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UniProtKB - Q96AX9 (MIB2_HUMAN)

Entry version 184 (23 Feb 2022)
Sequence version 4 (23 Feb 2022)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase MIB2

Gene

MIB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi91Zinc 1PROSITE-ProRule annotation1
Metal bindingi94Zinc 1PROSITE-ProRule annotation1
Metal bindingi106Zinc 2PROSITE-ProRule annotation1
Metal bindingi109Zinc 2PROSITE-ProRule annotation1
Metal bindingi115Zinc 1PROSITE-ProRule annotation1
Metal bindingi118Zinc 1PROSITE-ProRule annotation1
Metal bindingi124Zinc 2PROSITE-ProRule annotation1
Metal bindingi128Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri86 – 138ZZ-typePROSITE-ProRule annotationAdd BLAST53
Zinc fingeri832 – 867RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri911 – 944RING-type 2PROSITE-ProRule annotationAdd BLAST34

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Transferase
Biological processNotch signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96AX9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96AX9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q96AX9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MIB2Curated (EC:2.3.2.27)
Alternative name(s):
Mind bomb homolog 2
Novel zinc finger protein
Short name:
Novelzin
Putative NF-kappa-B-activating protein 002N
RING-type E3 ubiquitin transferase MIB2Curated
Skeletrophin
Zinc finger ZZ type with ankyrin repeat domain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIB2Imported
Synonyms:SKD, ZZANK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30577, MIB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611141, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96AX9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197530

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		142678

MalaCards human disease database

More...MalaCardsi		MIB2

Open Targets

More...OpenTargetsi		ENSG00000197530

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		54260, Left ventricular noncompaction

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134924284

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96AX9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MIB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572707

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559471 – 955E3 ubiquitin-protein ligase MIB2Add BLAST955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineCombined sources1
Isoform 8 (identifier: Q96AX9-8)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 10 (identifier: Q96AX9-10)
Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Possibly via autoubiquitination (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96AX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96AX9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96AX9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96AX9

PeptideAtlas

More...PeptideAtlasi		Q96AX9

PRoteomics IDEntifications database

More...PRIDEi		Q96AX9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20393
20580
30446
3825
76009 [Q96AX9-1]
76011 [Q96AX9-3]
76012 [Q96AX9-4]
76013 [Q96AX9-5]
76014 [Q96AX9-6]
76015 [Q96AX9-7]
76016 [Q96AX9-8]
76017 [Q96AX9-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96AX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96AX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197530, Expressed in pituitary gland and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96AX9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96AX9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197530, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126769, 55 interactors

Protein interaction database and analysis system

More...IntActi		Q96AX9, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000426103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96AX9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96AX9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 80MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST80
Domaini149 – 227MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST79
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati464 – 493ANK 1Add BLAST30
Repeati497 – 526ANK 2Add BLAST30
Repeati530 – 559ANK 3Add BLAST30
Repeati563 – 595ANK 4Add BLAST33
Repeati599 – 628ANK 5Add BLAST30
Repeati633 – 663ANK 6Add BLAST31
Repeati667 – 696ANK 7Add BLAST30
Repeati700 – 728ANK 8Add BLAST29
Repeati769 – 798ANK 9Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 21Polar residuesSequence analysisAdd BLAST15
Compositional biasi29 – 46Basic and acidic residuesSequence analysisAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri86 – 138ZZ-typePROSITE-ProRule annotationAdd BLAST53
Zinc fingeri832 – 867RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri911 – 944RING-type 2PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504, Eukaryota
KOG4582, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158097

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96AX9

Database of Orthologous Groups

More...OrthoDBi		220300at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96AX9

