1, 2001 - v1

Checksum:ⁱ98257459158407C2

Isoform 2 (identifier: Q96AY3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-177: Missing.
     184-212: TLLDGTSFDTSYSKGGTYDTYVGSGWLIK → SLMDGTLFDSSYSRNHTYNTYIGQGYIIP
     219-303: LGMCPGERRK...NGSLMDGTLF → QGACMGERRR...VKWASHADPQ
     304-354: Missing.

« Hide

        10         20         30         40         50
MRYHYNGSLM DGTLFDSSYS RNHTYNTYIG QGYIIPGMDQ GLQGACMGER 
        60         70         80         90        100
RRITIPPHLA YGENGTDSIG FLQGSAPLRP FRSGEGQPSL GREGGYGKTE 
       110        120        130        140        150
PAYPQDPAVL GASVSSPVKW ASHADPQGDK IPGSAVLIFN VHVIDFHNPA 
       160        170        180        190        200
DVVEIRTLSR PSETCNETTK LGDFVRYHYN CSLLDGTQLF TSHDYGAPQE 
       210        220        230        240        250
ATLGANKVIE GLDTGLQGMC VGERRQLIVP PHLAHGESGA RGVPGSAVLL 
       260        270        280        290        300
FEVELVSRED GLPTGYLFVW HKDPPANLFE DMDLNKDGEV PPEEFSTFIK 
       310        320        330        340        350
AQVSEGKGRL MPGQDPEKTI GDMFQNQDRN QDGKITVDEL KLKSDEDEER 

VHEEL

Note: No experimental confirmation available.

Show »

Length:355

Mass (Da):38,950

Checksum:ⁱDBECF4B8618BF54F

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y827	H0Y827_HUMAN	Peptidylprolyl isomerase Peptidylprolyl isomerase, EC 5.2.1.8	FKBP10	386	Annotation score:
K7EM43	K7EM43_HUMAN	Peptidylprolyl isomerase Peptidylprolyl isomerase, EC 5.2.1.8	FKBP10	147	Annotation score:
K7ELI6	K7ELI6_HUMAN	Peptidylprolyl isomerase Peptidylprolyl isomerase, EC 5.2.1.8	FKBP10	171	Annotation score:
K7ESG6	K7ESG6_HUMAN	Peptidylprolyl isomerase Peptidylprolyl isomerase, EC 5.2.1.8	FKBP10	172	Annotation score:
C9JPC3	C9JPC3_HUMAN	Peptidylprolyl isomerase Peptidylprolyl isomerase, EC 5.2.1.8	FKBP10	81	Annotation score:

Sequence cautionⁱ

The sequence BAB15220 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAD97695 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	190	S → F in BAB20974 (PubMed:16303743).Curated		1
Sequence conflictⁱ	456	V → L in CAD97695 (PubMed:17974005).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063601	107 – 117	Missing in OI11. Add BLAST	11
Natural variantⁱVAR_069902	113	E → K in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs397514674EnsemblClinVar.	1
Natural variantⁱVAR_069903	115	R → Q in BRKS1. 2 PublicationsCorresponds to variant dbSNP:rs387906960EnsemblClinVar.	1
Natural variantⁱVAR_069904	136	P → L in BRKS1. 1 PublicationCorresponds to variant dbSNP:rs782653042Ensembl.	1
Natural variantⁱVAR_050625	197	K → R. Corresponds to variant dbSNP:rs34764749EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056425	2 – 177	Missing in isoform 2. 1 PublicationAdd BLAST	176
Alternative sequenceⁱVSP_056426	184 – 212	TLLDG…GWLIK → SLMDGTLFDSSYSRNHTYNT YIGQGYIIP in isoform 2. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_056427	219 – 303	LGMCP…DGTLF → QGACMGERRRITIPPHLAYG ENGTDSIGFLQGSAPLRPFR SGEGQPSLGREGGYGKTEPA YPQDPAVLGASVSSPVKWAS HADPQ in isoform 2. 1 PublicationAdd BLAST	85
Alternative sequenceⁱVSP_056428	304 – 354	Missing in isoform 2. 1 PublicationAdd BLAST	51

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF337909 mRNA Translation: AAM15770.1 AK025694 mRNA Translation: BAB15220.1 Different initiation. AK025874 mRNA Translation: BAB15266.1 AB045981 mRNA Translation: BAB20974.1 BX537452 mRNA Translation: CAD97695.1 Different initiation. AL133116 mRNA Translation: CAB61418.1 AC091172 Genomic DNA No translation available. BC016467 mRNA Translation: AAH16467.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11409.1 [Q96AY3-1]
PIRⁱ	T42709
NCBI Reference Sequences More...RefSeqⁱ	NP_068758.3, NM_021939.3 [Q96AY3-1]
UniGeneⁱ	Hs.463035

Genome annotation databases

Ensemblⁱ	ENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1]
GeneIDⁱ	60681
KEGGⁱ	hsa:60681
UCSC genome browser More...UCSCⁱ	uc002hxv.3 human [Q96AY3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96AY3	Peptidylprolyl isomerase		HUMAN		582	UniRef100_Q96AY3
Q96AY3-2	Peptidylprolyl isomerase (Fragment)		HUMAN		386	UniRef100_Q96AY3-2