TreeFam database of animal gene trees

More...TreeFami		TF324147

Family and domain databases

Conserved Domains Database

More...CDDi		cd02339, ZZ_Mind_bomb, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits
3.30.40.10, 2 hits
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR042056, MIB1/2_ZZ
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR040847, SH3_15
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF13637, Ank_4, 1 hit
PF13857, Ank_5, 1 hit
PF06701, MIB_HERC2, 2 hits
PF18346, SH3_15, 2 hits
PF00569, ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 9 hits
SM00184, RING, 2 hits
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF159034, SSF159034, 2 hits
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51416, MIB_HERC2, 2 hits
PS50089, ZF_RING_2, 2 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96AX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPDPQAGVQ VGMRVVRGVD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR 
        60         70         80         90        100
TVVVQWDQGT RTNYRAGYQG AHDLLLYDNA QIGVRHPNII CDCCKKHGLR 
       110        120        130        140        150
GMRWKCRVCL DYDLCTQCYM HNKHELAHAF DRYETAHSRP VTLSPRQGLP 
       160        170        180        190        200
RIPLRGIFQG AKVVRGPDWE WGSQDGGEGK PGRVVDIRGW DVETGRSVAS 
       210        220        230        240        250
VTWADGTTNV YRVGHKGKVD LKCVGEAAGG FYYKDHLPRL GKPAELQRRV 
       260        270        280        290        300
SADSQPFQHG DKVKCLLDTD VLREMQEGHG GWNPRMAEFI GQTGTVHRIT 
       310        320        330        340        350
DRGDVRVQFN HETRWTFHPG ALTKHHSFWV GDVVRVIGDL DTVKRLQAGH 
       360        370        380        390        400
GEWTDDMAPA LGRVGKVVKV FGDGNLRVAV AGQRWTFSPS CLVAYRPEED 
       410        420        430        440        450
ANLDVAERAR ENKSSLSVAL DKLRAQKSDP EHPGRLVVEV ALGNAARALD 
       460        470        480        490        500
LLRRRPEQVD TKNQGRTALQ VAAYLGQVEL IRLLLQARAG VDLPDDEGNT 
       510        520        530        540        550
ALHYAALGNQ PEATRVLLSA GCRADAINST QSTALHVAVQ RGFLEVVRAL 
       560        570        580        590        600
CERGCDVNLP DAHSDTPLHS AISAGTGASG IVEVLTEVPN IDVTATNSQG 
       610        620        630        640        650
FTLLHHASLK GHALAVRKIL ARARQLVDAK KEDGFTALHL AALNNHREVA 
       660        670        680        690        700
QILIREGRCD VNVRNRKLQS PLHLAVQQAH VGLVPLLVDA GCSVNAEDEE 
       710        720        730        740        750
GDTALHVALQ RHQLLPLVAD GAGGDPGPLQ LLSRLQASGL PGSAELTVGA 
       760        770        780        790        800
AVACFLALEG ADVSYTNHRG RSPLDLAAEG RVLKALQGCA QRFRERQAGG 
       810        820        830        840        850
GAAPGPRQTL GTPNTVTNLH VGAAPGPEAA ECLVCSELAL LVLFSPCQHR 
       860        870        880        890        900
TVCEECARRM KKCIRCQVVV SKKLRPDGSE VASAAPAPGP PRQLVEELQS 
       910        920        930        940        950
RYRQMEERIT CPICIDSHIR LVFQCGHGAC APCGSALSAC PICRQPIRDR 

IQIFV
Length:955
Mass (Da):103,658
Last modified:February 23, 2022 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i899DCCBC60605F8B
GO
Isoform 3 (identifier: Q96AX9-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     289-292: Missing.

Show »
Length:951
Mass (Da):103,212
Checksum:i5A7FF08B320CFA33
GO
Isoform 4 (identifier: Q96AX9-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     176-240: Missing.

Show »
Length:890
Mass (Da):96,686
Checksum:iB9D9E2F4CE6E23FA
GO
Isoform 5 (identifier: Q96AX9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-359: Missing.

Show »
Length:920
Mass (Da):99,730
Checksum:iF5ED68B955A4274B
GO
Isoform 10 (identifier: Q96AX9-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-240: Missing.
     795-955: ERQAGGGAAP...PIRDRIQIFV → VRAQDEEVHQVPGGRQQETAPRRL

Show »
Length:753
Mass (Da):82,129
Checksum:i9447C993AF8726DC
GO
Isoform 7 (identifier: Q96AX9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:854
Mass (Da):92,680
Checksum:iC8390208E6E8CFDF
GO
Isoform 8 (identifier: Q96AX9-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     800-802: GGA → RGR
     803-955: Missing.

Show »
Length:802
Mass (Da):87,273
Checksum:i9142D07056C27DBE
GO
Isoform 9 (identifier: Q96AX9-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-955: Missing.

Show »
Length:614
Mass (Da):67,261
Checksum:i9D794B63C8468EBD
GO
Isoform 6 (identifier: Q96AX9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-324: Missing.

Show »
Length:919
Mass (Da):99,496
Checksum:i41E5BAFEC2881347
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAM8H0YAM8_HUMAN
RING-type E3 ubiquitin transferase
MIB2
829Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD12E9PD12_HUMAN
RING-type E3 ubiquitin transferase
MIB2
955Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2L2F2Z2L2_HUMAN
RING-type E3 ubiquitin transferase
MIB2
919Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAZ0D6RAZ0_HUMAN
RING-type E3 ubiquitin transferase
MIB2
816Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RED3D6RED3_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE96D6RE96_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFJ2D6RFJ2_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR95J3QR95_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLE0J3QLE0_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDI1D6RDI1_HUMAN
E3 ubiquitin-protein ligase MIB2
MIB2
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16490 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH37542 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB82979 differs from that shown. Reason: Frameshift.Curated
The sequence BAB92950 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC00992 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC00993 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC00994 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC03707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04646 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04752 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC04952 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC77353 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG53766 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG63969 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22K → N in AAH16490 (PubMed:15489334).Curated1
Sequence conflicti168D → F in BAC77353 (PubMed:12761501).Curated1
Sequence conflicti177G → R in BAG63969 (PubMed:14702039).Curated1
Sequence conflicti215H → Y in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti317F → L in BAC04646 (PubMed:14702039).Curated1
Sequence conflicti450D → G in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti579S → G in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti631K → E in BAC04752 (PubMed:14702039).Curated1
Sequence conflicti634G → D in BAG53705 (PubMed:14702039).Curated1
Sequence conflicti879S → F in BAC04646 (PubMed:14702039).Curated1
Sequence conflicti917S → R in BAC77353 (PubMed:12761501).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355081 – 101Missing in isoform 7. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_014393176 – 240Missing in isoform 4 and isoform 10. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_014394289 – 324Missing in isoform 6. CuratedAdd BLAST36
Alternative sequenceiVSP_014395289 – 292Missing in isoform 3. 1 Publication4
Alternative sequenceiVSP_014396325 – 359Missing in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_035510615 – 955Missing in isoform 9. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_045186795 – 955ERQAG…IQIFV → VRAQDEEVHQVPGGRQQETA PRRL in isoform 10. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_035511800 – 802GGA → RGR in isoform 8. 1 Publication3
Alternative sequenceiVSP_035512803 – 955Missing in isoform 8. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB074480 mRNA Translation: BAB92950.1 Different initiation.
AB064367 mRNA Translation: BAB82979.1 Frameshift.
AB076691 mRNA Translation: BAC00992.1 Different initiation.
AB076692 mRNA Translation: BAC00993.1 Different initiation.
AB076693 mRNA Translation: BAC00994.1 Different initiation.
AB097000 mRNA Translation: BAC77353.1 Different initiation.
AK091610 mRNA Translation: BAC03707.1 Different initiation.
AK095914 mRNA Translation: BAC04646.1 Different initiation.
AK096295 mRNA Translation: BAC04752.1 Different initiation.
AK097106 mRNA Translation: BAC04952.1 Different initiation.
AK098785 mRNA Translation: BAC05413.1
AK122751 mRNA Translation: BAG53705.1
AK122863 mRNA Translation: BAG53766.1 Different initiation.
AK128167 mRNA Translation: BAG54643.1
AK302757 mRNA Translation: BAG63969.1 Different initiation.
AL691432 Genomic DNA No translation available.
BC016490 mRNA Translation: AAH16490.1 Different initiation.
BC037542 mRNA Translation: AAH37542.1 Different initiation.
AL834527 mRNA Translation: CAD39183.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53264.1 [Q96AX9-10]

NCBI Reference Sequences

More...RefSeqi		NP_001164157.1, NM_001170686.1 [Q96AX9-3]
NP_001164158.1, NM_001170687.1
NP_001164159.1, NM_001170688.1
NP_001164160.1, NM_001170689.1 [Q96AX9-10]
NP_543151.2, NM_080875.2 [Q96AX9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000378712; ENSP00000367984; ENSG00000197530 [Q96AX9-10]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		142678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:142678