Protein	Similar proteins		Species	Score	Length	Source
Q96AY3	Peptidyl-prolyl cis-trans isomerase FKBP10		BOVIN		583	UniRef90_Q96AY3
Peptidyl-prolyl cis-trans isomerase FKBP10		MOUSE		581
Peptidylprolyl isomerase		HUMAN		582
Peptidylprolyl isomerase		AOTNA		592
Peptidylprolyl isomerase		SHEEP		587
+124
Q96AY3-2	Peptidylprolyl isomerase (Fragment)		HUMAN		386	UniRef90_Q96AY3-2
Peptidylprolyl isomerase (Fragment)		PANTR		385

Protein	Similar proteins		Species	Score	Length	Source
Q96AY3	Peptidyl-prolyl cis-trans isomerase FKBP10		BOVIN		583	UniRef50_Q96AY3
Peptidyl-prolyl cis-trans isomerase FKBP10		MOUSE		581
Peptidylprolyl isomerase		HUMAN		582
Peptidylprolyl isomerase		AOTNA		592
Peptidylprolyl isomerase		SHEEP		587
+226
Q96AY3-2	Peptidylprolyl isomerase (Fragment)		HUMAN		386	UniRef50_Q96AY3-2
Peptidylprolyl isomerase (Fragment)		PANTR		385
Peptidylprolyl isomerase		FUNHE		315

Cross-referencesⁱ

Web resourcesⁱ

Osteogenesis imperfecta variant database

Peptidyl-prolyl cis-trans isomerase FKBP10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF337909 mRNA Translation: AAM15770.1 AK025694 mRNA Translation: BAB15220.1 Different initiation. AK025874 mRNA Translation: BAB15266.1 AB045981 mRNA Translation: BAB20974.1 BX537452 mRNA Translation: CAD97695.1 Different initiation. AL133116 mRNA Translation: CAB61418.1 AC091172 Genomic DNA No translation available. BC016467 mRNA Translation: AAH16467.1
CCDSⁱ	CCDS11409.1 [Q96AY3-1]
PIRⁱ	T42709
RefSeqⁱ	NP_068758.3, NM_021939.3 [Q96AY3-1]
UniGeneⁱ	Hs.463035

3D structure databases

ProteinModelPortalⁱ	Q96AY3
SMRⁱ	Q96AY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121955, 28 interactors
IntActⁱ	Q96AY3, 7 interactors
STRINGⁱ	9606.ENSP00000317232

PTM databases

GlyConnectⁱ	1597
iPTMnetⁱ	Q96AY3
PhosphoSitePlusⁱ	Q96AY3
SwissPalmⁱ	Q96AY3

Polymorphism and mutation databases

BioMutaⁱ	FKBP10
DMDMⁱ	23396594

Proteomic databases

EPDⁱ	Q96AY3
MaxQBⁱ	Q96AY3
PaxDbⁱ	Q96AY3
PeptideAtlasⁱ	Q96AY3
PRIDEⁱ	Q96AY3
ProteomicsDBⁱ	76020
TopDownProteomicsⁱ	Q96AY3-1 [Q96AY3-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	60681
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000321562; ENSP00000317232; ENSG00000141756 [Q96AY3-1]
GeneIDⁱ	60681
KEGGⁱ	hsa:60681
UCSCⁱ	uc002hxv.3 human [Q96AY3-1]

Organism-specific databases

CTDⁱ	60681
DisGeNETⁱ	60681
EuPathDBⁱ	HostDB:ENSG00000141756.18
GeneCardsⁱ	FKBP10
HGNCⁱ	HGNC:18169 FKBP10
HPAⁱ	HPA051171 HPA057021
MalaCardsⁱ	FKBP10
MIMⁱ	259450 phenotype 607063 gene 610968 phenotype
neXtProtⁱ	NX_Q96AY3
OpenTargetsⁱ	ENSG00000141756
Orphanetⁱ	1149 Arthrogryposis-like syndrome 2771 Bruck syndrome 216812 Osteogenesis imperfecta type 3 216820 Osteogenesis imperfecta type 4
PharmGKBⁱ	PA28152
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0549 Eukaryota COG0545 LUCA
GeneTreeⁱ	ENSGT00530000062784
HOGENOMⁱ	HOG000230960
HOVERGENⁱ	HBG051620
InParanoidⁱ	Q96AY3
KOⁱ	K09575
OrthoDBⁱ	EOG091G02W1
PhylomeDBⁱ	Q96AY3
TreeFamⁱ	TF105296

Miscellaneous databases

ChiTaRSⁱ	FKBP10 human
GenomeRNAiⁱ	60681
Protein Ontology More...PROⁱ	PR:Q96AY3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141756 Expressed in 137 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_FKBP10
ExpressionAtlasⁱ	Q96AY3 baseline and differential
Genevisibleⁱ	Q96AY3 HS

Family and domain databases

CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR023566 PPIase_FKBP IPR001179 PPIase_FKBP_dom
PANTHERⁱ	PTHR10516 PTHR10516, 6 hits
Pfamⁱ	View protein in Pfam PF13202 EF-hand_5, 2 hits PF00254 FKBP_C, 4 hits
PIRSFⁱ	PIRSF001473 FK506-bp_FPR3, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits PS00014 ER_TARGET, 1 hit PS50059 FKBP_PPIASE, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FKB10_HUMAN
Accessionⁱ	Q96AY3Primary (citable) accession number: Q96AY3 Secondary accession number(s): Q7Z3R4 , Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q96AY3 (FKB10_HUMAN)

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Peptidyl-prolyl cis-trans isomerase FKBP10

FKBP10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