UCSC genome browser

More...UCSCi		uc001agg.4, human [Q96AX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074480 mRNA Translation: BAB92950.1 Different initiation.
AB064367 mRNA Translation: BAB82979.1 Frameshift.
AB076691 mRNA Translation: BAC00992.1 Different initiation.
AB076692 mRNA Translation: BAC00993.1 Different initiation.
AB076693 mRNA Translation: BAC00994.1 Different initiation.
AB097000 mRNA Translation: BAC77353.1 Different initiation.
AK091610 mRNA Translation: BAC03707.1 Different initiation.
AK095914 mRNA Translation: BAC04646.1 Different initiation.
AK096295 mRNA Translation: BAC04752.1 Different initiation.
AK097106 mRNA Translation: BAC04952.1 Different initiation.
AK098785 mRNA Translation: BAC05413.1
AK122751 mRNA Translation: BAG53705.1
AK122863 mRNA Translation: BAG53766.1 Different initiation.
AK128167 mRNA Translation: BAG54643.1
AK302757 mRNA Translation: BAG63969.1 Different initiation.
AL691432 Genomic DNA No translation available.
BC016490 mRNA Translation: AAH16490.1 Different initiation.
BC037542 mRNA Translation: AAH37542.1 Different initiation.
AL834527 mRNA Translation: CAD39183.1
CCDSiCCDS53264.1 [Q96AX9-10]
RefSeqiNP_001164157.1, NM_001170686.1 [Q96AX9-3]
NP_001164158.1, NM_001170687.1
NP_001164159.1, NM_001170688.1
NP_001164160.1, NM_001170689.1 [Q96AX9-10]
NP_543151.2, NM_080875.2 [Q96AX9-1]

3D structure databases

SMRiQ96AX9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126769, 55 interactors
IntActiQ96AX9, 17 interactors
STRINGi9606.ENSP00000426103

PTM databases

iPTMnetiQ96AX9
PhosphoSitePlusiQ96AX9

Genetic variation databases

BioMutaiMIB2
DMDMi209572707

Proteomic databases

jPOSTiQ96AX9
MassIVEiQ96AX9
MaxQBiQ96AX9
PaxDbiQ96AX9
PeptideAtlasiQ96AX9
PRIDEiQ96AX9
ProteomicsDBi20393
20580
30446
3825
76009 [Q96AX9-1]
76011 [Q96AX9-3]
76012 [Q96AX9-4]
76013 [Q96AX9-5]
76014 [Q96AX9-6]
76015 [Q96AX9-7]
76016 [Q96AX9-8]
76017 [Q96AX9-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26451, 107 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		142678

Genome annotation databases

EnsembliENST00000378712; ENSP00000367984; ENSG00000197530 [Q96AX9-10]
GeneIDi142678
KEGGihsa:142678
UCSCiuc001agg.4, human [Q96AX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		142678
DisGeNETi142678

GeneCards: human genes, protein and diseases

More...GeneCardsi		MIB2
HGNCiHGNC:30577, MIB2
HPAiENSG00000197530, Tissue enhanced (skeletal)
MalaCardsiMIB2
MIMi611141, gene
neXtProtiNX_Q96AX9
OpenTargetsiENSG00000197530
Orphaneti54260, Left ventricular noncompaction
PharmGKBiPA134924284
VEuPathDBiHostDB:ENSG00000197530

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
KOG4582, Eukaryota
GeneTreeiENSGT00940000158097
InParanoidiQ96AX9
OrthoDBi220300at2759
PhylomeDBiQ96AX9
TreeFamiTF324147

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ96AX9
ReactomeiR-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ96AX9
SIGNORiQ96AX9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		142678, 23 hits in 1087 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MIB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MIB2_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		142678
PharosiQ96AX9, Tbio

Protein Ontology

More...PROi		PR:Q96AX9
RNActiQ96AX9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197530, Expressed in pituitary gland and 183 other tissues
ExpressionAtlasiQ96AX9, baseline and differential
GenevisibleiQ96AX9, HS

Family and domain databases

CDDicd02339, ZZ_Mind_bomb, 1 hit
Gene3Di1.25.40.20, 3 hits
3.30.40.10, 2 hits
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR042056, MIB1/2_ZZ
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR040847, SH3_15
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF13637, Ank_4, 1 hit
PF13857, Ank_5, 1 hit
PF06701, MIB_HERC2, 2 hits
PF18346, SH3_15, 2 hits
PF00569, ZZ, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 9 hits
SM00184, RING, 2 hits
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF159034, SSF159034, 2 hits
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS51416, MIB_HERC2, 2 hits
PS50089, ZF_RING_2, 2 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96AX9
Secondary accession number(s): A2AGM5
, A2AGM6, B3KV93, B3KVF4, B3KXY1, B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7, Q7Z437, Q8IY62, Q8N786, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 23, 2022
Last modified: February 23, 2022
This is version 184 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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